P14207 (FOLR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Folate receptor beta
Short name=FR-beta

Alternative name(s):
Folate receptor 2
Folate receptor, fetal/placental
Placental folate-binding protein
Short name=FBP

Gene names

Name:

FOLR2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor. Secreted Probable Ref.5.
Tissue specificity	Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
Post-translational modification	Eight disulfide bonds are present Probable. N-glycosylated.
Sequence similarities	Belongs to the folate receptor family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Folate-binding
Molecular function	Receptor
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	folic acid transport Traceable author statement. Source: ProtInc
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane fraction Traceable author statement. Source: ProtInc plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	folic acid binding Traceable author statement. Source: ProtInc receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16
	Chain	17 – 230	214	Folate receptor beta		PRO_0000008806
	Propeptide	231 – 255	25	Removed in mature form		PRO_0000008807
Amino acid modifications
	Lipidation	230	1	GPI-anchor amidated asparagine Ref.5
	Glycosylation	115	1	N-linked (GlcNAc...) Potential
	Glycosylation	195	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	236	1	H → N in a breast cancer sample; somatic mutation. Ref.7		VAR_036408
Experimental info
	Sequence conflict	103	1	C → V AA sequence Ref.4
	Sequence conflict	111 – 112	2	IQ → VR AA sequence Ref.4
	Sequence conflict	115	1	N → D AA sequence Ref.4
	Sequence conflict	117	1	S → T in AAA35821. Ref.2
	Sequence conflict	117	1	S → T in AAA17370. Ref.3
	Sequence conflict	117	1	S → T AA sequence Ref.4
	Sequence conflict	141	1	H → L in AAA17370. Ref.3
	Sequence conflict	244	1	S → R in AAA17370. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P14207 [UniParc]. Last modified October 17, 2006. Version 4. Checksum: F585715CF5631C98	FASTA	255	29,280
	10 20 30 40 50 60 MVWKWMPLLL LLVCVATMCS AQDRTDLLNV CMDAKHHKTK PGPEDKLHDQ CSPWKKNACC 70 80 90 100 110 120 TASTSQELHK DTSRLYNFNW DHCGKMEPAC KRHFIQDTCL YECSPNLGPW IQQVNQSWRK 130 140 150 160 170 180 ERFLDVPLCK EDCQRWWEDC HTSHTCKSNW HRGWDWTSGV NKCPAGALCR TFESYFPTPA 190 200 210 220 230 240 ALCEGLWSHS YKVSNYSRGS GRCIQMWFDS AQGNPNEEVA RFYAAAMHVN AGEMLHGTGG 250 LLLSLALMLQ LWLLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene." Page S.T., Owen W.C., Price K., Elwood P.C. J. Mol. Biol. 229:1175-1183(1993) [PubMed: 8445646] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA." Ratnam M., Marquardt H., Duhring J.L., Freisheim J.H. Biochemistry 28:8249-8254(1989) [PubMed: 2605182] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Placenta.
[3]	"Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein." Sadasivan E., Cedeno M.M., Rothenberg S.P. J. Biol. Chem. 269:4725-4735(1994) [PubMed: 8106441] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[4]	"Folate coenzyme and antifolate transport proteins in normal and neoplastic cells." Freisheim J.H., Price E.M., Ratnam M. Adv. Enzyme Regul. 29:13-26(1989) [PubMed: 2561247] [Abstract] Cited for: PROTEIN SEQUENCE OF 68-86; 102-120 AND 173-184.
[5]	"Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal." Yan W., Ratnam M. Biochemistry 34:14594-14600(1995) [PubMed: 7578066] [Abstract] Cited for: GPI-ANCHOR AT ASN-230.
[6]	"Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion." Wang J., Shen F., Yan W., Wu M., Ratnam M. Biochemistry 36:14583-14592(1997) [PubMed: 9398177] [Abstract] Cited for: PROTEOLYTIC PROCESSING.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-236.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69516 Genomic DNA. Translation: CAA49267.1. J02876 mRNA. Translation: AAA35821.1. U02714, U02716 Genomic DNA. Translation: AAA17370.1.
IPI	IPI00784257.
PIR	A33417. A53315.
RefSeq	NP_000794.3. NM_000803.4. NP_001107006.1. NM_001113534.1. NP_001107007.1. NM_001113535.1. NP_001107008.1. NM_001113536.1.
UniGene	Hs.433159.
3D structure databases
ProteinModelPortal	P14207.
ModBase	Search...
Protein-protein interaction databases
STRING	P14207.
Polymorphism databases
DMDM	116241366.
Proteomic databases
PRIDE	P14207.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298223; ENSP00000298223; ENSG00000165457. ENST00000413873; ENSP00000412980; ENSG00000165457. ENST00000449475; ENSP00000405638; ENSG00000165457. ENST00000454954; ENSP00000414094; ENSG00000165457.
GeneID	2350.
KEGG	hsa:2350.
UCSC	uc001ose.2. human.
Organism-specific databases
CTD	2350.
GeneCards	GC11P071927.
H-InvDB	HIX0035968.
HGNC	HGNC:3793. FOLR2.
MIM	136425. gene.
neXtProt	NX_P14207.
PharmGKB	PA28209.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG447315.
HOVERGEN	HBG039612.
InParanoid	P14207.
OMA	CRTFEAY.
OrthoDB	EOG4HDSV6.
PhylomeDB	P14207.
Gene expression databases
ArrayExpress	P14207.
Bgee	P14207.
CleanEx	HS_FOLR2.
Genevestigator	P14207.
GermOnline	ENSG00000165457. Homo sapiens.
Family and domain databases
InterPro	IPR004269. Folate_rcpt. IPR018143. Folate_rcpt-like. [Graphical view]
KO	K13649.
PANTHER	PTHR10517. Folt_rcpt. 1 hit.
Pfam	PF03024. Folate_rec. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00158. Folic Acid.
NextBio	9533.
SOURCE	Search...

Entry information

Entry name

FOLR2_HUMAN

Accession

Primary (citable) accession number: P14207

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 112 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.