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P14204

- CMPA_BACSU

UniProt

P14204 - CMPA_BACSU

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Protein

Transcriptional regulatory protein ComA

Gene
comA, comA1, comAA, BSU31680
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates indirectly, through the regulation of comK transcription, the expression of late competence genes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi171 – 19020H-T-H motif By similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. phosphorelay response regulator activity Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. establishment of competence for transformation Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Competence, Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU31680-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein ComA
Alternative name(s):
Competence protein A
Gene namesi
Name:comA
Synonyms:comA1, comAA
Ordered Locus Names:BSU31680
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU31680. [Micado]

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Transcriptional regulatory protein ComAPRO_0000081075Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 5514-aspartylphosphate By similarity

Post-translational modificationi

Phosphorylated by ComP.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP14204.

Interactioni

Protein-protein interaction databases

DIPiDIP-59430N.
IntActiP14204. 1 interaction.
STRINGi224308.BSU31680.

Structurei

Secondary structure

1
214
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi150 – 1545
Helixi156 – 16611
Helixi171 – 1788
Helixi182 – 19514
Helixi201 – 2088

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KRFNMR-A/B146-214[»]
3ULQX-ray2.30B146-214[»]
ProteinModelPortaliP14204.
SMRiP14204. Positions 2-214.

Miscellaneous databases

EvolutionaryTraceiP14204.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 121119Response regulatoryAdd
BLAST
Domaini147 – 21266HTH luxR-typeAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2197.
HOGENOMiHOG000034813.
KOiK07691.
OMAiQRSIEYT.
OrthoDBiEOG69GZGV.
PhylomeDBiP14204.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14204-1 [UniParc]FASTAAdd to Basket

« Hide

MKKILVIDDH PAVMEGTKTI LETDSNLSVD CLSPEPSEQF IKQHDFSSYD    50
LILMDLNLGG EVNGMELSKQ ILQENPHCKI IVYTGYEVED YFEEAIRAGL 100
HGAISKTESK EKITQYIYHV LNGEILVDFA YFKQLMTQQK TKPAPSSQKE 150
QDVLTPRECL ILQEVEKGFT NQEIADALHL SKRSIEYSLT SIFNKLNVGS 200
RTEAVLIAKS DGVL 214
Length:214
Mass (Da):24,129
Last modified:January 1, 1990 - v1
Checksum:i52D01A9740759072
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22856 Genomic DNA. Translation: AAA22320.1.
Z93932 Genomic DNA. Translation: CAB07904.1.
AL009126 Genomic DNA. Translation: CAB15156.1.
PIRiA33591. RGBSCA.
RefSeqiNP_391046.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15156; CAB15156; BSU31680.
GeneIDi937179.
KEGGibsu:BSU31680.
PATRICi18978306. VBIBacSub10457_3316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22856 Genomic DNA. Translation: AAA22320.1 .
Z93932 Genomic DNA. Translation: CAB07904.1 .
AL009126 Genomic DNA. Translation: CAB15156.1 .
PIRi A33591. RGBSCA.
RefSeqi NP_391046.1. NC_000964.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KRF NMR - A/B 146-214 [» ]
3ULQ X-ray 2.30 B 146-214 [» ]
ProteinModelPortali P14204.
SMRi P14204. Positions 2-214.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59430N.
IntActi P14204. 1 interaction.
STRINGi 224308.BSU31680.

Proteomic databases

PaxDbi P14204.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15156 ; CAB15156 ; BSU31680 .
GeneIDi 937179.
KEGGi bsu:BSU31680.
PATRICi 18978306. VBIBacSub10457_3316.

Organism-specific databases

GenoListi BSU31680. [Micado ]

Phylogenomic databases

eggNOGi COG2197.
HOGENOMi HOG000034813.
KOi K07691.
OMAi QRSIEYT.
OrthoDBi EOG69GZGV.
PhylomeDBi P14204.

Enzyme and pathway databases

BioCyci BSUB:BSU31680-MONOMER.

Miscellaneous databases

EvolutionaryTracei P14204.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view ]
PRINTSi PR00038. HTHLUXR.
SMARTi SM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view ]
SUPFAMi SSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEi PS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and transcription mapping of Bacillus subtilis competence genes comB and comA, one of which is related to a family of bacterial regulatory determinants."
    Weinrauch Y., Guillen N., Dubnau D.
    J. Bacteriol. 171:5362-5375(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai)."
    Oudega B., Koningstein G., Rodrigues L., de Sales Ramon M., Hilbert H., Duesterhoeft A., Pohl T.M., Weitzenegger T.
    Microbiology 143:2769-2774(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "Conservation of genes and processes controlled by the quorum response in bacteria: characterization of genes controlled by the quorum-sensing transcription factor ComA in Bacillus subtilis."
    Comella N., Grossman A.D.
    Mol. Microbiol. 57:1159-1174(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCMPA_BACSU
AccessioniPrimary (citable) accession number: P14204
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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