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Protein

Protein ref(2)P

Gene

ref(2)P

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri121 – 16747ZZ-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • mitochondrion organization Source: FlyBase
  • positive regulation of macroautophagy Source: GO_Central
  • sperm mitochondrion organization Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
  • ubiquitin-dependent protein catabolic process Source: GO_Central
  • viral life cycle Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ref(2)P
Alternative name(s):
Refractory to sigma P
Gene namesi
Name:ref(2)P
ORF Names:CG10360
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0003231. ref(2)P.

Subcellular locationi

GO - Cellular componenti

  • aggresome Source: GO_Central
  • autophagosome Source: FlyBase
  • cytoplasm Source: FlyBase
  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Males are sterile, spermatids exhibit degenerated mitochondria. Reduced activation of the Drs promoter.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Protein ref(2)PPRO_0000097237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei447 – 4471Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP14199.
PRIDEiP14199.

PTM databases

iPTMnetiP14199.

Expressioni

Gene expression databases

BgeeiFBgn0003231.
GenevisibleiP14199. DM.

Interactioni

Subunit structurei

Interacts with aPKC and Traf6.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi61223. 26 interactions.
DIPiDIP-18088N.
IntActiP14199. 3 interactions.
MINTiMINT-747563.
STRINGi7227.FBpp0080794.

Structurei

3D structure databases

ProteinModelPortaliP14199.
SMRiP14199. Positions 122-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8886PB1PROSITE-ProRule annotationAdd
BLAST
Repeati386 – 39381
Repeati399 – 40682
Repeati407 – 41373
Domaini550 – 59546UBAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni386 – 413283 X 8 AA repeats of S-A-N-Q-S-X-X-PAdd
BLAST

Sequence similaritiesi

Contains 1 PB1 domain.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri121 – 16747ZZ-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQZA. Eukaryota.
ENOG410XWHN. LUCA.
InParanoidiP14199.
OMAiNEGAWLT.
OrthoDBiEOG091G08ES.
PhylomeDBiP14199.

Family and domain databases

InterProiIPR000270. PB1_dom.
IPR015940. UBA.
IPR009060. UBA-like.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00165. UBA. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50030. UBA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEKLLKITY QGAGPQKKIN AYLRMPSQNY TILRREIELY LFQERQLPKC
60 70 80 90 100
DVRTFWIDAD KDEIEIVNQN DYEIFLAKCE SNMHVQVAPL APVEEPKATK
110 120 130 140 150
QEGSSANAEA PSVDDPSNFT IHDAVECDGC GLAPLIGFRY KCVQCSNYDL
160 170 180 190 200
CQKCELAHKH PEHLMLRMPT NNGPGMVDAW FTGPGLGRRS GRRSRGHCPF
210 220 230 240 250
QETNQADPAG EPARDSRRER RQARRHAGVL TQFVEMMTNL PLNTTTATAP
260 270 280 290 300
AEPQKPKAAE QTESPPQAEP TVTAEKAAES EAKPTEPKKV NTDQSVPRTE
310 320 330 340 350
DPVTTPRSTQ PTTPVINLDN ISQIVPPEYM SAGIEILNNF SEMFSKIIDT
360 370 380 390 400
TEGGDSGIFA PSTTPSAENK KPEEQGQSSG QSGASSANQS AVPSAAPSAN
410 420 430 440 450
QSNVPSANQS ATPSISGSIP DAQLETEPLN PKPSETTTET EQERRRSDSL
460 470 480 490 500
DPEWQLIDNA YSANNSNLIN LDTTNPTAAP QEPVRDFGQL GELLRQHMNE
510 520 530 540 550
EARVEQASAN TQTAQVDTVS TSTSTTSVTT NSVGTSPAAP DDKRTVPVYH
560 570 580 590
TDESINKSIH AMMAMGFSNE GAWLTQLLES VQGNISAALD VMNVSQNRN
Length:599
Mass (Da):65,303
Last modified:January 23, 2002 - v2
Checksum:i946043CE19AAF126
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881R → S in CAA34861 (PubMed:2510997).Curated

Polymorphismi

Polymorphic for two allelic forms in natural populations of Drosophila melanogaster, ref2Po and ref2Pp. The latter allele confers resistance to the rhabdovirus sigma infecting wild populations.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 292QN → G in BPL_1D, BPL_2B, BPL_3E, BPL_3F, BPL_5A, BPL_5D, BPL_5F, BPL_6D, BPL_6E, BPL_7F, BPL_8A, BPL_8C, BPL_9H, BPL_10D, BPL_10G, BPL_11D, BPL_12B, BPL_13A, BPL_13F, Florida1Slow and Paris. 3 Publications
Natural varianti32 – 321I → A in strain: AfricaFast, BPL_1A, BPL_1B, BPL_1D, BPL_1G, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_4A, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5D, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7C, BPL_7E, BPL_7F, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_9A, BPL_9C, BPL_9F, BPL_9H, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_11B, BPL_11C, BPL_11D, BPL_11E, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_13A, BPL_13D, BPL_13F, FloridaFast, Florida1Slow, Paris and WashingtonFast. 3 Publications
Natural varianti32 – 321I → M in strain: JapanSlow. 1 Publication
Natural varianti32 – 321I → V in strain: BPL_1D, BPL_2B, BPL_3E, BPL_3F, BPL_9H, BPL_10D, BPL_10G, BPL_11D, BPL_12B and BPL_13A.
Natural varianti43 – 431Q → L in strain: AfricaFast, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_11B, BPL_11C, BPL_11D, BPL_11E, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_13A, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1D, BPL_1G, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3A, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_4A, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5D, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7C, BPL_7E, BPL_7F, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_9A, BPL_9C, BPL_9F, BPL_9H, Florida1Slow, FloridaFast, JapanSlow, Oregon-R, Paris and WashingtonFast. 4 Publications
Natural varianti60 – 601D → Y in strain: BPL_1A, BPL_1G, BPL_2A, BPL_2G, BPL_2H, BPL_3C, BPL_4A, BPL_4C, BPL_4G, BPL_5H, BPL_6H, BPL_7C, BPL_10E, BPL_11C, BPL_11H, BPL_12A and WashingtonFast. 2 Publications
Natural varianti79 – 791C → R in strain: BPL_1B, BPL_9F and BPL_13D. 1 Publication
Natural varianti186 – 1927Missing in strain: Paris. 2 Publications
Natural varianti231 – 2311T → S in strain: BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_10H, BPL_11B, BPL_11C, BPL_11D, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_13A, BPL_13C, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1C, BPL_1D, BPL_1E, BPL_1G, BPL_1H, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3A, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_3G, BPL_3H, BPL_4A, BPL_4B, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5D, BPL_5E, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7B, BPL_7C, BPL_7E, BPL_7F, BPL_7H, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_8G, BPL_9A, BPL_9C, BPL_9F, BPL_9H, FrenchSlow and Paris. 3 Publications
Natural varianti247 – 2471A → D in strain: BPL_7A, BPL_9D, BPL_10A and BPL_11E. 1 Publication
Natural varianti274 – 2741A → V in strain: BPL_1E. 1 Publication
Natural varianti290 – 2901V → D in strain: BPL_3G. 1 Publication
Natural varianti331 – 3311S → R in strain: AfricaFast, AfricaSlow, BPL_10A, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_10H, BPL_11B, BPL_11C, BPL_11D, BPL_11E, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_12F, BPL_13A, BPL_13B, BPL_13C, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1C, BPL_1D, BPL_1E, BPL_1F, BPL_1G, BPL_1H, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2F, BPL_2G, BPL_2H, BPL_3A, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_3G, BPL_3H, BPL_4A, BPL_4B, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5B, BPL_5D, BPL_5E, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7A, BPL_7B, BPL_7C, BPL_7E, BPL_7F, BPL_7G, BPL_7H, BPL_8A, BPL_8B, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_8G, BPL_8H, BPL_9A, BPL_9B, BPL_9C, BPL_9D, BPL_9F, BPL_9H, Florida1Slow, Florida2Slow, FloridaFast, FrenchFast, FrenchSlow, JapanFast, JapanSlow, Paris and WashingtonFast. 3 Publications
Natural varianti356 – 3561S → L in strain: BPL_6H, BPL_7C, BPL_11F and BPL_12A. 1 Publication
Natural varianti389 – 3891Q → E in strain: BPL_1C. 1 Publication
Natural varianti393 – 3931P → L in strain: BPL_1H, BPL_3H, BPL_4B, BPL_5E, BPL_7B, BPL_7H, BPL_8G, BPL_10H and BPL_13C. 1 Publication
Natural varianti397 – 3971P → S in strain: FrenchSlow. 1 Publication
Natural varianti403 – 4108Missing in strain: AfricaFast, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_11B, BPL_11D, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12C, BPL_13A, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1G, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3A, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_4A, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5B, BPL_5D, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6F, BPL_6H, BPL_7C, BPL_7E, BPL_7F, BPL_7G, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_9A, BPL_9C, BPL_9F, BPL_9H, Florida1Slow, Florida2Slow, FloridaFast, Paris and WashingtonFast. 3 Publications
Natural varianti432 – 4321K → M in strain: FrenchFast. 2 Publications
Natural varianti444 – 4441R → I in strain: BPL_3B and BPL_8F. 1 Publication
Natural varianti542 – 5421D → E in strain: AfricaSlow, AfricaFast, FloridaFast, Florida1Slow, Florida2Slow, FrenchSlow, JapanSlow, Paris and WashingtonFast. 2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16993 Genomic DNA. Translation: CAA34861.1.
X69828 Genomic DNA. Translation: CAA49482.1.
X69829 mRNA. Translation: CAA49483.1.
X69830 mRNA. Translation: CAA49484.1.
U23923 Genomic DNA. Translation: AAA98832.1.
U23924 Genomic DNA. Translation: AAA98833.1.
U23925 Genomic DNA. Translation: AAA98834.1.
U23926 Genomic DNA. Translation: AAA98835.1.
U23927 Genomic DNA. Translation: AAA98836.1.
U23928 Genomic DNA. Translation: AAA98837.1.
U23929 Genomic DNA. Translation: AAA98838.1.
U23931 Genomic DNA. Translation: AAA98839.1.
U23932 Genomic DNA. Translation: AAA98840.1.
U23933 Genomic DNA. Translation: AAA98841.1.
AE014134 Genomic DNA. Translation: AAF53824.1.
AE014134 Genomic DNA. Translation: AAX52671.1.
AY089494 mRNA. Translation: AAL90232.1.
AM114104 Genomic DNA. Translation: CAJ34995.2.
AM114105 Genomic DNA. Translation: CAJ34996.2.
AM114106 Genomic DNA. Translation: CAJ34997.2.
AM114107 Genomic DNA. Translation: CAJ34998.2.
AM114108 Genomic DNA. Translation: CAJ34999.2.
AM114109 Genomic DNA. Translation: CAJ35000.2.
AM114110 Genomic DNA. Translation: CAJ35001.2.
AM114111 Genomic DNA. Translation: CAJ35002.2.
AM114112 Genomic DNA. Translation: CAJ35003.2.
AM114113 Genomic DNA. Translation: CAJ35004.2.
AM114114 Genomic DNA. Translation: CAJ35005.2.
AM114115 Genomic DNA. Translation: CAJ35006.2.
AM114116 Genomic DNA. Translation: CAJ35007.2.
AM114117 Genomic DNA. Translation: CAJ35008.2.
AM114118 Genomic DNA. Translation: CAJ35009.2.
AM114119 Genomic DNA. Translation: CAJ35010.2.
AM114120 Genomic DNA. Translation: CAJ35011.1.
AM114120 Genomic DNA. Translation: CAJ38290.1.
AM114121 Genomic DNA. Translation: CAJ35012.2.
AM114122 Genomic DNA. Translation: CAJ35013.2.
AM114123 Genomic DNA. Translation: CAJ35014.2.
AM114124 Genomic DNA. Translation: CAJ35015.2.
AM114125 Genomic DNA. Translation: CAJ35016.2.
AM114126 Genomic DNA. Translation: CAJ35017.2.
AM114127 Genomic DNA. Translation: CAJ35018.2.
AM114128 Genomic DNA. Translation: CAJ35019.2.
AM114129 Genomic DNA. Translation: CAJ35020.2.
AM114130 Genomic DNA. Translation: CAJ35021.2.
AM114131 Genomic DNA. Translation: CAJ35022.2.
AM114132 Genomic DNA. Translation: CAJ35023.2.
AM114133 Genomic DNA. Translation: CAJ35024.2.
AM114134 Genomic DNA. Translation: CAJ35025.2.
AM114135 Genomic DNA. Translation: CAJ35026.2.
AM114136 Genomic DNA. Translation: CAJ35027.2.
AM114137 Genomic DNA. Translation: CAJ35028.2.
AM114138 Genomic DNA. Translation: CAJ35029.2.
AM114139 Genomic DNA. Translation: CAJ35030.2.
AM114140 Genomic DNA. Translation: CAJ35031.2.
AM114141 Genomic DNA. Translation: CAJ35032.2.
AM114142 Genomic DNA. Translation: CAJ35033.2.
AM114143 Genomic DNA. Translation: CAJ35034.2.
AM114144 Genomic DNA. Translation: CAJ35035.2.
AM114145 Genomic DNA. Translation: CAJ35036.2.
AM114146 Genomic DNA. Translation: CAJ35037.2.
AM114147 Genomic DNA. Translation: CAJ35038.2.
AM114148 Genomic DNA. Translation: CAJ35039.2.
AM114149 Genomic DNA. Translation: CAJ35040.2.
AM114150 Genomic DNA. Translation: CAJ35041.2.
AM114151 Genomic DNA. Translation: CAJ35042.2.
AM114152 Genomic DNA. Translation: CAJ35043.2.
AM114153 Genomic DNA. Translation: CAJ35044.2.
AM114154 Genomic DNA. Translation: CAJ35045.2.
AM114155 Genomic DNA. Translation: CAJ35046.2.
AM114156 Genomic DNA. Translation: CAJ35047.2.
AM114157 Genomic DNA. Translation: CAJ35048.2.
AM114158 Genomic DNA. Translation: CAJ35049.2.
AM114159 Genomic DNA. Translation: CAJ35050.2.
AM114160 Genomic DNA. Translation: CAJ35051.2.
AM114161 Genomic DNA. Translation: CAJ35052.2.
AM114162 Genomic DNA. Translation: CAJ35053.2.
AM114163 Genomic DNA. Translation: CAJ35054.2.
AM114164 Genomic DNA. Translation: CAJ35055.1.
AM114164 Genomic DNA. Translation: CAJ38334.1.
AM114165 Genomic DNA. Translation: CAJ35056.2.
AM114166 Genomic DNA. Translation: CAJ35057.2.
AM114167 Genomic DNA. Translation: CAJ35058.2.
AM114168 Genomic DNA. Translation: CAJ35059.2.
AM114169 Genomic DNA. Translation: CAJ35060.2.
AM114170 Genomic DNA. Translation: CAJ35061.2.
AM114171 Genomic DNA. Translation: CAJ35062.2.
AM114172 Genomic DNA. Translation: CAJ35063.2.
AM114173 Genomic DNA. Translation: CAJ35064.2.
AM114174 Genomic DNA. Translation: CAJ35065.2.
AM114175 Genomic DNA. Translation: CAJ35066.2.
AM114176 Genomic DNA. Translation: CAJ35067.2.
AM114177 Genomic DNA. Translation: CAJ35068.2.
AM114178 Genomic DNA. Translation: CAJ35069.2.
AM114179 Genomic DNA. Translation: CAJ35070.2.
AM114180 Genomic DNA. Translation: CAJ35071.2.
AM114181 Genomic DNA. Translation: CAJ35072.2.
AM114182 Genomic DNA. Translation: CAJ35073.2.
AM114183 Genomic DNA. Translation: CAJ35074.2.
AM114184 Genomic DNA. Translation: CAJ35075.1.
AM114184 Genomic DNA. Translation: CAJ38354.1.
AM114185 Genomic DNA. Translation: CAJ35076.2.
AM114186 Genomic DNA. Translation: CAJ35077.2.
AM114187 Genomic DNA. Translation: CAJ35078.2.
AM114188 Genomic DNA. Translation: CAJ35079.1.
AM114188 Genomic DNA. Translation: CAJ38358.1.
AM114189 Genomic DNA. Translation: CAJ35080.2.
AM114190 Genomic DNA. Translation: CAJ35081.2.
AM114191 Genomic DNA. Translation: CAJ35082.2.
PIRiS06785.
S33562. S29961.
S33563. S29963.
S33564. S29964.
RefSeqiNP_001014491.1. NM_001014491.2.
NP_476700.1. NM_057352.4.
UniGeneiDm.12210.

Genome annotation databases

EnsemblMetazoaiFBtr0081253; FBpp0080794; FBgn0003231.
FBtr0100289; FBpp0099683; FBgn0003231.
GeneIDi35246.
KEGGidme:Dmel_CG10360.
UCSCiCG10360-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16993 Genomic DNA. Translation: CAA34861.1.
X69828 Genomic DNA. Translation: CAA49482.1.
X69829 mRNA. Translation: CAA49483.1.
X69830 mRNA. Translation: CAA49484.1.
U23923 Genomic DNA. Translation: AAA98832.1.
U23924 Genomic DNA. Translation: AAA98833.1.
U23925 Genomic DNA. Translation: AAA98834.1.
U23926 Genomic DNA. Translation: AAA98835.1.
U23927 Genomic DNA. Translation: AAA98836.1.
U23928 Genomic DNA. Translation: AAA98837.1.
U23929 Genomic DNA. Translation: AAA98838.1.
U23931 Genomic DNA. Translation: AAA98839.1.
U23932 Genomic DNA. Translation: AAA98840.1.
U23933 Genomic DNA. Translation: AAA98841.1.
AE014134 Genomic DNA. Translation: AAF53824.1.
AE014134 Genomic DNA. Translation: AAX52671.1.
AY089494 mRNA. Translation: AAL90232.1.
AM114104 Genomic DNA. Translation: CAJ34995.2.
AM114105 Genomic DNA. Translation: CAJ34996.2.
AM114106 Genomic DNA. Translation: CAJ34997.2.
AM114107 Genomic DNA. Translation: CAJ34998.2.
AM114108 Genomic DNA. Translation: CAJ34999.2.
AM114109 Genomic DNA. Translation: CAJ35000.2.
AM114110 Genomic DNA. Translation: CAJ35001.2.
AM114111 Genomic DNA. Translation: CAJ35002.2.
AM114112 Genomic DNA. Translation: CAJ35003.2.
AM114113 Genomic DNA. Translation: CAJ35004.2.
AM114114 Genomic DNA. Translation: CAJ35005.2.
AM114115 Genomic DNA. Translation: CAJ35006.2.
AM114116 Genomic DNA. Translation: CAJ35007.2.
AM114117 Genomic DNA. Translation: CAJ35008.2.
AM114118 Genomic DNA. Translation: CAJ35009.2.
AM114119 Genomic DNA. Translation: CAJ35010.2.
AM114120 Genomic DNA. Translation: CAJ35011.1.
AM114120 Genomic DNA. Translation: CAJ38290.1.
AM114121 Genomic DNA. Translation: CAJ35012.2.
AM114122 Genomic DNA. Translation: CAJ35013.2.
AM114123 Genomic DNA. Translation: CAJ35014.2.
AM114124 Genomic DNA. Translation: CAJ35015.2.
AM114125 Genomic DNA. Translation: CAJ35016.2.
AM114126 Genomic DNA. Translation: CAJ35017.2.
AM114127 Genomic DNA. Translation: CAJ35018.2.
AM114128 Genomic DNA. Translation: CAJ35019.2.
AM114129 Genomic DNA. Translation: CAJ35020.2.
AM114130 Genomic DNA. Translation: CAJ35021.2.
AM114131 Genomic DNA. Translation: CAJ35022.2.
AM114132 Genomic DNA. Translation: CAJ35023.2.
AM114133 Genomic DNA. Translation: CAJ35024.2.
AM114134 Genomic DNA. Translation: CAJ35025.2.
AM114135 Genomic DNA. Translation: CAJ35026.2.
AM114136 Genomic DNA. Translation: CAJ35027.2.
AM114137 Genomic DNA. Translation: CAJ35028.2.
AM114138 Genomic DNA. Translation: CAJ35029.2.
AM114139 Genomic DNA. Translation: CAJ35030.2.
AM114140 Genomic DNA. Translation: CAJ35031.2.
AM114141 Genomic DNA. Translation: CAJ35032.2.
AM114142 Genomic DNA. Translation: CAJ35033.2.
AM114143 Genomic DNA. Translation: CAJ35034.2.
AM114144 Genomic DNA. Translation: CAJ35035.2.
AM114145 Genomic DNA. Translation: CAJ35036.2.
AM114146 Genomic DNA. Translation: CAJ35037.2.
AM114147 Genomic DNA. Translation: CAJ35038.2.
AM114148 Genomic DNA. Translation: CAJ35039.2.
AM114149 Genomic DNA. Translation: CAJ35040.2.
AM114150 Genomic DNA. Translation: CAJ35041.2.
AM114151 Genomic DNA. Translation: CAJ35042.2.
AM114152 Genomic DNA. Translation: CAJ35043.2.
AM114153 Genomic DNA. Translation: CAJ35044.2.
AM114154 Genomic DNA. Translation: CAJ35045.2.
AM114155 Genomic DNA. Translation: CAJ35046.2.
AM114156 Genomic DNA. Translation: CAJ35047.2.
AM114157 Genomic DNA. Translation: CAJ35048.2.
AM114158 Genomic DNA. Translation: CAJ35049.2.
AM114159 Genomic DNA. Translation: CAJ35050.2.
AM114160 Genomic DNA. Translation: CAJ35051.2.
AM114161 Genomic DNA. Translation: CAJ35052.2.
AM114162 Genomic DNA. Translation: CAJ35053.2.
AM114163 Genomic DNA. Translation: CAJ35054.2.
AM114164 Genomic DNA. Translation: CAJ35055.1.
AM114164 Genomic DNA. Translation: CAJ38334.1.
AM114165 Genomic DNA. Translation: CAJ35056.2.
AM114166 Genomic DNA. Translation: CAJ35057.2.
AM114167 Genomic DNA. Translation: CAJ35058.2.
AM114168 Genomic DNA. Translation: CAJ35059.2.
AM114169 Genomic DNA. Translation: CAJ35060.2.
AM114170 Genomic DNA. Translation: CAJ35061.2.
AM114171 Genomic DNA. Translation: CAJ35062.2.
AM114172 Genomic DNA. Translation: CAJ35063.2.
AM114173 Genomic DNA. Translation: CAJ35064.2.
AM114174 Genomic DNA. Translation: CAJ35065.2.
AM114175 Genomic DNA. Translation: CAJ35066.2.
AM114176 Genomic DNA. Translation: CAJ35067.2.
AM114177 Genomic DNA. Translation: CAJ35068.2.
AM114178 Genomic DNA. Translation: CAJ35069.2.
AM114179 Genomic DNA. Translation: CAJ35070.2.
AM114180 Genomic DNA. Translation: CAJ35071.2.
AM114181 Genomic DNA. Translation: CAJ35072.2.
AM114182 Genomic DNA. Translation: CAJ35073.2.
AM114183 Genomic DNA. Translation: CAJ35074.2.
AM114184 Genomic DNA. Translation: CAJ35075.1.
AM114184 Genomic DNA. Translation: CAJ38354.1.
AM114185 Genomic DNA. Translation: CAJ35076.2.
AM114186 Genomic DNA. Translation: CAJ35077.2.
AM114187 Genomic DNA. Translation: CAJ35078.2.
AM114188 Genomic DNA. Translation: CAJ35079.1.
AM114188 Genomic DNA. Translation: CAJ38358.1.
AM114189 Genomic DNA. Translation: CAJ35080.2.
AM114190 Genomic DNA. Translation: CAJ35081.2.
AM114191 Genomic DNA. Translation: CAJ35082.2.
PIRiS06785.
S33562. S29961.
S33563. S29963.
S33564. S29964.
RefSeqiNP_001014491.1. NM_001014491.2.
NP_476700.1. NM_057352.4.
UniGeneiDm.12210.

3D structure databases

ProteinModelPortaliP14199.
SMRiP14199. Positions 122-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61223. 26 interactions.
DIPiDIP-18088N.
IntActiP14199. 3 interactions.
MINTiMINT-747563.
STRINGi7227.FBpp0080794.

PTM databases

iPTMnetiP14199.

Proteomic databases

PaxDbiP14199.
PRIDEiP14199.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081253; FBpp0080794; FBgn0003231.
FBtr0100289; FBpp0099683; FBgn0003231.
GeneIDi35246.
KEGGidme:Dmel_CG10360.
UCSCiCG10360-RB. d. melanogaster.

Organism-specific databases

CTDi35246.
FlyBaseiFBgn0003231. ref(2)P.

Phylogenomic databases

eggNOGiENOG410IQZA. Eukaryota.
ENOG410XWHN. LUCA.
InParanoidiP14199.
OMAiNEGAWLT.
OrthoDBiEOG091G08ES.
PhylomeDBiP14199.

Miscellaneous databases

GenomeRNAii35246.
PROiP14199.

Gene expression databases

BgeeiFBgn0003231.
GenevisibleiP14199. DM.

Family and domain databases

InterProiIPR000270. PB1_dom.
IPR015940. UBA.
IPR009060. UBA-like.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00165. UBA. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50030. UBA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREF2P_DROME
AccessioniPrimary (citable) accession number: P14199
Secondary accession number(s): A6PX28
, A6PX29, A6PX30, A6PX31, A6PX32, A6PX33, A6PX35, A6PX37, A6PX38, A6PX44, A6PX45, A6PX46, A6PX51, A6PX56, A6PX61, A6PX72, A6PX73, A6PX89, A6PX90, A6PXA2, A6PXA4, A6PXB0, A6PXB1, Q04576, Q04577, Q04578, Q24063, Q24064, Q24065, Q24066, Q24067, Q24068, Q24069, Q24070, Q24071, Q24072, Q541D1, Q9VIU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2002
Last modified: September 7, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.