P14198 (AAC4_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
AAC-rich mRNA clone AAC4 protein

Gene names

Name:	AAC4
ORF Names:	DDB_G0267458

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	678 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Developmental stage	The concentration of AAC-rich mRNAs is low in dormant spores and growing cells, but increases during spore-germination and multicellular development. Ref.2
Miscellaneous	Several proteins derive from AAC-rich mRNA, which, due to a frameshift also have ACA and CAA codons and thus are Asn-, Thr- or Gln-rich.
Sequence caution	The sequence CAA34530.1 differs from that shown. Reason: Frameshift at position 251.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 678	678	AAC-rich mRNA clone AAC4 protein		PRO_0000064414
Regions
	Transmembrane	243 – 263	21	Helical; Potential
	Compositional bias	54 – 73	20	Poly-Asn
	Compositional bias	124 – 128	5	Poly-Glu
	Compositional bias	314 – 341	28	Poly-Asn
Experimental info
	Sequence conflict	51	1	K → E in CAA34530. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P14198 [UniParc]. Last modified January 19, 2010. Version 3. Checksum: A34C8F9C74796DD8	FASTA	678	77,544
	10 20 30 40 50 60 MSLSNNQTQF VTVFVPIQLS IDVFRKMNNI NSFVNDNLTN FPIVTVDQLI KVVNNNNNNN 70 80 90 100 110 120 NNNNNNNNNN NNNTSISNNG DINNCLATFE QVQNNCFETC DFKATEREHY FASGKQIQES 130 140 150 160 170 180 VLPEEEEEKI SVNNFAMVTV EPNNCFVKAQ QINSVAPLSL DNRNCVRRAH REVNTFVQVF 190 200 210 220 230 240 DVCVFNLKVV NVATNESQVN LFNGGNVENI CFDRSIQMPR SSADDFDWSS QQQSSWYSLA 250 260 270 280 290 300 LSIIPIYHEI ILVLCNWLVV AFYKYWQHQQ QKQLPPHPLN IIVPNVSKRI AVNLNNQLIS 310 320 330 340 350 360 LTFTNFLKNI FFLNNNNNNN NNNNNNNNNN NNNNNNNNNN NKTNNNQLNL SKEICNENLN 370 380 390 400 410 420 FEEFNFEDES VCKYNRLTNS CENISKIQQV NEESELLDWF SDFEEMDSVL LQNGTEFDND 430 440 450 460 470 480 HPMVKSQAPS ITFKSLDQFI KYLEENNCVD DIEVSPCSKS HTFNRPVSTP RLIIKPTWCV 490 500 510 520 530 540 YGDSLNTEFF HSCLKDKTCG DIIVDHFEPL VSSPTDFLLS NGGQRILDTP NAGGSSVWSE 550 560 570 580 590 600 VLSFEVLNQV FGAQLKKTET EIEYAPGSKI TDFSVDINNS HIGVSVVRII NFFDLNGRTY 610 620 630 640 650 660 KAVFTPEYAR NLLYKKLFGV IASTEAVVDK WEKQILYVWT TSSCVADIIV QEYWKVPAKL 670 RSNTLVYVNH ATNSEFLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"Nucleotide sequences of Dictyostelium discoideum developmentally regulated cDNAs rich in (AAC) imply proteins that contain clusters of asparagine, glutamine, or threonine." Shaw D.R., Richter H., Giorda R., Ohmachi T., Ennis H.L. Mol. Gen. Genet. 218:453-459(1989) [PubMed: 2511421] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-312, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000003 Genomic DNA. Translation: EEU04156.1. X16523 mRNA. Translation: CAA34530.1. Frameshift.
PIR	S05356.
RefSeq	XP_002649206.2. XM_002649160.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0305015; DDB0305015; DDB_G0267458.
GeneID	8615872.
GenomeReviews	Gene locus AAC4 in contig CM000150_GR.
KEGG	ddi:DDB_G0267458.
Organism-specific databases
dictyBase	DDB_G0267458.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

AAC4_DICDI

Accession

Primary (citable) accession number: P14198
Secondary accession number(s): C7FZW0, Q55GW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 19, 2010
Last modified:	November 16, 2011
This is version 46 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)