P14197 (AAC3_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein AAC3

Alternative name(s):
AAC-rich mRNA clone AAC3 protein

Gene names

Name:	AAC3
ORF Names:	DDB_G0276031

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Developmental stage	The concentration of AAC-rich mRNAs is low in dormant spores and growing cells, but increases during spore-germination and multicellular development. Ref.3
Miscellaneous	Several proteins derive from AAC-rich mRNA, which, due to a frameshift also have ACA and CAA codons and thus are Asn-, Thr- or Gln-rich.
Sequence similarities	Contains 7 WD repeats.

Ontologies

Keywords
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	WD repeat-containing protein AAC3		PRO_0000050830
Regions
	Repeat	163 – 202	40	WD 1
	Repeat	226 – 268	43	WD 2
	Repeat	270 – 307	38	WD 3
	Repeat	310 – 349	40	WD 4
	Repeat	357 – 396	40	WD 5
	Repeat	399 – 438	40	WD 6
	Repeat	440 – 478	39	WD 7
	Compositional bias	30 – 116	87	Gln-rich
	Compositional bias	199 – 217	19	Asn-rich

Sequences

	Sequence		Length	Mass (Da)
	P14197 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: 6B67D7BFDDED38EA	FASTA	478	53,771
	10 20 30 40 50 60 MGSRLNPSSN MYIPMNGPRG GYYGMPSMGQ LQHPLFNYQF PPGGFQHLQQ QQQQQQQQQQ 70 80 90 100 110 120 QQQQQQQQQT QVQQLHNQLH QQHNQQIQQQ AQATQQHLQT QQYLQSQIHQ QSQQSQLSNN 130 140 150 160 170 180 LNSNSKESTN IPKTNTQYTN FDSKNLDLAS RYFSECSTKD FIGNKKKSTS VAWNANGTKI 190 200 210 220 230 240 ASSGSDGIVR VWNFDPLGNS NNNNNSNNTS SNSKNNNIKE TIELKGHDGS IEKISWSPKN 250 260 270 280 290 300 NDLLASAGTD KVIKIWDVKI GKCIGTVSTN SENIDVRWSP DGQFIVACTR DDHLALIDLP 310 320 330 340 350 360 TIKTLKIYKF NGEELNQVGW DNNGDLILMA NSMGNIEAYK FLPKSTTHVK HLKTLYGHTA 370 380 390 400 410 420 SIYCMEFDPT GKYLAAGSAD SIVSLWDIED MMCVKTFIKS TFPCRSVSFS FDGQFIAASS 430 440 450 460 470 FESTIEIFHI ESSQPIHTIE CSGVSSLMWH PTLPLLAYAP EINENNKDPS IRVFGYHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"Nucleotide sequences of Dictyostelium discoideum developmentally regulated cDNAs rich in (AAC) imply proteins that contain clusters of asparagine, glutamine, or threonine." Shaw D.R., Richter H., Giorda R., Ohmachi T., Ennis H.L. Mol. Gen. Genet. 218:453-459(1989) [PubMed: 2511421] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-478, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000014 Genomic DNA. Translation: EAL69315.1. X16524 mRNA. Translation: CAA34531.1.
PIR	S05357.
RefSeq	XP_643326.1. XM_638234.1.
3D structure databases
ProteinModelPortal	P14197.
ModBase	Search...
Protein-protein interaction databases
STRING	P14197.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0185151; DDB0185151; DDB_G0276031.
GeneID	8620373.
GenomeReviews	Gene locus AAC3 in contig CM000151_GR.
KEGG	ddi:DDB_G0276031.
Organism-specific databases
dictyBase	DDB_G0276031.
Phylogenomic databases
eggNOG	KOG1407.
GeneTree	EPrGT00060000009869.
HOGENOM	HBG738639.
OMA	LILMANS.
PhylomeDB	P14197.
ProtClustDB	CLSZ2430924.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KO	K12880.
Pfam	PF00400. WD40. 5 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 5 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAC3_DICDI

Accession

Primary (citable) accession number: P14197
Secondary accession number(s): Q552A2, Q75JM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	December 4, 2007
Last modified:	January 25, 2012
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)