Reviewed, UniProtKB/Swiss-Prot P14196 (AAC2_DICDI)

Names and origin

Protein names

Recommended name:
    AAC-rich mRNA clone AAC11 protein

Gene names

Name:	AAC11
ORF Names:	DDB_G0284871

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Developmental stage	The concentration of AAC-rich mRNAs is low in dormant spores and growing cells, but increases during spore-germination and multicellular development.
Miscellaneous	Several proteins derive from AAC-rich mRNA, which, due to a frameshift also have ACA and CAA codons and thus are Asn-, Thr- or Gln-rich.
Sequence similarities	Contains 4 A.T hook DNA-binding domains.
Sequence caution	The sequence CAA34529.1 differs from that shown. Reason: Frameshift at positions 42 and 50.

Ontologies

Keywords
Domain	Repeat
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromatin Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	AAC-rich mRNA clone AAC11 protein		PRO_0000206716
Regions
	DNA binding	177 – 189	13	A.T hook 1
	DNA binding	198 – 210	13	A.T hook 2
	DNA binding	224 – 236	13	A.T hook 3
	DNA binding	255 – 267	13	A.T hook 4
	Compositional bias	11 – 65	55	Gln-rich
	Compositional bias	78 – 442	365	Asn-rich
Experimental info
	Sequence conflict	267	1	D → E in CAA34529. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P14196-1 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: 2D50A1A2AA4DDD4A	FASTA	464	50,619
	10 20 30 40 50 60 MSTPTLPNLS QLHGIQNQSL QQQQQQQPQQ QQQPQQQQQQ QQPQQTMQQP IQNLHQQAPQ 70 80 90 100 110 120 MQQPQYNLHT TLPPPLMNPN GLGLMGHNMM GGGNNGNNSG NNNGQPQMHG TNLNGLSLAI 130 140 150 160 170 180 QNQSSLPQPI NNNNNNNNNN SNINNNNNNS NNNNNNNNSN LGINSSPTQS SANSADKRSR 190 200 210 220 230 240 GRPRKNPPSE PKDTSGPKRK RGRPPKMDEE GNPQPKPVPQ PGSNKKRGRP KKPKDENESD 250 260 270 280 290 300 YNNTSFSDSN TDGTPKKRGR PPKAKGDSPS ASPTHNTLGN GILNSNNNNN NNNNNSNINN 310 320 330 340 350 360 INNNNNNNSN NNNNSSNNNN NNNNSTNNNT NNNNNNTNNN TNNNNNNINN NNNNTNNNNN 370 380 390 400 410 420 NANNQNTNNN NMGNNSNNNN NPNNNNHQNN NNNNTSNNSN TTTATTTAPG GNNLTNSLNN 430 440 450 460 AGNLGNLGRV SGLHSSDPNN PNAQKSFPDS TNTMDFQPNF SFFH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"Nucleotide sequences of Dictyostelium discoideum developmentally regulated cDNAs rich in (AAC) imply proteins that contain clusters of asparagine, glutamine, or threonine." Shaw D.R., Richter H., Giorda R., Ohmachi T., Ennis H.L. Mol. Gen. Genet. 218:453-459(1989) [PubMed: 2511421] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-464.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAFI02000073 Genomic DNA. Translation: EAL64899.1. X16522 mRNA. Translation: CAA34529.1. Frameshift.
PIR	S05355.
RefSeq	XP_639980.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3391002.
GenomeReviews	Gene locus AAC11 in contig CM000153_GR.
KEGG	ddi:DDB_0191407.
Organism-specific databases
dictyBase	DDB_G0284871. AAC11.
Phylogenomic databases
OMA	INIDEDI.
Family and domain databases
InterPro	IPR020478. A.T_hook_like. IPR017956. AT_hook_DNA-bd_motif. IPR000116. HMGI/HMGY. [Graphical view]
Pfam	PF02178. AT_hook. 3 hits. [Graphical view]
PRINTS	PR00929. ATHOOK. PR00930. HIGHMOBLTYIY.
SMART	SM00384. AT_hook. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAC2_DICDI

Accession

Primary (citable) accession number: P14196
Secondary accession number(s): Q54NT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	December 4, 2007
Last modified:	November 24, 2009
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)