P14195 (AAC1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-rich repeat-containing protein AAC1

Alternative name(s):
AAC-rich mRNA clone AAC1 protein

Gene names

Name:	AAC1
ORF Names:	DDB_G0291860

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	797 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Developmental stage	The concentration of AAC-rich mRNAs is low in dormant spores and growing cells, but increases during spore-germination and multicellular development. Ref.2
Miscellaneous	Several proteins derive from AAC-rich mRNA, which, due to a frameshift also have ACA and CAA codons and thus are Asn-, Thr- or Gln-rich.
Sequence similarities	Contains 10 LRR (leucine-rich) repeats.

Ontologies

Keywords
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 797	797	Leucine-rich repeat-containing protein AAC1		PRO_0000064408
Regions
	Repeat	376 – 397	22	LRR 1
	Repeat	406 – 425	20	LRR 2
	Repeat	435 – 456	22	LRR 3
	Repeat	464 – 484	21	LRR 4
	Repeat	492 – 513	22	LRR 5
	Repeat	514 – 535	22	LRR 6
	Repeat	543 – 564	22	LRR 7
	Repeat	572 – 593	22	LRR 8
	Repeat	601 – 622	22	LRR 9
	Repeat	633 – 653	21	LRR 10
	Compositional bias	19 – 165	147	Thr-rich
	Compositional bias	312 – 334	23	Pro-rich
	Compositional bias	345 – 350	6	Poly-Thr
	Compositional bias	355 – 384	30	Asn-rich
	Compositional bias	667 – 749	83	Asn-rich
Experimental info
	Sequence conflict	141 – 146	6	Missing in CAA34532. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P14195 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: 0CCB0676C5C581FF	FASTA	797	89,497
	10 20 30 40 50 60 MKRTSNRNEE ATAKLSSSTT ITTTTTNKYY NMANAEKSSK STTISNLIPK YSLFNEPNND 70 80 90 100 110 120 NDTNSSTRPN KQQKLLKSNE STTSTTTTTT PITTTTTTTT TTTTPNLSKY YNYNLYIEKQ 130 140 150 160 170 180 NEKQNLPTTE TETTTITPTL TTTTTTTTTT TTTTTKQIQN TTTSTINHFL PLIIQKEIIF 190 200 210 220 230 240 LLVELGSFLN ARKVCKYWKK VCNGCVENLN IYFTDIHLSA SVKHVSEVFV KSLNSDYFHL 250 260 270 280 290 300 QSVSFINGAK NSISYSEFYF NNVILPFIEN VVRYNQTIEN FTIKGFPITR INNKSSQQLL 310 320 330 340 350 360 PSYKLYHSTS VPSSPPPPPP PPPPQIQQPT ITAPTSTTAI AVSSTTTTAT GQTLNNNNNN 370 380 390 400 410 420 NNIPKGLNYY LTNNFKLKKI NLKNIGLDSR DKFDFFSSLS SSVNNTLETL IICDNIGDEG 430 440 450 460 470 480 MQLLSVILIK NLLKVLKRLE LQKNQFTNQS AYYLNKVLSC EQLQLETLNL SSNRIDEQGL 490 500 510 520 530 540 IMMKDGFGRN KSLKEFIFSK NRLGNTDSVD FGKSITSLDL HDSMVGSKQS IKGLSQYLKF 550 560 570 580 590 600 NESITSLNLS FNHIGSNEAI KSLSKSFAVN QTLKFVDLSF NKINSNFGLD HLVSSLLINH 610 620 630 640 650 660 SIHSISLQSN QIDNTSAITL SQLFNSSRQL FSPFKYLNLS GNKIGIGGLK KLINDLSKYS 670 680 690 700 710 720 KTHIIYNNND DNNNNKNENE NKSKIKNLSF NNNNNNFVKI IKNYHDTIPI IRTINNSNGK 730 740 750 760 770 780 NLLEEEVEQV INSSSNDTNQ NDNINNENNL TEISIDLSSN SPLEVSKVIG LIPRYKSKLT 790 FADRKPVKKY KLVKLLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"Nucleotide sequences of Dictyostelium discoideum developmentally regulated cDNAs rich in (AAC) imply proteins that contain clusters of asparagine, glutamine, or threonine." Shaw D.R., Richter H., Giorda R., Ohmachi T., Ennis H.L. Mol. Gen. Genet. 218:453-459(1989) [PubMed: 2511421] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-248, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000186 Genomic DNA. Translation: EAL61460.1. X16525 mRNA. Translation: CAA34532.1.
PIR	S05358.
RefSeq	XP_629873.1. XM_629871.1.
3D structure databases
ProteinModelPortal	P14195.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0201568; DDB0201568; DDB_G0291860.
GeneID	8628371.
GenomeReviews	Gene locus AAC1 in contig CM000155_GR.
KEGG	ddi:DDB_G0291860.
Organism-specific databases
dictyBase	DDB_G0291860.
Phylogenomic databases
GeneTree	EPrGT00050000001255.
PhylomeDB	P14195.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

AAC1_DICDI

Accession

Primary (citable) accession number: P14195
Secondary accession number(s): Q54E23

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	December 4, 2007
Last modified:	September 21, 2011
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)