Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c heme lyase

Gene

cyt-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Links covalently the heme group to the apoprotein of cytochrome c.

Catalytic activityi

Holocytochrome c = apocytochrome c + heme.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c heme lyase (EC:4.4.1.17)
Short name:
CCHL
Alternative name(s):
Holocytochrome-c synthase
Gene namesi
Name:cyt-2
ORF Names:NCU05601
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 5, Linkage Group VI

Organism-specific databases

EuPathDBiFungiDB:NCU05601.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Cytochrome c heme lyasePRO_0000121715Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 396HRM 1
Repeati66 – 716HRM 2

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000170352.
InParanoidiP14187.
KOiK01764.
OMAiEYVECPI.
OrthoDBiEOG72NS19.

Family and domain databases

InterProiIPR000511. Cyt_C/C1_haem_lyase.
[Graphical view]
PANTHERiPTHR12743. PTHR12743. 3 hits.
PfamiPF01265. Cyto_heme_lyase. 1 hit.
[Graphical view]
PROSITEiPS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14187-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWFWADGNA SAAAPVVPPS HKDLAASGAV PPPSCPMHNK TMDALSAHKP
60 70 80 90 100
VTPAPEPTPA AAAPSKCPVN HGAKDTLAAA AAAVAPKQPQ PENHQPAAAS
110 120 130 140 150
EPSFFSKLNP LNYMFSSISQ EPAPNQAIAL PTERDPSSIP KGTGDGNWEY
160 170 180 190 200
PSPQQMYNAL LRKGYTDTDI TAVESMVAVH NFLNEGAWNE IVEWERRFGK
210 220 230 240 250
GLMRGWEIMK RGEENAPMML RRLEAQENDP EPQPTLIRFQ GRPKDMTPKA
260 270 280 290 300
ALLQVLGRIN SKYATEPPFD RHDWYVSRDE NGQKKEVRYV IDFYSAPPEP
310 320 330 340
TGEPVFYLDV RPAVTVTGAC ERLLRWGGDV WWKASGGEVR ERERSK
Length:346
Mass (Da):38,147
Last modified:January 1, 1990 - v1
Checksum:i9A6167BF3A3C05D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05075 Genomic DNA. Translation: AAA33583.1.
CM002241 Genomic DNA. Translation: EAA31327.1.
PIRiA34365.
RefSeqiXP_960563.1. XM_955470.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000005563; EFNCRP00000005557; EFNCRG00000005553.
GeneIDi3876678.
KEGGincr:NCU05601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05075 Genomic DNA. Translation: AAA33583.1.
CM002241 Genomic DNA. Translation: EAA31327.1.
PIRiA34365.
RefSeqiXP_960563.1. XM_955470.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000005563; EFNCRP00000005557; EFNCRG00000005553.
GeneIDi3876678.
KEGGincr:NCU05601.

Organism-specific databases

EuPathDBiFungiDB:NCU05601.

Phylogenomic databases

HOGENOMiHOG000170352.
InParanoidiP14187.
KOiK01764.
OMAiEYVECPI.
OrthoDBiEOG72NS19.

Family and domain databases

InterProiIPR000511. Cyt_C/C1_haem_lyase.
[Graphical view]
PANTHERiPTHR12743. PTHR12743. 3 hits.
PfamiPF01265. Cyto_heme_lyase. 1 hit.
[Graphical view]
PROSITEiPS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and analysis of the Neurospora crassa gene for cytochrome c heme lyase."
    Drygas M.E., Lambowitz A.M., Nargang F.E.
    J. Biol. Chem. 264:17897-17906(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiCCHL_NEUCR
AccessioniPrimary (citable) accession number: P14187
Secondary accession number(s): Q7RVB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 11, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.