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P14176

- PROW_ECOLI

UniProt

P14176 - PROW_ECOLI

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Protein

Glycine betaine/L-proline transport system permease protein ProW

Gene

proW

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline.

GO - Molecular functioni

  1. transporter activity Source: EcoCyc

GO - Biological processi

  1. amino acid transport Source: UniProtKB-KW
  2. response to osmotic stress Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:PROW-MONOMER.
ECOL316407:JW2653-MONOMER.
MetaCyc:PROW-MONOMER.
RETL1328306-WGS:GSTH-4736-MONOMER.

Protein family/group databases

TCDBi3.A.1.12.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine betaine/L-proline transport system permease protein ProW
Gene namesi
Name:proW
Ordered Locus Names:b2678, JW2653
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10772. proW.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9999CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini121 – 1211PeriplasmicSequence Analysis
Transmembranei122 – 14221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini143 – 1508CytoplasmicSequence Analysis
Transmembranei151 – 17121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini172 – 19827PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini220 – 27051CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei271 – 29121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini292 – 3009PeriplasmicSequence Analysis
Transmembranei301 – 32121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini322 – 35433CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Glycine betaine/L-proline transport system permease protein ProWPRO_0000060191Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP14176.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
proVP141752EBI-8794761,EBI-546797

Protein-protein interaction databases

IntActiP14176. 1 interaction.
STRINGi511145.b2678.

Structurei

3D structure databases

ProteinModelPortaliP14176.
SMRiP14176. Positions 148-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 324180ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4176.
HOGENOMiHOG000279300.
InParanoidiP14176.
KOiK02001.
OMAiHFNIMDP.
OrthoDBiEOG6H4KBG.
PhylomeDBiP14176.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14176-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADQNNPWDT TPAADSAAQS ADAWGTPTTA PTDGGGADWL TSTPAPNVEH
60 70 80 90 100
FNILDPFHKT LIPLDSWVTE GIDWVVTHFR PVFQGVRVPV DYILNGFQQL
110 120 130 140 150
LLGMPAPVAI IVFALIAWQI SGVGMGVATL VSLIAIGAIG AWSQAMVTLA
160 170 180 190 200
LVLTALLFCI VIGLPLGIWL ARSPRAAKII RPLLDAMQTT PAFVYLVPIV
210 220 230 240 250
MLFGIGNVPG VVVTIIFALP PIIRLTILGI NQVPADLIEA SRSFGASPRQ
260 270 280 290 300
MLFKVQLPLA MPTIMAGVNQ TLMLALSMVV IASMIAVGGL GQMVLRGIGR
310 320 330 340 350
LDMGLATVGG VGIVILAIIL DRLTQAVGRD SRSRGNRRWY TTGPVGLLTR

PFIK
Length:354
Mass (Da):37,620
Last modified:January 1, 1990 - v1
Checksum:iD35F94A74E2779D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24856 Genomic DNA. Translation: AAA24428.1.
U00096 Genomic DNA. Translation: AAC75725.1.
AP009048 Genomic DNA. Translation: BAA16543.1.
PIRiJS0129. MMECPW.
RefSeqiNP_417164.1. NC_000913.3.
YP_490893.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75725; AAC75725; b2678.
BAA16543; BAA16543; BAA16543.
GeneIDi12930455.
947145.
KEGGiecj:Y75_p2621.
eco:b2678.
PATRICi32120746. VBIEscCol129921_2770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24856 Genomic DNA. Translation: AAA24428.1 .
U00096 Genomic DNA. Translation: AAC75725.1 .
AP009048 Genomic DNA. Translation: BAA16543.1 .
PIRi JS0129. MMECPW.
RefSeqi NP_417164.1. NC_000913.3.
YP_490893.1. NC_007779.1.

3D structure databases

ProteinModelPortali P14176.
SMRi P14176. Positions 148-273.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P14176. 1 interaction.
STRINGi 511145.b2678.

Protein family/group databases

TCDBi 3.A.1.12.1. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75725 ; AAC75725 ; b2678 .
BAA16543 ; BAA16543 ; BAA16543 .
GeneIDi 12930455.
947145.
KEGGi ecj:Y75_p2621.
eco:b2678.
PATRICi 32120746. VBIEscCol129921_2770.

Organism-specific databases

EchoBASEi EB0765.
EcoGenei EG10772. proW.

Phylogenomic databases

eggNOGi COG4176.
HOGENOMi HOG000279300.
InParanoidi P14176.
KOi K02001.
OMAi HFNIMDP.
OrthoDBi EOG6H4KBG.
PhylomeDBi P14176.

Enzyme and pathway databases

BioCyci EcoCyc:PROW-MONOMER.
ECOL316407:JW2653-MONOMER.
MetaCyc:PROW-MONOMER.
RETL1328306-WGS:GSTH-4736-MONOMER.

Miscellaneous databases

PROi P14176.

Gene expression databases

Genevestigatori P14176.

Family and domain databases

Gene3Di 1.10.3720.10. 1 hit.
InterProi IPR000515. MetI-like.
[Graphical view ]
Pfami PF00528. BPD_transp_1. 1 hit.
[Graphical view ]
SUPFAMi SSF161098. SSF161098. 1 hit.
PROSITEi PS50928. ABC_TM1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the osmoregulatory proU operon of Escherichia coli."
    Gowrishankar J.
    J. Bacteriol. 171:1923-1931(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Erratum
    Gowrishankar J.
    J. Bacteriol. 172:1165-1165(1990)
  3. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiPROW_ECOLI
AccessioniPrimary (citable) accession number: P14176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3