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Protein

Glycine betaine/proline betaine transport system ATP-binding protein ProV

Gene

proV

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake (PubMed:3305496, PubMed:7898450, PubMed:23249124). Probably responsible for energy coupling to the transport system (Probable).Curated3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi61 – 68ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: UniProtKB-KW
  • glycine betaine transport Source: EcoCyc
  • hyperosmotic response Source: EcoCyc

Keywordsi

Biological processAmino-acid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:PROV-MONOMER
MetaCyc:PROV-MONOMER

Protein family/group databases

TCDBi3.A.1.12.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine betaine/proline betaine transport system ATP-binding protein ProVCurated
Gene namesi
Name:proV1 Publication
Ordered Locus Names:b2677, JW2652
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10771 proV

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000927611 – 400Glycine betaine/proline betaine transport system ATP-binding protein ProVAdd BLAST400

Proteomic databases

PaxDbiP14175
PRIDEiP14175

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (ProV), two transmembrane proteins (ProW) and a solute-binding protein (ProX).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
proWP141762EBI-546797,EBI-8794761

Protein-protein interaction databases

BioGridi4262264, 24 interactors
DIPiDIP-10574N
IntActiP14175, 6 interactors
STRINGi316407.1800065

Structurei

3D structure databases

ProteinModelPortaliP14175
SMRiP14175
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 265ABC transporterPROSITE-ProRule annotationAdd BLAST237
Domaini282 – 341CBS 1PROSITE-ProRule annotationAdd BLAST60
Domaini343 – 400CBS 2PROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiENOG4108IJ7 Bacteria
COG4175 LUCA
InParanoidiP14175
KOiK02000
OMAiYKVFGRR
PhylomeDBiP14175

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR000644 CBS_dom
IPR005892 Gly-betaine_transp_ATP-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
PF00571 CBS, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01186 proV, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51371 CBS, 2 hits

Sequencei

Sequence statusi: Complete.

P14175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKLEIKNL YKIFGEHPQR AFKYIEQGLS KEQILEKTGL SLGVKDASLA
60 70 80 90 100
IEEGEIFVIM GLSGSGKSTM VRLLNRLIEP TRGQVLIDGV DIAKISDAEL
110 120 130 140 150
REVRRKKIAM VFQSFALMPH MTVLDNTAFG MELAGINAEE RREKALDALR
160 170 180 190 200
QVGLENYAHS YPDELSGGMR QRVGLARALA INPDILLMDE AFSALDPLIR
210 220 230 240 250
TEMQDELVKL QAKHQRTIVF ISHDLDEAMR IGDRIAIMQN GEVVQVGTPD
260 270 280 290 300
EILNNPANDY VRTFFRGVDI SQVFSAKDIA RRTPNGLIRK TPGFGPRSAL
310 320 330 340 350
KLLQDEDREY GYVIERGNKF VGAVSIDSLK TALTQQQGLD AALIDAPLAV
360 370 380 390 400
DAQTPLSELL SHVGQAPCAV PVVDEDQQYV GIISKGMLLR ALDREGVNNG
Length:400
Mass (Da):44,163
Last modified:January 1, 1990 - v1
Checksum:i45A98D45F028B1B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24856 Genomic DNA Translation: AAA24427.1
U00096 Genomic DNA Translation: AAC75724.1
AP009048 Genomic DNA Translation: BAA16542.1
X52694 Genomic DNA Translation: CAA36923.1
PIRiJS0128 BVECPV
RefSeqiNP_417163.1, NC_000913.3
WP_000985494.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75724; AAC75724; b2677
BAA16542; BAA16542; BAA16542
GeneIDi947148
KEGGiecj:JW2652
eco:b2677
PATRICifig|1411691.4.peg.4064

Similar proteinsi

Entry informationi

Entry nameiPROV_ECOLI
AccessioniPrimary (citable) accession number: P14175
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: March 28, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health