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Protein

Macrophage migration inhibitory factor

Gene

MIF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.3 Publications

Catalytic activityi

Keto-phenylpyruvate = enol-phenylpyruvate.
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

Kineticsi

  1. KM=249 µM for phenylpyruvate1 Publication
  2. KM=168 µM for p-hydroxyphenylpyruvate1 Publication
  1. Vmax=2113 µmol/min/mg enzyme toward phenylpyruvate1 Publication
  2. Vmax=524 µmol/min/mg enzyme toward p-hydroxyphenylpyruvate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Proton acceptor; via imino nitrogen1
Binding sitei33Substrate1
Binding sitei65Substrate; via amide nitrogen1
Binding sitei98Substrate1

GO - Molecular functioni

  • chemoattractant activity Source: BHF-UCL
  • cytokine activity Source: UniProtKB
  • cytokine receptor binding Source: BHF-UCL
  • dopachrome isomerase activity Source: UniProtKB
  • phenylpyruvate tautomerase activity Source: MGI
  • receptor binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Isomerase

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:HS01940-MONOMER.
BRENDAi5.3.2.1. 2681.
5.3.3.12. 2681.
ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-6798695. Neutrophil degranulation.
SIGNORiP14174.

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage migration inhibitory factor (EC:5.3.2.1)
Short name:
MIF
Alternative name(s):
Glycosylation-inhibiting factor
Short name:
GIF
L-dopachrome isomerase
L-dopachrome tautomerase (EC:5.3.3.12)
Phenylpyruvate tautomerase
Gene namesi
Name:MIF
Synonyms:GLIF, MMIF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:7097. MIF.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB-KW
  • myelin sheath Source: Ensembl
  • nucleoplasm Source: HPA
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Involvement in diseasei

Rheumatoid arthritis systemic juvenile (RASJ)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.Curated
Disease descriptionAn inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
See also OMIM:604302

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi111N → C: Causes formation of interchain disulfide bonds with Cys-81 from another subunit. 1 Publication1

Organism-specific databases

DisGeNETi4282.
MalaCardsiMIF.
MIMi604302. phenotype.
OpenTargetsiENSG00000240972.
ENSG00000276701.
Orphaneti85414. Systemic-onset juvenile idiopathic arthritis.
PharmGKBiPA30819.

Chemistry databases

ChEMBLiCHEMBL2085.

Polymorphism and mutation databases

DMDMi1170955.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00001580622 – 115Macrophage migration inhibitory factorAdd BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78N6-acetyllysine; alternateCombined sources1
Modified residuei78N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP14174.
MaxQBiP14174.
PaxDbiP14174.
PeptideAtlasiP14174.
PRIDEiP14174.
TopDownProteomicsiP14174.

2D gel databases

SWISS-2DPAGEP14174.

PTM databases

iPTMnetiP14174.
PhosphoSitePlusiP14174.
SwissPalmiP14174.

Expressioni

Inductioni

Up-regulated in concanavalin-A-treated lymphocytes. Up-regulated in macrophages upon exposure to M.tuberculosis antigens.2 Publications

Gene expression databases

BgeeiENSG00000240972.
CleanExiHS_MIF.
ExpressionAtlasiP14174. baseline and differential.
GenevisibleiP14174. HS.

Organism-specific databases

HPAiCAB005284.
HPA003868.

Interactioni

Subunit structurei

Homotrimer. Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, COPS5 and BNIPL.By similarity8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L11O43521-25EBI-372712,EBI-526420

GO - Molecular functioni

  • cytokine activity Source: UniProtKB
  • cytokine receptor binding Source: BHF-UCL
  • receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi110428. 57 interactors.
DIPiDIP-31137N.
IntActiP14174. 20 interactors.
MINTiMINT-5000040.
STRINGi9606.ENSP00000215754.

Chemistry databases

BindingDBiP14174.

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 10Combined sources8
Helixi12 – 14Combined sources3
Helixi19 – 31Combined sources13
Helixi35 – 37Combined sources3
Beta strandi39 – 43Combined sources5
Beta strandi47 – 50Combined sources4
Beta strandi58 – 66Combined sources9
Helixi70 – 88Combined sources19
Helixi92 – 94Combined sources3
Beta strandi95 – 101Combined sources7
Helixi104 – 106Combined sources3
Beta strandi107 – 109Combined sources3
Beta strandi112 – 114Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CA7X-ray2.50A/B/C2-115[»]
1CGQX-ray2.00A/B/C2-115[»]
1GCZX-ray1.90A/B/C2-115[»]
1GD0X-ray1.50A/B/C2-115[»]
1GIFX-ray1.90A/B/C1-115[»]
1LJTX-ray2.00A/B/C2-115[»]
1MIFX-ray2.60A/B/C1-115[»]
1P1GX-ray2.50A/B/C2-115[»]
2OOHX-ray1.85A/B/C2-115[»]
2OOWX-ray1.75A/B/C2-115[»]
2OOZX-ray1.80A/B/C2-115[»]
3B9SX-ray1.80A/B/C2-115[»]
3CE4X-ray1.55A/B/C2-115[»]
3DJHX-ray1.25A/B/C2-115[»]
3DJIX-ray1.95A/B/C/D/E/F2-115[»]
3HOFX-ray1.90A/B/C1-115[»]
3IJGX-ray1.70A/B/C2-115[»]
3IJJX-ray1.25A/B/C2-115[»]
3JSFX-ray1.93A/B/C2-115[»]
3JSGX-ray1.58A/B/C2-115[»]
3JTUX-ray1.86A/B/C2-115[»]
3L5PX-ray1.80A/B/C2-115[»]
3L5RX-ray1.94A/B/C2-115[»]
3L5SX-ray1.86A/B/C2-115[»]
3L5TX-ray1.86A/B/C2-115[»]
3L5UX-ray1.90A/B/C2-115[»]
3L5VX-ray1.70A/B/C2-115[»]
3SMBX-ray1.60A/B/C2-115[»]
3SMCX-ray1.80A/B/C2-115[»]
3U18X-ray1.90A/B/C2-115[»]
3WNRX-ray2.01A/B/C2-115[»]
3WNSX-ray1.66A/B/C2-115[»]
3WNTX-ray2.07A/B/C2-115[»]
4ETGX-ray1.61A/B/C2-115[»]
4EUIX-ray1.70A/B/C2-115[»]
4EVGX-ray1.70A/B/C2-115[»]
4F2KX-ray1.53A/B/C2-115[»]
4GRNX-ray1.25A/B/C2-115[»]
4GROX-ray2.00A/B/C/D/E/F/G/H2-115[»]
4GRPX-ray1.27A/B/C2-115[»]
4GRQX-ray1.65A/B/C2-115[»]
4GRRX-ray1.47A/B/C3-115[»]
4GRUX-ray1.92A/B/C2-115[»]
4GUMX-ray2.33A/B/C/D/E/F/G/H/I2-115[»]
4K9GX-ray1.55A/B/C2-115[»]
4OSFX-ray1.62A/B/C2-115[»]
4OYQX-ray1.70A/B/C2-115[»]
4P01X-ray2.07A/B/C2-115[»]
4P0HX-ray1.93A/B/C2-115[»]
4PKKX-ray1.78A/B/C2-115[»]
4PKZX-ray1.90A/B/C2-115[»]
4PLUX-ray1.63A/B/C2-115[»]
4TRFX-ray1.63A/B/C2-115[»]
4TRUX-ray1.81A/B/C2-115[»]
4WR8X-ray2.60A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-115[»]
4WRBX-ray1.81A/B/C2-115[»]
4XX7X-ray1.77A/B/C2-115[»]
4XX8X-ray1.77A/B/C3-115[»]
4Z15X-ray1.60A/B/C3-115[»]
4Z1TX-ray1.50A/B/C3-115[»]
4Z1UX-ray2.05A/B/C/D/E/F3-115[»]
5B4OX-ray1.37A/B/C2-115[»]
5BS9X-ray1.98A/B/C2-115[»]
5BSCX-ray1.89A/B/C2-115[»]
5BSIX-ray2.00A/B/C/D/E/F/G/J2-115[»]
5BSJX-ray2.00A/B/C2-115[»]
5CG4X-ray2.50A/B/C2-115[»]
5EIZX-ray1.96A/B/C2-115[»]
5HVSX-ray1.75A/B/C2-115[»]
5HVTX-ray1.75A/B/C2-115[»]
5HVVX-ray1.90A/B/C3-115[»]
5J7PX-ray1.85A/B/C2-115[»]
5J7QX-ray2.05A/B/C2-115[»]
ProteinModelPortaliP14174.
SMRiP14174.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14174.

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
GeneTreeiENSGT00840000129866.
HOGENOMiHOG000112325.
HOVERGENiHBG003240.
InParanoidiP14174.
KOiK07253.
OMAiMGKPAQY.
OrthoDBiEOG091G0ZNJ.
PhylomeDBiP14174.
TreeFamiTF313853.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMFIVNTNV PRASVPDGFL SELTQQLAQA TGKPPQYIAV HVVPDQLMAF
60 70 80 90 100
GGSSEPCALC SLHSIGKIGG AQNRSYSKLL CGLLAERLRI SPDRVYINYY
110
DMNAANVGWN NSTFA
Length:115
Mass (Da):12,476
Last modified:January 23, 2007 - v4
Checksum:i56D51107C05286B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57 – 59CAL → WAF in ABQ95571 (Ref. 6) Curated3
Sequence conflicti67K → R in CAG46452 (Ref. 9) Curated1
Sequence conflicti79L → Q in CAG46452 (Ref. 9) Curated1
Sequence conflicti81C → F in ABQ95571 (Ref. 6) Curated1
Sequence conflicti106N → S in AAA36315 (PubMed:2552447).Curated1
Sequence conflicti113T → P in ABQ95571 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25639 mRNA. Translation: AAA36315.1.
L10612 mRNA. Translation: AAA35892.1.
Z23063 mRNA. Translation: CAA80598.1.
L19686 Genomic DNA. Translation: AAA21814.1.
AF469046 mRNA. Translation: AAL78635.1.
EF611126 mRNA. Translation: ABQ95571.1.
CR456520 mRNA. Translation: CAG30406.1.
AK311929 mRNA. Translation: BAG34870.1.
CR407644 mRNA. Translation: CAG28572.1.
CR541651 mRNA. Translation: CAG46452.1.
BT007148 mRNA. Translation: AAP35812.1.
DQ307455 Genomic DNA. Translation: ABB96245.1.
CH471095 Genomic DNA. Translation: EAW59620.1.
BC000447 mRNA. Translation: AAH00447.1.
BC007676 mRNA. Translation: AAH07676.1.
BC008914 mRNA. Translation: AAH08914.1.
BC013976 mRNA. Translation: AAH13976.1.
BC022414 mRNA. Translation: AAH22414.1.
BC053376 mRNA. Translation: AAH53376.1.
M95775 mRNA. Translation: AAA36179.1.
CCDSiCCDS13819.1.
PIRiA48793.
RefSeqiNP_002406.1. NM_002415.1.
UniGeneiHs.407995.

Genome annotation databases

EnsembliENST00000215754; ENSP00000215754; ENSG00000240972.
ENST00000613839; ENSP00000482779; ENSG00000276701.
GeneIDi4282.
KEGGihsa:4282.
UCSCiuc002zyr.2. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25639 mRNA. Translation: AAA36315.1.
L10612 mRNA. Translation: AAA35892.1.
Z23063 mRNA. Translation: CAA80598.1.
L19686 Genomic DNA. Translation: AAA21814.1.
AF469046 mRNA. Translation: AAL78635.1.
EF611126 mRNA. Translation: ABQ95571.1.
CR456520 mRNA. Translation: CAG30406.1.
AK311929 mRNA. Translation: BAG34870.1.
CR407644 mRNA. Translation: CAG28572.1.
CR541651 mRNA. Translation: CAG46452.1.
BT007148 mRNA. Translation: AAP35812.1.
DQ307455 Genomic DNA. Translation: ABB96245.1.
CH471095 Genomic DNA. Translation: EAW59620.1.
BC000447 mRNA. Translation: AAH00447.1.
BC007676 mRNA. Translation: AAH07676.1.
BC008914 mRNA. Translation: AAH08914.1.
BC013976 mRNA. Translation: AAH13976.1.
BC022414 mRNA. Translation: AAH22414.1.
BC053376 mRNA. Translation: AAH53376.1.
M95775 mRNA. Translation: AAA36179.1.
CCDSiCCDS13819.1.
PIRiA48793.
RefSeqiNP_002406.1. NM_002415.1.
UniGeneiHs.407995.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CA7X-ray2.50A/B/C2-115[»]
1CGQX-ray2.00A/B/C2-115[»]
1GCZX-ray1.90A/B/C2-115[»]
1GD0X-ray1.50A/B/C2-115[»]
1GIFX-ray1.90A/B/C1-115[»]
1LJTX-ray2.00A/B/C2-115[»]
1MIFX-ray2.60A/B/C1-115[»]
1P1GX-ray2.50A/B/C2-115[»]
2OOHX-ray1.85A/B/C2-115[»]
2OOWX-ray1.75A/B/C2-115[»]
2OOZX-ray1.80A/B/C2-115[»]
3B9SX-ray1.80A/B/C2-115[»]
3CE4X-ray1.55A/B/C2-115[»]
3DJHX-ray1.25A/B/C2-115[»]
3DJIX-ray1.95A/B/C/D/E/F2-115[»]
3HOFX-ray1.90A/B/C1-115[»]
3IJGX-ray1.70A/B/C2-115[»]
3IJJX-ray1.25A/B/C2-115[»]
3JSFX-ray1.93A/B/C2-115[»]
3JSGX-ray1.58A/B/C2-115[»]
3JTUX-ray1.86A/B/C2-115[»]
3L5PX-ray1.80A/B/C2-115[»]
3L5RX-ray1.94A/B/C2-115[»]
3L5SX-ray1.86A/B/C2-115[»]
3L5TX-ray1.86A/B/C2-115[»]
3L5UX-ray1.90A/B/C2-115[»]
3L5VX-ray1.70A/B/C2-115[»]
3SMBX-ray1.60A/B/C2-115[»]
3SMCX-ray1.80A/B/C2-115[»]
3U18X-ray1.90A/B/C2-115[»]
3WNRX-ray2.01A/B/C2-115[»]
3WNSX-ray1.66A/B/C2-115[»]
3WNTX-ray2.07A/B/C2-115[»]
4ETGX-ray1.61A/B/C2-115[»]
4EUIX-ray1.70A/B/C2-115[»]
4EVGX-ray1.70A/B/C2-115[»]
4F2KX-ray1.53A/B/C2-115[»]
4GRNX-ray1.25A/B/C2-115[»]
4GROX-ray2.00A/B/C/D/E/F/G/H2-115[»]
4GRPX-ray1.27A/B/C2-115[»]
4GRQX-ray1.65A/B/C2-115[»]
4GRRX-ray1.47A/B/C3-115[»]
4GRUX-ray1.92A/B/C2-115[»]
4GUMX-ray2.33A/B/C/D/E/F/G/H/I2-115[»]
4K9GX-ray1.55A/B/C2-115[»]
4OSFX-ray1.62A/B/C2-115[»]
4OYQX-ray1.70A/B/C2-115[»]
4P01X-ray2.07A/B/C2-115[»]
4P0HX-ray1.93A/B/C2-115[»]
4PKKX-ray1.78A/B/C2-115[»]
4PKZX-ray1.90A/B/C2-115[»]
4PLUX-ray1.63A/B/C2-115[»]
4TRFX-ray1.63A/B/C2-115[»]
4TRUX-ray1.81A/B/C2-115[»]
4WR8X-ray2.60A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-115[»]
4WRBX-ray1.81A/B/C2-115[»]
4XX7X-ray1.77A/B/C2-115[»]
4XX8X-ray1.77A/B/C3-115[»]
4Z15X-ray1.60A/B/C3-115[»]
4Z1TX-ray1.50A/B/C3-115[»]
4Z1UX-ray2.05A/B/C/D/E/F3-115[»]
5B4OX-ray1.37A/B/C2-115[»]
5BS9X-ray1.98A/B/C2-115[»]
5BSCX-ray1.89A/B/C2-115[»]
5BSIX-ray2.00A/B/C/D/E/F/G/J2-115[»]
5BSJX-ray2.00A/B/C2-115[»]
5CG4X-ray2.50A/B/C2-115[»]
5EIZX-ray1.96A/B/C2-115[»]
5HVSX-ray1.75A/B/C2-115[»]
5HVTX-ray1.75A/B/C2-115[»]
5HVVX-ray1.90A/B/C3-115[»]
5J7PX-ray1.85A/B/C2-115[»]
5J7QX-ray2.05A/B/C2-115[»]
ProteinModelPortaliP14174.
SMRiP14174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110428. 57 interactors.
DIPiDIP-31137N.
IntActiP14174. 20 interactors.
MINTiMINT-5000040.
STRINGi9606.ENSP00000215754.

Chemistry databases

BindingDBiP14174.
ChEMBLiCHEMBL2085.

PTM databases

iPTMnetiP14174.
PhosphoSitePlusiP14174.
SwissPalmiP14174.

Polymorphism and mutation databases

DMDMi1170955.

2D gel databases

SWISS-2DPAGEP14174.

Proteomic databases

EPDiP14174.
MaxQBiP14174.
PaxDbiP14174.
PeptideAtlasiP14174.
PRIDEiP14174.
TopDownProteomicsiP14174.

Protocols and materials databases

DNASUi4282.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215754; ENSP00000215754; ENSG00000240972.
ENST00000613839; ENSP00000482779; ENSG00000276701.
GeneIDi4282.
KEGGihsa:4282.
UCSCiuc002zyr.2. human.

Organism-specific databases

CTDi4282.
DisGeNETi4282.
GeneCardsiMIF.
H-InvDBHIX0041297.
HGNCiHGNC:7097. MIF.
HPAiCAB005284.
HPA003868.
MalaCardsiMIF.
MIMi153620. gene.
604302. phenotype.
neXtProtiNX_P14174.
OpenTargetsiENSG00000240972.
ENSG00000276701.
Orphaneti85414. Systemic-onset juvenile idiopathic arthritis.
PharmGKBiPA30819.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
GeneTreeiENSGT00840000129866.
HOGENOMiHOG000112325.
HOVERGENiHBG003240.
InParanoidiP14174.
KOiK07253.
OMAiMGKPAQY.
OrthoDBiEOG091G0ZNJ.
PhylomeDBiP14174.
TreeFamiTF313853.

Enzyme and pathway databases

BioCyciZFISH:HS01940-MONOMER.
BRENDAi5.3.2.1. 2681.
5.3.3.12. 2681.
ReactomeiR-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-6798695. Neutrophil degranulation.
SIGNORiP14174.

Miscellaneous databases

EvolutionaryTraceiP14174.
GeneWikiiMacrophage_migration_inhibitory_factor.
GenomeRNAii4282.
PROiP14174.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000240972.
CleanExiHS_MIF.
ExpressionAtlasiP14174. baseline and differential.
GenevisibleiP14174. HS.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIF_HUMAN
AccessioniPrimary (citable) accession number: P14174
Secondary accession number(s): A5Z1R8
, B2R4S3, Q2V4Y5, Q6FHV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 200 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Serum levels of MIF are elevated in patients with severe sepsis or septic shock. High levels of MIF are correlated with low survival. Drugs that inhibit tautomerase activity protect against death due to sepsis.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.