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P14164

- ABF1_YEAST

UniProt

P14164 - ABF1_YEAST

Protein

ARS-binding factor 1

Gene

ABF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 4 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    General regulatory factor (GRF) that contributes to transcriptional activation of a large number of genes, as well as to DNA replication, silencing and telomere structure. Involved in the transcription activation of a subset of ribosomal protein genes. Binds the ARS-elements found in many promoters. Binds to the sequence 5'-TCN7ACG-3'. Influences on genome-wide nucleosome occupancy and affects chromatin structure, and probably dynamics. As a component of the global genome repair (GGR) complex, promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. Component of the regulatory network controlling mitotic and meiotic cell cycle progression.12 Publications

    GO - Molecular functioni

    1. DNA replication origin binding Source: SGD
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: SGD
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: SGD
    4. sequence-specific DNA binding Source: SGD
    5. sequence-specific DNA binding, bending Source: SGD

    GO - Biological processi

    1. chromatin remodeling Source: SGD
    2. chromatin silencing at silent mating-type cassette Source: SGD
    3. DNA-dependent DNA replication Source: SGD
    4. global genome nucleotide-excision repair Source: SGD
    5. negative regulation of transcription from RNA polymerase II promoter Source: SGD
    6. positive regulation of transcription from RNA polymerase II promoter Source: SGD

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    DNA damage, DNA repair, DNA replication, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31897-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ARS-binding factor 1
    Alternative name(s):
    Bidirectionally acting factor 1
    DNA replication enhancer-binding protein OBF1
    SFB-B
    Gene namesi
    Name:ABF1
    Synonyms:BAF1, OBF1, REB2, SBF1
    Ordered Locus Names:YKL112W
    ORF Names:YKL505
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    SGDiS000001595. ABF1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleotide-excision repair factor 4 complex Source: SGD
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi57 – 571H → Q: Loss of DNA binding. 1 Publication
    Mutagenesisi71 – 711C → S: Loss of DNA binding. 1 Publication
    Mutagenesisi625 – 6251K → I: Leads to mislocalization into the cytoplasm. 1 Publication
    Mutagenesisi720 – 7201S → A: Strongly reduces phosphorylation by CK2. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 731731ARS-binding factor 1PRO_0000064807Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei189 – 1891Phosphothreonine2 Publications
    Modified residuei193 – 1931Phosphoserine2 Publications
    Modified residuei467 – 4671Phosphoserine2 Publications
    Modified residuei554 – 5541Phosphoserine2 Publications
    Modified residuei618 – 6181Phosphoserine2 Publications
    Modified residuei624 – 6241Phosphoserine; by PKCSequence Analysis
    Modified residuei720 – 7201Phosphoserine; by CK25 Publications

    Post-translational modificationi

    Extensively phosphorylated on Ser and Thr residues.5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP14164.
    PaxDbiP14164.
    PeptideAtlasiP14164.

    Expressioni

    Gene expression databases

    GenevestigatoriP14164.

    Interactioni

    Subunit structurei

    Component of the global genome repair (GGR) complex composed of at least ABF1, RAD7 and RAD16. Interacts with PSE1.2 Publications

    Protein-protein interaction databases

    BioGridi34022. 37 interactions.
    DIPiDIP-2199N.
    IntActiP14164. 26 interactions.
    MINTiMINT-2783533.
    STRINGi4932.YKL112W.

    Structurei

    3D structure databases

    ProteinModelPortaliP14164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni624 – 6285C-terminal sequence 1
    Regioni639 – 66224C-terminal sequence 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi94 – 294201Asn-richAdd
    BLAST
    Compositional biasi449 – 51062Asn-richAdd
    BLAST

    Domaini

    Contains 2 important clusters of amino acid residues in the C terminus (C-terminal sequence 1 or CS1, residues 624 to 628; and CS2, residues 639 to 662). CS1 specifically participates in transcriptional silencing and/or repression in a context-dependent manner, whereas CS2 is universally required for all functions of ABF1.1 Publication

    Sequence similaritiesi

    Belongs to the BAF1 family.Curated

    Phylogenomic databases

    eggNOGiNOG43177.
    KOiK09249.
    OMAiACHLKNC.
    OrthoDBiEOG7KSXM9.

    Family and domain databases

    InterProiIPR006774. BAF1_ABF1.
    [Graphical view]
    PfamiPF04684. BAF1_ABF1. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14164-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKLVVNYYE YKHPIINKDL AIGAHGGKKF PTLGAWYDVI NEYEFQTRCP    50
    IILKNSHRNK HFTFACHLKN CPFKVLLSYA GNAASSETSS PSANNNTNPP 100
    GTPDHIHHHS NNMNNEDNDN NNGSNNKVSN DSKLDFVTDD LEYHLANTHP 150
    DDTNDKVESR SNEVNGNNDD DADANNIFKQ QGVTIKNDTE DDSINKASID 200
    RGLDDESGPT HGNDSGNHRH NEEDDVHTQM TKNYSDVVND EDINVAIANA 250
    VANVDSQSNN KHDGKDDDAT NNNDGQDNNT NNDHNNNSNI NNNNVGSHGI 300
    SSHSPSSIRD TSMNLDVFNS ATDDIPGPFV VTKIEPYHSH PLEDNLSLGK 350
    FILTKIPKIL QNDLKFDQIL ESSYNNSNHT VSKFKVSHYV EESGLLDILM 400
    QRYGLTAEDF EKRLLSQIAR RITTYKARFV LKKKKMGEYN DLQPSSSSNN 450
    NNNNDGELSG TNLRSNSIDY AKHQEISSAG TSSNTTKNVN NNKNDSNDDN 500
    NGNNNNDASN LMESVLDKTS SHRYQPKKMP SVNKWSKPDQ ITHSDVSMVG 550
    LDESNDGGNE NVHPTLAEVD AQEARETAQL AIDKINSYKR SIDDKNGDGH 600
    NNSSRNVVDE NLINDMDSED AHKSKRQHLS DITLEERNED DKLPHEVAEQ 650
    LRLLSSHLKE VENLHQNNDD DVDDVMVDVD VESQYNKNTT HHNNHHSQPH 700
    HDEEDVAGLI GKADDEEDLS DENIQPELRG Q 731
    Length:731
    Mass (Da):81,753
    Last modified:October 5, 2010 - v4
    Checksum:iBE338DA7C9514DC3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti125 – 1251N → K in CAA34421. (PubMed:2686983)Curated
    Sequence conflicti128 – 1281V → A in CAA35966. (PubMed:2620828)Curated
    Sequence conflicti128 – 1281V → A in AAA66311. (PubMed:2511628)Curated
    Sequence conflicti128 – 1281V → A in AAA34823. (PubMed:2034654)Curated
    Sequence conflicti148 – 1481T → I in CAA35966. (PubMed:2620828)Curated
    Sequence conflicti148 – 1481T → I in AAA66311. (PubMed:2511628)Curated
    Sequence conflicti148 – 1481T → I in AAA34823. (PubMed:2034654)Curated
    Sequence conflicti279 – 2802NT → TN in CAA35966. (PubMed:2620828)Curated
    Sequence conflicti279 – 2802NT → TN in AAA66311. (PubMed:2511628)Curated
    Sequence conflicti279 – 2802NT → TN in AAA34823. (PubMed:2034654)Curated
    Sequence conflicti690 – 6901T → N in CAA35966. (PubMed:2620828)Curated
    Sequence conflicti690 – 6901T → N in AAA66311. (PubMed:2511628)Curated
    Sequence conflicti690 – 6901T → N in AAA34823. (PubMed:2034654)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16385 Genomic DNA. Translation: CAA34421.1.
    X51654 Genomic DNA. Translation: CAA35966.1.
    M29067 Genomic DNA. Translation: AAA66311.1.
    M63578 Genomic DNA. Translation: AAA34823.1.
    S93804 Genomic DNA. Translation: AAB22002.1.
    Z28111 Genomic DNA. Translation: CAA81951.1.
    X77511 Genomic DNA. Translation: CAA54647.1.
    BK006944 Genomic DNA. Translation: DAA09046.1.
    PIRiS29870.
    RefSeqiNP_012810.1. NM_001179678.1.

    Genome annotation databases

    EnsemblFungiiYKL112W; YKL112W; YKL112W.
    GeneIDi853748.
    KEGGisce:YKL112W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16385 Genomic DNA. Translation: CAA34421.1 .
    X51654 Genomic DNA. Translation: CAA35966.1 .
    M29067 Genomic DNA. Translation: AAA66311.1 .
    M63578 Genomic DNA. Translation: AAA34823.1 .
    S93804 Genomic DNA. Translation: AAB22002.1 .
    Z28111 Genomic DNA. Translation: CAA81951.1 .
    X77511 Genomic DNA. Translation: CAA54647.1 .
    BK006944 Genomic DNA. Translation: DAA09046.1 .
    PIRi S29870.
    RefSeqi NP_012810.1. NM_001179678.1.

    3D structure databases

    ProteinModelPortali P14164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34022. 37 interactions.
    DIPi DIP-2199N.
    IntActi P14164. 26 interactions.
    MINTi MINT-2783533.
    STRINGi 4932.YKL112W.

    Proteomic databases

    MaxQBi P14164.
    PaxDbi P14164.
    PeptideAtlasi P14164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL112W ; YKL112W ; YKL112W .
    GeneIDi 853748.
    KEGGi sce:YKL112W.

    Organism-specific databases

    SGDi S000001595. ABF1.

    Phylogenomic databases

    eggNOGi NOG43177.
    KOi K09249.
    OMAi ACHLKNC.
    OrthoDBi EOG7KSXM9.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31897-MONOMER.

    Miscellaneous databases

    NextBioi 974810.

    Gene expression databases

    Genevestigatori P14164.

    Family and domain databases

    InterProi IPR006774. BAF1_ABF1.
    [Graphical view ]
    Pfami PF04684. BAF1_ABF1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, expression and mutational analysis of BAF1, a transcriptional activator and ARS1-binding protein of the yeast Saccharomyces cerevisiae."
      Halfter H., Kavety B., Vandekerckhove J., Kiefer F., Gallwitz D.
      EMBO J. 8:4265-4272(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 128-154 AND 535-555, MUTAGENESIS OF HIS-57 AND CYS-71.
    2. "The gene encoding ARS-binding factor I is essential for the viability of yeast."
      Rhode P.R., Sweder K.S., Oegema K.F., Campbell J.L.
      Genes Dev. 3:1926-1939(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Similarity between the transcriptional silencer binding proteins ABF1 and RAP1."
      Diffley J.F.X., Stillman B.
      Science 246:1034-1038(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The multifunctional protein OBF1 is phosphorylated at serine and threonine residues in Saccharomyces cerevisiae."
      Francesconi S.C., Eisenberg S.
      Proc. Natl. Acad. Sci. U.S.A. 88:4089-4093(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PHOSPHORYLATION.
    5. "Sequence of a 10.7 kb segment of yeast chromosome XI identifies the APN1 and the BAF1 loci and reveals one tRNA gene and several new open reading frames including homologs to RAD2 and kinases."
      Jacquier A., Legrain P., Dujon B.
      Yeast 8:121-132(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    7. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    8. "Two Saccharomyces cerevisiae genes which control sensitivity to G1 arrest induced by Kluyveromyces lactis toxin."
      Butler A.R., White J.H., Folawiyo Y., Edlin A., Gardiner D., Stark M.J.R.
      Mol. Cell. Biol. 14:6306-6316(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 585-731.
    9. "ABF1 Ser-720 is a predominant phosphorylation site for casein kinase II of Saccharomyces cerevisiae."
      Upton T., Wiltshire S., Francesconi S., Eisenberg S.
      J. Biol. Chem. 270:16153-16159(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-720, MUTAGENESIS OF SER-720.
    10. "Saccharomyces cerevisiae Cdc6 stimulates Abf1 DNA binding activity."
      Feng L., Wang B., Jong A.
      J. Biol. Chem. 273:1298-1302(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING.
    11. "Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair."
      Reed S.H., Akiyama M., Stillman B., Friedberg E.C.
      Genes Dev. 13:3052-3058(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE GGR COMPLEX, FUNCTION.
    12. "Different roles for abf1p and a T-rich promoter element in nucleosome organization of the yeast RPS28A gene."
      Lascaris R.F., Groot E., Hoen P.B., Mager W.H., Planta R.J.
      Nucleic Acids Res. 28:1390-1396(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "RNA polymerase II and III transcription factors can stimulate DNA replication by modifying origin chromatin structures."
      Bodmer-Glavas M., Edler K., Barberis A.
      Nucleic Acids Res. 29:4570-4580(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "General regulatory factors (GRFs) as genome partitioners."
      Fourel G., Miyake T., Defossez P.-A., Li R., Gilson E.
      J. Biol. Chem. 277:41736-41743(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. "Identification of a multifunctional domain in autonomously replicating sequence-binding factor 1 required for transcriptional activation, DNA replication, and gene silencing."
      Miyake T., Loch C.M., Li R.
      Mol. Cell. Biol. 22:505-516(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DOMAIN.
    16. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    17. "The yeast Rad7/Rad16/Abf1 complex generates superhelical torsion in DNA that is required for nucleotide excision repair."
      Yu S., Owen-Hughes T., Friedberg E.C., Waters R., Reed S.H.
      DNA Repair 3:277-287(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE GGR COMPLEX.
    18. "Comparison of ABF1 and RAP1 in chromatin opening and transactivator potentiation in the budding yeast Saccharomyces cerevisiae."
      Yarragudi A., Miyake T., Li R., Morse R.H.
      Mol. Cell. Biol. 24:9152-9164(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    19. "Functional and physical interactions between autonomously replicating sequence-binding factor 1 and the nuclear transport machinery."
      Loch C.M., Mosammaparast N., Miyake T., Pemberton L.F., Li R.
      Traffic 5:925-935(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-625, INTERACTION WITH PSE1.
    20. "In vitro selection of DNA binding sites for ABF1 protein from Saccharomyces cerevisiae."
      Beinoraviciute-Kellner R., Lipps G., Krauss G.
      FEBS Lett. 579:4535-4540(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING.
    21. "Asymmetric positioning of nucleosomes and directional establishment of transcriptionally silent chromatin by Saccharomyces cerevisiae silencers."
      Zou Y., Yu Q., Bi X.
      Mol. Cell. Biol. 26:7806-7819(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING, FUNCTION.
    22. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-467 AND SER-720, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    23. "Genome-wide analysis of transcriptional dependence and probable target sites for Abf1 and Rap1 in Saccharomyces cerevisiae."
      Yarragudi A., Parfrey L.W., Morse R.H.
      Nucleic Acids Res. 35:193-202(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING, FUNCTION.
    24. "Rapid chip-based capillary electrophoretic mobility shift assay with negative pressure injection for the binding study of transcription factor Abf1 in Saccharomyces cerevisiae."
      Yang Q., Zhao Y.C., Xiong Q., Cheng J.
      Electrophoresis 29:5003-5009(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING.
    25. "Genome-wide expression profiling, in vivo DNA binding analysis, and probabilistic motif prediction reveal novel Abf1 target genes during fermentation, respiration, and sporulation in yeast."
      Schlecht U., Erb I., Demougin P., Robine N., Borde V., van Nimwegen E., Nicolas A., Primig M.
      Mol. Biol. Cell 19:2193-2207(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING, FUNCTION.
    26. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-189; SER-193; SER-554; SER-618 AND SER-720, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    27. "ABF1-binding sites promote efficient global genome nucleotide excision repair."
      Yu S., Smirnova J.B., Friedberg E.C., Stillman B., Akiyama M., Owen-Hughes T., Waters R., Reed S.H.
      J. Biol. Chem. 284:966-973(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    28. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-720, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    29. "Blurring of high-resolution data shows that the effect of intrinsic nucleosome occupancy on transcription factor binding is mostly regional, not local."
      Goh W.S., Orlov Y., Li J., Clarke N.D.
      PLoS Comput. Biol. 6:E1000649-E1000649(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING.
    30. "Extensive role of the general regulatory factors, Abf1 and Rap1, in determining genome-wide chromatin structure in budding yeast."
      Ganapathi M., Palumbo M.J., Ansari S.A., He Q., Tsui K., Nislow C., Morse R.H.
      Nucleic Acids Res. 39:2032-2044(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    31. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiABF1_YEAST
    AccessioniPrimary (citable) accession number: P14164
    Secondary accession number(s): D6VXH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 130 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 4820 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3