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P14162

- VP6_ROTPC

UniProt

P14162 - VP6_ROTPC

Protein

Intermediate capsid protein VP6

Gene
N/A
Organism
Rotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. fusion of virus membrane with host plasma membrane Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intermediate capsid protein VP6
    OrganismiRotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
    Taxonomic identifieri10916 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiSus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000008175: Genome

    Subcellular locationi

    Virion By similarity
    Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.Curated

    GO - Cellular componenti

    1. viral envelope Source: InterPro
    2. viral intermediate capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Intermediate capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395Intermediate capsid protein VP6PRO_0000149574Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with VP2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP14162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the rotavirus VP6 family.Curated

    Family and domain databases

    InterProiIPR008980. Capsid_hemagglutn.
    IPR001385. Rotavirus_A/C_VP6.
    IPR008935. Virus_capsid_a-hlx_vir.
    [Graphical view]
    PfamiPF00980. Rota_Capsid_VP6. 1 hit.
    [Graphical view]
    ProDomiPD001812. Rota_Capsid_VP6. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF48345. SSF48345. 2 hits.
    SSF49818. SSF49818. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P14162-1 [UniParc]FASTAAdd to Basket

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    MDVLFSIAKT VSDLKKKVVV GTIYTNVEDI IQQTNELIRT LNGNTFHTGG    50
    IGTQPQKEWN FQLPQLGTTL LNLDDNYVQA TRSVIDYLAS FIEAVCDDEI 100
    VREASRNGMQ PQSPTLIALA SSKFKTINFN NSSQSIKNWS AQSRRENPVY 150
    EYKNPMVFEY RNSYILQRAN PQYGNVMGLR YYTASNTCQL AAFDSTLAEN 200
    APNNTQRFIY NGRLKRPISN VLMKIEAGAP NINNLTILPD PTNQTTWLYN 250
    PDQLMNGTFT IEFYNNGQLV DMVRNMGVVT VRTFDSYRIT IDMIRPAAMT 300
    QYVQRLFPQG GPYPYQAAYM LTLSILDATT ESVLCDSHSV DYSIVANVRR 350
    DSAMPAGTVF QPGFPWEQTL SNYTVAQEDN LERLLLVASV KRMVM 395
    Length:395
    Mass (Da):44,665
    Last modified:July 1, 1993 - v2
    Checksum:i9C92CAB56B048EE4
    GO

    Sequence cautioni

    The sequence AAA47096.1 differs from that shown. Reason: Frameshift at positions 144 and 153.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti348 – 3481V → W in AAA47096. (PubMed:2171196)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94157 Genomic RNA. Translation: AAA47097.1.
    M29287 mRNA. Translation: AAA47096.1. Frameshift.
    PIRiA36216. VPXRPR.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94157 Genomic RNA. Translation: AAA47097.1 .
    M29287 mRNA. Translation: AAA47096.1 . Frameshift.
    PIRi A36216. VPXRPR.

    3D structure databases

    ProteinModelPortali P14162.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR008980. Capsid_hemagglutn.
    IPR001385. Rotavirus_A/C_VP6.
    IPR008935. Virus_capsid_a-hlx_vir.
    [Graphical view ]
    Pfami PF00980. Rota_Capsid_VP6. 1 hit.
    [Graphical view ]
    ProDomi PD001812. Rota_Capsid_VP6. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF48345. SSF48345. 2 hits.
    SSF49818. SSF49818. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The correct sequence of the porcine group C/Cowden rotavirus major inner capsid protein shows close homology with human isolates from Brazil and the U.K."
      Cooke S.J., Clarke I.N., Freitas R.B., Gabbay Y.B., Lambden P.R.
      Virology 190:531-537(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Sequence analysis of the gene (6) encoding the major capsid protein (VP6) of group C rotavirus: higher than expected homology to the corresponding protein from group A virus."
      Bremont M., Chabanne-Vautherot D., Vannier P., McCrae A.E., Cohen J.
      Virology 178:579-583(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiVP6_ROTPC
    AccessioniPrimary (citable) accession number: P14162
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3