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P14162

- VP6_ROTPC

UniProt

P14162 - VP6_ROTPC

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Protein
Intermediate capsid protein VP6
Gene
N/A
Organism
Rotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. fusion of virus membrane with host plasma membrane Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate capsid protein VP6
OrganismiRotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
Taxonomic identifieri10916 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000008175: Genome

Subcellular locationi

Virion By similarity
Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Reviewed prediction.

GO - Cellular componenti

  1. viral envelope Source: InterPro
  2. viral intermediate capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Intermediate capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Intermediate capsid protein VP6
PRO_0000149574Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity. Interacts with VP2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP14162.

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus VP6 family.

Family and domain databases

InterProiIPR008980. Capsid_hemagglutn.
IPR001385. Rotavirus_A/C_VP6.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view]
PfamiPF00980. Rota_Capsid_VP6. 1 hit.
[Graphical view]
ProDomiPD001812. Rota_Capsid_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

P14162-1 [UniParc]FASTAAdd to Basket

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MDVLFSIAKT VSDLKKKVVV GTIYTNVEDI IQQTNELIRT LNGNTFHTGG    50
IGTQPQKEWN FQLPQLGTTL LNLDDNYVQA TRSVIDYLAS FIEAVCDDEI 100
VREASRNGMQ PQSPTLIALA SSKFKTINFN NSSQSIKNWS AQSRRENPVY 150
EYKNPMVFEY RNSYILQRAN PQYGNVMGLR YYTASNTCQL AAFDSTLAEN 200
APNNTQRFIY NGRLKRPISN VLMKIEAGAP NINNLTILPD PTNQTTWLYN 250
PDQLMNGTFT IEFYNNGQLV DMVRNMGVVT VRTFDSYRIT IDMIRPAAMT 300
QYVQRLFPQG GPYPYQAAYM LTLSILDATT ESVLCDSHSV DYSIVANVRR 350
DSAMPAGTVF QPGFPWEQTL SNYTVAQEDN LERLLLVASV KRMVM 395
Length:395
Mass (Da):44,665
Last modified:July 1, 1993 - v2
Checksum:i9C92CAB56B048EE4
GO

Sequence cautioni

The sequence AAA47096.1 differs from that shown. Reason: Frameshift at positions 144 and 153.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti348 – 3481V → W in AAA47096. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94157 Genomic RNA. Translation: AAA47097.1.
M29287 mRNA. Translation: AAA47096.1. Frameshift.
PIRiA36216. VPXRPR.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94157 Genomic RNA. Translation: AAA47097.1 .
M29287 mRNA. Translation: AAA47096.1 . Frameshift.
PIRi A36216. VPXRPR.

3D structure databases

ProteinModelPortali P14162.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR008980. Capsid_hemagglutn.
IPR001385. Rotavirus_A/C_VP6.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view ]
Pfami PF00980. Rota_Capsid_VP6. 1 hit.
[Graphical view ]
ProDomi PD001812. Rota_Capsid_VP6. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The correct sequence of the porcine group C/Cowden rotavirus major inner capsid protein shows close homology with human isolates from Brazil and the U.K."
    Cooke S.J., Clarke I.N., Freitas R.B., Gabbay Y.B., Lambden P.R.
    Virology 190:531-537(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Sequence analysis of the gene (6) encoding the major capsid protein (VP6) of group C rotavirus: higher than expected homology to the corresponding protein from group A virus."
    Bremont M., Chabanne-Vautherot D., Vannier P., McCrae A.E., Cohen J.
    Virology 178:579-583(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiVP6_ROTPC
AccessioniPrimary (citable) accession number: P14162
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 1, 1993
Last modified: December 11, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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