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P14162 (VP6_ROTPC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Intermediate capsid protein VP6
OrganismRotavirus C (strain Pig/United States/Cowden/1980) (RV-C) [Complete proteome]
Taxonomic identifier10916 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostSus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.

Subunit structure

Homotrimer By similarity. Interacts with VP2 By similarity.

Subcellular location

Virion By similarity. Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.

Sequence similarities

Belongs to the rotavirus VP6 family.

Sequence caution

The sequence AAA47096.1 differs from that shown. Reason: Frameshift at positions 144 and 153.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Intermediate capsid protein VP6
PRO_0000149574

Experimental info

Sequence conflict3481V → W in AAA47096. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P14162 [UniParc].

Last modified July 1, 1993. Version 2.
Checksum: 9C92CAB56B048EE4

FASTA39544,665
        10         20         30         40         50         60 
MDVLFSIAKT VSDLKKKVVV GTIYTNVEDI IQQTNELIRT LNGNTFHTGG IGTQPQKEWN 

        70         80         90        100        110        120 
FQLPQLGTTL LNLDDNYVQA TRSVIDYLAS FIEAVCDDEI VREASRNGMQ PQSPTLIALA 

       130        140        150        160        170        180 
SSKFKTINFN NSSQSIKNWS AQSRRENPVY EYKNPMVFEY RNSYILQRAN PQYGNVMGLR 

       190        200        210        220        230        240 
YYTASNTCQL AAFDSTLAEN APNNTQRFIY NGRLKRPISN VLMKIEAGAP NINNLTILPD 

       250        260        270        280        290        300 
PTNQTTWLYN PDQLMNGTFT IEFYNNGQLV DMVRNMGVVT VRTFDSYRIT IDMIRPAAMT 

       310        320        330        340        350        360 
QYVQRLFPQG GPYPYQAAYM LTLSILDATT ESVLCDSHSV DYSIVANVRR DSAMPAGTVF 

       370        380        390 
QPGFPWEQTL SNYTVAQEDN LERLLLVASV KRMVM 

« Hide

References

[1]"The correct sequence of the porcine group C/Cowden rotavirus major inner capsid protein shows close homology with human isolates from Brazil and the U.K."
Cooke S.J., Clarke I.N., Freitas R.B., Gabbay Y.B., Lambden P.R.
Virology 190:531-537(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Sequence analysis of the gene (6) encoding the major capsid protein (VP6) of group C rotavirus: higher than expected homology to the corresponding protein from group A virus."
Bremont M., Chabanne-Vautherot D., Vannier P., McCrae A.E., Cohen J.
Virology 178:579-583(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M94157 Genomic RNA. Translation: AAA47097.1.
M29287 mRNA. Translation: AAA47096.1. Frameshift.
PIRVPXRPR. A36216.

3D structure databases

ProteinModelPortalP14162.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008980. Capsid_hemagglutn.
IPR001385. Rotavirus_A/C_VP6.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view]
PfamPF00980. Rota_Capsid_VP6. 1 hit.
[Graphical view]
ProDomPD001812. Rota_Capsid_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVP6_ROTPC
AccessionPrimary (citable) accession number: P14162
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 1, 1993
Last modified: December 11, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families