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Protein

L-selectin

Gene

SELL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • glycosphingolipid binding Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • protease binding Source: BHF-UCL

GO - Biological processi

  • cell adhesion Source: ProtInc
  • leukocyte migration Source: Reactome
  • regulation of immune response Source: Reactome
  • response to ATP Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117489-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
L-selectin
Alternative name(s):
CD62 antigen-like family member L
Leukocyte adhesion molecule 1
Short name:
LAM-1
Leukocyte surface antigen Leu-8
Leukocyte-endothelial cell adhesion molecule 1
Short name:
LECAM1
Lymph node homing receptor
TQ1
gp90-MEL
CD_antigen: CD62L
Gene namesi
Name:SELL
Synonyms:LNHR, LYAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10720. SELL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 332ExtracellularSequence analysisAdd BLAST294
Transmembranei333 – 355HelicalSequence analysisAdd BLAST23
Topological domaini356 – 372CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6402.
OpenTargetsiENSG00000188404.
Orphaneti34145. Berger disease.
PharmGKBiPA35642.

Chemistry databases

ChEMBLiCHEMBL3161.

Polymorphism and mutation databases

BioMutaiSELL.
DMDMi126178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
PropeptideiPRO_000001747529 – 3810
ChainiPRO_000001747639 – 372L-selectinAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 155By similarity
Glycosylationi60N-linked (GlcNAc...)2 Publications1
Glycosylationi104N-linked (GlcNAc...)1 Publication1
Disulfide bondi128 ↔ 147By similarity
Disulfide bondi160 ↔ 171By similarity
Disulfide bondi165 ↔ 180By similarity
Glycosylationi177N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi182 ↔ 191By similarity
Disulfide bondi197 ↔ 241By similarity
Disulfide bondi227 ↔ 254By similarity
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Glycosylationi246N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi259 ↔ 303By similarity
Glycosylationi271N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi289 ↔ 316By similarity
Glycosylationi311N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP14151.
PaxDbiP14151.
PeptideAtlasiP14151.
PRIDEiP14151.

PTM databases

iPTMnetiP14151.
PhosphoSitePlusiP14151.
UniCarbKBiP14151.

Miscellaneous databases

PMAP-CutDBP14151.

Expressioni

Tissue specificityi

Expressed in B-cell lines and T-lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000188404.
CleanExiHS_SELL.
ExpressionAtlasiP14151. baseline and differential.
GenevisibleiP14151. HS.

Organism-specific databases

HPAiCAB002144.

Interactioni

Subunit structurei

Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding.

GO - Molecular functioni

  • protease binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi112302. 13 interactors.
STRINGi9606.ENSP00000236147.

Chemistry databases

BindingDBiP14151.

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 48Combined sources9
Helixi50 – 60Combined sources11
Beta strandi61 – 64Combined sources4
Helixi70 – 79Combined sources10
Beta strandi87 – 94Combined sources8
Beta strandi97 – 100Combined sources4
Turni101 – 103Combined sources3
Turni109 – 111Combined sources3
Helixi122 – 124Combined sources3
Beta strandi128 – 131Combined sources4
Beta strandi136 – 138Combined sources3
Beta strandi142 – 145Combined sources4
Beta strandi151 – 157Combined sources7
Beta strandi167 – 174Combined sources8
Beta strandi177 – 182Combined sources6
Beta strandi187 – 191Combined sources5
Helixi350 – 362Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KJBmodel-A39-158[»]
2LGFNMR-B349-363[»]
3CFWX-ray2.20A39-194[»]
ProteinModelPortaliP14151.
SMRiP14151.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14151.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 155C-type lectinPROSITE-ProRule annotationAdd BLAST101
Domaini156 – 192EGF-likePROSITE-ProRule annotationAdd BLAST37
Domaini195 – 256Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini257 – 318Sushi 2PROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS3T. Eukaryota.
ENOG410YB82. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP14151.
KOiK06495.
OMAiEAENWGD.
OrthoDBiEOG091G09HU.
PhylomeDBiP14151.
TreeFamiTF326910.

Family and domain databases

CDDicd00033. CCP. 2 hits.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR19325:SF352. PTHR19325:SF352. 1 hit.
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFiPIRSF002421. L-selectin. 1 hit.
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P14151-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIFPWKCQST QRDLWNIFKL WGWTMLCCDF LAHHGTDCWT YHYSEKPMNW
60 70 80 90 100
QRARRFCRDN YTDLVAIQNK AEIEYLEKTL PFSRSYYWIG IRKIGGIWTW
110 120 130 140 150
VGTNKSLTEE AENWGDGEPN NKKNKEDCVE IYIKRNKDAG KWNDDACHKL
160 170 180 190 200
KAALCYTASC QPWSCSGHGE CVEIINNYTC NCDVGYYGPQ CQFVIQCEPL
210 220 230 240 250
EAPELGTMDC THPLGNFSFS SQCAFSCSEG TNLTGIEETT CGPFGNWSSP
260 270 280 290 300
EPTCQVIQCE PLSAPDLGIM NCSHPLASFS FTSACTFICS EGTELIGKKK
310 320 330 340 350
TICESSGIWS NPSPICQKLD KSFSMIKEGD YNPLFIPVAV MVTAFSGLAF
360 370
IIWLARRLKK GKKSKRSMND PY
Length:372
Mass (Da):42,187
Last modified:February 1, 1991 - v2
Checksum:i6EA9918ECA2D3643
GO
Isoform 2 (identifier: P14151-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGCRRTREGPSKAM

Note: No experimental confirmation available.
Show »
Length:385
Mass (Da):43,618
Checksum:i1205F691BA638EF1
GO

Sequence cautioni

The sequence CAA34203 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB43536 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB43537 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37D → Y in CAA34203 (PubMed:2663882).Curated1
Sequence conflicti178Y → H in CAA34203 (PubMed:2663882).Curated1
Sequence conflicti214L → F in CAA34203 (PubMed:2663882).Curated1
Sequence conflicti218 – 220SFS → NFN in CAA34275 (PubMed:2473156).Curated3
Sequence conflicti242G → E in CAA34275 (PubMed:2473156).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019134193F → L.3 PublicationsCorresponds to variant rs1131498dbSNPEnsembl.1
Natural variantiVAR_019135201E → Q.1 PublicationCorresponds to variant rs2229568dbSNPEnsembl.1
Natural variantiVAR_019136213P → S.2 PublicationsCorresponds to variant rs2229569dbSNPEnsembl.1
Natural variantiVAR_019137369N → D.1 PublicationCorresponds to variant rs4987382dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0426501M → MGCRRTREGPSKAM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25280 mRNA. Translation: AAC63053.1.
X16150 mRNA. Translation: CAA34275.1.
X17519 mRNA. Translation: CAB43536.1. Different initiation.
X17519 mRNA. Translation: CAB43537.1. Different initiation.
X16070 mRNA. Translation: CAA34203.1. Different initiation.
M32414
, M32406, M32407, M32408, M32409, M32410, M32411, M32412, M32413 Genomic DNA. Translation: AAB60700.1.
AJ246000 mRNA. Translation: CAB55488.1.
AK312673 mRNA. Translation: BAG35555.1.
AY233976 Genomic DNA. Translation: AAO48272.1.
AL021940 Genomic DNA. Translation: CAI19356.1.
CH471067 Genomic DNA. Translation: EAW90856.1.
CCDSiCCDS53427.1. [P14151-2]
RefSeqiNP_000646.2. NM_000655.4. [P14151-2]
UniGeneiHs.728756.

Genome annotation databases

EnsembliENST00000236147; ENSP00000236147; ENSG00000188404. [P14151-2]
GeneIDi6402.
KEGGihsa:6402.
UCSCiuc001ggk.4. human. [P14151-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

L-selectin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25280 mRNA. Translation: AAC63053.1.
X16150 mRNA. Translation: CAA34275.1.
X17519 mRNA. Translation: CAB43536.1. Different initiation.
X17519 mRNA. Translation: CAB43537.1. Different initiation.
X16070 mRNA. Translation: CAA34203.1. Different initiation.
M32414
, M32406, M32407, M32408, M32409, M32410, M32411, M32412, M32413 Genomic DNA. Translation: AAB60700.1.
AJ246000 mRNA. Translation: CAB55488.1.
AK312673 mRNA. Translation: BAG35555.1.
AY233976 Genomic DNA. Translation: AAO48272.1.
AL021940 Genomic DNA. Translation: CAI19356.1.
CH471067 Genomic DNA. Translation: EAW90856.1.
CCDSiCCDS53427.1. [P14151-2]
RefSeqiNP_000646.2. NM_000655.4. [P14151-2]
UniGeneiHs.728756.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KJBmodel-A39-158[»]
2LGFNMR-B349-363[»]
3CFWX-ray2.20A39-194[»]
ProteinModelPortaliP14151.
SMRiP14151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112302. 13 interactors.
STRINGi9606.ENSP00000236147.

Chemistry databases

BindingDBiP14151.
ChEMBLiCHEMBL3161.

PTM databases

iPTMnetiP14151.
PhosphoSitePlusiP14151.
UniCarbKBiP14151.

Polymorphism and mutation databases

BioMutaiSELL.
DMDMi126178.

Proteomic databases

MaxQBiP14151.
PaxDbiP14151.
PeptideAtlasiP14151.
PRIDEiP14151.

Protocols and materials databases

DNASUi6402.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236147; ENSP00000236147; ENSG00000188404. [P14151-2]
GeneIDi6402.
KEGGihsa:6402.
UCSCiuc001ggk.4. human. [P14151-1]

Organism-specific databases

CTDi6402.
DisGeNETi6402.
GeneCardsiSELL.
HGNCiHGNC:10720. SELL.
HPAiCAB002144.
MIMi153240. gene.
neXtProtiNX_P14151.
OpenTargetsiENSG00000188404.
Orphaneti34145. Berger disease.
PharmGKBiPA35642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS3T. Eukaryota.
ENOG410YB82. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP14151.
KOiK06495.
OMAiEAENWGD.
OrthoDBiEOG091G09HU.
PhylomeDBiP14151.
TreeFamiTF326910.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117489-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiP14151.
GeneWikiiL-selectin.
GenomeRNAii6402.
PMAP-CutDBP14151.
PROiP14151.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188404.
CleanExiHS_SELL.
ExpressionAtlasiP14151. baseline and differential.
GenevisibleiP14151. HS.

Family and domain databases

CDDicd00033. CCP. 2 hits.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PANTHERiPTHR19325:SF352. PTHR19325:SF352. 1 hit.
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFiPIRSF002421. L-selectin. 1 hit.
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYAM1_HUMAN
AccessioniPrimary (citable) accession number: P14151
Secondary accession number(s): B2R6Q8, P15023, Q9UJ43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1991
Last modified: November 30, 2016
This is version 192 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.