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Protein

60S ribosomal protein L7

Gene

Rpl7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • ribosomal large subunit biogenesis Source: MGI
  • rRNA processing Source: MGI
  • translation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7
Gene namesi
Name:Rpl7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98073. Rpl7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosolic large ribosomal subunit Source: MGI
  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • intracellular ribonucleoprotein complex Source: MGI
  • membrane Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
  • polysome Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27027060S ribosomal protein L7PRO_0000104634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei146 – 1461N6-acetyllysineBy similarity
Modified residuei149 – 1491N6-succinyllysineCombined sources
Modified residuei161 – 1611PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP14148.
PaxDbiP14148.
PRIDEiP14148.
TopDownProteomicsiP14148.

PTM databases

iPTMnetiP14148.
PhosphoSiteiP14148.
SwissPalmiP14148.

Expressioni

Gene expression databases

BgeeiP14148.
CleanExiMM_RPL7.
ExpressionAtlasiP14148. baseline and differential.
GenevisibleiP14148. MM.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202988. 5 interactions.
IntActiP14148. 9 interactions.
MINTiMINT-1675976.
STRINGi10090.ENSMUSP00000071616.

Structurei

3D structure databases

ProteinModelPortaliP14148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati7 – 18121Add
BLAST
Repeati19 – 29112Add
BLAST
Repeati30 – 40113Add
BLAST
Repeati41 – 52124Add
BLAST
Repeati53 – 64125Add
BLAST
Repeati65 – 76126Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 76706 X 12 AA tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein L30P family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3184. Eukaryota.
COG1841. LUCA.
HOGENOMiHOG000170917.
HOVERGENiHBG003280.
InParanoidiP14148.
KOiK02937.
OrthoDBiEOG7K9K3X.
PhylomeDBiP14148.
TreeFamiTF300740.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiIPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
[Graphical view]
PfamiPF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
[Graphical view]
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. uL30_euk. 1 hit.
PROSITEiPS00634. RIBOSOMAL_L30. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAVPEKKKK VATVPGTLKK KVPAGPKTLK KKVPAVPETL KKKRRNFAEL
60 70 80 90 100
KVKRLRKKFA LKTLRKARRK LIYEKAKHYH KEYRQMYRTE IRMARMARKA
110 120 130 140 150
GNFYVPAEPK LAFVIRIRGI NGVSPKVRKV LQLLRLRQIF NGTFVKLNKA
160 170 180 190 200
SINMLRIVEP YIAWGYPNLK SVNELIYKRG YGKINKKRIA LTDNSLIARS
210 220 230 240 250
LGKFGIICME DLIHEIYTVG KRFKEANNFL WPFKLSSPRG GMKKKTTHFV
260 270
EGGDAGNRED QINRLIRRMN
Length:270
Mass (Da):31,420
Last modified:February 1, 1996 - v2
Checksum:iD006EDFB8CF95EFD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 295GPKTL → WAKNS in AAA40064 (Ref. 2) Curated
Sequence conflicti40 – 401L → R in AAA40064 (Ref. 2) Curated
Sequence conflicti64 – 641L → V in AAA40064 (Ref. 2) Curated
Sequence conflicti84 – 841R → G in AAH51261 (PubMed:15489334).Curated
Sequence conflicti268 – 2681R → Q in AAA40069 (PubMed:2365680).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29015 Genomic DNA. Translation: AAA40069.1.
M29016 mRNA. Translation: AAA40070.1.
M85235 mRNA. Translation: AAA40064.1.
BC025909 mRNA. Translation: AAH25909.1.
BC051261 mRNA. Translation: AAH51261.1.
X57960 mRNA. Translation: CAA41028.1.
X57961 mRNA. Translation: CAA41029.1.
CCDSiCCDS14829.1.
PIRiA37055.
RefSeqiNP_035421.2. NM_011291.5.
UniGeneiMm.319659.
Mm.379004.
Mm.397450.

Genome annotation databases

EnsembliENSMUST00000058437; ENSMUSP00000071616; ENSMUSG00000043716.
GeneIDi19989.
KEGGimmu:19989.
UCSCiuc007ajl.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29015 Genomic DNA. Translation: AAA40069.1.
M29016 mRNA. Translation: AAA40070.1.
M85235 mRNA. Translation: AAA40064.1.
BC025909 mRNA. Translation: AAH25909.1.
BC051261 mRNA. Translation: AAH51261.1.
X57960 mRNA. Translation: CAA41028.1.
X57961 mRNA. Translation: CAA41029.1.
CCDSiCCDS14829.1.
PIRiA37055.
RefSeqiNP_035421.2. NM_011291.5.
UniGeneiMm.319659.
Mm.379004.
Mm.397450.

3D structure databases

ProteinModelPortaliP14148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202988. 5 interactions.
IntActiP14148. 9 interactions.
MINTiMINT-1675976.
STRINGi10090.ENSMUSP00000071616.

PTM databases

iPTMnetiP14148.
PhosphoSiteiP14148.
SwissPalmiP14148.

Proteomic databases

EPDiP14148.
PaxDbiP14148.
PRIDEiP14148.
TopDownProteomicsiP14148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058437; ENSMUSP00000071616; ENSMUSG00000043716.
GeneIDi19989.
KEGGimmu:19989.
UCSCiuc007ajl.3. mouse.

Organism-specific databases

CTDi6129.
MGIiMGI:98073. Rpl7.

Phylogenomic databases

eggNOGiKOG3184. Eukaryota.
COG1841. LUCA.
HOGENOMiHOG000170917.
HOVERGENiHBG003280.
InParanoidiP14148.
KOiK02937.
OrthoDBiEOG7K9K3X.
PhylomeDBiP14148.
TreeFamiTF300740.

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpl7. mouse.
NextBioi297503.
PROiP14148.
SOURCEiSearch...

Gene expression databases

BgeeiP14148.
CleanExiMM_RPL7.
ExpressionAtlasiP14148. baseline and differential.
GenevisibleiP14148. MM.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiIPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
[Graphical view]
PfamiPF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
[Graphical view]
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. uL30_euk. 1 hit.
PROSITEiPS00634. RIBOSOMAL_L30. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse ribosomal protein L7 gene. Its primary structure and functional analysis of the promoter region."
    Meyuhas O., Klein A.
    J. Biol. Chem. 265:11465-11473(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Immunochemical and structural similarity between a mouse cytochrome oxidase subunit and ribosomal protein L7."
    Zheng Y.-M., Su P., Wang J.X., Basu A., Bhat K., Carter R., Avadhani N.G.
    Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SWR/J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hematopoietic stem cell and Mammary gland.
  4. "Structural and functional properties of ribosomal protein L7 from humans and rodents."
    Hemmerich P., von Mikecz A., Neumann F., Soezen O., Wolff-Vorbeck G., Zoebelein R., Krawinkel U.
    Nucleic Acids Res. 21:223-231(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 117-270.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-149, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiRL7_MOUSE
AccessioniPrimary (citable) accession number: P14148
Secondary accession number(s): Q80UR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.