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Protein

Solute carrier family 2, facilitated glucose transporter member 4

Gene

Slc2a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Insulin-regulated facilitative glucose transporter.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei333MonosaccharideBy similarity1
Binding sitei404MonosaccharideBy similarity1

GO - Molecular functioni

  • D-glucose transmembrane transporter activity Source: Ensembl
  • glucose transmembrane transporter activity Source: MGI
  • insulin-responsive hydrogen:glucose symporter activity Source: MGI

GO - Biological processi

  • amylopectin biosynthetic process Source: MGI
  • brown fat cell differentiation Source: MGI
  • cellular response to hypoxia Source: Ensembl
  • cellular response to insulin stimulus Source: UniProtKB
  • cellular response to osmotic stress Source: MGI
  • cellular response to tumor necrosis factor Source: MGI
  • glucose homeostasis Source: MGI
  • glucose transport Source: MGI
  • membrane organization Source: Reactome
  • response to ethanol Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.
R-MMU-428790. Facilitative Na+-independent glucose transporters.
R-MMU-70153. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 4
Alternative name(s):
GT2
Glucose transporter type 4, insulin-responsive
Short name:
GLUT-4
Gene namesi
Name:Slc2a4
Synonyms:Glut-4, Glut4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95758. Slc2a4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 80ExtracellularSequence analysisAdd BLAST36
Transmembranei81 – 101Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini102 – 110CytoplasmicSequence analysis9
Transmembranei111 – 131Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini132 – 141ExtracellularSequence analysis10
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 170CytoplasmicSequence analysis8
Transmembranei171 – 191Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini192 – 200ExtracellularSequence analysis9
Transmembranei201 – 221Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini222 – 286CytoplasmicSequence analysisAdd BLAST65
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 322ExtracellularSequence analysisAdd BLAST15
Transmembranei323 – 343Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini344 – 352CytoplasmicSequence analysis9
Transmembranei353 – 373Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini374 – 384ExtracellularSequence analysisAdd BLAST11
Transmembranei385 – 405Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini406 – 416CytoplasmicSequence analysisAdd BLAST11
Transmembranei417 – 437Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini438 – 444ExtracellularSequence analysis7
Transmembranei445 – 465Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini466 – 508CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

  • clathrin-coated pit Source: Ensembl
  • clathrin-coated vesicle Source: MGI
  • cytoplasmic vesicle membrane Source: MGI
  • cytosol Source: MGI
  • endomembrane system Source: UniProtKB
  • endosome Source: MGI
  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • insulin-responsive compartment Source: UniProtKB
  • integral component of membrane Source: MGI
  • integral component of plasma membrane Source: MGI
  • membrane Source: MGI
  • membrane raft Source: MGI
  • multivesicular body Source: Ensembl
  • perinuclear region of cytoplasm Source: MGI
  • plasma membrane Source: UniProtKB
  • sarcolemma Source: MGI
  • trans-Golgi network transport vesicle Source: MGI
  • T-tubule Source: Ensembl
  • vesicle membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Slc2a4 may be the cause of certain post-receptor defects in non-insulin-dependent diabetes mellitus (NIDDM).

Keywords - Diseasei

Diabetes mellitus

Chemistry databases

ChEMBLiCHEMBL1250410.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503641 – 509Solute carrier family 2, facilitated glucose transporter member 4Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Glycosylationi57N-linked (GlcNAc...)1 Publication1
Modified residuei274Phosphoserine; by SGK1By similarity1
Modified residuei486PhosphothreonineCombined sources1
Modified residuei488PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP14142.
PaxDbiP14142.
PeptideAtlasiP14142.
PRIDEiP14142.

PTM databases

iPTMnetiP14142.
PhosphoSitePlusiP14142.
SwissPalmiP14142.

Expressioni

Tissue specificityi

Skeletal and cardiac muscles; brown and white fat.

Gene expression databases

BgeeiENSMUSG00000018566.
ExpressionAtlasiP14142. baseline and differential.
GenevisibleiP14142. MM.

Interactioni

Subunit structurei

Binds to DAXX. Interacts via its N-terminus with SRFBP1. Interacts with NDUFA9 (By similarity).By similarity

Protein-protein interaction databases

BioGridi203307. 5 interactors.
DIPiDIP-42440N.
IntActiP14142. 1 interactor.
MINTiMINT-1342290.
STRINGi10090.ENSMUSP00000018710.

Structurei

3D structure databases

ProteinModelPortaliP14142.
SMRiP14142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 13SRFBP1-bindingBy similarity7
Regioni298 – 304Monosaccharide bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi489 – 490Dileucine internalization motifSequence analysis2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP14142.
KOiK07191.
OMAiSHTHRQP.
OrthoDBiEOG091G0A9K.
TreeFamiTF313762.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002441. Glc_transpt_4.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01193. GLUCTRSPORT4.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSGFQQIGS DDGEPPRQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK
60 70 80 90 100
VIEQSYNATW LGRQGPGGPD SIPQGTLTTL WALSVAIFSV GGMISSFLIG
110 120 130 140 150
IISQWLGRKR AMLANNVLAV LGGALMGLAN AAASYEILIL GRFLIGAYSG
160 170 180 190 200
LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI VIGILVAQVL GLESMLGTAT
210 220 230 240 250
LWPLLLALTV LPALLQLILL PFCPESPRYL YIIRNLEGPA RKSLKRLTGW
260 270 280 290 300
ADVSDALAEL KDEKRKLERE RPMSLLQLLG SRTHRQPLII AVVLQLSQQL
310 320 330 340 350
SGINAVFYYS TSIFESAGVG QPAYATIGAG VVNTVFTLVS VLLVERAGRR
360 370 380 390 400
TLHLLGLAGM CGCAILMTVA LLLLERVPAM SYVSIVAIFG FVAFFEIGPG
410 420 430 440 450
PIPWFIVAEL FSQGPRPAAM AVAGFSNWTC NFIVGMGFQY VADAMGPYVF
460 470 480 490 500
LLFAVLLLGF FIFTFLKVPE TRGRTFDQIS AAFRRTPSLL EQEVKPSTEL

EYLGPDEND
Length:509
Mass (Da):54,755
Last modified:July 27, 2011 - v3
Checksum:iA174212455EE0390
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11D → DVK in AAA37753 (PubMed:2654938).Curated1
Sequence conflicti132A → V in AAA37753 (PubMed:2654938).Curated1
Sequence conflicti177Q → R in AAA37753 (PubMed:2654938).Curated1
Sequence conflicti246R → P in AAA37753 (PubMed:2654938).Curated1
Sequence conflicti406Missing in AAA37753 (PubMed:2654938).Curated1
Sequence conflicti444A → R in AAA37753 (PubMed:2654938).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23383 mRNA. Translation: AAA37753.1.
AB008453 mRNA. Translation: BAB03251.1.
AY902342 Genomic DNA. Translation: AAX90627.1.
AK137607 mRNA. Translation: BAE23429.1.
AK164310 mRNA. Translation: BAE37730.1.
AL596185 Genomic DNA. Translation: CAI35157.1.
CH466596 Genomic DNA. Translation: EDL12494.1.
CH466596 Genomic DNA. Translation: EDL12496.1.
BC014282 mRNA. Translation: AAH14282.1.
CCDSiCCDS36201.1.
PIRiB30310.
RefSeqiNP_033230.2. NM_009204.2.
UniGeneiMm.10661.

Genome annotation databases

EnsembliENSMUST00000018710; ENSMUSP00000018710; ENSMUSG00000018566.
GeneIDi20528.
KEGGimmu:20528.
UCSCiuc007jsy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23383 mRNA. Translation: AAA37753.1.
AB008453 mRNA. Translation: BAB03251.1.
AY902342 Genomic DNA. Translation: AAX90627.1.
AK137607 mRNA. Translation: BAE23429.1.
AK164310 mRNA. Translation: BAE37730.1.
AL596185 Genomic DNA. Translation: CAI35157.1.
CH466596 Genomic DNA. Translation: EDL12494.1.
CH466596 Genomic DNA. Translation: EDL12496.1.
BC014282 mRNA. Translation: AAH14282.1.
CCDSiCCDS36201.1.
PIRiB30310.
RefSeqiNP_033230.2. NM_009204.2.
UniGeneiMm.10661.

3D structure databases

ProteinModelPortaliP14142.
SMRiP14142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203307. 5 interactors.
DIPiDIP-42440N.
IntActiP14142. 1 interactor.
MINTiMINT-1342290.
STRINGi10090.ENSMUSP00000018710.

Chemistry databases

ChEMBLiCHEMBL1250410.

PTM databases

iPTMnetiP14142.
PhosphoSitePlusiP14142.
SwissPalmiP14142.

Proteomic databases

MaxQBiP14142.
PaxDbiP14142.
PeptideAtlasiP14142.
PRIDEiP14142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018710; ENSMUSP00000018710; ENSMUSG00000018566.
GeneIDi20528.
KEGGimmu:20528.
UCSCiuc007jsy.1. mouse.

Organism-specific databases

CTDi6517.
MGIiMGI:95758. Slc2a4.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP14142.
KOiK07191.
OMAiSHTHRQP.
OrthoDBiEOG091G0A9K.
TreeFamiTF313762.

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.
R-MMU-428790. Facilitative Na+-independent glucose transporters.
R-MMU-70153. Glucose transport.

Miscellaneous databases

PROiP14142.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018566.
ExpressionAtlasiP14142. baseline and differential.
GenevisibleiP14142. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002441. Glc_transpt_4.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01193. GLUCTRSPORT4.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR4_MOUSE
AccessioniPrimary (citable) accession number: P14142
Secondary accession number(s): Q3TPK6, Q9JJN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 171 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.