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Protein

Solute carrier family 2, facilitated glucose transporter member 4

Gene

Slc2a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Insulin-regulated facilitative glucose transporter.

Miscellaneous

Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei333MonosaccharideBy similarity1
Binding sitei404MonosaccharideBy similarity1

GO - Molecular functioni

  • D-glucose transmembrane transporter activity Source: Ensembl
  • glucose transmembrane transporter activity Source: MGI
  • insulin-responsive glucose:proton symporter activity Source: MGI

GO - Biological processi

  • amylopectin biosynthetic process Source: MGI
  • brown fat cell differentiation Source: MGI
  • cellular response to hypoxia Source: Ensembl
  • cellular response to insulin stimulus Source: UniProtKB
  • cellular response to osmotic stress Source: MGI
  • cellular response to tumor necrosis factor Source: MGI
  • glucose homeostasis Source: MGI
  • glucose import in response to insulin stimulus Source: MGI
  • glucose transmembrane transport Source: MGI
  • response to ethanol Source: Ensembl

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 4
Alternative name(s):
GT2
Glucose transporter type 4, insulin-responsive
Short name:
GLUT-4
Gene namesi
Name:Slc2a4
Synonyms:Glut-4, Glut4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95758 Slc2a4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 80ExtracellularSequence analysisAdd BLAST36
Transmembranei81 – 101Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini102 – 110CytoplasmicSequence analysis9
Transmembranei111 – 131Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini132 – 141ExtracellularSequence analysis10
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 170CytoplasmicSequence analysis8
Transmembranei171 – 191Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini192 – 200ExtracellularSequence analysis9
Transmembranei201 – 221Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini222 – 286CytoplasmicSequence analysisAdd BLAST65
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 322ExtracellularSequence analysisAdd BLAST15
Transmembranei323 – 343Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini344 – 352CytoplasmicSequence analysis9
Transmembranei353 – 373Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini374 – 384ExtracellularSequence analysisAdd BLAST11
Transmembranei385 – 405Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini406 – 416CytoplasmicSequence analysisAdd BLAST11
Transmembranei417 – 437Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini438 – 444ExtracellularSequence analysis7
Transmembranei445 – 465Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini466 – 508CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Slc2a4 may be the cause of certain post-receptor defects in non-insulin-dependent diabetes mellitus (NIDDM).

Keywords - Diseasei

Diabetes mellitus

Chemistry databases

ChEMBLiCHEMBL1250410

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503641 – 509Solute carrier family 2, facilitated glucose transporter member 4Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Glycosylationi57N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei274Phosphoserine; by SGK1By similarity1
Modified residuei486PhosphothreonineCombined sources1
Modified residuei488PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP14142
PaxDbiP14142
PeptideAtlasiP14142
PRIDEiP14142

PTM databases

iPTMnetiP14142
PhosphoSitePlusiP14142
SwissPalmiP14142

Expressioni

Tissue specificityi

Skeletal and cardiac muscles; brown and white fat.

Gene expression databases

BgeeiENSMUSG00000018566
ExpressionAtlasiP14142 baseline and differential
GenevisibleiP14142 MM

Interactioni

Subunit structurei

Binds to DAXX. Interacts via its N-terminus with SRFBP1. Interacts with NDUFA9 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Esyt1Q3U7R12EBI-7540210,EBI-8398881

Protein-protein interaction databases

BioGridi203307, 4 interactors
DIPiDIP-42440N
ELMiP14142
IntActiP14142, 2 interactors
MINTiP14142
STRINGi10090.ENSMUSP00000018710

Structurei

3D structure databases

ProteinModelPortaliP14142
SMRiP14142
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 13SRFBP1-bindingBy similarity7
Regioni298 – 304Monosaccharide bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi489 – 490Dileucine internalization motifSequence analysis2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP14142
KOiK07191
OMAiNVYVVFF
OrthoDBiEOG091G0A9K
TreeFamiTF313762

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002441 Glc_transpt_4
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01193 GLUCTRSPORT4
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P14142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSGFQQIGS DDGEPPRQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK
60 70 80 90 100
VIEQSYNATW LGRQGPGGPD SIPQGTLTTL WALSVAIFSV GGMISSFLIG
110 120 130 140 150
IISQWLGRKR AMLANNVLAV LGGALMGLAN AAASYEILIL GRFLIGAYSG
160 170 180 190 200
LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI VIGILVAQVL GLESMLGTAT
210 220 230 240 250
LWPLLLALTV LPALLQLILL PFCPESPRYL YIIRNLEGPA RKSLKRLTGW
260 270 280 290 300
ADVSDALAEL KDEKRKLERE RPMSLLQLLG SRTHRQPLII AVVLQLSQQL
310 320 330 340 350
SGINAVFYYS TSIFESAGVG QPAYATIGAG VVNTVFTLVS VLLVERAGRR
360 370 380 390 400
TLHLLGLAGM CGCAILMTVA LLLLERVPAM SYVSIVAIFG FVAFFEIGPG
410 420 430 440 450
PIPWFIVAEL FSQGPRPAAM AVAGFSNWTC NFIVGMGFQY VADAMGPYVF
460 470 480 490 500
LLFAVLLLGF FIFTFLKVPE TRGRTFDQIS AAFRRTPSLL EQEVKPSTEL

EYLGPDEND
Length:509
Mass (Da):54,755
Last modified:July 27, 2011 - v3
Checksum:iA174212455EE0390
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11D → DVK in AAA37753 (PubMed:2654938).Curated1
Sequence conflicti132A → V in AAA37753 (PubMed:2654938).Curated1
Sequence conflicti177Q → R in AAA37753 (PubMed:2654938).Curated1
Sequence conflicti246R → P in AAA37753 (PubMed:2654938).Curated1
Sequence conflicti406Missing in AAA37753 (PubMed:2654938).Curated1
Sequence conflicti444A → R in AAA37753 (PubMed:2654938).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23383 mRNA Translation: AAA37753.1
AB008453 mRNA Translation: BAB03251.1
AY902342 Genomic DNA Translation: AAX90627.1
AK137607 mRNA Translation: BAE23429.1
AK164310 mRNA Translation: BAE37730.1
AL596185 Genomic DNA Translation: CAI35157.1
CH466596 Genomic DNA Translation: EDL12494.1
CH466596 Genomic DNA Translation: EDL12496.1
BC014282 mRNA Translation: AAH14282.1
CCDSiCCDS36201.1
PIRiB30310
RefSeqiNP_033230.2, NM_009204.2
UniGeneiMm.10661

Genome annotation databases

EnsembliENSMUST00000018710; ENSMUSP00000018710; ENSMUSG00000018566
GeneIDi20528
KEGGimmu:20528
UCSCiuc007jsy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGTR4_MOUSE
AccessioniPrimary (citable) accession number: P14142
Secondary accession number(s): Q3TPK6, Q9JJN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 184 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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