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Reviewed, UniProtKB/Swiss-Prot P14139 (ADH1B_PAPHA)

Last modified September 22, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 1B
    EC=1.1.1.1
Alternative name(s):
    Alcohol dehydrogenase subunit beta
Gene names
Name: ADH1B
OrganismPapio hamadryas (Hamadryas baboon)
Taxonomic identifier9557 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Papio

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Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit.

Subunit structure

Homodimer or heterodimer of closely related subunits By similarity.

Subcellular location

Cytoplasm.

Tissue specificity

Expressed in liver.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   PTMAcetylation
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalcohol dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 375374Alcohol dehydrogenase 1B
PRO_0000160663

Regions

Nucleotide binding200 – 2056NAD By similarity
Nucleotide binding293 – 2953NAD By similarity

Sites

Metal binding471Zinc 1; catalytic
Metal binding681Zinc 1; catalytic
Metal binding981Zinc 2
Metal binding1011Zinc 2
Metal binding1041Zinc 2
Metal binding1121Zinc 2
Metal binding1751Zinc 1; catalytic
Binding site2241NAD By similarity
Binding site2291NAD By similarity
Binding site3701NAD By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
P14139-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 4A617082B29F7C9B

FASTA37539,846
        10         20         30         40         50         60 
MSTAGKVIKC KAAVLWEVKK PFSIEDVEVA PPKAYEVRIK MVAVGICRTD DHVVSGNLVS 

        70         80         90        100        110        120 
PLPAILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK CRVCKSPEGN YCVKNDLSNP 

       130        140        150        160        170        180 
RGTLQDGTRR FTCRGKPIHH FVGTSTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG 

       190        200        210        220        230        240 
YGSAVNVAKV TPGSVCAVFG LGGVGLSAVM GCKAAGAARI IAVDINKDKF AKAKELGATE 

       250        260        270        280        290        300 
CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ 

       310        320        330        340        350        360 
NLSINPMLLL TGRTWKGAVY GGFKSREGIP KLVADFMAKK FSLDALITHV LPFEKINEGF 

       370 
DLLRSGKSIR TVLTF

« Hide

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References

[1]"Cloning and sequencing of cDNA encoding baboon liver alcohol dehydrogenase: evidence for a common ancestral lineage with the human alcohol dehydrogenase beta subunit and for class I ADH gene duplications predating primate radiation."
Trezise A.E.O., Godfrey E.A., Holmes R.S., Beacham I.R.
Proc. Natl. Acad. Sci. U.S.A. 86:5454-5458(1989) [PubMed: 2748595] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

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Cross-references

Sequence databases

M25035 mRNA. Translation: AAA35378.1.

3D structure databases

HSSPHSSP built from PDB template 1DEH based on UniProtKB P00325.
SMRP14139. Positions 2-375.
ModBaseSearch...

Phylogenomic databases

HOVERGENP14139.

Enzyme and pathway databases

BRENDA1.1.1.1. 39388.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADH1B_PAPHA
AccessionPrimary (citable) accession number: P14139
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: September 22, 2009
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents