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P14135

- RL6_HALMA

UniProt

P14135 - RL6_HALMA

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Protein
50S ribosomal protein L6
Gene
rpl6, rrnAC1596
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-1452-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L6
Alternative name(s):
Hl10
Hmal6
Gene namesi
Name:rpl6
Ordered Locus Names:rrnAC1596
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 17817750S ribosomal protein L6UniRule annotation
PRO_0000131083Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Interacts weakly with protein L13.9 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC1596.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 75
Beta strandi13 – 175
Beta strandi20 – 256
Beta strandi28 – 336
Beta strandi40 – 445
Beta strandi47 – 515
Helixi57 – 7721
Beta strandi81 – 888
Beta strandi90 – 923
Beta strandi95 – 995
Beta strandi102 – 1076
Helixi108 – 1103
Beta strandi115 – 1184
Beta strandi124 – 1285
Beta strandi131 – 1377
Helixi139 – 15113
Beta strandi156 – 1583
Turni160 – 1623
Beta strandi166 – 1716

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1C04X-ray5.00B21-25[»]
1FFKX-ray2.4012-178[»]
1JJ2X-ray2.40E2-178[»]
1K73X-ray3.01G2-178[»]
1K8AX-ray3.00G2-178[»]
1K9MX-ray3.00G2-178[»]
1KC8X-ray3.01G2-178[»]
1KD1X-ray3.00G2-178[»]
1KQSX-ray3.10E2-178[»]
1M1KX-ray3.20G2-178[»]
1M90X-ray2.80G2-178[»]
1N8RX-ray3.00G2-178[»]
1NJIX-ray3.00G2-178[»]
1Q7YX-ray3.20G2-178[»]
1Q81X-ray2.95G2-178[»]
1Q82X-ray2.98G2-178[»]
1Q86X-ray3.00G2-178[»]
1QVFX-ray3.10E2-178[»]
1QVGX-ray2.90E2-178[»]
1S72X-ray2.40E1-178[»]
1VQ4X-ray2.70E1-178[»]
1VQ5X-ray2.60E1-178[»]
1VQ6X-ray2.70E1-178[»]
1VQ7X-ray2.50E1-178[»]
1VQ8X-ray2.20E1-178[»]
1VQ9X-ray2.40E1-178[»]
1VQKX-ray2.30E1-178[»]
1VQLX-ray2.30E1-178[»]
1VQMX-ray2.30E1-178[»]
1VQNX-ray2.40E1-178[»]
1VQOX-ray2.20E1-178[»]
1VQPX-ray2.25E1-178[»]
1W2BX-ray3.50E2-178[»]
1YHQX-ray2.40E1-178[»]
1YI2X-ray2.65E1-178[»]
1YIJX-ray2.60E1-178[»]
1YITX-ray2.80E1-178[»]
1YJ9X-ray2.90E1-178[»]
1YJNX-ray3.00E1-178[»]
1YJWX-ray2.90E1-178[»]
2OTJX-ray2.90E1-178[»]
2OTLX-ray2.70E1-178[»]
2QA4X-ray3.00E1-178[»]
2QEXX-ray2.90E1-178[»]
3CC2X-ray2.40E1-178[»]
3CC4X-ray2.70E1-178[»]
3CC7X-ray2.70E1-178[»]
3CCEX-ray2.75E1-178[»]
3CCJX-ray2.70E1-178[»]
3CCLX-ray2.90E1-178[»]
3CCMX-ray2.55E1-178[»]
3CCQX-ray2.90E1-178[»]
3CCRX-ray3.00E1-178[»]
3CCSX-ray2.95E1-178[»]
3CCUX-ray2.80E1-178[»]
3CCVX-ray2.90E1-178[»]
3CD6X-ray2.75E1-178[»]
3CMAX-ray2.80E1-178[»]
3CMEX-ray2.95E1-178[»]
3CPWX-ray2.70E1-178[»]
3CXCX-ray3.00E2-178[»]
3G4SX-ray3.20E2-173[»]
3G6EX-ray2.70E2-173[»]
3G71X-ray2.85E2-173[»]
3I55X-ray3.11E1-178[»]
3I56X-ray2.90E1-178[»]
3OW2X-ray2.70E2-173[»]
4ADXelectron microscopy6.60E1-178[»]
4HUBX-ray2.40E1-178[»]
ProteinModelPortaliP14135.
SMRiP14135. Positions 2-173.

Miscellaneous databases

EvolutionaryTraceiP14135.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0097.
HOGENOMiHOG000039905.
KOiK02933.
OMAiPRRTTIH.

Family and domain databases

Gene3Di3.90.930.12. 2 hits.
HAMAPiMF_01365_A. Ribosomal_L6_A.
InterProiIPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR002359. Ribosomal_L6_CS2.
IPR019907. Ribosomal_L6P_arc.
[Graphical view]
PANTHERiPTHR11655. PTHR11655. 1 hit.
PfamiPF00347. Ribosomal_L6. 2 hits.
[Graphical view]
PIRSFiPIRSF002162. Ribosomal_L6. 1 hit.
SUPFAMiSSF56053. SSF56053. 2 hits.
TIGRFAMsiTIGR03653. arch_L6P. 1 hit.
PROSITEiPS00700. RIBOSOMAL_L6_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14135-1 [UniParc]FASTAAdd to Basket

« Hide

MPRVELEIPE DVDAEQDHLD ITVEGDNGSV TRRLWYPDID VSVDGDTVVI    50
ESDEDNAKTM STIGTFQSHI ENMFHGVTEG WEYGMEVFYS HFPMQVNVEG 100
DEVVIENFLG EKAPRRTTIH GDTDVEIDGE ELTVSGPDIE AVGQTAADIE 150
QLTRINDKDV RVFQDGVYIT RKPNRGDA 178
Length:178
Mass (Da):19,944
Last modified:January 23, 2007 - v3
Checksum:i380872452165689C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31R → S.
Natural varianti24 – 241E → S.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58395 Genomic DNA. Translation: CAA41287.1.
AY596297 Genomic DNA. Translation: AAV46514.1.
PIRiS16538. R5HS6L.
RefSeqiWP_011223740.1. NC_006396.1.
YP_136220.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV46514; AAV46514; rrnAC1596.
GeneIDi3127517.
KEGGihma:rrnAC1596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58395 Genomic DNA. Translation: CAA41287.1 .
AY596297 Genomic DNA. Translation: AAV46514.1 .
PIRi S16538. R5HS6L.
RefSeqi WP_011223740.1. NC_006396.1.
YP_136220.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1C04 X-ray 5.00 B 21-25 [» ]
1FFK X-ray 2.40 1 2-178 [» ]
1JJ2 X-ray 2.40 E 2-178 [» ]
1K73 X-ray 3.01 G 2-178 [» ]
1K8A X-ray 3.00 G 2-178 [» ]
1K9M X-ray 3.00 G 2-178 [» ]
1KC8 X-ray 3.01 G 2-178 [» ]
1KD1 X-ray 3.00 G 2-178 [» ]
1KQS X-ray 3.10 E 2-178 [» ]
1M1K X-ray 3.20 G 2-178 [» ]
1M90 X-ray 2.80 G 2-178 [» ]
1N8R X-ray 3.00 G 2-178 [» ]
1NJI X-ray 3.00 G 2-178 [» ]
1Q7Y X-ray 3.20 G 2-178 [» ]
1Q81 X-ray 2.95 G 2-178 [» ]
1Q82 X-ray 2.98 G 2-178 [» ]
1Q86 X-ray 3.00 G 2-178 [» ]
1QVF X-ray 3.10 E 2-178 [» ]
1QVG X-ray 2.90 E 2-178 [» ]
1S72 X-ray 2.40 E 1-178 [» ]
1VQ4 X-ray 2.70 E 1-178 [» ]
1VQ5 X-ray 2.60 E 1-178 [» ]
1VQ6 X-ray 2.70 E 1-178 [» ]
1VQ7 X-ray 2.50 E 1-178 [» ]
1VQ8 X-ray 2.20 E 1-178 [» ]
1VQ9 X-ray 2.40 E 1-178 [» ]
1VQK X-ray 2.30 E 1-178 [» ]
1VQL X-ray 2.30 E 1-178 [» ]
1VQM X-ray 2.30 E 1-178 [» ]
1VQN X-ray 2.40 E 1-178 [» ]
1VQO X-ray 2.20 E 1-178 [» ]
1VQP X-ray 2.25 E 1-178 [» ]
1W2B X-ray 3.50 E 2-178 [» ]
1YHQ X-ray 2.40 E 1-178 [» ]
1YI2 X-ray 2.65 E 1-178 [» ]
1YIJ X-ray 2.60 E 1-178 [» ]
1YIT X-ray 2.80 E 1-178 [» ]
1YJ9 X-ray 2.90 E 1-178 [» ]
1YJN X-ray 3.00 E 1-178 [» ]
1YJW X-ray 2.90 E 1-178 [» ]
2OTJ X-ray 2.90 E 1-178 [» ]
2OTL X-ray 2.70 E 1-178 [» ]
2QA4 X-ray 3.00 E 1-178 [» ]
2QEX X-ray 2.90 E 1-178 [» ]
3CC2 X-ray 2.40 E 1-178 [» ]
3CC4 X-ray 2.70 E 1-178 [» ]
3CC7 X-ray 2.70 E 1-178 [» ]
3CCE X-ray 2.75 E 1-178 [» ]
3CCJ X-ray 2.70 E 1-178 [» ]
3CCL X-ray 2.90 E 1-178 [» ]
3CCM X-ray 2.55 E 1-178 [» ]
3CCQ X-ray 2.90 E 1-178 [» ]
3CCR X-ray 3.00 E 1-178 [» ]
3CCS X-ray 2.95 E 1-178 [» ]
3CCU X-ray 2.80 E 1-178 [» ]
3CCV X-ray 2.90 E 1-178 [» ]
3CD6 X-ray 2.75 E 1-178 [» ]
3CMA X-ray 2.80 E 1-178 [» ]
3CME X-ray 2.95 E 1-178 [» ]
3CPW X-ray 2.70 E 1-178 [» ]
3CXC X-ray 3.00 E 2-178 [» ]
3G4S X-ray 3.20 E 2-173 [» ]
3G6E X-ray 2.70 E 2-173 [» ]
3G71 X-ray 2.85 E 2-173 [» ]
3I55 X-ray 3.11 E 1-178 [» ]
3I56 X-ray 2.90 E 1-178 [» ]
3OW2 X-ray 2.70 E 2-173 [» ]
4ADX electron microscopy 6.60 E 1-178 [» ]
4HUB X-ray 2.40 E 1-178 [» ]
ProteinModelPortali P14135.
SMRi P14135. Positions 2-173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC1596.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV46514 ; AAV46514 ; rrnAC1596 .
GeneIDi 3127517.
KEGGi hma:rrnAC1596.

Phylogenomic databases

eggNOGi COG0097.
HOGENOMi HOG000039905.
KOi K02933.
OMAi PRRTTIH.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-1452-MONOMER.

Miscellaneous databases

EvolutionaryTracei P14135.

Family and domain databases

Gene3Di 3.90.930.12. 2 hits.
HAMAPi MF_01365_A. Ribosomal_L6_A.
InterProi IPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR002359. Ribosomal_L6_CS2.
IPR019907. Ribosomal_L6P_arc.
[Graphical view ]
PANTHERi PTHR11655. PTHR11655. 1 hit.
Pfami PF00347. Ribosomal_L6. 2 hits.
[Graphical view ]
PIRSFi PIRSF002162. Ribosomal_L6. 1 hit.
SUPFAMi SSF56053. SSF56053. 2 hits.
TIGRFAMsi TIGR03653. arch_L6P. 1 hit.
PROSITEi PS00700. RIBOSOMAL_L6_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organization and nucleotide sequence of ten ribosomal protein genes from the region equivalent to the spectinomycin operon in the archaebacterium Halobacterium marismortui."
    Scholzen T., Arndt E.
    Mol. Gen. Genet. 228:70-80(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  3. "The N-terminal sequence of ribosomal protein L10 from the archaebacterium Halobacterium marismortui and its relationship to eubacterial protein L6 and other ribosomal proteins."
    Dijk J., van den Broek R., Nasiulas G., Beck A., Reinhardt R., Wittmann-Liebold B.
    Biol. Chem. Hoppe-Seyler 368:921-925(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-55.
  4. "Extended N-terminal sequencing of proteins of archaebacterial ribosomes blotted from two-dimensional gels onto glass fiber and poly(vinylidene difluoride) membrane."
    Walsh M.J., McDougall J., Wittmann-Liebold B.
    Biochemistry 27:6867-6876(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-31.
  5. "Placement of protein and RNA structures into a 5 A-resolution map of the 50S ribosomal subunit."
    Ban N., Nissen P., Hansen J., Capel M., Moore P.B., Steitz T.A.
    Nature 400:841-847(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.
  6. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
    Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
    Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  7. "The structural basis of ribosome activity in peptide bond synthesis."
    Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
    Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  8. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
    Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
    Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  9. "The kink-turn: a new RNA secondary structure motif."
    Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
    EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  10. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
    Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
    Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  11. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  12. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
    Hansen J.L., Moore P.B., Steitz T.A.
    J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  13. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
    Schmeing T.M., Moore P.B., Steitz T.A.
    RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
  14. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
    Gabdulkhakov A., Nikonov S., Garber M.
    Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

Entry informationi

Entry nameiRL6_HALMA
AccessioniPrimary (citable) accession number: P14135
Secondary accession number(s): P12739, Q5V1T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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