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Protein

50S ribosomal protein L5

Gene

rpl5

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This is 1 of 5 proteins that mediates the attachment of the 5S rRNA onto the large ribosomal subunit, stabilizing the orientation of adjacent RNA domains. Forms part of the central protuberance. Modeling places the A and P site tRNAs in close proximity to this protein; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. In the 70S ribosome it is thought to contact protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L5
Alternative name(s):
Hl13
Hmal5
Gene namesi
Name:rpl5
Ordered Locus Names:rrnAC1598
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001250512 – 17750S ribosomal protein L5Add BLAST176

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Interacts with protein L18 and the 5S rRNA, and probably with tRNAs. Forms a bridge to the 30S subunit in the 70S ribosome (By similarity).By similarity

Protein-protein interaction databases

STRINGi272569.rrnAC1598.

Structurei

Secondary structure

1177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni13 – 15Combined sources3
Beta strandi18 – 27Combined sources10
Helixi39 – 45Combined sources7
Beta strandi46 – 48Combined sources3
Beta strandi51 – 54Combined sources4
Turni60 – 62Combined sources3
Beta strandi66 – 76Combined sources11
Helixi79 – 88Combined sources10
Helixi89 – 91Combined sources3
Helixi96 – 98Combined sources3
Beta strandi101 – 103Combined sources3
Beta strandi105 – 107Combined sources3
Beta strandi130 – 136Combined sources7
Helixi138 – 143Combined sources6
Beta strandi145 – 148Combined sources4
Helixi154 – 156Combined sources3
Helixi160 – 168Combined sources9
Turni169 – 171Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40D2-177[»]
1JJ2X-ray2.40D2-177[»]
1K73X-ray3.01F2-177[»]
1K8AX-ray3.00F2-177[»]
1K9MX-ray3.00F2-177[»]
1KC8X-ray3.01F2-177[»]
1KD1X-ray3.00F2-177[»]
1KQSX-ray3.10D2-177[»]
1M1KX-ray3.20F2-177[»]
1M90X-ray2.80F2-177[»]
1N8RX-ray3.00F2-177[»]
1NJIX-ray3.00F2-177[»]
1Q7YX-ray3.20F2-177[»]
1Q81X-ray2.95F2-177[»]
1Q82X-ray2.98F2-177[»]
1Q86X-ray3.00F2-177[»]
1QVFX-ray3.10D2-177[»]
1QVGX-ray2.90D2-177[»]
1S72X-ray2.40D1-177[»]
1VQ4X-ray2.70D1-177[»]
1VQ5X-ray2.60D1-177[»]
1VQ6X-ray2.70D1-177[»]
1VQ7X-ray2.50D1-177[»]
1VQ8X-ray2.20D1-177[»]
1VQ9X-ray2.40D1-177[»]
1VQKX-ray2.30D1-177[»]
1VQLX-ray2.30D1-177[»]
1VQMX-ray2.30D1-177[»]
1VQNX-ray2.40D1-177[»]
1VQOX-ray2.20D1-177[»]
1VQPX-ray2.25D1-177[»]
1W2BX-ray3.50D2-177[»]
1YHQX-ray2.40D1-177[»]
1YI2X-ray2.65D1-177[»]
1YIJX-ray2.60D1-177[»]
1YITX-ray2.80D1-177[»]
1YJ9X-ray2.90D1-177[»]
1YJNX-ray3.00D1-177[»]
1YJWX-ray2.90D1-177[»]
2OTJX-ray2.90D1-177[»]
2OTLX-ray2.70D1-177[»]
2QA4X-ray3.00D1-177[»]
2QEXX-ray2.90D1-177[»]
3CC2X-ray2.40D1-177[»]
3CC4X-ray2.70D1-177[»]
3CC7X-ray2.70D1-177[»]
3CCEX-ray2.75D1-177[»]
3CCJX-ray2.70D1-177[»]
3CCLX-ray2.90D1-177[»]
3CCMX-ray2.55D1-177[»]
3CCQX-ray2.90D1-177[»]
3CCRX-ray3.00D1-177[»]
3CCSX-ray2.95D1-177[»]
3CCUX-ray2.80D1-177[»]
3CCVX-ray2.90D1-177[»]
3CD6X-ray2.75D1-177[»]
3CMAX-ray2.80D1-177[»]
3CMEX-ray2.95D1-177[»]
3CPWX-ray2.70D1-177[»]
3CXCX-ray3.00D2-177[»]
3G4SX-ray3.20D1-177[»]
3G6EX-ray2.70D1-177[»]
3G71X-ray2.85D1-177[»]
3I55X-ray3.11D1-177[»]
3I56X-ray2.90D1-177[»]
3OW2X-ray2.70D11-175[»]
4ADXelectron microscopy6.60D1-177[»]
4V4SX-ray6.76G2-177[»]
4V4TX-ray6.46G2-177[»]
4V9FX-ray2.40D1-177[»]
ProteinModelPortaliP14124.
SMRiP14124.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14124.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L5P family.Curated

Phylogenomic databases

eggNOGiarCOG04092. Archaea.
COG0094. LUCA.
HOGENOMiHOG000231312.
KOiK02931.
OMAiEHTEFPS.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
HAMAPiMF_01333_A. Ribosomal_L5_A. 1 hit.
InterProiIPR002132. Ribosomal_L5.
IPR022804. Ribosomal_L5_arc.
IPR031309. Ribosomal_L5_C.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
IPR031310. Ribosomal_L5_N.
[Graphical view]
PfamiPF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.
PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSESESGGD FHEMREPRIE KVVVHMGIGH GGRDLANAED ILGEITGQMP
60 70 80 90 100
VRTKAKRTVG EFDIREGDPI GAKVTLRDEM AEEFLQTALP LAELATSQFD
110 120 130 140 150
DTGNFSFGVE EHTEFPSQEY DPSIGIYGLD VTVNLVRPGY RVAKRDKASR
160 170
SIPTKHRLNP ADAVAFIEST YDVEVSE
Length:177
Mass (Da):19,528
Last modified:January 23, 2007 - v4
Checksum:i565902FAA3D95FB6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134N → R AA sequence (PubMed:2198942).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58395 Genomic DNA. Translation: CAA41284.1.
AY596297 Genomic DNA. Translation: AAV46516.1.
PIRiS16535. R5HSL5.
RefSeqiWP_004957391.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV46516; AAV46516; rrnAC1598.
GeneIDi3128287.
KEGGihma:rrnAC1598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58395 Genomic DNA. Translation: CAA41284.1.
AY596297 Genomic DNA. Translation: AAV46516.1.
PIRiS16535. R5HSL5.
RefSeqiWP_004957391.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40D2-177[»]
1JJ2X-ray2.40D2-177[»]
1K73X-ray3.01F2-177[»]
1K8AX-ray3.00F2-177[»]
1K9MX-ray3.00F2-177[»]
1KC8X-ray3.01F2-177[»]
1KD1X-ray3.00F2-177[»]
1KQSX-ray3.10D2-177[»]
1M1KX-ray3.20F2-177[»]
1M90X-ray2.80F2-177[»]
1N8RX-ray3.00F2-177[»]
1NJIX-ray3.00F2-177[»]
1Q7YX-ray3.20F2-177[»]
1Q81X-ray2.95F2-177[»]
1Q82X-ray2.98F2-177[»]
1Q86X-ray3.00F2-177[»]
1QVFX-ray3.10D2-177[»]
1QVGX-ray2.90D2-177[»]
1S72X-ray2.40D1-177[»]
1VQ4X-ray2.70D1-177[»]
1VQ5X-ray2.60D1-177[»]
1VQ6X-ray2.70D1-177[»]
1VQ7X-ray2.50D1-177[»]
1VQ8X-ray2.20D1-177[»]
1VQ9X-ray2.40D1-177[»]
1VQKX-ray2.30D1-177[»]
1VQLX-ray2.30D1-177[»]
1VQMX-ray2.30D1-177[»]
1VQNX-ray2.40D1-177[»]
1VQOX-ray2.20D1-177[»]
1VQPX-ray2.25D1-177[»]
1W2BX-ray3.50D2-177[»]
1YHQX-ray2.40D1-177[»]
1YI2X-ray2.65D1-177[»]
1YIJX-ray2.60D1-177[»]
1YITX-ray2.80D1-177[»]
1YJ9X-ray2.90D1-177[»]
1YJNX-ray3.00D1-177[»]
1YJWX-ray2.90D1-177[»]
2OTJX-ray2.90D1-177[»]
2OTLX-ray2.70D1-177[»]
2QA4X-ray3.00D1-177[»]
2QEXX-ray2.90D1-177[»]
3CC2X-ray2.40D1-177[»]
3CC4X-ray2.70D1-177[»]
3CC7X-ray2.70D1-177[»]
3CCEX-ray2.75D1-177[»]
3CCJX-ray2.70D1-177[»]
3CCLX-ray2.90D1-177[»]
3CCMX-ray2.55D1-177[»]
3CCQX-ray2.90D1-177[»]
3CCRX-ray3.00D1-177[»]
3CCSX-ray2.95D1-177[»]
3CCUX-ray2.80D1-177[»]
3CCVX-ray2.90D1-177[»]
3CD6X-ray2.75D1-177[»]
3CMAX-ray2.80D1-177[»]
3CMEX-ray2.95D1-177[»]
3CPWX-ray2.70D1-177[»]
3CXCX-ray3.00D2-177[»]
3G4SX-ray3.20D1-177[»]
3G6EX-ray2.70D1-177[»]
3G71X-ray2.85D1-177[»]
3I55X-ray3.11D1-177[»]
3I56X-ray2.90D1-177[»]
3OW2X-ray2.70D11-175[»]
4ADXelectron microscopy6.60D1-177[»]
4V4SX-ray6.76G2-177[»]
4V4TX-ray6.46G2-177[»]
4V9FX-ray2.40D1-177[»]
ProteinModelPortaliP14124.
SMRiP14124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272569.rrnAC1598.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV46516; AAV46516; rrnAC1598.
GeneIDi3128287.
KEGGihma:rrnAC1598.

Phylogenomic databases

eggNOGiarCOG04092. Archaea.
COG0094. LUCA.
HOGENOMiHOG000231312.
KOiK02931.
OMAiEHTEFPS.

Miscellaneous databases

EvolutionaryTraceiP14124.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
HAMAPiMF_01333_A. Ribosomal_L5_A. 1 hit.
InterProiIPR002132. Ribosomal_L5.
IPR022804. Ribosomal_L5_arc.
IPR031309. Ribosomal_L5_C.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
IPR031310. Ribosomal_L5_N.
[Graphical view]
PfamiPF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.
PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL5_HALMA
AccessioniPrimary (citable) accession number: P14124
Secondary accession number(s): Q5V1T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.