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P14119

- RL19E_HALMA

UniProt

P14119 - RL19E_HALMA

Protein

50S ribosomal protein L19e

Gene

rpl19e

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Binds to the 23S rRNA. Located at the polypeptide exit tunnel on the outside of the subunit.

    GO - Molecular functioni

    1. large ribosomal subunit rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-1450-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L19eUniRule annotation
    Alternative name(s):
    Hl24
    Hmal19
    Gene namesi
    Name:rpl19eUniRule annotation
    Ordered Locus Names:rrnAC1594
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 14914850S ribosomal protein L19ePRO_0000131187Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit.3 PublicationsUniRule annotation

    Protein-protein interaction databases

    STRINGi272569.rrnAC1594.

    Structurei

    Secondary structure

    1
    149
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1410
    Helixi19 – 213
    Beta strandi22 – 243
    Helixi26 – 283
    Helixi29 – 346
    Helixi38 – 469
    Beta strandi49 – 524
    Helixi61 – 7111
    Helixi78 – 803
    Helixi85 – 884
    Helixi91 – 11121
    Beta strandi112 – 1154
    Helixi117 – 12711
    Turni128 – 1303
    Helixi135 – 1428

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FFKX-ray2.40M2-149[»]
    1JJ2X-ray2.40O2-149[»]
    1K73X-ray3.01Q2-149[»]
    1K8AX-ray3.00Q2-149[»]
    1K9MX-ray3.00Q2-149[»]
    1KC8X-ray3.01Q2-149[»]
    1KD1X-ray3.00Q2-149[»]
    1KQSX-ray3.10O2-149[»]
    1M1KX-ray3.20Q2-149[»]
    1M90X-ray2.80Q2-149[»]
    1N8RX-ray3.00Q2-149[»]
    1NJIX-ray3.00Q2-149[»]
    1Q7YX-ray3.20Q2-149[»]
    1Q81X-ray2.95Q2-149[»]
    1Q82X-ray2.98Q2-149[»]
    1Q86X-ray3.00Q2-149[»]
    1QVFX-ray3.10O2-149[»]
    1QVGX-ray2.90O2-149[»]
    1S72X-ray2.40P1-149[»]
    1VQ4X-ray2.70P1-149[»]
    1VQ5X-ray2.60P1-149[»]
    1VQ6X-ray2.70P1-149[»]
    1VQ7X-ray2.50P1-149[»]
    1VQ8X-ray2.20P1-149[»]
    1VQ9X-ray2.40P1-149[»]
    1VQKX-ray2.30P1-149[»]
    1VQLX-ray2.30P1-149[»]
    1VQMX-ray2.30P1-149[»]
    1VQNX-ray2.40P1-149[»]
    1VQOX-ray2.20P1-149[»]
    1VQPX-ray2.25P1-149[»]
    1W2BX-ray3.50O2-149[»]
    1YHQX-ray2.40P1-149[»]
    1YI2X-ray2.65P1-149[»]
    1YIJX-ray2.60P1-149[»]
    1YITX-ray2.80P1-149[»]
    1YJ9X-ray2.90P1-149[»]
    1YJNX-ray3.00P1-149[»]
    1YJWX-ray2.90P1-149[»]
    2OTJX-ray2.90P1-149[»]
    2OTLX-ray2.70P1-149[»]
    2QA4X-ray3.00P1-149[»]
    2QEXX-ray2.90P1-149[»]
    3CC2X-ray2.40P1-149[»]
    3CC4X-ray2.70P1-149[»]
    3CC7X-ray2.70P1-149[»]
    3CCEX-ray2.75P1-149[»]
    3CCJX-ray2.70P1-149[»]
    3CCLX-ray2.90P1-149[»]
    3CCMX-ray2.55P1-149[»]
    3CCQX-ray2.90P1-149[»]
    3CCRX-ray3.00P1-149[»]
    3CCSX-ray2.95P1-149[»]
    3CCUX-ray2.80P1-149[»]
    3CCVX-ray2.90P1-149[»]
    3CD6X-ray2.75P1-149[»]
    3CMAX-ray2.80P1-149[»]
    3CMEX-ray2.95P1-149[»]
    3CPWX-ray2.70O1-149[»]
    3CXCX-ray3.00O2-149[»]
    3G4SX-ray3.20P2-144[»]
    3G6EX-ray2.70P2-144[»]
    3G71X-ray2.85P2-144[»]
    3I55X-ray3.11P1-149[»]
    3I56X-ray2.90P1-149[»]
    3OW2X-ray2.70O2-144[»]
    4ADXelectron microscopy6.60P1-149[»]
    4HUBX-ray2.40P1-149[»]
    ProteinModelPortaliP14119.
    SMRiP14119. Positions 2-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP14119.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L19e family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2147.
    HOGENOMiHOG000231276.
    KOiK02885.
    OMAiNRIWIDP.

    Family and domain databases

    Gene3Di1.10.1200.60. 1 hit.
    1.10.1650.10. 1 hit.
    1.20.5.560. 1 hit.
    HAMAPiMF_01475. Ribosomal_L19e.
    InterProiIPR027547. Ribosomal_L19/L19e.
    IPR023638. Ribosomal_L19/L19e_CS.
    IPR000196. Ribosomal_L19/L19e_dom.
    IPR015972. Ribosomal_L19/L19e_dom1.
    IPR015973. Ribosomal_L19/L19e_dom2.
    IPR015974. Ribosomal_L19/L19e_dom3.
    [Graphical view]
    PfamiPF01280. Ribosomal_L19e. 1 hit.
    [Graphical view]
    SUPFAMiSSF48140. SSF48140. 1 hit.
    PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14119-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDLSAQKRL AADVLDVGKN RVWFNPERQG DIADAITRED VRELVDEGAI    50
    QAKDKKGNSR GRARERQKKR AYGHQKGAGS RKGKAGARQN SKEDWESRIR 100
    AQRTKLRELR DEGTLSSSQY RDLYDKAGGG EFDSVADLER YIDANHGDA 149
    Length:149
    Mass (Da):16,762
    Last modified:January 23, 2007 - v3
    Checksum:i210F99E836B0B817
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821K → G AA sequence (PubMed:2591382)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58395 Genomic DNA. Translation: CAA41289.1.
    AY596297 Genomic DNA. Translation: AAV46512.1.
    PIRiS16540. R5HSH4.
    RefSeqiYP_136218.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV46512; AAV46512; rrnAC1594.
    GeneIDi3127911.
    KEGGihma:rrnAC1594.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58395 Genomic DNA. Translation: CAA41289.1 .
    AY596297 Genomic DNA. Translation: AAV46512.1 .
    PIRi S16540. R5HSH4.
    RefSeqi YP_136218.1. NC_006396.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FFK X-ray 2.40 M 2-149 [» ]
    1JJ2 X-ray 2.40 O 2-149 [» ]
    1K73 X-ray 3.01 Q 2-149 [» ]
    1K8A X-ray 3.00 Q 2-149 [» ]
    1K9M X-ray 3.00 Q 2-149 [» ]
    1KC8 X-ray 3.01 Q 2-149 [» ]
    1KD1 X-ray 3.00 Q 2-149 [» ]
    1KQS X-ray 3.10 O 2-149 [» ]
    1M1K X-ray 3.20 Q 2-149 [» ]
    1M90 X-ray 2.80 Q 2-149 [» ]
    1N8R X-ray 3.00 Q 2-149 [» ]
    1NJI X-ray 3.00 Q 2-149 [» ]
    1Q7Y X-ray 3.20 Q 2-149 [» ]
    1Q81 X-ray 2.95 Q 2-149 [» ]
    1Q82 X-ray 2.98 Q 2-149 [» ]
    1Q86 X-ray 3.00 Q 2-149 [» ]
    1QVF X-ray 3.10 O 2-149 [» ]
    1QVG X-ray 2.90 O 2-149 [» ]
    1S72 X-ray 2.40 P 1-149 [» ]
    1VQ4 X-ray 2.70 P 1-149 [» ]
    1VQ5 X-ray 2.60 P 1-149 [» ]
    1VQ6 X-ray 2.70 P 1-149 [» ]
    1VQ7 X-ray 2.50 P 1-149 [» ]
    1VQ8 X-ray 2.20 P 1-149 [» ]
    1VQ9 X-ray 2.40 P 1-149 [» ]
    1VQK X-ray 2.30 P 1-149 [» ]
    1VQL X-ray 2.30 P 1-149 [» ]
    1VQM X-ray 2.30 P 1-149 [» ]
    1VQN X-ray 2.40 P 1-149 [» ]
    1VQO X-ray 2.20 P 1-149 [» ]
    1VQP X-ray 2.25 P 1-149 [» ]
    1W2B X-ray 3.50 O 2-149 [» ]
    1YHQ X-ray 2.40 P 1-149 [» ]
    1YI2 X-ray 2.65 P 1-149 [» ]
    1YIJ X-ray 2.60 P 1-149 [» ]
    1YIT X-ray 2.80 P 1-149 [» ]
    1YJ9 X-ray 2.90 P 1-149 [» ]
    1YJN X-ray 3.00 P 1-149 [» ]
    1YJW X-ray 2.90 P 1-149 [» ]
    2OTJ X-ray 2.90 P 1-149 [» ]
    2OTL X-ray 2.70 P 1-149 [» ]
    2QA4 X-ray 3.00 P 1-149 [» ]
    2QEX X-ray 2.90 P 1-149 [» ]
    3CC2 X-ray 2.40 P 1-149 [» ]
    3CC4 X-ray 2.70 P 1-149 [» ]
    3CC7 X-ray 2.70 P 1-149 [» ]
    3CCE X-ray 2.75 P 1-149 [» ]
    3CCJ X-ray 2.70 P 1-149 [» ]
    3CCL X-ray 2.90 P 1-149 [» ]
    3CCM X-ray 2.55 P 1-149 [» ]
    3CCQ X-ray 2.90 P 1-149 [» ]
    3CCR X-ray 3.00 P 1-149 [» ]
    3CCS X-ray 2.95 P 1-149 [» ]
    3CCU X-ray 2.80 P 1-149 [» ]
    3CCV X-ray 2.90 P 1-149 [» ]
    3CD6 X-ray 2.75 P 1-149 [» ]
    3CMA X-ray 2.80 P 1-149 [» ]
    3CME X-ray 2.95 P 1-149 [» ]
    3CPW X-ray 2.70 O 1-149 [» ]
    3CXC X-ray 3.00 O 2-149 [» ]
    3G4S X-ray 3.20 P 2-144 [» ]
    3G6E X-ray 2.70 P 2-144 [» ]
    3G71 X-ray 2.85 P 2-144 [» ]
    3I55 X-ray 3.11 P 1-149 [» ]
    3I56 X-ray 2.90 P 1-149 [» ]
    3OW2 X-ray 2.70 O 2-144 [» ]
    4ADX electron microscopy 6.60 P 1-149 [» ]
    4HUB X-ray 2.40 P 1-149 [» ]
    ProteinModelPortali P14119.
    SMRi P14119. Positions 2-144.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC1594.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV46512 ; AAV46512 ; rrnAC1594 .
    GeneIDi 3127911.
    KEGGi hma:rrnAC1594.

    Phylogenomic databases

    eggNOGi COG2147.
    HOGENOMi HOG000231276.
    KOi K02885.
    OMAi NRIWIDP.

    Enzyme and pathway databases

    BioCyci HMAR272569:GJDH-1450-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P14119.

    Family and domain databases

    Gene3Di 1.10.1200.60. 1 hit.
    1.10.1650.10. 1 hit.
    1.20.5.560. 1 hit.
    HAMAPi MF_01475. Ribosomal_L19e.
    InterProi IPR027547. Ribosomal_L19/L19e.
    IPR023638. Ribosomal_L19/L19e_CS.
    IPR000196. Ribosomal_L19/L19e_dom.
    IPR015972. Ribosomal_L19/L19e_dom1.
    IPR015973. Ribosomal_L19/L19e_dom2.
    IPR015974. Ribosomal_L19/L19e_dom3.
    [Graphical view ]
    Pfami PF01280. Ribosomal_L19e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48140. SSF48140. 1 hit.
    PROSITEi PS00526. RIBOSOMAL_L19E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization and nucleotide sequence of ten ribosomal protein genes from the region equivalent to the spectinomycin operon in the archaebacterium Halobacterium marismortui."
      Scholzen T., Arndt E.
      Mol. Gen. Genet. 228:70-80(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    3. "Primary structures of five ribosomal proteins from the archaebacterium Halobacterium marismortui and their structural relationships to eubacterial and eukaryotic ribosomal proteins."
      Hatakeyama T., Kaufmann F., Schroeter B., Hatakeyama T.
      Eur. J. Biochem. 185:685-693(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-149, SUBUNIT.
    4. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
      Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
      Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    5. "The structural basis of ribosome activity in peptide bond synthesis."
      Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
      Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    6. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
      Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
      Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    7. "The kink-turn: a new RNA secondary structure motif."
      Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
      EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    8. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
      Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
      Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    9. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    10. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
      Hansen J.L., Moore P.B., Steitz T.A.
      J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    11. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
      Schmeing T.M., Moore P.B., Steitz T.A.
      RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
    12. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
      Gabdulkhakov A., Nikonov S., Garber M.
      Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

    Entry informationi

    Entry nameiRL19E_HALMA
    AccessioniPrimary (citable) accession number: P14119
    Secondary accession number(s): Q5V1U0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3