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P14119

- RL19E_HALMA

UniProt

P14119 - RL19E_HALMA

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Protein

50S ribosomal protein L19e

Gene
rpl19e, rrnAC1594
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA. Located at the polypeptide exit tunnel on the outside of the subunit.UniRule annotation

GO - Molecular functioni

  1. large ribosomal subunit rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-1450-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L19e
Alternative name(s):
Hl24
Hmal19
Gene namesi
Name:rpl19e
Ordered Locus Names:rrnAC1594
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 14914850S ribosomal protein L19eUniRule annotationPRO_0000131187Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.10 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC1594.

Structurei

Secondary structure

1
149
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1410
Helixi19 – 213
Beta strandi22 – 243
Helixi26 – 283
Helixi29 – 346
Helixi38 – 469
Beta strandi49 – 524
Helixi61 – 7111
Helixi78 – 803
Helixi85 – 884
Helixi91 – 11121
Beta strandi112 – 1154
Helixi117 – 12711
Turni128 – 1303
Helixi135 – 1428

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40M2-149[»]
1JJ2X-ray2.40O2-149[»]
1K73X-ray3.01Q2-149[»]
1K8AX-ray3.00Q2-149[»]
1K9MX-ray3.00Q2-149[»]
1KC8X-ray3.01Q2-149[»]
1KD1X-ray3.00Q2-149[»]
1KQSX-ray3.10O2-149[»]
1M1KX-ray3.20Q2-149[»]
1M90X-ray2.80Q2-149[»]
1N8RX-ray3.00Q2-149[»]
1NJIX-ray3.00Q2-149[»]
1Q7YX-ray3.20Q2-149[»]
1Q81X-ray2.95Q2-149[»]
1Q82X-ray2.98Q2-149[»]
1Q86X-ray3.00Q2-149[»]
1QVFX-ray3.10O2-149[»]
1QVGX-ray2.90O2-149[»]
1S72X-ray2.40P1-149[»]
1VQ4X-ray2.70P1-149[»]
1VQ5X-ray2.60P1-149[»]
1VQ6X-ray2.70P1-149[»]
1VQ7X-ray2.50P1-149[»]
1VQ8X-ray2.20P1-149[»]
1VQ9X-ray2.40P1-149[»]
1VQKX-ray2.30P1-149[»]
1VQLX-ray2.30P1-149[»]
1VQMX-ray2.30P1-149[»]
1VQNX-ray2.40P1-149[»]
1VQOX-ray2.20P1-149[»]
1VQPX-ray2.25P1-149[»]
1W2BX-ray3.50O2-149[»]
1YHQX-ray2.40P1-149[»]
1YI2X-ray2.65P1-149[»]
1YIJX-ray2.60P1-149[»]
1YITX-ray2.80P1-149[»]
1YJ9X-ray2.90P1-149[»]
1YJNX-ray3.00P1-149[»]
1YJWX-ray2.90P1-149[»]
2OTJX-ray2.90P1-149[»]
2OTLX-ray2.70P1-149[»]
2QA4X-ray3.00P1-149[»]
2QEXX-ray2.90P1-149[»]
3CC2X-ray2.40P1-149[»]
3CC4X-ray2.70P1-149[»]
3CC7X-ray2.70P1-149[»]
3CCEX-ray2.75P1-149[»]
3CCJX-ray2.70P1-149[»]
3CCLX-ray2.90P1-149[»]
3CCMX-ray2.55P1-149[»]
3CCQX-ray2.90P1-149[»]
3CCRX-ray3.00P1-149[»]
3CCSX-ray2.95P1-149[»]
3CCUX-ray2.80P1-149[»]
3CCVX-ray2.90P1-149[»]
3CD6X-ray2.75P1-149[»]
3CMAX-ray2.80P1-149[»]
3CMEX-ray2.95P1-149[»]
3CPWX-ray2.70O1-149[»]
3CXCX-ray3.00O2-149[»]
3G4SX-ray3.20P2-144[»]
3G6EX-ray2.70P2-144[»]
3G71X-ray2.85P2-144[»]
3I55X-ray3.11P1-149[»]
3I56X-ray2.90P1-149[»]
3OW2X-ray2.70O2-144[»]
4ADXelectron microscopy6.60P1-149[»]
4HUBX-ray2.40P1-149[»]
ProteinModelPortaliP14119.
SMRiP14119. Positions 2-144.

Miscellaneous databases

EvolutionaryTraceiP14119.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2147.
HOGENOMiHOG000231276.
KOiK02885.
OMAiNRIWIDP.

Family and domain databases

Gene3Di1.10.1200.60. 1 hit.
1.10.1650.10. 1 hit.
1.20.5.560. 1 hit.
HAMAPiMF_01475. Ribosomal_L19e.
InterProiIPR027547. Ribosomal_L19/L19e.
IPR023638. Ribosomal_L19/L19e_CS.
IPR000196. Ribosomal_L19/L19e_dom.
IPR015972. Ribosomal_L19/L19e_dom1.
IPR015973. Ribosomal_L19/L19e_dom2.
IPR015974. Ribosomal_L19/L19e_dom3.
[Graphical view]
PfamiPF01280. Ribosomal_L19e. 1 hit.
[Graphical view]
SUPFAMiSSF48140. SSF48140. 1 hit.
PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14119-1 [UniParc]FASTAAdd to Basket

« Hide

MTDLSAQKRL AADVLDVGKN RVWFNPERQG DIADAITRED VRELVDEGAI    50
QAKDKKGNSR GRARERQKKR AYGHQKGAGS RKGKAGARQN SKEDWESRIR 100
AQRTKLRELR DEGTLSSSQY RDLYDKAGGG EFDSVADLER YIDANHGDA 149
Length:149
Mass (Da):16,762
Last modified:January 23, 2007 - v3
Checksum:i210F99E836B0B817
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821K → G AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58395 Genomic DNA. Translation: CAA41289.1.
AY596297 Genomic DNA. Translation: AAV46512.1.
PIRiS16540. R5HSH4.
RefSeqiYP_136218.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV46512; AAV46512; rrnAC1594.
GeneIDi3127911.
KEGGihma:rrnAC1594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58395 Genomic DNA. Translation: CAA41289.1 .
AY596297 Genomic DNA. Translation: AAV46512.1 .
PIRi S16540. R5HSH4.
RefSeqi YP_136218.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FFK X-ray 2.40 M 2-149 [» ]
1JJ2 X-ray 2.40 O 2-149 [» ]
1K73 X-ray 3.01 Q 2-149 [» ]
1K8A X-ray 3.00 Q 2-149 [» ]
1K9M X-ray 3.00 Q 2-149 [» ]
1KC8 X-ray 3.01 Q 2-149 [» ]
1KD1 X-ray 3.00 Q 2-149 [» ]
1KQS X-ray 3.10 O 2-149 [» ]
1M1K X-ray 3.20 Q 2-149 [» ]
1M90 X-ray 2.80 Q 2-149 [» ]
1N8R X-ray 3.00 Q 2-149 [» ]
1NJI X-ray 3.00 Q 2-149 [» ]
1Q7Y X-ray 3.20 Q 2-149 [» ]
1Q81 X-ray 2.95 Q 2-149 [» ]
1Q82 X-ray 2.98 Q 2-149 [» ]
1Q86 X-ray 3.00 Q 2-149 [» ]
1QVF X-ray 3.10 O 2-149 [» ]
1QVG X-ray 2.90 O 2-149 [» ]
1S72 X-ray 2.40 P 1-149 [» ]
1VQ4 X-ray 2.70 P 1-149 [» ]
1VQ5 X-ray 2.60 P 1-149 [» ]
1VQ6 X-ray 2.70 P 1-149 [» ]
1VQ7 X-ray 2.50 P 1-149 [» ]
1VQ8 X-ray 2.20 P 1-149 [» ]
1VQ9 X-ray 2.40 P 1-149 [» ]
1VQK X-ray 2.30 P 1-149 [» ]
1VQL X-ray 2.30 P 1-149 [» ]
1VQM X-ray 2.30 P 1-149 [» ]
1VQN X-ray 2.40 P 1-149 [» ]
1VQO X-ray 2.20 P 1-149 [» ]
1VQP X-ray 2.25 P 1-149 [» ]
1W2B X-ray 3.50 O 2-149 [» ]
1YHQ X-ray 2.40 P 1-149 [» ]
1YI2 X-ray 2.65 P 1-149 [» ]
1YIJ X-ray 2.60 P 1-149 [» ]
1YIT X-ray 2.80 P 1-149 [» ]
1YJ9 X-ray 2.90 P 1-149 [» ]
1YJN X-ray 3.00 P 1-149 [» ]
1YJW X-ray 2.90 P 1-149 [» ]
2OTJ X-ray 2.90 P 1-149 [» ]
2OTL X-ray 2.70 P 1-149 [» ]
2QA4 X-ray 3.00 P 1-149 [» ]
2QEX X-ray 2.90 P 1-149 [» ]
3CC2 X-ray 2.40 P 1-149 [» ]
3CC4 X-ray 2.70 P 1-149 [» ]
3CC7 X-ray 2.70 P 1-149 [» ]
3CCE X-ray 2.75 P 1-149 [» ]
3CCJ X-ray 2.70 P 1-149 [» ]
3CCL X-ray 2.90 P 1-149 [» ]
3CCM X-ray 2.55 P 1-149 [» ]
3CCQ X-ray 2.90 P 1-149 [» ]
3CCR X-ray 3.00 P 1-149 [» ]
3CCS X-ray 2.95 P 1-149 [» ]
3CCU X-ray 2.80 P 1-149 [» ]
3CCV X-ray 2.90 P 1-149 [» ]
3CD6 X-ray 2.75 P 1-149 [» ]
3CMA X-ray 2.80 P 1-149 [» ]
3CME X-ray 2.95 P 1-149 [» ]
3CPW X-ray 2.70 O 1-149 [» ]
3CXC X-ray 3.00 O 2-149 [» ]
3G4S X-ray 3.20 P 2-144 [» ]
3G6E X-ray 2.70 P 2-144 [» ]
3G71 X-ray 2.85 P 2-144 [» ]
3I55 X-ray 3.11 P 1-149 [» ]
3I56 X-ray 2.90 P 1-149 [» ]
3OW2 X-ray 2.70 O 2-144 [» ]
4ADX electron microscopy 6.60 P 1-149 [» ]
4HUB X-ray 2.40 P 1-149 [» ]
ProteinModelPortali P14119.
SMRi P14119. Positions 2-144.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC1594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV46512 ; AAV46512 ; rrnAC1594 .
GeneIDi 3127911.
KEGGi hma:rrnAC1594.

Phylogenomic databases

eggNOGi COG2147.
HOGENOMi HOG000231276.
KOi K02885.
OMAi NRIWIDP.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-1450-MONOMER.

Miscellaneous databases

EvolutionaryTracei P14119.

Family and domain databases

Gene3Di 1.10.1200.60. 1 hit.
1.10.1650.10. 1 hit.
1.20.5.560. 1 hit.
HAMAPi MF_01475. Ribosomal_L19e.
InterProi IPR027547. Ribosomal_L19/L19e.
IPR023638. Ribosomal_L19/L19e_CS.
IPR000196. Ribosomal_L19/L19e_dom.
IPR015972. Ribosomal_L19/L19e_dom1.
IPR015973. Ribosomal_L19/L19e_dom2.
IPR015974. Ribosomal_L19/L19e_dom3.
[Graphical view ]
Pfami PF01280. Ribosomal_L19e. 1 hit.
[Graphical view ]
SUPFAMi SSF48140. SSF48140. 1 hit.
PROSITEi PS00526. RIBOSOMAL_L19E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organization and nucleotide sequence of ten ribosomal protein genes from the region equivalent to the spectinomycin operon in the archaebacterium Halobacterium marismortui."
    Scholzen T., Arndt E.
    Mol. Gen. Genet. 228:70-80(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  3. "Primary structures of five ribosomal proteins from the archaebacterium Halobacterium marismortui and their structural relationships to eubacterial and eukaryotic ribosomal proteins."
    Hatakeyama T., Kaufmann F., Schroeter B., Hatakeyama T.
    Eur. J. Biochem. 185:685-693(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-149, SUBUNIT.
  4. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
    Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
    Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  5. "The structural basis of ribosome activity in peptide bond synthesis."
    Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
    Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  6. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
    Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
    Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  7. "The kink-turn: a new RNA secondary structure motif."
    Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
    EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  8. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
    Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
    Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  9. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  10. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
    Hansen J.L., Moore P.B., Steitz T.A.
    J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  11. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
    Schmeing T.M., Moore P.B., Steitz T.A.
    RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
  12. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
    Gabdulkhakov A., Nikonov S., Garber M.
    Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

Entry informationi

Entry nameiRL19E_HALMA
AccessioniPrimary (citable) accession number: P14119
Secondary accession number(s): Q5V1U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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