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P14116 (RL24E_HALMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L24e
Alternative name(s):
Hl21/Hl22
Gene names
Name:rpl24e
Ordered Locus Names:rrnAC0104
OrganismHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]
Taxonomic identifier272569 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula

Protein attributes

Sequence length67 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the 23S rRNA. HAMAP-Rule MF_00773

Cofactor

Binds 1 zinc ion per subunit Probable.

Subunit structure

Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11

Sequence similarities

Belongs to the ribosomal protein L24e family.

Sequence caution

The sequence AAV45180.1 differs from that shown. Reason: Frameshift at position 67.

Ontologies

Keywords
   DomainZinc-finger
   LigandMetal-binding
RNA-binding
rRNA-binding
Zinc
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 676650S ribosomal protein L24e HAMAP-Rule MF_00773
PRO_0000136913

Regions

Zinc finger7 – 3731C4-type Probable

Sites

Metal binding71Zinc Probable
Metal binding101Zinc Probable
Metal binding331Zinc Probable
Metal binding371Zinc Probable

Secondary structure

............... 67
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P14116 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: D4FCAE00935B7305

FASTA677,356
        10         20         30         40         50         60 
MPRTRECDYC GTDIEPGTGT MFVHKDGATT HFCSSKCENN ADLGREARNL EWTDTARGEA 


GEAEDEA 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[2]"Primary structures of five ribosomal proteins from the archaebacterium Halobacterium marismortui and their structural relationships to eubacterial and eukaryotic ribosomal proteins."
Hatakeyama T., Kaufmann F., Schroeter B., Hatakeyama T.
Eur. J. Biochem. 185:685-693(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-67.
[3]"The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[4]"The structural basis of ribosome activity in peptide bond synthesis."
Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[5]"A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[6]"The kink-turn: a new RNA secondary structure motif."
Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[7]"The structures of four macrolide antibiotics bound to the large ribosomal subunit."
Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[8]"Structural insights into peptide bond formation."
Hansen J.L., Schmeing T.M., Moore P.B., Steitz T.A.
Proc. Natl. Acad. Sci. U.S.A. 99:11670-11675(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[9]"Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
Hansen J.L., Moore P.B., Steitz T.A.
J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[10]"Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
Schmeing T.M., Moore P.B., Steitz T.A.
RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
[11]"Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
Gabdulkhakov A., Nikonov S., Garber M.
Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY596297 Genomic DNA. Translation: AAV45180.1. Frameshift.
PIRR6HS21. S06846.
RefSeqYP_134886.1. NC_006396.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40R2-67[»]
1JJ2X-ray2.40T2-67[»]
1K73X-ray3.01V2-67[»]
1K8AX-ray3.00V2-67[»]
1K9MX-ray3.00V2-67[»]
1KC8X-ray3.01V2-67[»]
1KD1X-ray3.00V2-67[»]
1KQSX-ray3.10T2-67[»]
1M1KX-ray3.20V2-67[»]
1M90X-ray2.80V2-67[»]
1ML5electron microscopy14.00r2-67[»]
1N8RX-ray3.00V2-67[»]
1NJIX-ray3.00V2-67[»]
1Q7YX-ray3.20V2-67[»]
1Q81X-ray2.95V2-67[»]
1Q82X-ray2.98V2-67[»]
1Q86X-ray3.00V2-67[»]
1QVFX-ray3.10T2-67[»]
1QVGX-ray2.90T2-67[»]
1S72X-ray2.40U2-67[»]
1VQ4X-ray2.70U2-67[»]
1VQ5X-ray2.60U2-67[»]
1VQ6X-ray2.70U2-67[»]
1VQ7X-ray2.50U2-67[»]
1VQ8X-ray2.20U2-67[»]
1VQ9X-ray2.40U2-67[»]
1VQKX-ray2.30U2-67[»]
1VQLX-ray2.30U2-67[»]
1VQMX-ray2.30U2-67[»]
1VQNX-ray2.40U2-67[»]
1VQOX-ray2.20U2-67[»]
1VQPX-ray2.25U2-67[»]
1W2BX-ray3.50T2-67[»]
1YHQX-ray2.40U2-67[»]
1YI2X-ray2.65U2-67[»]
1YIJX-ray2.60U2-67[»]
1YITX-ray2.80U2-67[»]
1YJ9X-ray2.80U2-67[»]
1YJNX-ray3.00U2-67[»]
1YJWX-ray2.90U2-67[»]
2B9PX-ray6.46T2-67[»]
2OTJX-ray2.90U2-67[»]
2OTLX-ray2.70U2-67[»]
2QA4X-ray3.00U1-67[»]
2QEXX-ray2.90U1-67[»]
3CC2X-ray2.40U1-67[»]
3CC4X-ray2.70U1-67[»]
3CC7X-ray2.70U1-67[»]
3CCEX-ray2.75U1-67[»]
3CCJX-ray2.70U1-67[»]
3CCLX-ray2.90U1-67[»]
3CCMX-ray2.55U1-67[»]
3CCQX-ray2.90U1-67[»]
3CCRX-ray3.00U1-67[»]
3CCSX-ray2.95U1-67[»]
3CCUX-ray2.80U1-67[»]
3CCVX-ray2.90U1-67[»]
3CD6X-ray2.75U1-67[»]
3CMAX-ray2.80U1-67[»]
3CMEX-ray2.95U1-67[»]
3CPWX-ray2.70T1-67[»]
3CXCX-ray3.00T2-67[»]
3G4SX-ray3.20U5-57[»]
3G6EX-ray2.70U5-57[»]
3G71X-ray2.85U5-57[»]
3I55X-ray3.11U2-67[»]
3I56X-ray2.90U2-67[»]
3OW2X-ray2.70T5-57[»]
4HUBX-ray2.40U1-67[»]
ProteinModelPortalP14116.
SMRP14116. Positions 5-57.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272569.rrnAC0104.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV45180; AAV45180; rrnAC0104.
GeneID3130240.
KEGGhma:rrnAC0104.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2075.
HOGENOMHOG000156057.
KOK02896.
ProtClustDBPRK14891.

Enzyme and pathway databases

BioCycHMAR272569:GJDH-97-MONOMER.

Family and domain databases

Gene3D2.30.170.20. 1 hit.
HAMAPMF_00773. Ribosomal_L24e.
InterProIPR023438. Ribosomal_L24e_arc.
IPR023442. Ribosomal_L24e_CS.
IPR023441. Ribosomal_L24e_dom.
IPR000988. Ribosomal_L24e_rel.
IPR011017. TRASH_dom.
[Graphical view]
PANTHERPTHR10792. PTHR10792. 1 hit.
PfamPF01246. Ribosomal_L24e. 1 hit.
[Graphical view]
SMARTSM00746. TRASH. 1 hit.
[Graphical view]
PROSITEPS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP14116.

Entry information

Entry nameRL24E_HALMA
AccessionPrimary (citable) accession number: P14116
Secondary accession number(s): Q5V5M2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references