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P14116

- RL24E_HALMA

UniProt

P14116 - RL24E_HALMA

Protein

50S ribosomal protein L24e

Gene

rpl24e

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to the 23S rRNA.

    Cofactori

    Binds 1 zinc ion per subunit.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi7 – 71ZincCurated
    Metal bindingi10 – 101ZincCurated
    Metal bindingi33 – 331ZincCurated
    Metal bindingi37 – 371ZincCurated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri7 – 3731C4-typeCuratedAdd
    BLAST

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    Metal-binding, RNA-binding, rRNA-binding, Zinc

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-97-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L24e
    Alternative name(s):
    Hl21/Hl22
    Gene namesi
    Name:rpl24e
    Ordered Locus Names:rrnAC0104
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 676650S ribosomal protein L24ePRO_0000136913Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.2 Publications

    Protein-protein interaction databases

    STRINGi272569.rrnAC0104.

    Structurei

    Secondary structure

    1
    67
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni8 – 103
    Beta strandi20 – 234
    Beta strandi25 – 273
    Beta strandi29 – 335
    Helixi35 – 428
    Helixi47 – 493
    Beta strandi50 – 534
    Turni54 – 563

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FFKX-ray2.40R2-67[»]
    1JJ2X-ray2.40T2-67[»]
    1K73X-ray3.01V2-67[»]
    1K8AX-ray3.00V2-67[»]
    1K9MX-ray3.00V2-67[»]
    1KC8X-ray3.01V2-67[»]
    1KD1X-ray3.00V2-67[»]
    1KQSX-ray3.10T2-67[»]
    1M1KX-ray3.20V2-67[»]
    1M90X-ray2.80V2-67[»]
    1ML5electron microscopy14.00r2-67[»]
    1N8RX-ray3.00V2-67[»]
    1NJIX-ray3.00V2-67[»]
    1Q7YX-ray3.20V2-67[»]
    1Q81X-ray2.95V2-67[»]
    1Q82X-ray2.98V2-67[»]
    1Q86X-ray3.00V2-67[»]
    1QVFX-ray3.10T2-67[»]
    1QVGX-ray2.90T2-67[»]
    1S72X-ray2.40U2-67[»]
    1VQ4X-ray2.70U2-67[»]
    1VQ5X-ray2.60U2-67[»]
    1VQ6X-ray2.70U2-67[»]
    1VQ7X-ray2.50U2-67[»]
    1VQ8X-ray2.20U2-67[»]
    1VQ9X-ray2.40U2-67[»]
    1VQKX-ray2.30U2-67[»]
    1VQLX-ray2.30U2-67[»]
    1VQMX-ray2.30U2-67[»]
    1VQNX-ray2.40U2-67[»]
    1VQOX-ray2.20U2-67[»]
    1VQPX-ray2.25U2-67[»]
    1W2BX-ray3.50T2-67[»]
    1YHQX-ray2.40U2-67[»]
    1YI2X-ray2.65U2-67[»]
    1YIJX-ray2.60U2-67[»]
    1YITX-ray2.80U2-67[»]
    1YJ9X-ray2.80U2-67[»]
    1YJNX-ray3.00U2-67[»]
    1YJWX-ray2.90U2-67[»]
    2B66X-ray5.90T2-67[»]
    2B9NX-ray6.76T2-67[»]
    2B9PX-ray6.46T2-67[»]
    2OTJX-ray2.90U2-67[»]
    2OTLX-ray2.70U2-67[»]
    2QA4X-ray3.00U1-67[»]
    2QEXX-ray2.90U1-67[»]
    3CC2X-ray2.40U1-67[»]
    3CC4X-ray2.70U1-67[»]
    3CC7X-ray2.70U1-67[»]
    3CCEX-ray2.75U1-67[»]
    3CCJX-ray2.70U1-67[»]
    3CCLX-ray2.90U1-67[»]
    3CCMX-ray2.55U1-67[»]
    3CCQX-ray2.90U1-67[»]
    3CCRX-ray3.00U1-67[»]
    3CCSX-ray2.95U1-67[»]
    3CCUX-ray2.80U1-67[»]
    3CCVX-ray2.90U1-67[»]
    3CD6X-ray2.75U1-67[»]
    3CMAX-ray2.80U1-67[»]
    3CMEX-ray2.95U1-67[»]
    3CPWX-ray2.70T1-67[»]
    3CXCX-ray3.00T2-67[»]
    3G4SX-ray3.20U5-57[»]
    3G6EX-ray2.70U5-57[»]
    3G71X-ray2.85U5-57[»]
    3I55X-ray3.11U2-67[»]
    3I56X-ray2.90U2-67[»]
    3OW2X-ray2.70T5-57[»]
    4ADXelectron microscopy6.60U1-67[»]
    4HUBX-ray2.40U1-67[»]
    ProteinModelPortaliP14116.
    SMRiP14116. Positions 5-57.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP14116.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L24e family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri7 – 3731C4-typeCuratedAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG2075.
    HOGENOMiHOG000156057.
    KOiK02896.

    Family and domain databases

    Gene3Di2.30.170.20. 1 hit.
    HAMAPiMF_00773. Ribosomal_L24e.
    InterProiIPR023438. Ribosomal_L24e_arc.
    IPR023442. Ribosomal_L24e_CS.
    IPR023441. Ribosomal_L24e_dom.
    IPR000988. Ribosomal_L24e_rel.
    IPR011017. TRASH_dom.
    [Graphical view]
    PANTHERiPTHR10792. PTHR10792. 1 hit.
    PfamiPF01246. Ribosomal_L24e. 1 hit.
    [Graphical view]
    SMARTiSM00746. TRASH. 1 hit.
    [Graphical view]
    PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14116-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRTRECDYC GTDIEPGTGT MFVHKDGATT HFCSSKCENN ADLGREARNL   50
    EWTDTARGEA GEAEDEA 67
    Length:67
    Mass (Da):7,356
    Last modified:January 23, 2007 - v2
    Checksum:iD4FCAE00935B7305
    GO

    Sequence cautioni

    The sequence AAV45180.1 differs from that shown. Reason: Frameshift at position 67.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV45180.1. Frameshift.
    PIRiS06846. R6HS21.
    RefSeqiYP_134886.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV45180; AAV45180; rrnAC0104.
    GeneIDi3130240.
    KEGGihma:rrnAC0104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV45180.1 . Frameshift.
    PIRi S06846. R6HS21.
    RefSeqi YP_134886.1. NC_006396.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FFK X-ray 2.40 R 2-67 [» ]
    1JJ2 X-ray 2.40 T 2-67 [» ]
    1K73 X-ray 3.01 V 2-67 [» ]
    1K8A X-ray 3.00 V 2-67 [» ]
    1K9M X-ray 3.00 V 2-67 [» ]
    1KC8 X-ray 3.01 V 2-67 [» ]
    1KD1 X-ray 3.00 V 2-67 [» ]
    1KQS X-ray 3.10 T 2-67 [» ]
    1M1K X-ray 3.20 V 2-67 [» ]
    1M90 X-ray 2.80 V 2-67 [» ]
    1ML5 electron microscopy 14.00 r 2-67 [» ]
    1N8R X-ray 3.00 V 2-67 [» ]
    1NJI X-ray 3.00 V 2-67 [» ]
    1Q7Y X-ray 3.20 V 2-67 [» ]
    1Q81 X-ray 2.95 V 2-67 [» ]
    1Q82 X-ray 2.98 V 2-67 [» ]
    1Q86 X-ray 3.00 V 2-67 [» ]
    1QVF X-ray 3.10 T 2-67 [» ]
    1QVG X-ray 2.90 T 2-67 [» ]
    1S72 X-ray 2.40 U 2-67 [» ]
    1VQ4 X-ray 2.70 U 2-67 [» ]
    1VQ5 X-ray 2.60 U 2-67 [» ]
    1VQ6 X-ray 2.70 U 2-67 [» ]
    1VQ7 X-ray 2.50 U 2-67 [» ]
    1VQ8 X-ray 2.20 U 2-67 [» ]
    1VQ9 X-ray 2.40 U 2-67 [» ]
    1VQK X-ray 2.30 U 2-67 [» ]
    1VQL X-ray 2.30 U 2-67 [» ]
    1VQM X-ray 2.30 U 2-67 [» ]
    1VQN X-ray 2.40 U 2-67 [» ]
    1VQO X-ray 2.20 U 2-67 [» ]
    1VQP X-ray 2.25 U 2-67 [» ]
    1W2B X-ray 3.50 T 2-67 [» ]
    1YHQ X-ray 2.40 U 2-67 [» ]
    1YI2 X-ray 2.65 U 2-67 [» ]
    1YIJ X-ray 2.60 U 2-67 [» ]
    1YIT X-ray 2.80 U 2-67 [» ]
    1YJ9 X-ray 2.80 U 2-67 [» ]
    1YJN X-ray 3.00 U 2-67 [» ]
    1YJW X-ray 2.90 U 2-67 [» ]
    2B66 X-ray 5.90 T 2-67 [» ]
    2B9N X-ray 6.76 T 2-67 [» ]
    2B9P X-ray 6.46 T 2-67 [» ]
    2OTJ X-ray 2.90 U 2-67 [» ]
    2OTL X-ray 2.70 U 2-67 [» ]
    2QA4 X-ray 3.00 U 1-67 [» ]
    2QEX X-ray 2.90 U 1-67 [» ]
    3CC2 X-ray 2.40 U 1-67 [» ]
    3CC4 X-ray 2.70 U 1-67 [» ]
    3CC7 X-ray 2.70 U 1-67 [» ]
    3CCE X-ray 2.75 U 1-67 [» ]
    3CCJ X-ray 2.70 U 1-67 [» ]
    3CCL X-ray 2.90 U 1-67 [» ]
    3CCM X-ray 2.55 U 1-67 [» ]
    3CCQ X-ray 2.90 U 1-67 [» ]
    3CCR X-ray 3.00 U 1-67 [» ]
    3CCS X-ray 2.95 U 1-67 [» ]
    3CCU X-ray 2.80 U 1-67 [» ]
    3CCV X-ray 2.90 U 1-67 [» ]
    3CD6 X-ray 2.75 U 1-67 [» ]
    3CMA X-ray 2.80 U 1-67 [» ]
    3CME X-ray 2.95 U 1-67 [» ]
    3CPW X-ray 2.70 T 1-67 [» ]
    3CXC X-ray 3.00 T 2-67 [» ]
    3G4S X-ray 3.20 U 5-57 [» ]
    3G6E X-ray 2.70 U 5-57 [» ]
    3G71 X-ray 2.85 U 5-57 [» ]
    3I55 X-ray 3.11 U 2-67 [» ]
    3I56 X-ray 2.90 U 2-67 [» ]
    3OW2 X-ray 2.70 T 5-57 [» ]
    4ADX electron microscopy 6.60 U 1-67 [» ]
    4HUB X-ray 2.40 U 1-67 [» ]
    ProteinModelPortali P14116.
    SMRi P14116. Positions 5-57.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC0104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV45180 ; AAV45180 ; rrnAC0104 .
    GeneIDi 3130240.
    KEGGi hma:rrnAC0104.

    Phylogenomic databases

    eggNOGi COG2075.
    HOGENOMi HOG000156057.
    KOi K02896.

    Enzyme and pathway databases

    BioCyci HMAR272569:GJDH-97-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P14116.

    Family and domain databases

    Gene3Di 2.30.170.20. 1 hit.
    HAMAPi MF_00773. Ribosomal_L24e.
    InterProi IPR023438. Ribosomal_L24e_arc.
    IPR023442. Ribosomal_L24e_CS.
    IPR023441. Ribosomal_L24e_dom.
    IPR000988. Ribosomal_L24e_rel.
    IPR011017. TRASH_dom.
    [Graphical view ]
    PANTHERi PTHR10792. PTHR10792. 1 hit.
    Pfami PF01246. Ribosomal_L24e. 1 hit.
    [Graphical view ]
    SMARTi SM00746. TRASH. 1 hit.
    [Graphical view ]
    PROSITEi PS01073. RIBOSOMAL_L24E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    2. "Primary structures of five ribosomal proteins from the archaebacterium Halobacterium marismortui and their structural relationships to eubacterial and eukaryotic ribosomal proteins."
      Hatakeyama T., Kaufmann F., Schroeter B., Hatakeyama T.
      Eur. J. Biochem. 185:685-693(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-67.
    3. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
      Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
      Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    4. "The structural basis of ribosome activity in peptide bond synthesis."
      Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
      Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    5. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
      Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
      Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    6. "The kink-turn: a new RNA secondary structure motif."
      Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
      EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    7. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
      Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
      Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    8. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    9. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
      Hansen J.L., Moore P.B., Steitz T.A.
      J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    10. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
      Schmeing T.M., Moore P.B., Steitz T.A.
      RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
    11. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
      Gabdulkhakov A., Nikonov S., Garber M.
      Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

    Entry informationi

    Entry nameiRL24E_HALMA
    AccessioniPrimary (citable) accession number: P14116
    Secondary accession number(s): Q5V5M2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3