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P14116

- RL24E_HALMA

UniProt

P14116 - RL24E_HALMA

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Protein
50S ribosomal protein L24e
Gene
rpl24e, rrnAC0104
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit Inferred.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Zinc Inferred
Metal bindingi10 – 101Zinc Inferred
Metal bindingi33 – 331Zinc Inferred
Metal bindingi37 – 371Zinc Inferred

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 3731C4-type Inferred
Add
BLAST

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, RNA-binding, rRNA-binding, Zinc

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-97-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L24e
Alternative name(s):
Hl21/Hl22
Gene namesi
Name:rpl24e
Ordered Locus Names:rrnAC0104
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 676650S ribosomal protein L24eUniRule annotation
PRO_0000136913Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.9 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC0104.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni8 – 103
Beta strandi20 – 234
Beta strandi25 – 273
Beta strandi29 – 335
Helixi35 – 428
Helixi47 – 493
Beta strandi50 – 534
Turni54 – 563

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40R2-67[»]
1JJ2X-ray2.40T2-67[»]
1K73X-ray3.01V2-67[»]
1K8AX-ray3.00V2-67[»]
1K9MX-ray3.00V2-67[»]
1KC8X-ray3.01V2-67[»]
1KD1X-ray3.00V2-67[»]
1KQSX-ray3.10T2-67[»]
1M1KX-ray3.20V2-67[»]
1M90X-ray2.80V2-67[»]
1ML5electron microscopy14.00r2-67[»]
1N8RX-ray3.00V2-67[»]
1NJIX-ray3.00V2-67[»]
1Q7YX-ray3.20V2-67[»]
1Q81X-ray2.95V2-67[»]
1Q82X-ray2.98V2-67[»]
1Q86X-ray3.00V2-67[»]
1QVFX-ray3.10T2-67[»]
1QVGX-ray2.90T2-67[»]
1S72X-ray2.40U2-67[»]
1VQ4X-ray2.70U2-67[»]
1VQ5X-ray2.60U2-67[»]
1VQ6X-ray2.70U2-67[»]
1VQ7X-ray2.50U2-67[»]
1VQ8X-ray2.20U2-67[»]
1VQ9X-ray2.40U2-67[»]
1VQKX-ray2.30U2-67[»]
1VQLX-ray2.30U2-67[»]
1VQMX-ray2.30U2-67[»]
1VQNX-ray2.40U2-67[»]
1VQOX-ray2.20U2-67[»]
1VQPX-ray2.25U2-67[»]
1W2BX-ray3.50T2-67[»]
1YHQX-ray2.40U2-67[»]
1YI2X-ray2.65U2-67[»]
1YIJX-ray2.60U2-67[»]
1YITX-ray2.80U2-67[»]
1YJ9X-ray2.80U2-67[»]
1YJNX-ray3.00U2-67[»]
1YJWX-ray2.90U2-67[»]
2B66X-ray5.90T2-67[»]
2B9NX-ray6.76T2-67[»]
2B9PX-ray6.46T2-67[»]
2OTJX-ray2.90U2-67[»]
2OTLX-ray2.70U2-67[»]
2QA4X-ray3.00U1-67[»]
2QEXX-ray2.90U1-67[»]
3CC2X-ray2.40U1-67[»]
3CC4X-ray2.70U1-67[»]
3CC7X-ray2.70U1-67[»]
3CCEX-ray2.75U1-67[»]
3CCJX-ray2.70U1-67[»]
3CCLX-ray2.90U1-67[»]
3CCMX-ray2.55U1-67[»]
3CCQX-ray2.90U1-67[»]
3CCRX-ray3.00U1-67[»]
3CCSX-ray2.95U1-67[»]
3CCUX-ray2.80U1-67[»]
3CCVX-ray2.90U1-67[»]
3CD6X-ray2.75U1-67[»]
3CMAX-ray2.80U1-67[»]
3CMEX-ray2.95U1-67[»]
3CPWX-ray2.70T1-67[»]
3CXCX-ray3.00T2-67[»]
3G4SX-ray3.20U5-57[»]
3G6EX-ray2.70U5-57[»]
3G71X-ray2.85U5-57[»]
3I55X-ray3.11U2-67[»]
3I56X-ray2.90U2-67[»]
3OW2X-ray2.70T5-57[»]
4ADXelectron microscopy6.60U1-67[»]
4HUBX-ray2.40U1-67[»]
ProteinModelPortaliP14116.
SMRiP14116. Positions 5-57.

Miscellaneous databases

EvolutionaryTraceiP14116.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG2075.
HOGENOMiHOG000156057.
KOiK02896.

Family and domain databases

Gene3Di2.30.170.20. 1 hit.
HAMAPiMF_00773. Ribosomal_L24e.
InterProiIPR023438. Ribosomal_L24e_arc.
IPR023442. Ribosomal_L24e_CS.
IPR023441. Ribosomal_L24e_dom.
IPR000988. Ribosomal_L24e_rel.
IPR011017. TRASH_dom.
[Graphical view]
PANTHERiPTHR10792. PTHR10792. 1 hit.
PfamiPF01246. Ribosomal_L24e. 1 hit.
[Graphical view]
SMARTiSM00746. TRASH. 1 hit.
[Graphical view]
PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14116-1 [UniParc]FASTAAdd to Basket

« Hide

MPRTRECDYC GTDIEPGTGT MFVHKDGATT HFCSSKCENN ADLGREARNL   50
EWTDTARGEA GEAEDEA 67
Length:67
Mass (Da):7,356
Last modified:January 23, 2007 - v2
Checksum:iD4FCAE00935B7305
GO

Sequence cautioni

The sequence AAV45180.1 differs from that shown. Reason: Frameshift at position 67.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV45180.1. Frameshift.
PIRiS06846. R6HS21.
RefSeqiYP_134886.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV45180; AAV45180; rrnAC0104.
GeneIDi3130240.
KEGGihma:rrnAC0104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV45180.1 . Frameshift.
PIRi S06846. R6HS21.
RefSeqi YP_134886.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FFK X-ray 2.40 R 2-67 [» ]
1JJ2 X-ray 2.40 T 2-67 [» ]
1K73 X-ray 3.01 V 2-67 [» ]
1K8A X-ray 3.00 V 2-67 [» ]
1K9M X-ray 3.00 V 2-67 [» ]
1KC8 X-ray 3.01 V 2-67 [» ]
1KD1 X-ray 3.00 V 2-67 [» ]
1KQS X-ray 3.10 T 2-67 [» ]
1M1K X-ray 3.20 V 2-67 [» ]
1M90 X-ray 2.80 V 2-67 [» ]
1ML5 electron microscopy 14.00 r 2-67 [» ]
1N8R X-ray 3.00 V 2-67 [» ]
1NJI X-ray 3.00 V 2-67 [» ]
1Q7Y X-ray 3.20 V 2-67 [» ]
1Q81 X-ray 2.95 V 2-67 [» ]
1Q82 X-ray 2.98 V 2-67 [» ]
1Q86 X-ray 3.00 V 2-67 [» ]
1QVF X-ray 3.10 T 2-67 [» ]
1QVG X-ray 2.90 T 2-67 [» ]
1S72 X-ray 2.40 U 2-67 [» ]
1VQ4 X-ray 2.70 U 2-67 [» ]
1VQ5 X-ray 2.60 U 2-67 [» ]
1VQ6 X-ray 2.70 U 2-67 [» ]
1VQ7 X-ray 2.50 U 2-67 [» ]
1VQ8 X-ray 2.20 U 2-67 [» ]
1VQ9 X-ray 2.40 U 2-67 [» ]
1VQK X-ray 2.30 U 2-67 [» ]
1VQL X-ray 2.30 U 2-67 [» ]
1VQM X-ray 2.30 U 2-67 [» ]
1VQN X-ray 2.40 U 2-67 [» ]
1VQO X-ray 2.20 U 2-67 [» ]
1VQP X-ray 2.25 U 2-67 [» ]
1W2B X-ray 3.50 T 2-67 [» ]
1YHQ X-ray 2.40 U 2-67 [» ]
1YI2 X-ray 2.65 U 2-67 [» ]
1YIJ X-ray 2.60 U 2-67 [» ]
1YIT X-ray 2.80 U 2-67 [» ]
1YJ9 X-ray 2.80 U 2-67 [» ]
1YJN X-ray 3.00 U 2-67 [» ]
1YJW X-ray 2.90 U 2-67 [» ]
2B66 X-ray 5.90 T 2-67 [» ]
2B9N X-ray 6.76 T 2-67 [» ]
2B9P X-ray 6.46 T 2-67 [» ]
2OTJ X-ray 2.90 U 2-67 [» ]
2OTL X-ray 2.70 U 2-67 [» ]
2QA4 X-ray 3.00 U 1-67 [» ]
2QEX X-ray 2.90 U 1-67 [» ]
3CC2 X-ray 2.40 U 1-67 [» ]
3CC4 X-ray 2.70 U 1-67 [» ]
3CC7 X-ray 2.70 U 1-67 [» ]
3CCE X-ray 2.75 U 1-67 [» ]
3CCJ X-ray 2.70 U 1-67 [» ]
3CCL X-ray 2.90 U 1-67 [» ]
3CCM X-ray 2.55 U 1-67 [» ]
3CCQ X-ray 2.90 U 1-67 [» ]
3CCR X-ray 3.00 U 1-67 [» ]
3CCS X-ray 2.95 U 1-67 [» ]
3CCU X-ray 2.80 U 1-67 [» ]
3CCV X-ray 2.90 U 1-67 [» ]
3CD6 X-ray 2.75 U 1-67 [» ]
3CMA X-ray 2.80 U 1-67 [» ]
3CME X-ray 2.95 U 1-67 [» ]
3CPW X-ray 2.70 T 1-67 [» ]
3CXC X-ray 3.00 T 2-67 [» ]
3G4S X-ray 3.20 U 5-57 [» ]
3G6E X-ray 2.70 U 5-57 [» ]
3G71 X-ray 2.85 U 5-57 [» ]
3I55 X-ray 3.11 U 2-67 [» ]
3I56 X-ray 2.90 U 2-67 [» ]
3OW2 X-ray 2.70 T 5-57 [» ]
4ADX electron microscopy 6.60 U 1-67 [» ]
4HUB X-ray 2.40 U 1-67 [» ]
ProteinModelPortali P14116.
SMRi P14116. Positions 5-57.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC0104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV45180 ; AAV45180 ; rrnAC0104 .
GeneIDi 3130240.
KEGGi hma:rrnAC0104.

Phylogenomic databases

eggNOGi COG2075.
HOGENOMi HOG000156057.
KOi K02896.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-97-MONOMER.

Miscellaneous databases

EvolutionaryTracei P14116.

Family and domain databases

Gene3Di 2.30.170.20. 1 hit.
HAMAPi MF_00773. Ribosomal_L24e.
InterProi IPR023438. Ribosomal_L24e_arc.
IPR023442. Ribosomal_L24e_CS.
IPR023441. Ribosomal_L24e_dom.
IPR000988. Ribosomal_L24e_rel.
IPR011017. TRASH_dom.
[Graphical view ]
PANTHERi PTHR10792. PTHR10792. 1 hit.
Pfami PF01246. Ribosomal_L24e. 1 hit.
[Graphical view ]
SMARTi SM00746. TRASH. 1 hit.
[Graphical view ]
PROSITEi PS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  2. "Primary structures of five ribosomal proteins from the archaebacterium Halobacterium marismortui and their structural relationships to eubacterial and eukaryotic ribosomal proteins."
    Hatakeyama T., Kaufmann F., Schroeter B., Hatakeyama T.
    Eur. J. Biochem. 185:685-693(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-67.
  3. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
    Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
    Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  4. "The structural basis of ribosome activity in peptide bond synthesis."
    Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
    Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  5. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
    Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
    Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  6. "The kink-turn: a new RNA secondary structure motif."
    Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
    EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  7. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
    Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
    Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  9. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
    Hansen J.L., Moore P.B., Steitz T.A.
    J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  10. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
    Schmeing T.M., Moore P.B., Steitz T.A.
    RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
  11. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
    Gabdulkhakov A., Nikonov S., Garber M.
    Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

Entry informationi

Entry nameiRL24E_HALMA
AccessioniPrimary (citable) accession number: P14116
Secondary accession number(s): Q5V5M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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