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Protein

Complement C1q subcomponent subunit B

Gene

C1qb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-166663. Initial triggering of complement.
R-MMU-173623. Classical antibody-mediated complement activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q subcomponent subunit B
Gene namesi
Name:C1qb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88224. C1qb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000000352226 – 253Complement C1q subcomponent subunit BAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi29Interchain (with C-26 in chain A)By similarity
Modified residuei334-hydroxyprolineBy similarity1
Modified residuei364-hydroxyprolineBy similarity1
Modified residuei394-hydroxyprolineBy similarity1
Modified residuei514-hydroxyprolineBy similarity1
Modified residuei544-hydroxyprolineBy similarity1
Modified residuei575-hydroxylysineBy similarity1
Modified residuei605-hydroxylysineBy similarity1
Modified residuei634-hydroxyprolineBy similarity1
Modified residuei755-hydroxylysineBy similarity1
Modified residuei814-hydroxyprolineBy similarity1
Modified residuei844-hydroxyprolineBy similarity1
Modified residuei905-hydroxylysineBy similarity1
Modified residuei965-hydroxylysineBy similarity1
Modified residuei994-hydroxyprolineBy similarity1
Modified residuei1085-hydroxylysineBy similarity1

Post-translational modificationi

Hydroxylated on lysine and proline residues. Hydroxylated lysine residues can be glycosylated. Mouse C1Q contains up to 64.0 hydroxylysine-galactosylglucose residues. Total percentage hydroxylysine residues glycosylated is 95.1%. Contains no hydroxylysine-monosaccharides.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP14106.
PeptideAtlasiP14106.
PRIDEiP14106.

PTM databases

PhosphoSitePlusiP14106.
SwissPalmiP14106.

Expressioni

Tissue specificityi

Highest expression in thioglycolate-activated peritoneal macrophages. Also found in spleen, thymus and heart. Very weak expression liver, kidney, lung and intestine.1 Publication

Gene expression databases

BgeeiENSMUSG00000036905.
GenevisibleiP14106. MM.

Interactioni

Subunit structurei

C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

IntActiP14106. 1 interactor.
STRINGi10090.ENSMUSP00000040246.

Structurei

3D structure databases

ProteinModelPortaliP14106.
SMRiP14106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 112Collagen-likeAdd BLAST84
Domaini115 – 253C1qPROSITE-ProRule annotationAdd BLAST139

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IWVM. Eukaryota.
ENOG4111MQB. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiP14106.
KOiK03987.
OMAiFFTYHAS.
OrthoDBiEOG091G0L3Y.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTQWGEVWT HLLLLLLGFL HVSWAQSSCT GPPGIPGIPG VPGVPGSDGQ
60 70 80 90 100
PGTPGIKGEK GLPGLAGDLG EFGEKGDPGI PGTPGKVGPK GPVGPKGTPG
110 120 130 140 150
PSGPRGPKGD SGDYGATQKV AFSALRTINS PLRPNQVIRF EKVITNANEN
160 170 180 190 200
YEPRNGKFTC KVPGLYYFTY HASSRGNLCV NLVRGRDRDS MQKVVTFCDY
210 220 230 240 250
AQNTFQVTTG GVVLKLEQEE VVHLQATDKN SLLGIEGANS IFTGFLLFPD

MDA
Length:253
Mass (Da):26,717
Last modified:October 3, 2012 - v2
Checksum:i0F5C33EA2DE2E253
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115G → R in CAA34757 (PubMed:2591537).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16874 mRNA. Translation: CAA34757.1.
M36293 mRNA. Translation: AAA37283.1.
M22531 mRNA. Translation: AAA37335.1.
X92959 Genomic DNA. Translation: CAA63534.1.
AK152764 mRNA. Translation: BAE31477.1.
AL627214 Genomic DNA. Translation: CAM46144.1.
BC067001 mRNA. Translation: AAH67001.1.
CCDSiCCDS18810.1.
PIRiI49560.
RefSeqiNP_033907.1. NM_009777.2.
UniGeneiMm.2570.

Genome annotation databases

EnsembliENSMUST00000046384; ENSMUSP00000040246; ENSMUSG00000036905.
GeneIDi12260.
KEGGimmu:12260.
UCSCiuc008vip.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16874 mRNA. Translation: CAA34757.1.
M36293 mRNA. Translation: AAA37283.1.
M22531 mRNA. Translation: AAA37335.1.
X92959 Genomic DNA. Translation: CAA63534.1.
AK152764 mRNA. Translation: BAE31477.1.
AL627214 Genomic DNA. Translation: CAM46144.1.
BC067001 mRNA. Translation: AAH67001.1.
CCDSiCCDS18810.1.
PIRiI49560.
RefSeqiNP_033907.1. NM_009777.2.
UniGeneiMm.2570.

3D structure databases

ProteinModelPortaliP14106.
SMRiP14106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP14106. 1 interactor.
STRINGi10090.ENSMUSP00000040246.

PTM databases

PhosphoSitePlusiP14106.
SwissPalmiP14106.

Proteomic databases

PaxDbiP14106.
PeptideAtlasiP14106.
PRIDEiP14106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046384; ENSMUSP00000040246; ENSMUSG00000036905.
GeneIDi12260.
KEGGimmu:12260.
UCSCiuc008vip.2. mouse.

Organism-specific databases

CTDi713.
MGIiMGI:88224. C1qb.

Phylogenomic databases

eggNOGiENOG410IWVM. Eukaryota.
ENOG4111MQB. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiP14106.
KOiK03987.
OMAiFFTYHAS.
OrthoDBiEOG091G0L3Y.
TreeFamiTF329591.

Enzyme and pathway databases

ReactomeiR-MMU-166663. Initial triggering of complement.
R-MMU-173623. Classical antibody-mediated complement activation.

Miscellaneous databases

PROiP14106.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036905.
GenevisibleiP14106. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1QB_MOUSE
AccessioniPrimary (citable) accession number: P14106
Secondary accession number(s): Q3U793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.