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Protein

Complement C1q subcomponent subunit B

Gene

C1qb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Biological processComplement pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-166663 Initial triggering of complement
R-MMU-173623 Classical antibody-mediated complement activation
R-MMU-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q subcomponent subunit B
Gene namesi
Name:C1qb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88224 C1qb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000000352226 – 253Complement C1q subcomponent subunit BAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi29Interchain (with C-26 in chain A)By similarity
Modified residuei334-hydroxyprolineBy similarity1
Modified residuei364-hydroxyprolineBy similarity1
Modified residuei394-hydroxyprolineBy similarity1
Modified residuei514-hydroxyprolineBy similarity1
Modified residuei544-hydroxyprolineBy similarity1
Modified residuei575-hydroxylysineBy similarity1
Modified residuei605-hydroxylysineBy similarity1
Modified residuei634-hydroxyprolineBy similarity1
Modified residuei755-hydroxylysineBy similarity1
Modified residuei814-hydroxyprolineBy similarity1
Modified residuei844-hydroxyprolineBy similarity1
Modified residuei905-hydroxylysineBy similarity1
Modified residuei965-hydroxylysineBy similarity1
Modified residuei994-hydroxyprolineBy similarity1
Modified residuei1085-hydroxylysineBy similarity1

Post-translational modificationi

Hydroxylated on lysine and proline residues. Hydroxylated lysine residues can be glycosylated. Mouse C1Q contains up to 64.0 hydroxylysine-galactosylglucose residues. Total percentage hydroxylysine residues glycosylated is 95.1%. Contains no hydroxylysine-monosaccharides.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP14106
PeptideAtlasiP14106
PRIDEiP14106

PTM databases

PhosphoSitePlusiP14106
SwissPalmiP14106

Expressioni

Tissue specificityi

Highest expression in thioglycolate-activated peritoneal macrophages. Also found in spleen, thymus and heart. Very weak expression liver, kidney, lung and intestine.1 Publication

Gene expression databases

BgeeiENSMUSG00000036905
GenevisibleiP14106 MM

Interactioni

Subunit structurei

C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi198413, 1 interactor
IntActiP14106, 1 interactor
STRINGi10090.ENSMUSP00000040246

Structurei

3D structure databases

ProteinModelPortaliP14106
SMRiP14106
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 112Collagen-likeAdd BLAST84
Domaini115 – 253C1qPROSITE-ProRule annotationAdd BLAST139

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IWVM Eukaryota
ENOG4111MQB LUCA
GeneTreeiENSGT00760000118830
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiP14106
KOiK03987
OMAiCDYAYNT
OrthoDBiEOG091G0L3Y
TreeFamiTF329591

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR037573 Complement_C1qB
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR44403:SF2 PTHR44403:SF2, 1 hit
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 2 hits
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTQWGEVWT HLLLLLLGFL HVSWAQSSCT GPPGIPGIPG VPGVPGSDGQ
60 70 80 90 100
PGTPGIKGEK GLPGLAGDLG EFGEKGDPGI PGTPGKVGPK GPVGPKGTPG
110 120 130 140 150
PSGPRGPKGD SGDYGATQKV AFSALRTINS PLRPNQVIRF EKVITNANEN
160 170 180 190 200
YEPRNGKFTC KVPGLYYFTY HASSRGNLCV NLVRGRDRDS MQKVVTFCDY
210 220 230 240 250
AQNTFQVTTG GVVLKLEQEE VVHLQATDKN SLLGIEGANS IFTGFLLFPD

MDA
Length:253
Mass (Da):26,717
Last modified:October 3, 2012 - v2
Checksum:i0F5C33EA2DE2E253
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115G → R in CAA34757 (PubMed:2591537).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16874 mRNA Translation: CAA34757.1
M36293 mRNA Translation: AAA37283.1
M22531 mRNA Translation: AAA37335.1
X92959 Genomic DNA Translation: CAA63534.1
AK152764 mRNA Translation: BAE31477.1
AL627214 Genomic DNA Translation: CAM46144.1
BC067001 mRNA Translation: AAH67001.1
CCDSiCCDS18810.1
PIRiI49560
RefSeqiNP_033907.1, NM_009777.2
UniGeneiMm.2570

Genome annotation databases

EnsembliENSMUST00000046384; ENSMUSP00000040246; ENSMUSG00000036905
GeneIDi12260
KEGGimmu:12260
UCSCiuc008vip.2 mouse

Similar proteinsi

Entry informationi

Entry nameiC1QB_MOUSE
AccessioniPrimary (citable) accession number: P14106
Secondary accession number(s): Q3U793
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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