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Protein

Myosin-9

Gene

MYH9

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi174 – 181ATPSequence analysis8

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • microfilament motor activity Source: UniProtKB
  • protein anchor Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein self-association Source: AgBase

GO - Biological processi

  • actin cytoskeleton reorganization Source: UniProtKB
  • actin filament-based movement Source: UniProtKB
  • angiogenesis Source: UniProtKB
  • blood vessel endothelial cell migration Source: UniProtKB
  • cytokinesis Source: UniProtKB
  • membrane protein ectodomain proteolysis Source: UniProtKB
  • monocyte differentiation Source: UniProtKB
  • myosin filament assembly Source: AgBase
  • platelet formation Source: UniProtKB
  • protein transport Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Cell shape

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-9
Alternative name(s):
Cellular myosin heavy chain, type A
Myosin heavy chain 9
Myosin heavy chain, non-muscle IIa
Non-muscle myosin heavy chain A
Short name:
NMMHC-A
Non-muscle myosin heavy chain IIa
Short name:
NMMHC II-a
Short name:
NMMHC-IIA
Gene namesi
Name:MYH9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: UniProtKB
  • actomyosin contractile ring Source: UniProtKB
  • cell leading edge Source: UniProtKB
  • cleavage furrow Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • myosin complex Source: UniProtKB-KW
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • protein complex Source: UniProtKB
  • ruffle Source: UniProtKB
  • stress fiber Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234191 – 1959Myosin-9Add BLAST1959

Proteomic databases

PRIDEiP14105.

PTM databases

iPTMnetiP14105.

Expressioni

Tissue specificityi

Expressed in fibroblasts, brain, lung, kidney, spleen, and skeletal, cardiac and smooth muscles.1 Publication

Interactioni

Subunit structurei

Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • protein anchor Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein self-association Source: AgBase

Structurei

3D structure databases

ProteinModelPortaliP14105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 776Myosin motorAdd BLAST696
Domaini779 – 808IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni654 – 676Actin-bindingAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili837 – 1925Sequence analysisAdd BLAST1089

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG004704.
InParanoidiP14105.
KOiK10352.
PhylomeDBiP14105.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRDADKYL YVDKNIINNP LTQADWAAKK LVWVPSEKSG FEAASLKEEV
60 70 80 90 100
GDEAIVELAE NGKKVKVNKD DIQKMNPPKF SKVEDMAELT CLNEASVLHN
110 120 130 140 150
LKERYYSGLI YTYSGLFCVV INPYKNLPIY SEEIVEMYKG KKRHEMPPHI
160 170 180 190 200
YAITDTAYRS MMQDREDQSI LCTGESGAGK TENTKKVIQY LAHVASSHKS
210 220 230 240 250
KKDQGELERQ LLQANPILEA FGNAKTVKND NSSRFGKFIR INFDVNGYIV
260 270 280 290 300
GANIETYLLE KSRAIRQAKE ERTFHIFYYL LSGAGEHLKT DLLLEPYNKY
310 320 330 340 350
RFLSNGHVTI PGQQDKDMFQ ETMEAMRIMG IPDEEQIGLL KVISGVLQLG
360 370 380 390 400
NIVFKKERNT DQASMPDNTA AQKVSHLLGI NVTDFTRGIL TPRIKVGRDY
410 420 430 440 450
VQKAQTKEQA DFAIEALAKA TYEQMFRWLV MRINKALDKT KRQGASFIGI
460 470 480 490 500
LDIAGFEIFE LNSFEQLCIN YTNEKLQQLF NHTMFILEQE EYQNEGIEWN
510 520 530 540 550
FIDFGLDLQP CIDLIEKPAG PPGILALLDE ECWFPKATDK SFVEKVVQEQ
560 570 580 590 600
GTHPKFQKPK QLKDKADFCI IHYAGKVDYK ADEWLMKNMD PLNDNIATLL
610 620 630 640 650
HQSSDKFVSE LWKDVDRIVG LDQVAGMSET ALPGAFKTRK GMFRTVGQLY
660 670 680 690 700
KEQLAKLMAT LRNTNPNFVR CIIPNHEKKA GKLDPHLVLD QLRCNGVLEG
710 720 730 740 750
IRICRQGFPN RVVFQEFRQR YEILTPNAIP KGFMDGKQAC VLMIKALELD
760 770 780 790 800
SNLYRIGQSK VFFRAGVLAH LEEERDLKIT DVIIGFQACC RGYLARKAFA
810 820 830 840 850
KRQQQLTAMK VLQRNCAAYL KLRNWQWWRL FTKVKPLLQV SRQEEEMMAK
860 870 880 890 900
EEELIKVKEK QLAAENRLSE METFQAQLMA EKMQLQEQLQ AEAELCAEAE
910 920 930 940 950
EIRARLTAKK QELEEICHDL EARVEEEEER CQHLQAEKKK MQQNIQELEE
960 970 980 990 1000
QLEEEESARQ KLQLEKVTTE AKLKKLEEDV IVLEDQNLKL AKEKKLLEDR
1010 1020 1030 1040 1050
MSEFTTNLTE EEEKSKSLAK LKNKHEAMIT DLEERLRREE KQRQELEKTR
1060 1070 1080 1090 1100
RKLEGDSSDL HDQIAELQAQ IAELKIQLSK KEEELQAALA RVEEEAAQKN
1110 1120 1130 1140 1150
MALKKIRELE SQITELQEDL ESERASRNKA EKQKRDLGEE LEALKTELED
1160 1170 1180 1190 1200
TLDSTAAQQE LRSKREQEVT VLKKTLEDEA KTHEAQIQEM RQKHSQAIEE
1210 1220 1230 1240 1250
LAEQLEQTKR VKANLEKAKQ ALESERAELS NEVKVLLQGK GDAEHKRKKV
1260 1270 1280 1290 1300
DAQLQELQVK FTEGERVKTE LAERVNKLQV ELDNVTGLLN QSDSKSIKLA
1310 1320 1330 1340 1350
KDFSALESQL QDTQELLQEE TRLKLSFSTK LKQTEDEKNA LKEQLEEEEE
1360 1370 1380 1390 1400
AKRNLEKQIS VLQQQAVEAR KKMDDGLGCL EIAEEAKKKL QKDLESLTQR
1410 1420 1430 1440 1450
YEEKIAAYDK LEKTKTRLQQ ELDDIAVDLD HQRQTVSNLE KKQKKFDQLL
1460 1470 1480 1490 1500
AEEKNISAKY AEERDRAEAE AREKETKALS LARALEEAIE QKAELERVNK
1510 1520 1530 1540 1550
QFRTEMEDLM SSKDDVGKSV HELEKAKRAL EQQVEEMKTQ LEELEDELQA
1560 1570 1580 1590 1600
TEDAKLRLEV NQQAMKAQFD RDLLGRDEQN EEKRKQLIRQ VREMEVELED
1610 1620 1630 1640 1650
ERKQRSIAVA ARKKLELDLK DLESHIDTAN KNRDEAIKHV RKLQAQMKDY
1660 1670 1680 1690 1700
MRELEDTRTS REEILAQAKE NEKKLKSMEA EMIQLQEELA AAERAKRQAQ
1710 1720 1730 1740 1750
QERDELADEI ANSSGKGALA MEEKRRLEAR IAQLEEELEE EQGNTEIIND
1760 1770 1780 1790 1800
RLKKANLQID QMNADLNAER SNAQKNENAR QQMERQNKEL KLKLQEMESA
1810 1820 1830 1840 1850
VKSKYKATIT ALEAKIVQLE EQLDMETKER QAASKQVRRA EKKLKDILLQ
1860 1870 1880 1890 1900
VDDERRNAEQ FKDQADKANM RLKQLKRQLE EAEEEAQRAN VRRKLQRELD
1910 1920 1930 1940 1950
DATETADAMN REVSSLKSKL RRGDLPFVVT RRLVRKGTGE CSDEEVDGKA

EAGDAKATE
Length:1,959
Mass (Da):226,503
Last modified:January 1, 1990 - v1
Checksum:iA75C86086FD3A1A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26510 mRNA. Translation: AAA48974.1.
PIRiA33977.
RefSeqiNP_990808.1. NM_205477.1.
UniGeneiGga.4462.

Genome annotation databases

GeneIDi396469.
KEGGigga:396469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26510 mRNA. Translation: AAA48974.1.
PIRiA33977.
RefSeqiNP_990808.1. NM_205477.1.
UniGeneiGga.4462.

3D structure databases

ProteinModelPortaliP14105.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP14105.

Proteomic databases

PRIDEiP14105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396469.
KEGGigga:396469.

Organism-specific databases

CTDi4627.

Phylogenomic databases

HOVERGENiHBG004704.
InParanoidiP14105.
KOiK10352.
PhylomeDBiP14105.

Miscellaneous databases

PROiP14105.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYH9_CHICK
AccessioniPrimary (citable) accession number: P14105
Secondary accession number(s): Q9TNS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 5, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.