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Protein

C-C motif chemokine 4

Gene

Ccl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Immune activation protein 2
Short name:
ACT-2
Short name:
ACT2
Macrophage inflammatory protein 1-beta
Short name:
MIP-1-beta
Protein H400
SIS-gamma
Small-inducible cytokine A4
Gene namesi
Name:Ccl4
Synonyms:Mip1b, Scya4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98261. Ccl4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 9269C-C motif chemokine 4PRO_0000005166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP14097.
PeptideAtlasiP14097.
PRIDEiP14097.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018930.
CleanExiMM_CCL4.
ExpressionAtlasiP14097. baseline and differential.
GenevisibleiP14097. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019074.

Structurei

3D structure databases

ProteinModelPortaliP14097.
SMRiP14097. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4I9. Eukaryota.
ENOG410YXJU. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP14097.
KOiK12964.
OMAiWVQEYVD.
OrthoDBiEOG091G14Y2.
PhylomeDBiP14097.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLCVSALSL LLLVAAFCAP GFSAPMGSDP PTSCCFSYTS RQLHRSFVMD
60 70 80 90
YYETSSLCSK PAVVFLTKRG RQICANPSEP WVTEYMSDLE LN
Length:92
Mass (Da):10,168
Last modified:February 1, 1996 - v3
Checksum:i8853FD58FDE61BAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35590 mRNA. Translation: AAA39708.1.
M23503 mRNA. Translation: AAA40148.1.
X62502 Genomic DNA. Translation: CAA44364.1.
AF128218 mRNA. Translation: AAF22559.1.
AF128219 mRNA. Translation: AAF22560.1.
CCDSiCCDS36256.1.
PIRiC30552.
RefSeqiNP_038680.1. NM_013652.2.
XP_011247134.1. XM_011248832.1.
UniGeneiMm.244263.

Genome annotation databases

EnsembliENSMUST00000019074; ENSMUSP00000019074; ENSMUSG00000018930.
GeneIDi20303.
KEGGimmu:20303.
UCSCiuc007kpp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35590 mRNA. Translation: AAA39708.1.
M23503 mRNA. Translation: AAA40148.1.
X62502 Genomic DNA. Translation: CAA44364.1.
AF128218 mRNA. Translation: AAF22559.1.
AF128219 mRNA. Translation: AAF22560.1.
CCDSiCCDS36256.1.
PIRiC30552.
RefSeqiNP_038680.1. NM_013652.2.
XP_011247134.1. XM_011248832.1.
UniGeneiMm.244263.

3D structure databases

ProteinModelPortaliP14097.
SMRiP14097. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019074.

Proteomic databases

PaxDbiP14097.
PeptideAtlasiP14097.
PRIDEiP14097.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019074; ENSMUSP00000019074; ENSMUSG00000018930.
GeneIDi20303.
KEGGimmu:20303.
UCSCiuc007kpp.1. mouse.

Organism-specific databases

CTDi6351.
MGIiMGI:98261. Ccl4.

Phylogenomic databases

eggNOGiENOG410J4I9. Eukaryota.
ENOG410YXJU. LUCA.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP14097.
KOiK12964.
OMAiWVQEYVD.
OrthoDBiEOG091G14Y2.
PhylomeDBiP14097.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.

Miscellaneous databases

PROiP14097.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018930.
CleanExiMM_CCL4.
ExpressionAtlasiP14097. baseline and differential.
GenevisibleiP14097. MM.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL4_MOUSE
AccessioniPrimary (citable) accession number: P14097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.