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P14097

- CCL4_MOUSE

UniProt

P14097 - CCL4_MOUSE

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Protein

C-C motif chemokine 4

Gene

Ccl4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Monokine with inflammatory and chemokinetic properties.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_230248. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Immune activation protein 2
Short name:
ACT-2
Short name:
ACT2
Macrophage inflammatory protein 1-beta
Short name:
MIP-1-beta
Protein H400
SIS-gamma
Small-inducible cytokine A4
Gene namesi
Name:Ccl4
Synonyms:Mip1b, Scya4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98261. Ccl4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 9269C-C motif chemokine 4PRO_0000005166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP14097.

Expressioni

Gene expression databases

BgeeiP14097.
CleanExiMM_CCL4.
ExpressionAtlasiP14097. baseline and differential.
GenevestigatoriP14097.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019074.

Structurei

3D structure databases

ProteinModelPortaliP14097.
SMRiP14097. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG124416.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP14097.
KOiK12964.
OMAiLRKIPRN.
OrthoDBiEOG7CVQ1F.
PhylomeDBiP14097.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14097-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLCVSALSL LLLVAAFCAP GFSAPMGSDP PTSCCFSYTS RQLHRSFVMD
60 70 80 90
YYETSSLCSK PAVVFLTKRG RQICANPSEP WVTEYMSDLE LN
Length:92
Mass (Da):10,168
Last modified:February 1, 1996 - v3
Checksum:i8853FD58FDE61BAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35590 mRNA. Translation: AAA39708.1.
M23503 mRNA. Translation: AAA40148.1.
X62502 Genomic DNA. Translation: CAA44364.1.
AF128218 mRNA. Translation: AAF22559.1.
AF128219 mRNA. Translation: AAF22560.1.
CCDSiCCDS36256.1.
PIRiC30552.
RefSeqiNP_038680.1. NM_013652.2.
UniGeneiMm.244263.

Genome annotation databases

EnsembliENSMUST00000019074; ENSMUSP00000019074; ENSMUSG00000018930.
GeneIDi20303.
KEGGimmu:20303.
UCSCiuc007kpp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35590 mRNA. Translation: AAA39708.1 .
M23503 mRNA. Translation: AAA40148.1 .
X62502 Genomic DNA. Translation: CAA44364.1 .
AF128218 mRNA. Translation: AAF22559.1 .
AF128219 mRNA. Translation: AAF22560.1 .
CCDSi CCDS36256.1.
PIRi C30552.
RefSeqi NP_038680.1. NM_013652.2.
UniGenei Mm.244263.

3D structure databases

ProteinModelPortali P14097.
SMRi P14097. Positions 24-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000019074.

Proteomic databases

PRIDEi P14097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019074 ; ENSMUSP00000019074 ; ENSMUSG00000018930 .
GeneIDi 20303.
KEGGi mmu:20303.
UCSCi uc007kpp.1. mouse.

Organism-specific databases

CTDi 6351.
MGIi MGI:98261. Ccl4.

Phylogenomic databases

eggNOGi NOG124416.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi P14097.
KOi K12964.
OMAi LRKIPRN.
OrthoDBi EOG7CVQ1F.
PhylomeDBi P14097.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_230248. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi 298051.
PROi P14097.
SOURCEi Search...

Gene expression databases

Bgeei P14097.
CleanExi MM_CCL4.
ExpressionAtlasi P14097. baseline and differential.
Genevestigatori P14097.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta."
    Sherry B., Tekamp-Olson P., Gallegos C., Bauer D., Davatelis G., Wolpe S.D., Masiarz F., Coit D., Cerami A.
    J. Exp. Med. 168:2251-2259(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Macrophage.
  2. "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
    Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
    J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Helper T-cell.
  3. "Sequence of the murine macrophage inflammatory protein 1b gene."
    Daubersies P., Lepretre F., Bailleul B., Grove M., Pragnell I., Plumb M.A.
    Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.
    Tissue: Liver.
  4. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B10.S/J and SJL/J.
    Tissue: Spleen.

Entry informationi

Entry nameiCCL4_MOUSE
AccessioniPrimary (citable) accession number: P14097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3