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P14097

- CCL4_MOUSE

UniProt

P14097 - CCL4_MOUSE

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Protein
C-C motif chemokine 4
Gene
Ccl4, Mip1b, Scya4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Monokine with inflammatory and chemokinetic properties.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Immune activation protein 2
Short name:
ACT-2
Short name:
ACT2
Macrophage inflammatory protein 1-beta
Short name:
MIP-1-beta
Protein H400
SIS-gamma
Small-inducible cytokine A4
Gene namesi
Name:Ccl4
Synonyms:Mip1b, Scya4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98261. Ccl4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323
Add
BLAST
Chaini24 – 9269C-C motif chemokine 4
PRO_0000005166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58 By similarity
Disulfide bondi35 ↔ 74 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP14097.

Expressioni

Gene expression databases

ArrayExpressiP14097.
BgeeiP14097.
CleanExiMM_CCL4.
GenevestigatoriP14097.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019074.

Structurei

3D structure databases

ProteinModelPortaliP14097.
SMRiP14097. Positions 24-92.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG124416.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP14097.
KOiK12964.
OMAiLRKIPRN.
OrthoDBiEOG7CVQ1F.
PhylomeDBiP14097.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14097-1 [UniParc]FASTAAdd to Basket

« Hide

MKLCVSALSL LLLVAAFCAP GFSAPMGSDP PTSCCFSYTS RQLHRSFVMD   50
YYETSSLCSK PAVVFLTKRG RQICANPSEP WVTEYMSDLE LN 92
Length:92
Mass (Da):10,168
Last modified:February 1, 1996 - v3
Checksum:i8853FD58FDE61BAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35590 mRNA. Translation: AAA39708.1.
M23503 mRNA. Translation: AAA40148.1.
X62502 Genomic DNA. Translation: CAA44364.1.
AF128218 mRNA. Translation: AAF22559.1.
AF128219 mRNA. Translation: AAF22560.1.
CCDSiCCDS36256.1.
PIRiC30552.
RefSeqiNP_038680.1. NM_013652.2.
UniGeneiMm.244263.

Genome annotation databases

EnsembliENSMUST00000019074; ENSMUSP00000019074; ENSMUSG00000018930.
GeneIDi20303.
KEGGimmu:20303.
UCSCiuc007kpp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35590 mRNA. Translation: AAA39708.1 .
M23503 mRNA. Translation: AAA40148.1 .
X62502 Genomic DNA. Translation: CAA44364.1 .
AF128218 mRNA. Translation: AAF22559.1 .
AF128219 mRNA. Translation: AAF22560.1 .
CCDSi CCDS36256.1.
PIRi C30552.
RefSeqi NP_038680.1. NM_013652.2.
UniGenei Mm.244263.

3D structure databases

ProteinModelPortali P14097.
SMRi P14097. Positions 24-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000019074.

Proteomic databases

PRIDEi P14097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019074 ; ENSMUSP00000019074 ; ENSMUSG00000018930 .
GeneIDi 20303.
KEGGi mmu:20303.
UCSCi uc007kpp.1. mouse.

Organism-specific databases

CTDi 6351.
MGIi MGI:98261. Ccl4.

Phylogenomic databases

eggNOGi NOG124416.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi P14097.
KOi K12964.
OMAi LRKIPRN.
OrthoDBi EOG7CVQ1F.
PhylomeDBi P14097.
TreeFami TF334888.

Miscellaneous databases

NextBioi 298051.
PROi P14097.
SOURCEi Search...

Gene expression databases

ArrayExpressi P14097.
Bgeei P14097.
CleanExi MM_CCL4.
Genevestigatori P14097.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta."
    Sherry B., Tekamp-Olson P., Gallegos C., Bauer D., Davatelis G., Wolpe S.D., Masiarz F., Coit D., Cerami A.
    J. Exp. Med. 168:2251-2259(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Macrophage.
  2. "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
    Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
    J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Helper T-cell.
  3. "Sequence of the murine macrophage inflammatory protein 1b gene."
    Daubersies P., Lepretre F., Bailleul B., Grove M., Pragnell I., Plumb M.A.
    Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.
    Tissue: Liver.
  4. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B10.S/J and SJL/J.
    Tissue: Spleen.

Entry informationi

Entry nameiCCL4_MOUSE
AccessioniPrimary (citable) accession number: P14097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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