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P14097 (CCL4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 4
Alternative name(s):
Immune activation protein 2
Short name=ACT-2
Short name=ACT2
Macrophage inflammatory protein 1-beta
Short name=MIP-1-beta
Protein H400
SIS-gamma
Small-inducible cytokine A4
Gene names
Name:Ccl4
Synonyms:Mip1b, Scya4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Monokine with inflammatory and chemokinetic properties.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 7594543. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323
Chain24 – 9269C-C motif chemokine 4
PRO_0000005166

Amino acid modifications

Disulfide bond34 ↔ 58 By similarity
Disulfide bond35 ↔ 74 By similarity

Sequences

Sequence LengthMass (Da)Tools
P14097 [UniParc].

Last modified February 1, 1996. Version 3.
Checksum: 8853FD58FDE61BAC

FASTA9210,168
        10         20         30         40         50         60 
MKLCVSALSL LLLVAAFCAP GFSAPMGSDP PTSCCFSYTS RQLHRSFVMD YYETSSLCSK 

        70         80         90 
PAVVFLTKRG RQICANPSEP WVTEYMSDLE LN 

« Hide

References

[1]"Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta."
Sherry B., Tekamp-Olson P., Gallegos C., Bauer D., Davatelis G., Wolpe S.D., Masiarz F., Coit D., Cerami A.
J. Exp. Med. 168:2251-2259(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Macrophage.
[2]"A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Helper T-cell.
[3]"Sequence of the murine macrophage inflammatory protein 1b gene."
Daubersies P., Lepretre F., Bailleul B., Grove M., Pragnell I., Plumb M.A.
Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DBA/2J.
Tissue: Liver.
[4]"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: B10.S/J and SJL/J.
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M35590 mRNA. Translation: AAA39708.1.
M23503 mRNA. Translation: AAA40148.1.
X62502 Genomic DNA. Translation: CAA44364.1.
AF128218 mRNA. Translation: AAF22559.1.
AF128219 mRNA. Translation: AAF22560.1.
CCDSCCDS36256.1.
PIRC30552.
RefSeqNP_038680.1. NM_013652.2.
UniGeneMm.244263.

3D structure databases

ProteinModelPortalP14097.
SMRP14097. Positions 24-92.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000019074.

Proteomic databases

PRIDEP14097.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019074; ENSMUSP00000019074; ENSMUSG00000018930.
GeneID20303.
KEGGmmu:20303.
UCSCuc007kpp.1. mouse.

Organism-specific databases

CTD6351.
MGIMGI:98261. Ccl4.

Phylogenomic databases

eggNOGNOG124416.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidP14097.
KOK12964.
OMALRKIPRN.
OrthoDBEOG7CVQ1F.
PhylomeDBP14097.
TreeFamTF334888.

Gene expression databases

ArrayExpressP14097.
BgeeP14097.
CleanExMM_CCL4.
GenevestigatorP14097.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298051.
PROP14097.
SOURCESearch...

Entry information

Entry nameCCL4_MOUSE
AccessionPrimary (citable) accession number: P14097
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot