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P14097

- CCL4_MOUSE

UniProt

P14097 - CCL4_MOUSE

Protein

C-C motif chemokine 4

Gene

Ccl4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Monokine with inflammatory and chemokinetic properties.

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 4
    Alternative name(s):
    Immune activation protein 2
    Short name:
    ACT-2
    Short name:
    ACT2
    Macrophage inflammatory protein 1-beta
    Short name:
    MIP-1-beta
    Protein H400
    SIS-gamma
    Small-inducible cytokine A4
    Gene namesi
    Name:Ccl4
    Synonyms:Mip1b, Scya4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98261. Ccl4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Add
    BLAST
    Chaini24 – 9269C-C motif chemokine 4PRO_0000005166Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 58By similarity
    Disulfide bondi35 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP14097.

    Expressioni

    Gene expression databases

    ArrayExpressiP14097.
    BgeeiP14097.
    CleanExiMM_CCL4.
    GenevestigatoriP14097.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000019074.

    Structurei

    3D structure databases

    ProteinModelPortaliP14097.
    SMRiP14097. Positions 24-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG124416.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiP14097.
    KOiK12964.
    OMAiLRKIPRN.
    OrthoDBiEOG7CVQ1F.
    PhylomeDBiP14097.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14097-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLCVSALSL LLLVAAFCAP GFSAPMGSDP PTSCCFSYTS RQLHRSFVMD   50
    YYETSSLCSK PAVVFLTKRG RQICANPSEP WVTEYMSDLE LN 92
    Length:92
    Mass (Da):10,168
    Last modified:February 1, 1996 - v3
    Checksum:i8853FD58FDE61BAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35590 mRNA. Translation: AAA39708.1.
    M23503 mRNA. Translation: AAA40148.1.
    X62502 Genomic DNA. Translation: CAA44364.1.
    AF128218 mRNA. Translation: AAF22559.1.
    AF128219 mRNA. Translation: AAF22560.1.
    CCDSiCCDS36256.1.
    PIRiC30552.
    RefSeqiNP_038680.1. NM_013652.2.
    UniGeneiMm.244263.

    Genome annotation databases

    EnsembliENSMUST00000019074; ENSMUSP00000019074; ENSMUSG00000018930.
    GeneIDi20303.
    KEGGimmu:20303.
    UCSCiuc007kpp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35590 mRNA. Translation: AAA39708.1 .
    M23503 mRNA. Translation: AAA40148.1 .
    X62502 Genomic DNA. Translation: CAA44364.1 .
    AF128218 mRNA. Translation: AAF22559.1 .
    AF128219 mRNA. Translation: AAF22560.1 .
    CCDSi CCDS36256.1.
    PIRi C30552.
    RefSeqi NP_038680.1. NM_013652.2.
    UniGenei Mm.244263.

    3D structure databases

    ProteinModelPortali P14097.
    SMRi P14097. Positions 24-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000019074.

    Proteomic databases

    PRIDEi P14097.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019074 ; ENSMUSP00000019074 ; ENSMUSG00000018930 .
    GeneIDi 20303.
    KEGGi mmu:20303.
    UCSCi uc007kpp.1. mouse.

    Organism-specific databases

    CTDi 6351.
    MGIi MGI:98261. Ccl4.

    Phylogenomic databases

    eggNOGi NOG124416.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi P14097.
    KOi K12964.
    OMAi LRKIPRN.
    OrthoDBi EOG7CVQ1F.
    PhylomeDBi P14097.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 298051.
    PROi P14097.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14097.
    Bgeei P14097.
    CleanExi MM_CCL4.
    Genevestigatori P14097.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta."
      Sherry B., Tekamp-Olson P., Gallegos C., Bauer D., Davatelis G., Wolpe S.D., Masiarz F., Coit D., Cerami A.
      J. Exp. Med. 168:2251-2259(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Macrophage.
    2. "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes."
      Brown K.D., Zurawski S.M., Mosmann T.R., Zurawski G.
      J. Immunol. 142:679-687(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Helper T-cell.
    3. "Sequence of the murine macrophage inflammatory protein 1b gene."
      Daubersies P., Lepretre F., Bailleul B., Grove M., Pragnell I., Plumb M.A.
      Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DBA/2J.
      Tissue: Liver.
    4. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
      Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
      J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: B10.S/J and SJL/J.
      Tissue: Spleen.

    Entry informationi

    Entry nameiCCL4_MOUSE
    AccessioniPrimary (citable) accession number: P14097
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3