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Protein

Growth-regulated alpha protein

Gene

Cxcl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation.

GO - Molecular functioni

  • chemokine activity Source: RGD

GO - Biological processi

  • acute inflammatory response Source: RGD
  • immune response Source: InterPro
  • neutrophil chemotaxis Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of potassium ion transport Source: RGD
  • positive regulation of sodium ion transport Source: RGD
  • response to amphetamine Source: RGD
  • response to estradiol Source: RGD
  • response to gamma radiation Source: RGD
  • response to glucocorticoid Source: RGD
  • response to heat Source: RGD
  • response to lipopolysaccharide Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Growth-regulated alpha protein
Alternative name(s):
C-X-C motif chemokine 1
Cytokine-induced neutrophil chemoattractant 1
Short name:
CINC-1
Platelet-derived growth factor-inducible protein KC
Gene namesi
Name:Cxcl1
Synonyms:Cinc1, Gro, Scyb1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619869. Cxcl1.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24242 PublicationsAdd
BLAST
Chaini25 – 9672Growth-regulated alpha proteinPRO_0000005055Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP14095.
PRIDEiP14095.

Expressioni

Tissue specificityi

At least expressed in the lung and trachea.

Inductioni

By lipopolysaccharides (LPS) and inflammation.

Interactioni

Subunit structurei

Monomer and homodimer.

GO - Molecular functioni

  • chemokine activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003778.

Structurei

3D structure databases

ProteinModelPortaliP14095.
SMRiP14095. Positions 30-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP14095.
KOiK05505.
PhylomeDBiP14095.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSATRSLLC AALPVLATSR QATGAPVANE LRCQCLQTVA GIHFKNIQSL
60 70 80 90
KVMPPGPHCT QTEVIATLKN GREACLDPEA PMVQKIVQKM LKGVPK
Length:96
Mass (Da):10,249
Last modified:November 1, 1995 - v2
Checksum:i6046C9E2C2582652
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11445 Genomic DNA. Translation: BAA02009.1.
D11444 mRNA. Translation: BAA02008.1.
M86536 mRNA. Translation: AAA42053.1.
S45856 mRNA. No translation available.
PIRiJN0572.
RefSeqiNP_110472.1. NM_030845.1.
UniGeneiRn.10907.

Genome annotation databases

GeneIDi81503.
KEGGirno:81503.
UCSCiRGD:619869. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11445 Genomic DNA. Translation: BAA02009.1.
D11444 mRNA. Translation: BAA02008.1.
M86536 mRNA. Translation: AAA42053.1.
S45856 mRNA. No translation available.
PIRiJN0572.
RefSeqiNP_110472.1. NM_030845.1.
UniGeneiRn.10907.

3D structure databases

ProteinModelPortaliP14095.
SMRiP14095. Positions 30-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003778.

Proteomic databases

PaxDbiP14095.
PRIDEiP14095.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81503.
KEGGirno:81503.
UCSCiRGD:619869. rat.

Organism-specific databases

CTDi2919.
RGDi619869. Cxcl1.

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP14095.
KOiK05505.
PhylomeDBiP14095.

Miscellaneous databases

PROiP14095.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure of the gene encoding rat neutrophil chemo-attractant Gro."
    Konishi K., Tanaka Y., Yamamoto M., Yomogida K., Watanabe K., Tsurufuji S., Fujioka M.
    Gene 126:285-286(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Rat KC cDNA cloning and mRNA expression in lung macrophages and fibroblasts."
    Huang S., Paulauskis J.D., Kobzik L.
    Biochem. Biophys. Res. Commun. 184:922-929(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The neutrophil chemoattractant produced by the rat kidney epithelioid cell line NRK-52E is a protein related to the KC/gro protein."
    Watanabe K., Konishi K., Fujioka M., Kinoshita S., Nakagawa H.
    J. Biol. Chem. 264:19559-19563(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-96.
  4. "Cytokine-induced neutrophil chemoattractant (CINC)-2 alpha, a novel member of rat GRO/CINCs, is a predominant chemokine produced by lipopolysaccharide-stimulated rat macrophages in culture."
    Nakagawa H., Shiota S., Takano K., Shibata F., Kato H.
    Biochem. Biophys. Res. Commun. 220:945-948(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-56.
    Strain: Wistar.
  5. "Expression of macrophage inflammatory protein-2 and KC mRNA in pulmonary inflammation."
    Huang S., Paulauskis J.D., Godleski J.J., Kobzik L.
    Am. J. Pathol. 141:981-988(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-88.
    Tissue: Lung.
  6. "The three dimensional structure of rat cytokine CINC/Gro in solution by homonuclear 3D NMR."
    Hanzawa H., Haruyama H., Watanabe K., Tsurufuji S.
    FEBS Lett. 354:207-212(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  7. "Subunit association and monomer structure of CINC/Gro revealed by 1H-NMR."
    Hanzawa H., Haruyama H., Konishi K., Watanabe K., Tsurufuji S.
    J. Biochem. 121:835-841(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  8. "Solution structure of CINC/Gro investigated by heteronuclear NMR."
    Hanzawa H., Haruyama H., Konishi K., Watanabe K., Tsurufuji S.
    J. Biochem. 123:62-70(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiGROA_RAT
AccessioniPrimary (citable) accession number: P14095
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.