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Protein

Growth-regulated alpha protein

Gene

Cxcl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation.

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR chemokine receptor binding Source: GO_Central
  • growth factor activity Source: UniProtKB-KW

GO - Biological processi

  • acute inflammatory response Source: RGD
  • chemokine-mediated signaling pathway Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: GO_Central
  • neutrophil chemotaxis Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of neutrophil chemotaxis Source: GO_Central
  • positive regulation of potassium ion transport Source: RGD
  • positive regulation of sodium ion transport Source: RGD
  • regulation of cell proliferation Source: GO_Central
  • response to amphetamine Source: RGD
  • response to estradiol Source: RGD
  • response to gamma radiation Source: RGD
  • response to glucocorticoid Source: RGD
  • response to heat Source: RGD
  • response to lipopolysaccharide Source: RGD

Keywordsi

Molecular functionCytokine, Growth factor
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Growth-regulated alpha protein
Alternative name(s):
C-X-C motif chemokine 1
Cytokine-induced neutrophil chemoattractant 1
Short name:
CINC-1
Platelet-derived growth factor-inducible protein KC
Gene namesi
Name:Cxcl1
Synonyms:Cinc1, Gro, Scyb1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619869 Cxcl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 242 PublicationsAdd BLAST24
ChainiPRO_000000505525 – 96Growth-regulated alpha proteinAdd BLAST72

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP14095
PRIDEiP14095

Expressioni

Tissue specificityi

At least expressed in the lung and trachea.

Inductioni

By lipopolysaccharides (LPS) and inflammation.

Interactioni

Subunit structurei

Monomer and homodimer.

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR chemokine receptor binding Source: GO_Central
  • growth factor activity Source: UniProtKB-KW

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003778

Structurei

3D structure databases

ProteinModelPortaliP14095
SMRiP14095
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE Eukaryota
ENOG410ZT1C LUCA
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP14095
KOiK05505
PhylomeDBiP14095

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSATRSLLC AALPVLATSR QATGAPVANE LRCQCLQTVA GIHFKNIQSL
60 70 80 90
KVMPPGPHCT QTEVIATLKN GREACLDPEA PMVQKIVQKM LKGVPK
Length:96
Mass (Da):10,249
Last modified:November 1, 1995 - v2
Checksum:i6046C9E2C2582652
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11445 Genomic DNA Translation: BAA02009.1
D11444 mRNA Translation: BAA02008.1
M86536 mRNA Translation: AAA42053.1
S45856 mRNA No translation available.
PIRiJN0572
RefSeqiNP_110472.1, NM_030845.1
UniGeneiRn.10907

Genome annotation databases

GeneIDi81503
KEGGirno:81503
UCSCiRGD:619869 rat

Similar proteinsi

Entry informationi

Entry nameiGROA_RAT
AccessioniPrimary (citable) accession number: P14095
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health