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Protein

Sodium/potassium-transporting ATPase subunit beta-1

Gene

Atp1b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Involved in cell adhesion and establishing epithelial cell polarity.By similarity

GO - Molecular functioni

GO - Biological processi

  • ATP metabolic process Source: MGI
  • cardiac muscle contraction Source: BHF-UCL
  • cell adhesion Source: UniProtKB-KW
  • cellular calcium ion homeostasis Source: BHF-UCL
  • cellular potassium ion homeostasis Source: MGI
  • cellular sodium ion homeostasis Source: MGI
  • membrane repolarization Source: MGI
  • positive regulation of ATPase activity Source: MGI
  • positive regulation of calcium:sodium antiporter activity Source: BHF-UCL
  • positive regulation of potassium ion import Source: MGI
  • positive regulation of potassium ion transmembrane transporter activity Source: MGI
  • positive regulation of sodium ion export from cell Source: MGI
  • potassium ion import Source: MGI
  • protein localization to plasma membrane Source: MGI
  • protein stabilization Source: BHF-UCL
  • regulation of calcium ion transmembrane transport Source: BHF-UCL
  • regulation of cardiac muscle contraction by calcium ion signaling Source: BHF-UCL
  • regulation of gene expression Source: BHF-UCL
  • relaxation of cardiac muscle Source: BHF-UCL
  • response to hypoxia Source: Ensembl
  • sodium ion export from cell Source: MGI

Keywordsi

Biological processCell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-1
Gene namesi
Name:Atp1b1
Synonyms:Atp4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88108. Atp1b1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 62Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST28
Topological domaini63 – 304ExtracellularSequence analysisAdd BLAST242

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190981 – 304Sodium/potassium-transporting ATPase subunit beta-1Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei101PhosphotyrosineCombined sources1
Disulfide bondi126 ↔ 149By similarity
Glycosylationi158N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi159 ↔ 175By similarity
Glycosylationi163N-linked (GlcNAc...) asparagine; atypical1 Publication1
Glycosylationi193N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi214 ↔ 277By similarity
Glycosylationi266N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Glutathionylated.1 Publication

Keywords - PTMi

Disulfide bond, Glutathionylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP14094.
PeptideAtlasiP14094.
PRIDEiP14094.

PTM databases

iPTMnetiP14094.
PhosphoSitePlusiP14094.
SwissPalmiP14094.

Expressioni

Tissue specificityi

Expressed in cardiac muscle and in flexor digitorum brevis (FDB) muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000026576.
CleanExiMM_ATP1B1.
MM_ATP4B.
ExpressionAtlasiP14094. baseline and differential.
GenevisibleiP14094. MM.

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (PubMed:15743908). Interacts with NKAIN1, NKAIN2 and NKAIN4 (PubMed:17606467). Interacts with MLC1 (By similarity). Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM (By similarity). Interacts with KIRREL3 (By similarity). Interacts with OBSCN (via protein kinase domain 1) (PubMed:23392350).By similarity3 Publications

GO - Molecular functioni

  • ATPase binding Source: MGI
  • MHC class II protein complex binding Source: MGI
  • protein C-terminus binding Source: MGI
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi198244. 3 interactors.
IntActiP14094. 11 interactors.
MINTiMINT-4088581.
STRINGi10090.ENSMUSP00000027863.

Structurei

3D structure databases

ProteinModelPortaliP14094.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 304immunoglobulin-likeBy similarityAdd BLAST114

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP14094.
KOiK01540.
OMAiTELRIEC.
OrthoDBiEOG091G0DJ4.
PhylomeDBiP14094.
TreeFamiTF314618.

Family and domain databases

InterProiView protein in InterPro
IPR000402. Na/K_ATPase_sub_beta.
IPR015565. Na/K_ATPase_sub_beta_chordates.
PANTHERiPTHR11523. PTHR11523. 1 hit.
PTHR11523:SF41. PTHR11523:SF41. 1 hit.
PfamiView protein in Pfam
PF00287. Na_K-ATPase. 1 hit.
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiView protein in PROSITE
PS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P14094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF
60 70 80 90 100
IGTIQVMLLT ISELKPTYQD RVAPPGLTQI PQIQKTEISF RPNDPKSYEA
110 120 130 140 150
YVLNIIRFLE KYKDSAQKDD MIFEDCGNVP SEPKERGDIN HERGERKVCR
160 170 180 190 200
FKLDWLGNCS GLNDDSYGYR EGKPCIIIKL NRVLGFKPKP PKNESLETYP
210 220 230 240 250
LMMKYNPNVL PVQCTGKRDE DKDKVGNIEY FGMGGYYGFP LQYYPYYGKL
260 270 280 290 300
LQPKYLQPLL AVQFTNLTVD TEIRVECKAY GENIGYSEKD RFQGRFDVKI

EIKS
Length:304
Mass (Da):35,195
Last modified:January 1, 1990 - v1
Checksum:i8E15D8F860932680
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16646 mRNA. Translation: CAA34639.1.
BC027319 mRNA. Translation: AAH27319.1.
X61433 mRNA. Translation: CAA43675.1.
CCDSiCCDS35755.1.
PIRiS09601.
RefSeqiNP_033851.1. NM_009721.6.
UniGeneiMm.4550.

Genome annotation databases

EnsembliENSMUST00000027863; ENSMUSP00000027863; ENSMUSG00000026576.
GeneIDi11931.
KEGGimmu:11931.
UCSCiuc007dip.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiAT1B1_MOUSE
AccessioniPrimary (citable) accession number: P14094
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 27, 2017
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families