Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endoglucanase C

Gene

cenC

Organism
Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei831PROSITE-ProRule annotation1
Active sitei882PROSITE-ProRule annotation1
Active sitei891PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiCBM4. Carbohydrate-Binding Module Family 4.
GH9. Glycoside Hydrolase Family 9.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase C (EC:3.2.1.4)
Alternative name(s):
Cellulase C
Endo-1,4-beta-glucanase C
Gene namesi
Name:cenC
Ordered Locus Names:Celf_1537
OrganismiCellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547)
Taxonomic identifieri590998 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesCellulomonadaceaeCellulomonas
Proteomesi
  • UP000008460 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 321 PublicationAdd BLAST32
ChainiPRO_000000794633 – 1101Endoglucanase CAdd BLAST1069

Interactioni

Protein-protein interaction databases

STRINGi590998.Celf_1537.

Structurei

Secondary structure

11101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 44Combined sources3
Beta strandi49 – 52Combined sources4
Beta strandi62 – 68Combined sources7
Beta strandi76 – 84Combined sources9
Beta strandi91 – 102Combined sources12
Beta strandi107 – 114Combined sources8
Beta strandi119 – 123Combined sources5
Beta strandi132 – 139Combined sources8
Beta strandi155 – 160Combined sources6
Beta strandi169 – 180Combined sources12
Beta strandi184 – 186Combined sources3
Turni190 – 192Combined sources3
Beta strandi198 – 203Combined sources6
Beta strandi212 – 215Combined sources4
Beta strandi226 – 230Combined sources5
Beta strandi239 – 251Combined sources13
Beta strandi253 – 260Combined sources8
Beta strandi262 – 265Combined sources4
Beta strandi272 – 277Combined sources6
Beta strandi282 – 289Combined sources8
Beta strandi296 – 299Combined sources4
Beta strandi303 – 307Combined sources5
Beta strandi315 – 324Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CX1NMR-A178-328[»]
1GU3X-ray2.30A33-181[»]
1ULONMR-A33-184[»]
1ULPNMR-A33-184[»]
ProteinModelPortaliP14090.
SMRiP14090.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14090.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 173CBM-cenC 1Add BLAST110
Domaini212 – 318CBM-cenC 2Add BLAST107
Domaini918 – 1006Ig-like 1Add BLAST89
Domaini1008 – 1097Ig-like 2Add BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni329 – 880CatalyticAdd BLAST552

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105E08. Bacteria.
ENOG410XNTA. LUCA.
KOiK01179.
OMAiNEHTINW.
OrthoDBiPOG091H04TS.

Family and domain databases

CDDicd02850. E_set_Cellulase_N. 1 hit.
Gene3Di1.50.10.10. 1 hit.
2.60.120.260. 2 hits.
2.60.40.10. 3 hits.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR004197. Cellulase_Ig-like.
IPR003305. CenC_carb-bd.
IPR008979. Galactose-bd-like.
IPR001701. Glyco_hydro_9.
IPR033126. Glyco_hydro_9_Asp/Glu_AS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF02018. CBM_4_9. 1 hit.
PF02927. CelD_N. 1 hit.
PF00759. Glyco_hydro_9. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.
SSF48726. SSF48726. 2 hits.
SSF49785. SSF49785. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00698. GLYCOSYL_HYDROL_F9_2. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSRRSSQAR GALTAVVATL ALALAGSGTA LAASPIGEGT FDDGPEGWVA
60 70 80 90 100
YGTDGPLDTS TGALCVAVPA GSAQYGVGVV LNGVAIEEGT TYTLRYTATA
110 120 130 140 150
STDVTVRALV GQNGAPYGTV LDTSPALTSE PRQVTETFTA SATYPATPAA
160 170 180 190 200
DDPEGQIAFQ LGGFSADAWT FCLDDVALDS EVELLPHTSF AESLGPWSLY
210 220 230 240 250
GTSEPVFADG RMCVDLPGGQ GNPWDAGLVY NGVPVGEGES YVLSFTASAT
260 270 280 290 300
PDMPVRVLVG EGGGAYRTAF EQGSAPLTGE PATREYAFTS NLTFPPDGDA
310 320 330 340 350
PGQVAFHLGK AGAYEFCISQ VSLTTSATPP PGYEPDTGPR VRVNQVGYLP
360 370 380 390 400
FGPKRATLVT DAAEPVAWEL RDADGVVVAD GTSEPRGVEP SAAQAVHVLD
410 420 430 440 450
FSDVTTQGAG YTLVADGETS RPFDIDGDLY QQLRYDALNY FYLARSGTEI
460 470 480 490 500
EADVVGEEYA REAGHVGVAP NQGDTDVPCI GPRDYYDGWT CDYRLDVSGG
510 520 530 540 550
WYDAGDHGKY VVNGGIAVGQ LLQTYERALH AGTADALADG TLDVPEHGND
560 570 580 590 600
VPDVLDEARW ELEWMLSMIV PEGEYAGMVH HKVHDEGWTG LPLLPADDPQ
610 620 630 640 650
ARSLHRPSTA ATLNLSAVAA QGARLLEPYD PQLAQTLLEA ARTTWAAAQE
660 670 680 690 700
HPALYAPGEA GADGGGAYND SQVADEFYWA AAELYLTTGE DAFATAVTTS
710 720 730 740 750
PLHTADVFTA DGFGWGSVAA LGRLDLATVP NELPGLDAVQ SSVVEGAQEY
760 770 780 790 800
LAAQAGQGFG SLYSPPGGEY VWGSSSQVAN NLVVVATAYD LTGDERFRAA
810 820 830 840 850
TLEGLDYLFG RNALNQSYVT GWGEVASHQQ HSRWFAHQLD PSLPSPPPGS
860 870 880 890 900
LAGGPNSQAA TWDPTTKAAF PDGCAPSACY VDEIQAWSTN ELTVNWNSAL
910 920 930 940 950
SWVASWVADQ GSAEPVPTAP VVTRQPVDAT VALGADATFT AEASGVPAPT
960 970 980 990 1000
VRWQVRAGRG WKDVAGATGT TLTVRATART DGTRYRAVFT NAAGSVESAV
1010 1020 1030 1040 1050
VRLTVERAAP VVTQHPADVR ARVGTRAVFR AAADGYPTPC VVWQVRWGGG
1060 1070 1080 1090 1100
SWRPIPWATS TTLSVPVTVL AAGTEYRAVF TNAVGTAATE PAELAVQRPR

S
Length:1,101
Mass (Da):115,216
Last modified:March 1, 1992 - v2
Checksum:i1FBAD189CC5F8B5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57858 Genomic DNA. Translation: CAA40993.1.
CP002666 Genomic DNA. Translation: AEE45671.1.
M29707 Genomic DNA. Translation: AAA23087.1. Different termination.
M29708 Genomic DNA. Translation: AAA23088.1. Sequence problems.
PIRiS15271.
RefSeqiWP_013770697.1. NC_015514.1.

Genome annotation databases

EnsemblBacteriaiAEE45671; AEE45671; Celf_1537.
KEGGicfi:Celf_1537.
PATRICi54613973. VBICelFim18861_1533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57858 Genomic DNA. Translation: CAA40993.1.
CP002666 Genomic DNA. Translation: AEE45671.1.
M29707 Genomic DNA. Translation: AAA23087.1. Different termination.
M29708 Genomic DNA. Translation: AAA23088.1. Sequence problems.
PIRiS15271.
RefSeqiWP_013770697.1. NC_015514.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CX1NMR-A178-328[»]
1GU3X-ray2.30A33-181[»]
1ULONMR-A33-184[»]
1ULPNMR-A33-184[»]
ProteinModelPortaliP14090.
SMRiP14090.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi590998.Celf_1537.

Protein family/group databases

CAZyiCBM4. Carbohydrate-Binding Module Family 4.
GH9. Glycoside Hydrolase Family 9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEE45671; AEE45671; Celf_1537.
KEGGicfi:Celf_1537.
PATRICi54613973. VBICelFim18861_1533.

Phylogenomic databases

eggNOGiENOG4105E08. Bacteria.
ENOG410XNTA. LUCA.
KOiK01179.
OMAiNEHTINW.
OrthoDBiPOG091H04TS.

Miscellaneous databases

EvolutionaryTraceiP14090.

Family and domain databases

CDDicd02850. E_set_Cellulase_N. 1 hit.
Gene3Di1.50.10.10. 1 hit.
2.60.120.260. 2 hits.
2.60.40.10. 3 hits.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR004197. Cellulase_Ig-like.
IPR003305. CenC_carb-bd.
IPR008979. Galactose-bd-like.
IPR001701. Glyco_hydro_9.
IPR033126. Glyco_hydro_9_Asp/Glu_AS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF02018. CBM_4_9. 1 hit.
PF02927. CelD_N. 1 hit.
PF00759. Glyco_hydro_9. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.
SSF48726. SSF48726. 2 hits.
SSF49785. SSF49785. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00698. GLYCOSYL_HYDROL_F9_2. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUNC_CELFA
AccessioniPrimary (citable) accession number: P14090
Secondary accession number(s): F4H737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.