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Protein

Chymopapain

Gene
N/A
Organism
Carica papaya (Papaya)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Specificity similar to that of papain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1591
Active sitei2931
Active sitei3131

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.6. 1191.

Protein family/group databases

MEROPSiI29.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymopapain (EC:3.4.22.6)
Alternative name(s):
Papaya proteinase II
Short name:
PPII
OrganismiCarica papaya (Papaya)
Taxonomic identifieri3649 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesCaricaceaeCarica

Pathology & Biotechi

Protein family/group databases

Allergomei1540. Car p Chymopapain.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000002640819 – 134Activation peptide2 PublicationsAdd BLAST116
ChainiPRO_0000026409135 – 352ChymopapainAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi156 ↔ 197
Disulfide bondi190 ↔ 229
Disulfide bondi287 ↔ 338

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

Secondary structure

1352
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni141 – 145Combined sources5
Beta strandi155 – 157Combined sources3
Helixi159 – 176Combined sources18
Helixi184 – 190Combined sources7
Helixi202 – 212Combined sources11
Turni217 – 219Combined sources3
Helixi231 – 233Combined sources3
Beta strandi242 – 246Combined sources5
Beta strandi249 – 251Combined sources3
Helixi252 – 259Combined sources8
Beta strandi264 – 268Combined sources5
Helixi273 – 276Combined sources4
Beta strandi280 – 283Combined sources4
Beta strandi293 – 303Combined sources11
Beta strandi306 – 312Combined sources7
Beta strandi324 – 328Combined sources5
Beta strandi332 – 334Combined sources3
Helixi337 – 339Combined sources3
Beta strandi345 – 348Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YALX-ray1.70A135-352[»]
ProteinModelPortaliP14080.
SMRiP14080.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14080.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

KOiK20738.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMSSISKI IFLATCLIIH MGLSSADFYT VGYSQDDLTS IERLIQLFDS
60 70 80 90 100
WMLKHNKIYE SIDEKIYRFE IFRDNLMYID ETNKKNNSYW LGLNGFADLS
110 120 130 140 150
NDEFKKKYVG FVAEDFTGLE HFDNEDFTYK HVTNYPQSID WRAKGAVTPV
160 170 180 190 200
KNQGACGSCW AFSTIATVEG INKIVTGNLL ELSEQELVDC DKHSYGCKGG
210 220 230 240 250
YQTTSLQYVA NNGVHTSKVY PYQAKQYKCR ATDKPGPKVK ITGYKRVPSN
260 270 280 290 300
CETSFLGALA NQPLSVLVEA GGKPFQLYKS GVFDGPCGTK LDHAVTAVGY
310 320 330 340 350
GTSDGKNYII IKNSWGPNWG EKGYMRLKRQ SGNSQGTCGV YKSSYYPFKG

FA
Length:352
Mass (Da):39,415
Last modified:November 1, 1997 - v2
Checksum:i50EA31EBFCF0AF9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97789 mRNA. Translation: CAA66378.1.
PIRiT09760.

Genome annotation databases

KEGGiag:CAA66378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97789 mRNA. Translation: CAA66378.1.
PIRiT09760.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YALX-ray1.70A135-352[»]
ProteinModelPortaliP14080.
SMRiP14080.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1540. Car p Chymopapain.
MEROPSiI29.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:CAA66378.

Phylogenomic databases

KOiK20738.

Enzyme and pathway databases

BRENDAi3.4.22.6. 1191.

Miscellaneous databases

EvolutionaryTraceiP14080.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAPA2_CARPA
AccessioniPrimary (citable) accession number: P14080
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.