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Protein

Chymopapain

Gene
N/A
Organism
Carica papaya (Papaya)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Specificity similar to that of papain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei159 – 1591
Active sitei293 – 2931
Active sitei313 – 3131

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.6. 1191.

Protein family/group databases

MEROPSiI29.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymopapain (EC:3.4.22.6)
Alternative name(s):
Papaya proteinase II
Short name:
PPII
OrganismiCarica papaya (Papaya)
Taxonomic identifieri3649 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesCaricaceaeCarica

Pathology & Biotechi

Protein family/group databases

Allergomei1540. Car p Chymopapain.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 134116Activation peptide2 PublicationsPRO_0000026408Add
BLAST
Chaini135 – 352218ChymopapainPRO_0000026409Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi156 ↔ 197
Disulfide bondi190 ↔ 229
Disulfide bondi287 ↔ 338

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

Secondary structure

1
352
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni141 – 1455Combined sources
Beta strandi155 – 1573Combined sources
Helixi159 – 17618Combined sources
Helixi184 – 1907Combined sources
Helixi202 – 21211Combined sources
Turni217 – 2193Combined sources
Helixi231 – 2333Combined sources
Beta strandi242 – 2465Combined sources
Beta strandi249 – 2513Combined sources
Helixi252 – 2598Combined sources
Beta strandi264 – 2685Combined sources
Helixi273 – 2764Combined sources
Beta strandi280 – 2834Combined sources
Beta strandi293 – 30311Combined sources
Beta strandi306 – 3127Combined sources
Beta strandi324 – 3285Combined sources
Beta strandi332 – 3343Combined sources
Helixi337 – 3393Combined sources
Beta strandi345 – 3484Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YALX-ray1.70A135-352[»]
ProteinModelPortaliP14080.
SMRiP14080. Positions 38-352.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14080.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMSSISKI IFLATCLIIH MGLSSADFYT VGYSQDDLTS IERLIQLFDS
60 70 80 90 100
WMLKHNKIYE SIDEKIYRFE IFRDNLMYID ETNKKNNSYW LGLNGFADLS
110 120 130 140 150
NDEFKKKYVG FVAEDFTGLE HFDNEDFTYK HVTNYPQSID WRAKGAVTPV
160 170 180 190 200
KNQGACGSCW AFSTIATVEG INKIVTGNLL ELSEQELVDC DKHSYGCKGG
210 220 230 240 250
YQTTSLQYVA NNGVHTSKVY PYQAKQYKCR ATDKPGPKVK ITGYKRVPSN
260 270 280 290 300
CETSFLGALA NQPLSVLVEA GGKPFQLYKS GVFDGPCGTK LDHAVTAVGY
310 320 330 340 350
GTSDGKNYII IKNSWGPNWG EKGYMRLKRQ SGNSQGTCGV YKSSYYPFKG

FA
Length:352
Mass (Da):39,415
Last modified:November 1, 1997 - v2
Checksum:i50EA31EBFCF0AF9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97789 mRNA. Translation: CAA66378.1.
PIRiT09760.

Genome annotation databases

KEGGiag:CAA66378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97789 mRNA. Translation: CAA66378.1.
PIRiT09760.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YALX-ray1.70A135-352[»]
ProteinModelPortaliP14080.
SMRiP14080. Positions 38-352.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1540. Car p Chymopapain.
MEROPSiI29.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:CAA66378.

Enzyme and pathway databases

BRENDAi3.4.22.6. 1191.

Miscellaneous databases

EvolutionaryTraceiP14080.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAPA2_CARPA
AccessioniPrimary (citable) accession number: P14080
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.