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P14069 (S10A6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A6
Alternative name(s):
5B10
Calcyclin
Prolactin receptor-associated protein
S100 calcium-binding protein A6
Gene names
Name:S100a6
Synonyms:Cacy
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length89 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative By similarity.

Subunit structure

Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity By similarity. Ref.6 Ref.8

Subcellular location

Nucleus envelope By similarity. Cytoplasm By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CacybpQ9CXW34EBI-6478740,EBI-767146

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8989Protein S100-A6
PRO_0000143985

Regions

Domain12 – 4736EF-hand 1
Domain48 – 8336EF-hand 2
Calcium binding20 – 33141 By similarity
Calcium binding61 – 72122 By similarity

Amino acid modifications

Modified residue401N6-acetyllysine By similarity
Modified residue471N6-acetyllysine; alternate Ref.9
Modified residue471N6-succinyllysine; alternate Ref.9

Experimental info

Sequence conflict511A → R in CAA36521. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P14069 [UniParc].

Last modified May 1, 1991. Version 3.
Checksum: 2AA1A4018B8CA687

FASTA8910,051
        10         20         30         40         50         60 
MACPLDQAIG LLVAIFHKYS GKEGDKHTLS KKELKELIQK ELTIGSKLQD AEIARLMDDL 

        70         80 
DRNKDQEVNF QEYVAFLGAL ALIYNEALK 

« Hide

References

« Hide 'large scale' references
[1]"The gene encoding the calcium binding protein calcyclin is expressed at sites of exocytosis in the mouse."
Timmons P.M., Chan C.T.J., Rigby P.W.J., Poirier F.
J. Cell Sci. 104:187-196(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129.
[2]"Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cells."
Guo X., Chambers A.F., Parfett C.L., Waterhouse P., Murphy L.C., Reid R.E., Craig A.M., Edwards D.R., Denhardt D.T.
Cell Growth Differ. 1:333-338(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Expression of calcyclin, a calcium-binding protein, in the keratogenous region of growing hair follicles."
Wood L., Carter D., Mills M., Hatzenbuhler N., Vogeli G.
J. Invest. Dermatol. 96:383-387(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: TUC CF1.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Mammary tumor.
[5]"Calcium-binding protein from mouse Ehrlich ascites-tumour cells is homologous to human calcyclin."
Kuznicki J., Filipek A., Hunziker P.E., Huber S., Heizmann C.W.
Biochem. J. 263:951-956(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 56-69.
[6]"Characterization of the cell-cycle-regulated protein calcyclin from Ehrlich ascites tumor cells. Identification of two binding proteins obtained by Ca2(+)-dependent affinity chromatography."
Filipek A., Gerke V., Weber K., Kuznicki J.
Eur. J. Biochem. 195:795-800(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 6-89, INTERACTION WITH OTHER PROTEINS.
[7]"Purification and characterization of mouse decidual calcyclin: a novel stimulator of mouse placental lactogen-II secretion."
Thordarson G., Southard J.N., Talamantes F.
Endocrinology 129:1257-1265(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-33 AND 37-89.
[8]"CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family."
Filipek A., Jastrzebska B., Nowotny M., Kuznicki J.
J. Biol. Chem. 277:28848-28852(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CACYBP.
[9]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-47, SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-47, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M37761 mRNA. Translation: AAA37358.1.
X66449 mRNA. Translation: CAA47065.1.
X52278 mRNA. Translation: CAA36521.1.
BC003832 mRNA. Translation: AAH03832.1.
BC010774 mRNA. Translation: AAH10774.1.
PIRA54314.
RefSeqNP_035443.1. NM_011313.2.
UniGeneMm.100144.

3D structure databases

ProteinModelPortalP14069.
SMRP14069. Positions 2-89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203055. 2 interactions.
IntActP14069. 4 interactions.
MINTMINT-239145.
STRING10090.ENSMUSP00000001051.

PTM databases

PhosphoSiteP14069.

2D gel databases

DOSAC-COBS-2DPAGEP14069.

Proteomic databases

PaxDbP14069.
PRIDEP14069.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001051; ENSMUSP00000001051; ENSMUSG00000001025.
GeneID20200.
KEGGmmu:20200.
UCSCuc008qdb.1. mouse.

Organism-specific databases

CTD6277.
MGIMGI:1339467. S100a6.

Phylogenomic databases

eggNOGNOG40006.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidP14069.
OMAVVNFQEY.
OrthoDBEOG78WKVD.
PhylomeDBP14069.
TreeFamTF332727.

Gene expression databases

ArrayExpressP14069.
BgeeP14069.
CleanExMM_S100A6.
GenevestigatorP14069.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028497. S100-A5/S100-A6.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERPTHR11639:SF14. PTHR11639:SF14. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSS100A6. mouse.
NextBio297775.
PROP14069.
SOURCESearch...

Entry information

Entry nameS10A6_MOUSE
AccessionPrimary (citable) accession number: P14069
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: May 1, 1991
Last modified: April 16, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot