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Protein

Protein S100-A6

Gene

S100a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331PROSITE-ProRule annotationAdd BLAST14
Calcium bindingi61 – 722PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A6
Alternative name(s):
5B10
Calcyclin
Prolactin receptor-associated protein
S100 calcium-binding protein A6
Gene namesi
Name:S100a6
Synonyms:Cacy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1339467. S100a6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439851 – 89Protein S100-A6Add BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-acetyllysineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei47N6-acetyllysine; alternateCombined sources1
Modified residuei47N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP14069.
PaxDbiP14069.
PeptideAtlasiP14069.
PRIDEiP14069.

2D gel databases

DOSAC-COBS-2DPAGEP14069.

PTM databases

iPTMnetiP14069.
PhosphoSitePlusiP14069.
SwissPalmiP14069.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001025.
CleanExiMM_S100A6.
ExpressionAtlasiP14069. baseline and differential.
GenevisibleiP14069. MM.

Interactioni

Subunit structurei

Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CacybpQ9CXW34EBI-6478740,EBI-767146

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203055. 2 interactors.
IntActiP14069. 4 interactors.
MINTiMINT-239145.
STRINGi10090.ENSMUSP00000001051.

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 20Combined sources17
Beta strandi22 – 25Combined sources4
Helixi31 – 41Combined sources11
Helixi43 – 45Combined sources3
Helixi50 – 60Combined sources11
Beta strandi62 – 66Combined sources5
Helixi70 – 88Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P2YX-ray2.30B1-89[»]
ProteinModelPortaliP14069.
SMRiP14069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini48 – 83EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYT5. Eukaryota.
ENOG410Z6I6. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP14069.
OMAiQVVNFQE.
OrthoDBiEOG091G10JX.
PhylomeDBiP14069.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACPLDQAIG LLVAIFHKYS GKEGDKHTLS KKELKELIQK ELTIGSKLQD
60 70 80
AEIARLMDDL DRNKDQEVNF QEYVAFLGAL ALIYNEALK
Length:89
Mass (Da):10,051
Last modified:May 1, 1991 - v3
Checksum:i2AA1A4018B8CA687
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51A → R in CAA36521 (PubMed:2177633).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37761 mRNA. Translation: AAA37358.1.
X66449 mRNA. Translation: CAA47065.1.
X52278 mRNA. Translation: CAA36521.1.
BC003832 mRNA. Translation: AAH03832.1.
BC010774 mRNA. Translation: AAH10774.1.
CCDSiCCDS38506.1.
PIRiA54314.
RefSeqiNP_035443.1. NM_011313.2.
UniGeneiMm.100144.

Genome annotation databases

EnsembliENSMUST00000001051; ENSMUSP00000001051; ENSMUSG00000001025.
ENSMUST00000198128; ENSMUSP00000143111; ENSMUSG00000001025.
ENSMUST00000200289; ENSMUSP00000143720; ENSMUSG00000001025.
GeneIDi20200.
KEGGimmu:20200.
UCSCiuc008qdb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37761 mRNA. Translation: AAA37358.1.
X66449 mRNA. Translation: CAA47065.1.
X52278 mRNA. Translation: CAA36521.1.
BC003832 mRNA. Translation: AAH03832.1.
BC010774 mRNA. Translation: AAH10774.1.
CCDSiCCDS38506.1.
PIRiA54314.
RefSeqiNP_035443.1. NM_011313.2.
UniGeneiMm.100144.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P2YX-ray2.30B1-89[»]
ProteinModelPortaliP14069.
SMRiP14069.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203055. 2 interactors.
IntActiP14069. 4 interactors.
MINTiMINT-239145.
STRINGi10090.ENSMUSP00000001051.

PTM databases

iPTMnetiP14069.
PhosphoSitePlusiP14069.
SwissPalmiP14069.

2D gel databases

DOSAC-COBS-2DPAGEP14069.

Proteomic databases

EPDiP14069.
PaxDbiP14069.
PeptideAtlasiP14069.
PRIDEiP14069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001051; ENSMUSP00000001051; ENSMUSG00000001025.
ENSMUST00000198128; ENSMUSP00000143111; ENSMUSG00000001025.
ENSMUST00000200289; ENSMUSP00000143720; ENSMUSG00000001025.
GeneIDi20200.
KEGGimmu:20200.
UCSCiuc008qdb.1. mouse.

Organism-specific databases

CTDi6277.
MGIiMGI:1339467. S100a6.

Phylogenomic databases

eggNOGiENOG410IYT5. Eukaryota.
ENOG410Z6I6. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP14069.
OMAiQVVNFQE.
OrthoDBiEOG091G10JX.
PhylomeDBiP14069.
TreeFamiTF332727.

Miscellaneous databases

ChiTaRSiS100a6. mouse.
PROiP14069.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001025.
CleanExiMM_S100A6.
ExpressionAtlasiP14069. baseline and differential.
GenevisibleiP14069. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10A6_MOUSE
AccessioniPrimary (citable) accession number: P14069
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: May 1, 1991
Last modified: November 2, 2016
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.