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Protein

Exportin-1

Gene

xpo1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the leucine-rich nuclear export signal (NES).1 Publication

Miscellaneous

Cellular target of leptomycin B (LMB), a nuclear export inhibitor. LMB alkylates Cys-529 leading to CRM1 inactivation.

GO - Molecular functioni

  • GTP binding Source: PomBase
  • nuclear export signal receptor activity Source: PomBase
  • Ran GTPase binding Source: InterPro

GO - Biological processi

  • cellular response to oxidative stress Source: PomBase
  • protein export from nucleus Source: PomBase
  • regulation of protein export from nucleus Source: GO_Central
  • ribosomal large subunit export from nucleus Source: PomBase
  • ribosomal small subunit export from nucleus Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-69273 Cyclin A/B1/B2 associated events during G2/M transition

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-1
Alternative name(s):
Caffeine resistance protein 2
Chromosome region maintenance protein 1
Gene namesi
Name:xpo1
Synonyms:caf2, crm1
ORF Names:SPAC1805.17, SPAC1B2.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1805.17
PomBaseiSPAC1805.17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi129E → K in crm1-1R-9R. 1 Publication1
Mutagenesisi299E → K in crm1-14-R. 1 Publication1
Mutagenesisi430E → K in crm1-809; cold-sensitive and LMB hypersensitive. 1 Publication1
Mutagenesisi503G → D in crm1-N1. 1 Publication1
Mutagenesisi529C → S in crm1-K1; LMB resistant. 1 Publication1
Mutagenesisi546M → I in crm1-N1. 1 Publication1
Mutagenesisi992F → S in crm1-119; LMB resistant. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047091 – 1078Exportin-1Add BLAST1078

Proteomic databases

MaxQBiP14068
PaxDbiP14068
PRIDEiP14068

Interactioni

Subunit structurei

Interacts with php4.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi280563, 13 interactors
STRINGi4896.SPAC1805.17.1

Structurei

3D structure databases

ProteinModelPortaliP14068
SMRiP14068
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 100Importin N-terminalPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

InParanoidiP14068
KOiK14290
OMAiCENNMII
OrthoDBiEOG092C0C5J
PhylomeDBiP14068

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014877 CRM1_C_dom
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequencei

Sequence statusi: Complete.

P14068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGILAFDRE LDVALLDRVV QTFYQGVGAE QQQAQQVLTQ FQAHPDAWSQ
60 70 80 90 100
AYSILEKSEY PQTKYIALSV LDKLITTRWK MLPKEQRLGI RNYIVAVMIK
110 120 130 140 150
NSSDETVLQQ QKTFLNKLDL TLVQILKQEW PHNWPNFIPE IVQASKTNLS
160 170 180 190 200
LCENNMIVLR LLSEEIFDYS AEQMTQLKTK NLKNQMCGEF AEIFQLCSQI
210 220 230 240 250
LERAQKPSLI KATLGTLLRF LNWIPLGYIF ETNIVELITN RFLNVPDFRN
260 270 280 290 300
VTIECLTEIA SLTSQPQYND KFVTMFNLVM TSVNSMLPLQ TDFREAYEES
310 320 330 340 350
STNEQDFIQN LALFLCAFFS SHLRPLENPE NQEVLLNAHS YLLNISRINE
360 370 380 390 400
REIFKICLEY WSKLVAQLYE EMQQIPMSEM NPLLNLSSPT SLISSNPNML
410 420 430 440 450
ANLPLRKHIY KDILSTLRLV MIENMVKPEE VLIVENDEGE IVREFVKETD
460 470 480 490 500
TITLYKSMRE VLVYLTHLDV VDTEIVMTEK LARIVVGTEW SWQNLNTLCW
510 520 530 540 550
AIGSISGAMN EEMEKRFLVN VIKDLLGLCE MKRGKDNKAV VASNIMYVVG
560 570 580 590 600
QYPRFLKAHW KFLKTVVNKL FEFMHEYHEG VQDMACDTFI KIAQKCRRHF
610 620 630 640 650
VAQQLGETEP FINEIIRNLA KTTEDLTPQQ THTFYEACGY MISAQPQKHL
660 670 680 690 700
QERLIFDLMA LPNQAWENIV AQAAQNAQVL GDPQTVKILA NVLKTNVAAC
710 720 730 740 750
TSIGSGFYPQ IAKNYVDMLG LYKAVSGLIS EVVAAQGNIA TKTPHVRGLR
760 770 780 790 800
TIKKEILKLV DAYISRAEDL ELVGNTLIPA LFEAVLLDYL QNVPDARDAE
810 820 830 840 850
VLNLITTIVN QLSELLTDKI PLVLDAVFGC TLEMISKDFS EYPEHRAAFF
860 870 880 890 900
QLLRAINLNC FPALLNIPAP QFKLVINSIV WSFKHVSRDI QETGLNILLE
910 920 930 940 950
LINNMASMGP DVSNAFFQTY YISLLQDILY VLTDSDHKSG FKLQSLILAR
960 970 980 990 1000
LFYLVESNQI TVPLYDPSQF PQEMNNQLFL RQYIMNLLVT AFPHLQPIQI
1010 1020 1030 1040 1050
QEFVQTVLAL NQDSIKFKLA LRDFLIQLKE FGGDNAELYL EEKEQELAAQ
1060 1070
QKAQLEKAMT VPGMIKPVDM PTMEEEEL
Length:1,078
Mass (Da):123,567
Last modified:August 14, 2001 - v3
Checksum:i6CFA6955F1DF9F6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192 – 208EIFQL…AQKPS → RFFNYAHKFSNVRKNLA no nucleotide entry (PubMed:1448080).CuratedAdd BLAST17
Sequence conflicti192 – 208EIFQL…AQKPS → RFFNYAHKFSNVRKNLA in BAA03858 (PubMed:8119981).CuratedAdd BLAST17
Sequence conflicti484 – 485IV → VI in AAG35722 (PubMed:11318103).Curated2
Sequence conflicti989Missing no nucleotide entry (PubMed:1448080).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15482 Genomic DNA Translation: CAB40824.2
D16355 Genomic DNA Translation: BAA03858.1
AB027496 Genomic DNA Translation: BAA83345.1
AB027497 Genomic DNA Translation: BAA83346.1
AF208056 Genomic DNA Translation: AAG35722.1
CU329670 Genomic DNA Translation: CAB55858.1
PIRiD45029
T43511
T50137
RefSeqiXP_001713070.1, XM_001713018.2

Genome annotation databases

EnsemblFungiiSPAC1805.17.1; SPAC1805.17.1:pep; SPAC1805.17
KEGGispo:SPAC1805.17

Similar proteinsi

Entry informationi

Entry nameiXPO1_SCHPO
AccessioniPrimary (citable) accession number: P14068
Secondary accession number(s): Q09197
, Q9HF66, Q9URF4, Q9UTF9, Q9UTG0, Q9UUL0, Q9UUL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 14, 2001
Last modified: May 23, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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