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Protein

Exportin-1

Gene

xpo1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the leucine-rich nuclear export signal (NES).1 Publication

GO - Molecular functioni

  • nuclear export signal receptor activity Source: PomBase

GO - Biological processi

  • cellular response to oxidative stress Source: PomBase
  • protein export from nucleus Source: PomBase
  • regulation of protein export from nucleus Source: GO_Central
  • ribosomal large subunit export from nucleus Source: PomBase
  • ribosomal small subunit export from nucleus Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-1
Alternative name(s):
Caffeine resistance protein 2
Chromosome region maintenance protein 1
Gene namesi
Name:xpo1
Synonyms:caf2, crm1
ORF Names:SPAC1805.17, SPAC1B2.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1805.17.
PomBaseiSPAC1805.17.

Subcellular locationi

  • Nucleus

  • Note: Localized in the nucleus and at its periphery.

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
  • nuclear envelope Source: PomBase
  • nuclear periphery Source: PomBase
  • nuclear pore Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi129E → K in crm1-1R-9R. 1 Publication1
Mutagenesisi299E → K in crm1-14-R. 1 Publication1
Mutagenesisi430E → K in crm1-809; cold-sensitive and LMB hypersensitive. 1 Publication1
Mutagenesisi503G → D in crm1-N1. 1 Publication1
Mutagenesisi529C → S in crm1-K1; LMB resistant. 1 Publication1
Mutagenesisi546M → I in crm1-N1. 1 Publication1
Mutagenesisi992F → S in crm1-119; LMB resistant. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047091 – 1078Exportin-1Add BLAST1078

Proteomic databases

MaxQBiP14068.
PRIDEiP14068.

Interactioni

Subunit structurei

Interacts with php4.1 Publication

Protein-protein interaction databases

BioGridi280563. 13 interactors.
MINTiMINT-4687292.

Structurei

3D structure databases

ProteinModelPortaliP14068.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 100Importin N-terminalPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the exportin family.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiP14068.
KOiK14290.
OMAiCENETIF.
OrthoDBiEOG092C0C5J.
PhylomeDBiP14068.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF08767. CRM1_C. 1 hit.
PF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM01102. CRM1_C. 1 hit.
SM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGILAFDRE LDVALLDRVV QTFYQGVGAE QQQAQQVLTQ FQAHPDAWSQ
60 70 80 90 100
AYSILEKSEY PQTKYIALSV LDKLITTRWK MLPKEQRLGI RNYIVAVMIK
110 120 130 140 150
NSSDETVLQQ QKTFLNKLDL TLVQILKQEW PHNWPNFIPE IVQASKTNLS
160 170 180 190 200
LCENNMIVLR LLSEEIFDYS AEQMTQLKTK NLKNQMCGEF AEIFQLCSQI
210 220 230 240 250
LERAQKPSLI KATLGTLLRF LNWIPLGYIF ETNIVELITN RFLNVPDFRN
260 270 280 290 300
VTIECLTEIA SLTSQPQYND KFVTMFNLVM TSVNSMLPLQ TDFREAYEES
310 320 330 340 350
STNEQDFIQN LALFLCAFFS SHLRPLENPE NQEVLLNAHS YLLNISRINE
360 370 380 390 400
REIFKICLEY WSKLVAQLYE EMQQIPMSEM NPLLNLSSPT SLISSNPNML
410 420 430 440 450
ANLPLRKHIY KDILSTLRLV MIENMVKPEE VLIVENDEGE IVREFVKETD
460 470 480 490 500
TITLYKSMRE VLVYLTHLDV VDTEIVMTEK LARIVVGTEW SWQNLNTLCW
510 520 530 540 550
AIGSISGAMN EEMEKRFLVN VIKDLLGLCE MKRGKDNKAV VASNIMYVVG
560 570 580 590 600
QYPRFLKAHW KFLKTVVNKL FEFMHEYHEG VQDMACDTFI KIAQKCRRHF
610 620 630 640 650
VAQQLGETEP FINEIIRNLA KTTEDLTPQQ THTFYEACGY MISAQPQKHL
660 670 680 690 700
QERLIFDLMA LPNQAWENIV AQAAQNAQVL GDPQTVKILA NVLKTNVAAC
710 720 730 740 750
TSIGSGFYPQ IAKNYVDMLG LYKAVSGLIS EVVAAQGNIA TKTPHVRGLR
760 770 780 790 800
TIKKEILKLV DAYISRAEDL ELVGNTLIPA LFEAVLLDYL QNVPDARDAE
810 820 830 840 850
VLNLITTIVN QLSELLTDKI PLVLDAVFGC TLEMISKDFS EYPEHRAAFF
860 870 880 890 900
QLLRAINLNC FPALLNIPAP QFKLVINSIV WSFKHVSRDI QETGLNILLE
910 920 930 940 950
LINNMASMGP DVSNAFFQTY YISLLQDILY VLTDSDHKSG FKLQSLILAR
960 970 980 990 1000
LFYLVESNQI TVPLYDPSQF PQEMNNQLFL RQYIMNLLVT AFPHLQPIQI
1010 1020 1030 1040 1050
QEFVQTVLAL NQDSIKFKLA LRDFLIQLKE FGGDNAELYL EEKEQELAAQ
1060 1070
QKAQLEKAMT VPGMIKPVDM PTMEEEEL
Length:1,078
Mass (Da):123,567
Last modified:August 14, 2001 - v3
Checksum:i6CFA6955F1DF9F6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192 – 208EIFQL…AQKPS → RFFNYAHKFSNVRKNLA no nucleotide entry (PubMed:1448080).CuratedAdd BLAST17
Sequence conflicti192 – 208EIFQL…AQKPS → RFFNYAHKFSNVRKNLA in BAA03858 (PubMed:8119981).CuratedAdd BLAST17
Sequence conflicti484 – 485IV → VI in AAG35722 (PubMed:11318103).Curated2
Sequence conflicti989Missing no nucleotide entry (PubMed:1448080).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15482 Genomic DNA. Translation: CAB40824.2.
D16355 Genomic DNA. Translation: BAA03858.1.
AB027496 Genomic DNA. Translation: BAA83345.1.
AB027497 Genomic DNA. Translation: BAA83346.1.
AF208056 Genomic DNA. Translation: AAG35722.1.
CU329670 Genomic DNA. Translation: CAB55858.1.
PIRiD45029.
T43511.
T50137.
RefSeqiXP_001713070.1. XM_001713018.2.

Genome annotation databases

EnsemblFungiiSPAC1805.17.1; SPAC1805.17.1:pep; SPAC1805.17.
GeneIDi3361487.
KEGGispo:SPAC1805.17.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15482 Genomic DNA. Translation: CAB40824.2.
D16355 Genomic DNA. Translation: BAA03858.1.
AB027496 Genomic DNA. Translation: BAA83345.1.
AB027497 Genomic DNA. Translation: BAA83346.1.
AF208056 Genomic DNA. Translation: AAG35722.1.
CU329670 Genomic DNA. Translation: CAB55858.1.
PIRiD45029.
T43511.
T50137.
RefSeqiXP_001713070.1. XM_001713018.2.

3D structure databases

ProteinModelPortaliP14068.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi280563. 13 interactors.
MINTiMINT-4687292.

Proteomic databases

MaxQBiP14068.
PRIDEiP14068.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1805.17.1; SPAC1805.17.1:pep; SPAC1805.17.
GeneIDi3361487.
KEGGispo:SPAC1805.17.

Organism-specific databases

EuPathDBiFungiDB:SPAC1805.17.
PomBaseiSPAC1805.17.

Phylogenomic databases

InParanoidiP14068.
KOiK14290.
OMAiCENETIF.
OrthoDBiEOG092C0C5J.
PhylomeDBiP14068.

Miscellaneous databases

PROiP14068.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF08767. CRM1_C. 1 hit.
PF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM01102. CRM1_C. 1 hit.
SM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXPO1_SCHPO
AccessioniPrimary (citable) accession number: P14068
Secondary accession number(s): Q09197
, Q9HF66, Q9URF4, Q9UTF9, Q9UTG0, Q9UUL0, Q9UUL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 14, 2001
Last modified: November 30, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Cellular target of leptomycin B (LMB), a nuclear export inhibitor. LMB alkylates Cys-529 leading to CRM1 inactivation.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.