Reviewed,
UniProtKB/Swiss-Prot P14062 (6PGD_SALTY)
Last modified
June 16, 2009.
Version 79.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: 6-phosphogluconate dehydrogenase, decarboxylating EC=1.1.1.44 | ||||
| Gene names |
| ||||
| Organism | Salmonella typhimurium [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 90371 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 468 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. |
| Pathway | |
| Sequence similarities | Belongs to the 6-phosphogluconate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Gluconate utilization Pentose shunt |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shuntInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 468 | 468 | 6-phosphogluconate dehydrogenase, decarboxylating | PRO_0000090047 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and nucleotide sequence of the Salmonella typhimurium LT2 gnd gene and its homology with the corresponding sequence of Escherichia coli K12." Reeves P., Stevenson G. Mol. Gen. Genet. 217:182-184(1989) [PubMed: 2671649] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2. |
| [2] | "Recombination in Escherichia coli and the definition of biological species." Dykhuizen D.E., Green L. J. Bacteriol. 173:7257-7268(1991) [PubMed: 1938920] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2. |
| [3] | "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. Wilson R.K.Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720. |
| [4] | "Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2)." Jiang X.-M., Neal B., Santiago F., Lee S.J., Romana L.K., Reeves P.R. Mol. Microbiol. 5:695-713(1991) [PubMed: 1710759] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57. Strain: LT2. |
Cross-references
Sequence databases | |
|---|---|
| X15651 Genomic DNA. Translation: CAA33677.1. M64332 Genomic DNA. Translation: AAA27137.1. AE008792 Genomic DNA. Translation: AAL20985.1. X56793 Genomic DNA. Translation: CAA40131.1. | |
| PIR | S04397. |
| RefSeq | NP_461026.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2PGD based on UniProtKB P00349. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1253602. |
| GenomeReviews | Gene locus STM2081 in contig AE006468_GR. |
| KEGG | stm:STM2081. |
| NMPDR | fig|99287.1.peg.2006. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P14062. |
| OMA | P14062. PRKVMLM. |
Enzyme and pathway databases | |
| BioCyc | STYP99287:STM2081-MON. |
| BRENDA | 1.1.1.44. 2. |
Family and domain databases | |
| InterPro | IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| Pfam | PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view] |
| PRINTS | PR00076. 6PGDHDRGNASE. |
| TIGRFAMs | TIGR00873. gnd. 1 hit. |
| PROSITE | PS00461. 6PGD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | 6PGD_SALTY | ||||||||
| Accession | Primary (citable) accession number: P14062 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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