Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P14062

- 6PGD_SALTY

UniProt

P14062 - 6PGD_SALTY

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei102 – 1021NADPBy similarity
    Binding sitei102 – 1021SubstrateBy similarity
    Active sitei183 – 1831Proton acceptorBy similarity
    Active sitei190 – 1901Proton donorBy similarity
    Binding sitei191 – 1911SubstrateBy similarity
    Binding sitei260 – 2601Substrate; via amide nitrogenBy similarity
    Binding sitei287 – 2871SubstrateBy similarity
    Binding sitei445 – 4451Substrate; shared with dimeric partnerBy similarity
    Binding sitei451 – 4511Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADPBy similarity
    Nucleotide bindingi33 – 353NADPBy similarity
    Nucleotide bindingi74 – 763NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-2093-MONOMER.
    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:gnd
    Ordered Locus Names:STM2081
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4684686-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090047Add
    BLAST

    Proteomic databases

    PaxDbiP14062.
    PRIDEiP14062.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi99287.STM2081.

    Structurei

    3D structure databases

    ProteinModelPortaliP14062.
    SMRiP14062. Positions 1-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni128 – 1303Substrate bindingBy similarity
    Regioni186 – 1872Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0362.
    HOGENOMiHOG000255147.
    KOiK00033.
    OMAiDKDGVFH.
    OrthoDBiEOG6MSS4W.
    PhylomeDBiP14062.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14062-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKQQIGVVG MAVMGRNLAL NIESRGYTVS VFNRSREKTE EVIAENPGKK    50
    LVPYYTVKEF VESLETPRRI LLMVKAGAGT DAAIDSLKPY LEKGDIIIDG 100
    GNTFFQDTIR RNRELSAEGF NFIGTGVSGG EEGALKGPSI MPGGQKDAYE 150
    LVAPILTKIA AVAEDGEPCV TYIGADGAGH YVKMVHNGIE YGDMQLIAEA 200
    YSLLKGGLNL SNEELANTFT EWNNGELSSY LIDITKDIFT KKDEDGNYLV 250
    DVILDEAANK GTGKWTSQSA LDLGEPLSLI TESVFARYIS SLKAQRVAAS 300
    KVLSGPKAQP AGDKAEFIEK VRRALYLGKI VSYAQGFSQL RAASDEYHWD 350
    LNYGEIAKIF RAGCIIRAQF LQKITDAYAE NADIANLLLA PYFKKIADEY 400
    QQALRDVVAY AVQNGIPVPT FSAAVAYYDS YRAAVLPANL IQAQRDYFGA 450
    HTYKRTDKEG IFHTEWLE 468
    Length:468
    Mass (Da):51,395
    Last modified:January 1, 1990 - v1
    Checksum:iD8EBB53A2DAADBF7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15651 Genomic DNA. Translation: CAA33677.1.
    M64332 Genomic DNA. Translation: AAA27137.1.
    AE006468 Genomic DNA. Translation: AAL20985.1.
    X56793 Genomic DNA. Translation: CAA40131.1.
    PIRiS04397.
    RefSeqiNP_461026.1. NC_003197.1.
    WP_000043530.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20985; AAL20985; STM2081.
    GeneIDi1253602.
    KEGGistm:STM2081.
    PATRICi32382745. VBISalEnt20916_2203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15651 Genomic DNA. Translation: CAA33677.1 .
    M64332 Genomic DNA. Translation: AAA27137.1 .
    AE006468 Genomic DNA. Translation: AAL20985.1 .
    X56793 Genomic DNA. Translation: CAA40131.1 .
    PIRi S04397.
    RefSeqi NP_461026.1. NC_003197.1.
    WP_000043530.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali P14062.
    SMRi P14062. Positions 1-466.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM2081.

    Proteomic databases

    PaxDbi P14062.
    PRIDEi P14062.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20985 ; AAL20985 ; STM2081 .
    GeneIDi 1253602.
    KEGGi stm:STM2081.
    PATRICi 32382745. VBISalEnt20916_2203.

    Phylogenomic databases

    eggNOGi COG0362.
    HOGENOMi HOG000255147.
    KOi K00033.
    OMAi DKDGVFH.
    OrthoDBi EOG6MSS4W.
    PhylomeDBi P14062.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .
    BioCyci SENT99287:GCTI-2093-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and nucleotide sequence of the Salmonella typhimurium LT2 gnd gene and its homology with the corresponding sequence of Escherichia coli K12."
      Reeves P., Stevenson G.
      Mol. Gen. Genet. 217:182-184(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    2. "Recombination in Escherichia coli and the definition of biological species."
      Dykhuizen D.E., Green L.
      J. Bacteriol. 173:7257-7268(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    4. "Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2)."
      Jiang X.-M., Neal B., Santiago F., Lee S.J., Romana L.K., Reeves P.R.
      Mol. Microbiol. 5:695-713(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57.
      Strain: LT2.

    Entry informationi

    Entry namei6PGD_SALTY
    AccessioniPrimary (citable) accession number: P14062
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3