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Protein

Estradiol 17-beta-dehydrogenase 1

Gene

HSD17B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

Pathwayi: estrogen biosynthesis

This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66NADP1 Publication1
Binding sitei143Substrate1 Publication1
Active sitei156Proton acceptor1
Binding sitei160NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 38NADP1 PublicationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

  • bone development Source: Ensembl
  • cellular response to metal ion Source: Ensembl
  • estrogen biosynthetic process Source: Reactome
  • estrogen metabolic process Source: ProtInc
  • steroid biosynthetic process Source: ProtInc
  • testosterone biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciZFISH:HS03155-MONOMER.
BRENDAi1.1.1.62. 2681.
ReactomeiR-HSA-193144. Estrogen biosynthesis.
R-HSA-2453902. The canonical retinoid cycle in rods (twilight vision).
SABIO-RKP14061.
UniPathwayiUPA00769.

Chemistry databases

SwissLipidsiSLP:000001218.

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 1 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 1
Short name:
17-beta-HSD 1
20 alpha-hydroxysteroid dehydrogenase
Short name:
20-alpha-HSD
E2DH
Placental 17-beta-hydroxysteroid dehydrogenase
Short chain dehydrogenase/reductase family 28C member 1
Gene namesi
Name:HSD17B1
Synonyms:E17KSR, EDH17B1, EDH17B2, EDHB17, SDR28C1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5210. HSD17B1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi150L → V: Alters substrate specificity. 1 Publication1

Organism-specific databases

DisGeNETi3292.
OpenTargetsiENSG00000108786.
PharmGKBiPA29478.

Chemistry databases

ChEMBLiCHEMBL3181.
DrugBankiDB02187. Equilin.

Polymorphism and mutation databases

BioMutaiHSD17B1.
DMDMi313104233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000545672 – 328Estradiol 17-beta-dehydrogenase 1Add BLAST327

Proteomic databases

PaxDbiP14061.
PeptideAtlasiP14061.
PRIDEiP14061.

PTM databases

SwissPalmiP14061.

Expressioni

Gene expression databases

BgeeiENSG00000108786.
CleanExiHS_HSD17B1.
ExpressionAtlasiP14061. baseline and differential.
GenevisibleiP14061. HS.

Organism-specific databases

HPAiHPA021032.
HPA065296.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi109525. 2 interactors.
STRINGi9606.ENSP00000466799.

Chemistry databases

BindingDBiP14061.

Structurei

Secondary structure

1328
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Helixi14 – 24Combined sources11
Beta strandi31 – 38Combined sources8
Helixi40 – 42Combined sources3
Helixi44 – 52Combined sources9
Beta strandi59 – 64Combined sources6
Helixi70 – 78Combined sources9
Beta strandi86 – 90Combined sources5
Helixi100 – 102Combined sources3
Helixi105 – 115Combined sources11
Helixi117 – 133Combined sources17
Beta strandi136 – 143Combined sources8
Helixi144 – 146Combined sources3
Helixi154 – 174Combined sources21
Helixi175 – 177Combined sources3
Beta strandi179 – 186Combined sources8
Beta strandi189 – 192Combined sources4
Turni193 – 196Combined sources4
Helixi201 – 206Combined sources6
Helixi210 – 230Combined sources21
Helixi234 – 246Combined sources13
Beta strandi252 – 256Combined sources5
Beta strandi258 – 260Combined sources3
Helixi261 – 269Combined sources9
Helixi274 – 285Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A27X-ray1.90A2-290[»]
1BHSX-ray2.20A2-328[»]
1DHTX-ray2.24A2-328[»]
1EQUX-ray3.00A/B2-328[»]
1FDSX-ray1.70A2-328[»]
1FDTX-ray2.20A2-328[»]
1FDUX-ray2.70A/B/C/D2-328[»]
1FDVX-ray3.10A/B/C/D2-328[»]
1FDWX-ray2.70A2-328[»]
1I5RX-ray1.60A2-328[»]
1IOLX-ray2.30A2-328[»]
1JTVX-ray1.54A2-328[»]
1QYVX-ray1.81A2-328[»]
1QYWX-ray1.63A2-328[»]
1QYXX-ray1.89A2-328[»]
3DEYX-ray1.70X2-328[»]
3DHEX-ray2.30A2-328[»]
3HB4X-ray2.21X2-328[»]
3HB5X-ray2.00X2-328[»]
3KLMX-ray1.70X2-328[»]
3KLPX-ray2.50X2-328[»]
3KM0X-ray2.30A/B2-328[»]
DisProtiDP00023.
ProteinModelPortaliP14061.
SMRiP14061.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14061.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00860000133667.
HOVERGENiHBG014077.
InParanoidiP14061.
KOiK00044.
PhylomeDBiP14061.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011348. 17beta_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA
60 70 80 90 100
RALACPPGSL ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL
110 120 130 140 150
EALGEDAVAS VLDVNVVGTV RMLQAFLPDM KRRGSGRVLV TGSVGGLMGL
160 170 180 190 200
PFNDVYCASK FALEGLCESL AVLLLPFGVH LSLIECGPVH TAFMEKVLGS
210 220 230 240 250
PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV FLTALRAPKP
260 270 280 290 300
TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG
310 320
GAGPGAEDEA GRGAVGDPEL GDPPAAPQ
Length:328
Mass (Da):34,950
Last modified:November 30, 2010 - v3
Checksum:i5B5C8909F9120832
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3R → E AA sequence (PubMed:5045524).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_006951238A → V.1 PublicationCorresponds to variant rs147402365dbSNPEnsembl.1
Natural variantiVAR_006952313G → S.10 PublicationsCorresponds to variant rs605059dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13440 mRNA. Translation: CAA31792.1.
M36263 mRNA. Translation: AAA35600.1.
M27138 Genomic DNA. Translation: AAB16941.1.
M84472 Genomic DNA. Translation: AAB16942.1.
U34879 Genomic DNA. Translation: AAD05019.1.
AK127832 mRNA. Translation: BAG54583.1.
AC067852 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60836.1.
BC104752 mRNA. Translation: AAI04753.1.
BC111935 mRNA. Translation: AAI11936.1.
CCDSiCCDS11428.1.
PIRiA36081. DEHUE7.
RefSeqiNP_000404.2. NM_000413.3.
UniGeneiHs.654385.
Hs.655222.

Genome annotation databases

EnsembliENST00000585807; ENSP00000466799; ENSG00000108786.
GeneIDi3292.
KEGGihsa:3292.
UCSCiuc002hzw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13440 mRNA. Translation: CAA31792.1.
M36263 mRNA. Translation: AAA35600.1.
M27138 Genomic DNA. Translation: AAB16941.1.
M84472 Genomic DNA. Translation: AAB16942.1.
U34879 Genomic DNA. Translation: AAD05019.1.
AK127832 mRNA. Translation: BAG54583.1.
AC067852 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60836.1.
BC104752 mRNA. Translation: AAI04753.1.
BC111935 mRNA. Translation: AAI11936.1.
CCDSiCCDS11428.1.
PIRiA36081. DEHUE7.
RefSeqiNP_000404.2. NM_000413.3.
UniGeneiHs.654385.
Hs.655222.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A27X-ray1.90A2-290[»]
1BHSX-ray2.20A2-328[»]
1DHTX-ray2.24A2-328[»]
1EQUX-ray3.00A/B2-328[»]
1FDSX-ray1.70A2-328[»]
1FDTX-ray2.20A2-328[»]
1FDUX-ray2.70A/B/C/D2-328[»]
1FDVX-ray3.10A/B/C/D2-328[»]
1FDWX-ray2.70A2-328[»]
1I5RX-ray1.60A2-328[»]
1IOLX-ray2.30A2-328[»]
1JTVX-ray1.54A2-328[»]
1QYVX-ray1.81A2-328[»]
1QYWX-ray1.63A2-328[»]
1QYXX-ray1.89A2-328[»]
3DEYX-ray1.70X2-328[»]
3DHEX-ray2.30A2-328[»]
3HB4X-ray2.21X2-328[»]
3HB5X-ray2.00X2-328[»]
3KLMX-ray1.70X2-328[»]
3KLPX-ray2.50X2-328[»]
3KM0X-ray2.30A/B2-328[»]
DisProtiDP00023.
ProteinModelPortaliP14061.
SMRiP14061.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109525. 2 interactors.
STRINGi9606.ENSP00000466799.

Chemistry databases

BindingDBiP14061.
ChEMBLiCHEMBL3181.
DrugBankiDB02187. Equilin.
SwissLipidsiSLP:000001218.

PTM databases

SwissPalmiP14061.

Polymorphism and mutation databases

BioMutaiHSD17B1.
DMDMi313104233.

Proteomic databases

PaxDbiP14061.
PeptideAtlasiP14061.
PRIDEiP14061.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585807; ENSP00000466799; ENSG00000108786.
GeneIDi3292.
KEGGihsa:3292.
UCSCiuc002hzw.4. human.

Organism-specific databases

CTDi3292.
DisGeNETi3292.
GeneCardsiHSD17B1.
H-InvDBHIX0202506.
HGNCiHGNC:5210. HSD17B1.
HPAiHPA021032.
HPA065296.
MIMi109684. gene.
neXtProtiNX_P14061.
OpenTargetsiENSG00000108786.
PharmGKBiPA29478.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00860000133667.
HOVERGENiHBG014077.
InParanoidiP14061.
KOiK00044.
PhylomeDBiP14061.

Enzyme and pathway databases

UniPathwayiUPA00769.
BioCyciZFISH:HS03155-MONOMER.
BRENDAi1.1.1.62. 2681.
ReactomeiR-HSA-193144. Estrogen biosynthesis.
R-HSA-2453902. The canonical retinoid cycle in rods (twilight vision).
SABIO-RKP14061.

Miscellaneous databases

EvolutionaryTraceiP14061.
GeneWikiiHSD17B1.
GenomeRNAii3292.
PROiP14061.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108786.
CleanExiHS_HSD17B1.
ExpressionAtlasiP14061. baseline and differential.
GenevisibleiP14061. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011348. 17beta_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHB1_HUMAN
AccessioniPrimary (citable) accession number: P14061
Secondary accession number(s): B3KXS1, Q2M2L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 185 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.