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P14061

- DHB1_HUMAN

UniProt

P14061 - DHB1_HUMAN

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Protein

Estradiol 17-beta-dehydrogenase 1

Gene

HSD17B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661NADP1 Publication
Binding sitei143 – 1431Substrate1 Publication
Active sitei156 – 1561Proton acceptor
Binding sitei160 – 1601NADP1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 3829NADP1 PublicationAdd
BLAST

GO - Molecular functioni

  1. catalytic activity Source: ProtInc
  2. estradiol 17-beta-dehydrogenase activity Source: Reactome

GO - Biological processi

  1. bone development Source: Ensembl
  2. cellular response to metal ion Source: Ensembl
  3. estrogen biosynthetic process Source: Reactome
  4. estrogen metabolic process Source: ProtInc
  5. small molecule metabolic process Source: Reactome
  6. steroid biosynthetic process Source: ProtInc
  7. steroid metabolic process Source: Reactome
  8. testosterone biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_11037. Estrogen biosynthesis.
REACT_160156. The canonical retinoid cycle in rods (twilight vision).
SABIO-RKP14061.
UniPathwayiUPA00769.

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 1 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 1
Short name:
17-beta-HSD 1
20 alpha-hydroxysteroid dehydrogenase
Short name:
20-alpha-HSD
E2DH
Placental 17-beta-hydroxysteroid dehydrogenase
Gene namesi
Name:HSD17B1
Synonyms:E17KSR, EDH17B1, EDH17B2, EDHB17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:5210. HSD17B1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. nuclear membrane Source: HPA
  4. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi150 – 1501L → V: Alters substrate specificity. 1 Publication

Organism-specific databases

PharmGKBiPA29478.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 328327Estradiol 17-beta-dehydrogenase 1PRO_0000054567Add
BLAST

Proteomic databases

PaxDbiP14061.
PRIDEiP14061.

Expressioni

Gene expression databases

BgeeiP14061.
CleanExiHS_HSD17B1.
ExpressionAtlasiP14061. baseline and differential.
GenevestigatoriP14061.

Organism-specific databases

HPAiHPA021032.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi109525. 1 interaction.
STRINGi9606.ENSP00000225929.

Structurei

Secondary structure

1
328
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 96Combined sources
Helixi14 – 2411Combined sources
Beta strandi31 – 388Combined sources
Helixi40 – 423Combined sources
Helixi44 – 529Combined sources
Beta strandi59 – 646Combined sources
Helixi70 – 789Combined sources
Beta strandi86 – 905Combined sources
Helixi100 – 1023Combined sources
Helixi105 – 11511Combined sources
Helixi117 – 13317Combined sources
Beta strandi136 – 1438Combined sources
Helixi144 – 1463Combined sources
Helixi154 – 17421Combined sources
Helixi175 – 1773Combined sources
Beta strandi179 – 1868Combined sources
Beta strandi189 – 1924Combined sources
Turni193 – 1964Combined sources
Helixi201 – 2066Combined sources
Helixi210 – 23021Combined sources
Helixi234 – 24613Combined sources
Beta strandi252 – 2565Combined sources
Beta strandi258 – 2603Combined sources
Helixi261 – 2699Combined sources
Helixi274 – 28512Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A27X-ray1.90A2-290[»]
1BHSX-ray2.20A2-328[»]
1DHTX-ray2.24A2-328[»]
1EQUX-ray3.00A/B2-328[»]
1FDSX-ray1.70A2-328[»]
1FDTX-ray2.20A2-328[»]
1FDUX-ray2.70A/B/C/D2-328[»]
1FDVX-ray3.10A/B/C/D2-328[»]
1FDWX-ray2.70A2-328[»]
1I5RX-ray1.60A2-328[»]
1IOLX-ray2.30A2-328[»]
1JTVX-ray1.54A2-328[»]
1QYVX-ray1.81A2-328[»]
1QYWX-ray1.63A2-328[»]
1QYXX-ray1.89A2-328[»]
3DEYX-ray1.70X2-328[»]
3DHEX-ray2.30A2-328[»]
3HB4X-ray2.21X2-328[»]
3HB5X-ray2.00X2-328[»]
3KLMX-ray1.70X2-328[»]
3KLPX-ray2.50X2-328[»]
3KM0X-ray2.30A/B2-328[»]
DisProtiDP00023.
ProteinModelPortaliP14061.
SMRiP14061. Positions 2-286.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14061.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00770000120481.
HOVERGENiHBG014077.
InParanoidiP14061.
KOiK00044.
OrthoDBiEOG76T9RW.
PhylomeDBiP14061.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011348. 17beta_DH.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000095. 17beta-HSD. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14061-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA
60 70 80 90 100
RALACPPGSL ETLQLDVRDS KSVAAARERV TEGRVDVLVC NAGLGLLGPL
110 120 130 140 150
EALGEDAVAS VLDVNVVGTV RMLQAFLPDM KRRGSGRVLV TGSVGGLMGL
160 170 180 190 200
PFNDVYCASK FALEGLCESL AVLLLPFGVH LSLIECGPVH TAFMEKVLGS
210 220 230 240 250
PEEVLDRTDI HTFHRFYQYL AHSKQVFREA AQNPEEVAEV FLTALRAPKP
260 270 280 290 300
TLRYFTTERF LPLLRMRLDD PSGSNYVTAM HREVFGDVPA KAEAGAEAGG
310 320
GAGPGAEDEA GRGAVGDPEL GDPPAAPQ
Length:328
Mass (Da):34,950
Last modified:November 30, 2010 - v3
Checksum:i5B5C8909F9120832
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31R → E AA sequence (PubMed:5045524)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti238 – 2381A → V.1 Publication
VAR_006951
Natural varianti313 – 3131G → S.10 Publications
Corresponds to variant rs605059 [ dbSNP | Ensembl ].
VAR_006952

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13440 mRNA. Translation: CAA31792.1.
M36263 mRNA. Translation: AAA35600.1.
M27138 Genomic DNA. Translation: AAB16941.1.
M84472 Genomic DNA. Translation: AAB16942.1.
U34879 Genomic DNA. Translation: AAD05019.1.
AK127832 mRNA. Translation: BAG54583.1.
AC067852 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60836.1.
BC104752 mRNA. Translation: AAI04753.1.
BC111935 mRNA. Translation: AAI11936.1.
CCDSiCCDS11428.1.
PIRiA36081. DEHUE7.
RefSeqiNP_000404.2. NM_000413.2.
UniGeneiHs.654385.
Hs.655222.

Genome annotation databases

EnsembliENST00000585807; ENSP00000466799; ENSG00000108786.
GeneIDi3292.
KEGGihsa:3292.
UCSCiuc002hzw.3. human.

Polymorphism databases

DMDMi313104233.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13440 mRNA. Translation: CAA31792.1 .
M36263 mRNA. Translation: AAA35600.1 .
M27138 Genomic DNA. Translation: AAB16941.1 .
M84472 Genomic DNA. Translation: AAB16942.1 .
U34879 Genomic DNA. Translation: AAD05019.1 .
AK127832 mRNA. Translation: BAG54583.1 .
AC067852 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60836.1 .
BC104752 mRNA. Translation: AAI04753.1 .
BC111935 mRNA. Translation: AAI11936.1 .
CCDSi CCDS11428.1.
PIRi A36081. DEHUE7.
RefSeqi NP_000404.2. NM_000413.2.
UniGenei Hs.654385.
Hs.655222.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A27 X-ray 1.90 A 2-290 [» ]
1BHS X-ray 2.20 A 2-328 [» ]
1DHT X-ray 2.24 A 2-328 [» ]
1EQU X-ray 3.00 A/B 2-328 [» ]
1FDS X-ray 1.70 A 2-328 [» ]
1FDT X-ray 2.20 A 2-328 [» ]
1FDU X-ray 2.70 A/B/C/D 2-328 [» ]
1FDV X-ray 3.10 A/B/C/D 2-328 [» ]
1FDW X-ray 2.70 A 2-328 [» ]
1I5R X-ray 1.60 A 2-328 [» ]
1IOL X-ray 2.30 A 2-328 [» ]
1JTV X-ray 1.54 A 2-328 [» ]
1QYV X-ray 1.81 A 2-328 [» ]
1QYW X-ray 1.63 A 2-328 [» ]
1QYX X-ray 1.89 A 2-328 [» ]
3DEY X-ray 1.70 X 2-328 [» ]
3DHE X-ray 2.30 A 2-328 [» ]
3HB4 X-ray 2.21 X 2-328 [» ]
3HB5 X-ray 2.00 X 2-328 [» ]
3KLM X-ray 1.70 X 2-328 [» ]
3KLP X-ray 2.50 X 2-328 [» ]
3KM0 X-ray 2.30 A/B 2-328 [» ]
DisProti DP00023.
ProteinModelPortali P14061.
SMRi P14061. Positions 2-286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109525. 1 interaction.
STRINGi 9606.ENSP00000225929.

Chemistry

BindingDBi P14061.
ChEMBLi CHEMBL3181.
DrugBanki DB02187. Equilin.

Polymorphism databases

DMDMi 313104233.

Proteomic databases

PaxDbi P14061.
PRIDEi P14061.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000585807 ; ENSP00000466799 ; ENSG00000108786 .
GeneIDi 3292.
KEGGi hsa:3292.
UCSCi uc002hzw.3. human.

Organism-specific databases

CTDi 3292.
GeneCardsi GC17P040701.
H-InvDB HIX0202506.
HGNCi HGNC:5210. HSD17B1.
HPAi HPA021032.
MIMi 109684. gene.
neXtProti NX_P14061.
PharmGKBi PA29478.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1028.
GeneTreei ENSGT00770000120481.
HOVERGENi HBG014077.
InParanoidi P14061.
KOi K00044.
OrthoDBi EOG76T9RW.
PhylomeDBi P14061.

Enzyme and pathway databases

UniPathwayi UPA00769 .
Reactomei REACT_11037. Estrogen biosynthesis.
REACT_160156. The canonical retinoid cycle in rods (twilight vision).
SABIO-RK P14061.

Miscellaneous databases

EvolutionaryTracei P14061.
GeneWikii HSD17B1.
GenomeRNAii 3292.
NextBioi 13059.
PROi P14061.
SOURCEi Search...

Gene expression databases

Bgeei P14061.
CleanExi HS_HSD17B1.
ExpressionAtlasi P14061. baseline and differential.
Genevestigatori P14061.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011348. 17beta_DH.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PIRSFi PIRSF000095. 17beta-HSD. 1 hit.
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA."
    Peltoketo H., Isomaa V., Maeentausta O., Vihko R.
    FEBS Lett. 239:73-77(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-313.
    Tissue: Placenta.
  2. "Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta."
    Luu-The V., Labrie C., Zhao H.F., Couet J., Lachance Y., Simard J., Leblanc G., Labrie F.
    Mol. Endocrinol. 3:1301-1309(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-313.
    Tissue: Placenta.
  3. "Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes."
    Luu-The V., Labrie C., Simard J., Lachance Y., Zhao H.F., Couet J., Leblanc G., Labrie F.
    Mol. Endocrinol. 4:268-275(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-313.
  4. "Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase."
    Luu-The V., Labrie C., Zhao H.F., Couet J., Lachance Y., Simard J., Cote J., Leblanc G., Lagace L., Berube D., Gagne R., Labrie F.
    Ann. N. Y. Acad. Sci. 595:40-52(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-313.
  5. "Genomic organization and DNA sequences of human 17 beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements."
    Peltoketo H.E., Isomma V., Vihko R.
    Eur. J. Biochem. 209:459-466(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-313.
  6. Shen Y., Gibbs R.A.
    Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-313.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-313.
    Tissue: Placenta.
  8. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-313.
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-313.
    Tissue: Brain.
  11. "Amino acid composition and subunit structure. Human placental 17 - estradiol dehydrogenase."
    Burns D.J.W., Engel L.L., Bethune J.L.
    Biochemistry 11:2699-2703(1972) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-6.
  12. "Human placental 17 -oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine."
    Nicholas J.C., Harris J.I.
    FEBS Lett. 29:173-176(1973) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 52-68.
  13. "Human placental estradiol 17 beta-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region."
    Murdock G.L., Chin C.-C., Warren J.C.
    Biochemistry 25:641-646(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 205-224.
  14. "Human placental estradiol 17 beta-dehydrogenase. Identification of a single histidine residue affinity-labeled by both 3-bromoacetoxyestrone and 12 beta-bromoacetoxy-4-estrene-3,17-dione."
    Murdock G.L., Chin C.C., Offord R.E., Bradshaw R.A., Warren J.C.
    J. Biol. Chem. 258:11460-11464(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 220-224.
  15. "Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti."
    Baker M.E.
    Mol. Endocrinol. 3:881-884(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: SIMILARITY TO SHORT CHAIN DEHYDROGENASES.
  16. "Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20-A resolution."
    Ghosh D., Pletnev V.Z., Zhu D.W., Wawrzak Z., Duax W.L., Pangborn W., Labrie F., Lin S.-X.
    Structure 3:503-513(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
  17. "Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol."
    Azzi A., Rehse P.H., Zhu D.W., Campbell R.L., Labrie F., Lin S.X.
    Nat. Struct. Biol. 3:665-668(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
  18. "The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors."
    Breton R., Housset D., Mazza C., Fontecilla-Camps J.-C.
    Structure 4:905-915(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH SUBSTRATE AND NADP.
  19. "Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase."
    Mazza C., Breton R., Housset D., Fontecilla-Camps J.-C.
    J. Biol. Chem. 273:8145-8152(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
  20. "Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+."
    Sawicki M.W., Erman M., Puranen T., Vihko P., Ghosh D.
    Proc. Natl. Acad. Sci. U.S.A. 96:840-845(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
  21. "Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain."
    Han Q., Campbell R.L., Gangloff A., Huang Y.-W., Lin S.-X.
    J. Biol. Chem. 275:1105-1111(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 39-328, MUTAGENESIS OF LEU-150.
  22. "A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity."
    Qiu W., Campbell R.L., Gangloff A., Dupuis P., Boivin R.P., Tremblay M.R., Poirier D., Lin S.X.
    FASEB J. 16:1829-1831(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).
  23. "Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase."
    Gangloff A., Shi R., Nahoum V., Lin S.X.
    FASEB J. 17:274-276(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS).
  24. "Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation."
    Shi R., Lin S.X.
    J. Biol. Chem. 279:16778-16785(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS).
  25. "Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21."
    Normand T., Narod S., Labrie F., Simard J.
    Hum. Mol. Genet. 2:479-483(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-238 AND SER-313.

Entry informationi

Entry nameiDHB1_HUMAN
AccessioniPrimary (citable) accession number: P14061
Secondary accession number(s): B3KXS1, Q2M2L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 30, 2010
Last modified: November 26, 2014
This is version 163 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3