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Protein

Alpha-1-inhibitor 3

Gene

A1i3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function.

GO - Molecular functioni

  • peptidase inhibitor activity Source: RGD
  • serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  • inflammatory response Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-inhibitor 3
Alternative name(s):
Alpha-1-inhibitor 3 variant II
Short name:
Alpha-1-inhibitor III
Gene namesi
Name:A1i3
Synonyms:Mug1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621366. Mug1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 14771453Alpha-1-inhibitor 3PRO_0000000061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 86By similarity
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence analysis
Disulfide bondi251 ↔ 295By similarity
Disulfide bondi269 ↔ 283By similarity
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence analysis
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence analysis
Disulfide bondi468 ↔ 563By similarity
Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence analysis
Disulfide bondi595 ↔ 774By similarity
Disulfide bondi643 ↔ 678By similarity
Glycosylationi750 – 7501N-linked (GlcNAc...)Sequence analysis
Glycosylationi777 – 7771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi850 ↔ 886By similarity
Glycosylationi872 – 8721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi924 ↔ 1324By similarity
Cross-linki975 ↔ 978Isoglutamyl cysteine thioester (Cys-Gln)
Glycosylationi994 – 9941N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1082 ↔ 1130By similarity
Glycosylationi1143 – 11431N-linked (GlcNAc...)Sequence analysis
Glycosylationi1314 – 13141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1355 ↔ 1470By similarity
Glycosylationi1427 – 14271N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Thioester bond

Proteomic databases

PaxDbiP14046.
PRIDEiP14046.

PTM databases

iPTMnetiP14046.
PhosphoSiteiP14046.
UniCarbKBiP14046.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiP14046. 1 interaction.
STRINGi10116.ENSRNOP00000040516.

Structurei

3D structure databases

ProteinModelPortaliP14046.
SMRiP14046. Positions 126-227, 1344-1476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni601 – 750150Bait region (approximate)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

eggNOGiENOG410IMYG. Eukaryota.
ENOG410XQIV. LUCA.
HOGENOMiHOG000220939.
HOVERGENiHBG000039.
PhylomeDBiP14046.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
IPR010916. TonB_box_CS.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SMARTiSM01360. A2M. 1 hit.
SM01359. A2M_N_2. 1 hit.
SM01361. A2M_recep. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKDREAQLC LFSALLAFLP FASLLNGNSK YMVLVPSQLY TETPEKICLH
60 70 80 90 100
LYHLNETVTV TASLISQRGT RKLFDELVVD KDLFHCVSFT IPRLPSSEEE
110 120 130 140 150
ESLDINIEGA KHKFSERRVV LVKNKESVVF VQTDKPMYKP GQSVKFRVVS
160 170 180 190 200
MDKNLHPLNE LFPLAYIEDP KMNRIMQWQD VKTENGLKQL SFSLSAEPIQ
210 220 230 240 250
GPYKIVILKQ SGVKEEHSFT VMEFVLPRFG VDVKVPNAIS VYDEIINVTA
260 270 280 290 300
CATYTYGKPV PGHVKISLCH GNPTFSSETK SGCKEEDSRL DNNGCSTQEV
310 320 330 340 350
NITEFQLKEN YLKMHQAFHV NATVTEEGTG SEFSGSGRIE VERTRNKFLF
360 370 380 390 400
LKADSHFRHG IPFFVKVRLV DIKGDPIPNE QVLIKARDAG YTNATTTDQH
410 420 430 440 450
GLAKFSIDTN GISDYSLNIK VYHKEESSCI HSSCTAERHA EAHHTAYAVY
460 470 480 490 500
SLSKSYIYLD TEAGVLPCNQ IHTVQAHFIL KGQVLGVLQQ IVFHYLVMAQ
510 520 530 540 550
GSILQTGNHT HQVEPGESQV QGNFALEIPV EFSMVPVAKM LIYTILPDGE
560 570 580 590 600
VIADSVKFQV EKCLRNKVHL SFSPSQSLPA SQTHMRVTAS PQSLCGLRAV
610 620 630 640 650
DQSVLLQKPE AELSPSLIYD LPGMQDSNFI ASSNDPFEDE DYCLMYQPIA
660 670 680 690 700
REKDVYRYVR ETGLMAFTNL KIKLPTYCNT DYDMVPLAVP AVALDSSTDR
710 720 730 740 750
GMYESLPVVA VKSPLPQEPP RKDPPPKDPV IETIRNYFPE TWIWDLVTVN
760 770 780 790 800
SSGVTELEMT VPDTITEWKA GALCLSNDTG LGLSSVASFQ AFQPFFVELT
810 820 830 840 850
MPYSVIRGEA FTLKATVLNY LPTSLPMAVL LEASPDFTAV PVENNQDSYC
860 870 880 890 900
LGANGRHTSS WLVTPKSLGN VNFSVSAEAR QSPGPCGSEV ATVPETGRKD
910 920 930 940 950
TVVKVLIVEP EGIKKEHTFS SLLCASDAEL SETLSLLLPP TVVKDSARAH
960 970 980 990 1000
FSVMGDILSS AIKNTQNLIQ MPYGCGEQNM VLFAPNIYVL KYLNETQQLT
1010 1020 1030 1040 1050
EKIKSKALGY LRAGYQRELN YKHKDGSYSA FGDHNGQGQG NTWLTAFVLK
1060 1070 1080 1090 1100
SFAQARAFIF IDESHITDAF TWLSKQQKDS GCFRSSGSLL NNAMKGGVDD
1110 1120 1130 1140 1150
EITLSAYITM ALLESSLPDT DPVVSKALSC LESSWENIEQ GGNGSFVYTK
1160 1170 1180 1190 1200
ALMAYAFALA GNQEKRNEIL KSLDKEAIKE DNSIHWERPQ KPTKSEGYLY
1210 1220 1230 1240 1250
TPQASSAEVE MSAYVVLARL TAQPAPSPED LALSMGTIKW LTKQQNSYGG
1260 1270 1280 1290 1300
FSSTQDTVVA LDALSKYGAA TFSKSQKTPS VTVQSSGSFS QKFQVDKSNR
1310 1320 1330 1340 1350
LLLQQVSLPY IPGNYTVSVS GEGCVYAQTT LRYNVPLEKQ QPAFALKVQT
1360 1370 1380 1390 1400
VPLTCNNPKG QNSFQISLEI SYMGSRPASN MVIADVKMLS GFIPLKPTVK
1410 1420 1430 1440 1450
KLERLGHVSR TEVTTNNVLL YLDQVTNQTL SFSFIIQQDI PVKNLQPAIV
1460 1470
KVYDYYETDE VAFAEYSSPC SSDDQNV
Length:1,477
Mass (Da):163,773
Last modified:April 1, 1990 - v1
Checksum:i4DC05367C8385D2B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti677 – 6771Y → T AA sequence (PubMed:2472396).Curated
Sequence conflicti1373 – 13731M → T in AAH98768 (PubMed:2436907).Curated
Sequence conflicti1406 – 14061G → E in AAA63494 (PubMed:2436907).Curated
Sequence conflicti1474 – 14741D → N in AAA63494 (PubMed:2436907).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03552 mRNA. Translation: AAA40628.1.
M22993 Genomic DNA. Translation: AAA79025.1.
BC098768 mRNA. Translation: AAH98768.1.
M28297 mRNA. Translation: AAA63493.1.
M28298 mRNA. Translation: AAA63494.1.
PIRiA29952.
UniGeneiRn.109457.
Rn.162783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03552 mRNA. Translation: AAA40628.1.
M22993 Genomic DNA. Translation: AAA79025.1.
BC098768 mRNA. Translation: AAH98768.1.
M28297 mRNA. Translation: AAA63493.1.
M28298 mRNA. Translation: AAA63494.1.
PIRiA29952.
UniGeneiRn.109457.
Rn.162783.

3D structure databases

ProteinModelPortaliP14046.
SMRiP14046. Positions 126-227, 1344-1476.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP14046. 1 interaction.
STRINGi10116.ENSRNOP00000040516.

PTM databases

iPTMnetiP14046.
PhosphoSiteiP14046.
UniCarbKBiP14046.

Proteomic databases

PaxDbiP14046.
PRIDEiP14046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi621366. Mug1.

Phylogenomic databases

eggNOGiENOG410IMYG. Eukaryota.
ENOG410XQIV. LUCA.
HOGENOMiHOG000220939.
HOVERGENiHBG000039.
PhylomeDBiP14046.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
IPR010916. TonB_box_CS.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SMARTiSM01360. A2M. 1 hit.
SM01359. A2M_N_2. 1 hit.
SM01361. A2M_recep. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA1I3_RAT
AccessioniPrimary (citable) accession number: P14046
Secondary accession number(s): Q4G042
, Q63266, Q6LDP2, Q6LDR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 8, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.