P14019 (DCOR_CRIGR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine decarboxylase
Short name=ODC
EC=4.1.1.17

Gene names

Name:	ODC1
Synonyms:	ODC

Organism

Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

Taxonomic identifier

10029 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Cricetulus

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	polyamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ornithine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Ornithine decarboxylase		PRO_0000149890
Sites
	Active site	354	1	Proton donor; shared with dimeric partner By similarity
Amino acid modifications
	Modified residue	67	1	N6-(pyridoxal phosphate)lysine By similarity
	Modified residue	297	1	Phosphoserine; by CK2 By similarity
Experimental info
	Sequence conflict	452	1	S → R Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P14019 [UniParc]. Last modified February 1, 1996. Version 3. Checksum: 14162985F188C89F	FASTA	455	50,454
	10 20 30 40 50 60 MNSFNKDEFD CHILDEGFTA KDILDQKINE VSSDDKDAFY VADLGDVLKK HLRWLKALPV 70 80 90 100 110 120 TPFYAVKCND SRALVNTLAA ITVDCASKTE IQLVQGLGVP PERVIYANPC KQVSQIKYAA 130 140 150 160 170 180 SNGVQMMTFD SEIELMKVAR AHPKVTKLVL RIATDDSKAV CRLSVKFGAT LRTSRLLLER 190 200 210 220 230 240 AKELNIDVIG VSFHVGSGCT DPETFVQALS DARCVFDMGT EVGFSMYLLD IGGGFPGSED 250 260 270 280 290 300 TKLKFEEITS VINPALDKYF PPDSGVRVIA EPGRYYVASA FTLAVNIIAK KIVSKGSDDE 310 320 330 340 350 360 DESSEQTFMY YVNDGVYGSF NCILYDHAHV KPLLPKRPKP DEKYYSSSIW GPTCDGLDRI 370 380 390 400 410 420 VERCNLPEMH VGDWMLFENM GAYTVAAAST FNGFQRPSIY YVMSRPMWQL MKQIQNHGFP 430 440 450 PEVEEQDVGT LPISCAQESG MDRHPAACAS ASINV

References

[1]	"Nucleotide sequence of the Chinese hamster ornithine decarboxylase gene." Grens A., Steglich C., Pilz R., Scheffler I.E. Nucleic Acids Res. 17:10497-10497(1989) [PubMed: 2602162] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The gene for ornithine decarboxylase is co-amplified in hydroxyurea-resistant hamster cells." Srinivasan P.R., Tonin P.N., Wensing E.J., Lewis W.H. J. Biol. Chem. 262:12871-12878(1987) [PubMed: 2887574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 163-455.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X16910 mRNA. Translation: CAA34784.1. J02813 mRNA. Translation: AAA36963.1.
PIR	DCHYOC. S09574.
3D structure databases
ProteinModelPortal	P14019.
SMR	P14019. Positions 7-415.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG005456.
Family and domain databases
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR022643. De-COase2_C. IPR022644. De-COase2_N. IPR022653. De-COase2_pyr-phos_BS. IPR000183. Orn/DAP/Arg_de-COase. IPR002433. Orn_de-COase. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCOR_CRIGR

Accession

Primary (citable) accession number: P14019

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	February 1, 1996
Last modified:	January 25, 2012
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program