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P14017

- PYRF_ACRCH

UniProt

P14017 - PYRF_ACRCH

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
PYR4
Organism
Acremonium chrysogenum (Cephalosporium acremonium)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Substrate By similarity
Active sitei101 – 1011Proton donor By similarity
Binding sitei329 – 3291Substrate By similarity
Binding sitei348 – 3481Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:PYR4
OrganismiAcremonium chrysogenum (Cephalosporium acremonium)
Taxonomic identifieri5044 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesmitosporic HypocrealesAcremonium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Orotidine 5'-phosphate decarboxylase
PRO_0000134655Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP14017.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 663Substrate binding By similarity
Regioni99 – 10810Substrate binding By similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14017-1 [UniParc]FASTAAdd to Basket

« Hide

MAPHPTLKST YSTRAETVTH PLSAYLYKLM DLKASNLCLS ADVANARELL    50
HVADKVGPSI VVLKTHYDMV AGWDFTPETG TGARLAKLAR KHGFLIFEDR 100
KFGDIGNTVE LQYTQGAARI IEWAHIVNVN MVPGKASVTS LANAAAKWLE 150
RLPYEVKTSV TVGTPRNTDE DDDDEDDGNA GEMERSHTFG LNGNNGVPIK 200
ESSDGRKGSI VSVTTVTQQY ESAHSPRLTK TIAEEGDMLL AGLEEPPLNR 250
GLLILAQMSS AGNFMNAEYT QACVEAAREH KDFVMGFVSQ EALNSQPDDD 300
FIHMTPGCQL PPEHEEDAEL RGDGKGQQYN TPEKLIGVCG ADIVIVGRGI 350
LKAGDLQHEA ERYRSAAWKA YTERVR 376
Length:376
Mass (Da):41,128
Last modified:January 1, 1990 - v1
Checksum:i462A23AD21814FA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15937 Genomic DNA. Translation: CAA34063.1.
PIRiS06746. DCCEOC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15937 Genomic DNA. Translation: CAA34063.1 .
PIRi S06746. DCCEOC.

3D structure databases

ProteinModelPortali P14017.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the Cephalosporium acremonium pyr4 gene."
    Vian A., Penalva M.A.
    Nucleic Acids Res. 17:8874-8874(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 11550 / CBS 779.69 / DSM 880 / IMI 49137.
  2. "Cloning of the pyr4 gene encoding orotidine-5'-phosphate decarboxylase in Cephalosporium acremonium."
    Vian A., Penalva M.A.
    Curr. Genet. 17:223-227(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.

Entry informationi

Entry nameiPYRF_ACRCH
AccessioniPrimary (citable) accession number: P14017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 16, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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