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P14017 (PYRF_ACRCH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:PYR4
OrganismAcremonium chrysogenum (Cephalosporium acremonium)
Taxonomic identifier5044 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesmitosporic HypocrealesAcremonium

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Orotidine 5'-phosphate decarboxylase
PRO_0000134655

Regions

Region64 – 663Substrate binding By similarity
Region99 – 10810Substrate binding By similarity

Sites

Active site1011Proton donor By similarity
Binding site421Substrate By similarity
Binding site3291Substrate By similarity
Binding site3481Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P14017 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 462A23AD21814FA7

FASTA37641,128
        10         20         30         40         50         60 
MAPHPTLKST YSTRAETVTH PLSAYLYKLM DLKASNLCLS ADVANARELL HVADKVGPSI 

        70         80         90        100        110        120 
VVLKTHYDMV AGWDFTPETG TGARLAKLAR KHGFLIFEDR KFGDIGNTVE LQYTQGAARI 

       130        140        150        160        170        180 
IEWAHIVNVN MVPGKASVTS LANAAAKWLE RLPYEVKTSV TVGTPRNTDE DDDDEDDGNA 

       190        200        210        220        230        240 
GEMERSHTFG LNGNNGVPIK ESSDGRKGSI VSVTTVTQQY ESAHSPRLTK TIAEEGDMLL 

       250        260        270        280        290        300 
AGLEEPPLNR GLLILAQMSS AGNFMNAEYT QACVEAAREH KDFVMGFVSQ EALNSQPDDD 

       310        320        330        340        350        360 
FIHMTPGCQL PPEHEEDAEL RGDGKGQQYN TPEKLIGVCG ADIVIVGRGI LKAGDLQHEA 

       370 
ERYRSAAWKA YTERVR 

« Hide

References

[1]"Nucleotide sequence of the Cephalosporium acremonium pyr4 gene."
Vian A., Penalva M.A.
Nucleic Acids Res. 17:8874-8874(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 11550 / CBS 779.69 / DSM 880 / IMI 49137.
[2]"Cloning of the pyr4 gene encoding orotidine-5'-phosphate decarboxylase in Cephalosporium acremonium."
Vian A., Penalva M.A.
Curr. Genet. 17:223-227(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: DISCUSSION OF SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15937 Genomic DNA. Translation: CAA34063.1.
PIRDCCEOC. S06746.

3D structure databases

ProteinModelPortalP14017.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 2 hits.
InterProIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 2 hits.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_ACRCH
AccessionPrimary (citable) accession number: P14017
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 16, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways