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P14017

- PYRF_ACRCH

UniProt

P14017 - PYRF_ACRCH

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

PYR4

Organism
Acremonium chrysogenum (Cephalosporium acremonium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421SubstrateBy similarity
Active sitei101 – 1011Proton donorPROSITE-ProRule annotation
Binding sitei329 – 3291SubstrateBy similarity
Binding sitei348 – 3481SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:PYR4
OrganismiAcremonium chrysogenum (Cephalosporium acremonium)
Taxonomic identifieri5044 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesmitosporic HypocrealesAcremonium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Orotidine 5'-phosphate decarboxylasePRO_0000134655Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP14017.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 663Substrate bindingBy similarity
Regioni99 – 10810Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14017 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPHPTLKST YSTRAETVTH PLSAYLYKLM DLKASNLCLS ADVANARELL
60 70 80 90 100
HVADKVGPSI VVLKTHYDMV AGWDFTPETG TGARLAKLAR KHGFLIFEDR
110 120 130 140 150
KFGDIGNTVE LQYTQGAARI IEWAHIVNVN MVPGKASVTS LANAAAKWLE
160 170 180 190 200
RLPYEVKTSV TVGTPRNTDE DDDDEDDGNA GEMERSHTFG LNGNNGVPIK
210 220 230 240 250
ESSDGRKGSI VSVTTVTQQY ESAHSPRLTK TIAEEGDMLL AGLEEPPLNR
260 270 280 290 300
GLLILAQMSS AGNFMNAEYT QACVEAAREH KDFVMGFVSQ EALNSQPDDD
310 320 330 340 350
FIHMTPGCQL PPEHEEDAEL RGDGKGQQYN TPEKLIGVCG ADIVIVGRGI
360 370
LKAGDLQHEA ERYRSAAWKA YTERVR
Length:376
Mass (Da):41,128
Last modified:January 1, 1990 - v1
Checksum:i462A23AD21814FA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15937 Genomic DNA. Translation: CAA34063.1.
PIRiS06746. DCCEOC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15937 Genomic DNA. Translation: CAA34063.1 .
PIRi S06746. DCCEOC.

3D structure databases

ProteinModelPortali P14017.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the Cephalosporium acremonium pyr4 gene."
    Vian A., Penalva M.A.
    Nucleic Acids Res. 17:8874-8874(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 11550 / CBS 779.69 / DSM 880 / IMI 49137.
  2. "Cloning of the pyr4 gene encoding orotidine-5'-phosphate decarboxylase in Cephalosporium acremonium."
    Vian A., Penalva M.A.
    Curr. Genet. 17:223-227(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.

Entry informationi

Entry nameiPYRF_ACRCH
AccessioniPrimary (citable) accession number: P14017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 1, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3