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P14017

- PYRF_ACRCH

UniProt

P14017 - PYRF_ACRCH

Protein

Orotidine 5'-phosphate decarboxylase

Gene

PYR4

Organism
Acremonium chrysogenum (Cephalosporium acremonium)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421SubstrateBy similarity
    Active sitei101 – 1011Proton donorPROSITE-ProRule annotation
    Binding sitei329 – 3291SubstrateBy similarity
    Binding sitei348 – 3481SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:PYR4
    OrganismiAcremonium chrysogenum (Cephalosporium acremonium)
    Taxonomic identifieri5044 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesmitosporic HypocrealesAcremonium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Orotidine 5'-phosphate decarboxylasePRO_0000134655Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP14017.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni64 – 663Substrate bindingBy similarity
    Regioni99 – 10810Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    InterProiIPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 2 hits.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14017-1 [UniParc]FASTAAdd to Basket

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    MAPHPTLKST YSTRAETVTH PLSAYLYKLM DLKASNLCLS ADVANARELL    50
    HVADKVGPSI VVLKTHYDMV AGWDFTPETG TGARLAKLAR KHGFLIFEDR 100
    KFGDIGNTVE LQYTQGAARI IEWAHIVNVN MVPGKASVTS LANAAAKWLE 150
    RLPYEVKTSV TVGTPRNTDE DDDDEDDGNA GEMERSHTFG LNGNNGVPIK 200
    ESSDGRKGSI VSVTTVTQQY ESAHSPRLTK TIAEEGDMLL AGLEEPPLNR 250
    GLLILAQMSS AGNFMNAEYT QACVEAAREH KDFVMGFVSQ EALNSQPDDD 300
    FIHMTPGCQL PPEHEEDAEL RGDGKGQQYN TPEKLIGVCG ADIVIVGRGI 350
    LKAGDLQHEA ERYRSAAWKA YTERVR 376
    Length:376
    Mass (Da):41,128
    Last modified:January 1, 1990 - v1
    Checksum:i462A23AD21814FA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15937 Genomic DNA. Translation: CAA34063.1.
    PIRiS06746. DCCEOC.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15937 Genomic DNA. Translation: CAA34063.1 .
    PIRi S06746. DCCEOC.

    3D structure databases

    ProteinModelPortali P14017.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    InterProi IPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 2 hits.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the Cephalosporium acremonium pyr4 gene."
      Vian A., Penalva M.A.
      Nucleic Acids Res. 17:8874-8874(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 11550 / CBS 779.69 / DSM 880 / IMI 49137.
    2. "Cloning of the pyr4 gene encoding orotidine-5'-phosphate decarboxylase in Cephalosporium acremonium."
      Vian A., Penalva M.A.
      Curr. Genet. 17:223-227(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF SEQUENCE.

    Entry informationi

    Entry nameiPYRF_ACRCH
    AccessioniPrimary (citable) accession number: P14017
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3