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Reviewed, UniProtKB/Swiss-Prot P14012 (ARGI_AGRT5)

Last modified November 3, 2009. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Arginase
    EC=3.5.3.1
Gene names
Name: arcA
Synonyms: arc
Ordered Locus Names: Atu6018
ORF Names: AGR_pTi_56
Encoded onPlasmid pTiC58
OrganismAgrobacterium tumefaciens (strain C58 / ATCC 33970) [Complete proteome] [HAMAP]
Taxonomic identifier176299 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

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Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

L-arginine + H2O = L-ornithine + urea.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Pathway

Amino-acid degradation; nopaline degradation.

Subunit structure

Homohexamer Probable.

Induction

By nopaline. But not by L-arginine or L-ornithine.

Sequence similarities

Belongs to the arginase family.

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Ontologies

Keywords
   Biological processArginine metabolism
   LigandManganese
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionarginase activity

Inferred from electronic annotation. Source: EC

manganese ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Arginase
PRO_0000173712

Regions

Region144 – 1485Substrate binding By similarity
Region155 – 1573Substrate binding By similarity

Sites

Metal binding1151Manganese 1 By similarity
Metal binding1421Manganese 1 By similarity
Metal binding1421Manganese 2 By similarity
Metal binding1441Manganese 2 By similarity
Metal binding1461Manganese 1 By similarity
Metal binding2441Manganese 1 By similarity
Metal binding2441Manganese 2 By similarity
Metal binding2461Manganese 2 By similarity
Binding site1961Substrate By similarity
Binding site2891Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
P14012-1 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 6719BFF66B80571D

FASTA32434,695
        10         20         30         40         50         60 
MNGAGEINAS RHRKENELKT CQILGAPVQS GASQPGCLMG PDAFRTAGLT QVLTELGWAV 

        70         80         90        100        110        120 
TDLGDATPTV EPELSHPNSA VKNLDALVGW TRSLSQKALE MARSCDLPVF LGGDHSMSAG 

       130        140        150        160        170        180 
TVSGVAQRTA ELGKEQFVLW LDAHTDLHTL HTTASGNLHG TPVAYYTGQS GFEGLPPLAA 

       190        200        210        220        230        240 
PVNPRNVSMM GIRSVDPEER RRVAEIGVQV ADMRVLDEQG VVRPLEAFLD RVSKVSGRLH 

       250        260        270        280        290        300 
VSLDVDFLDP AIAPAVGTTV PGGATFREAH LIMEMLHDSG LVTSLDLAEL NPFLDERGRT 

       310        320 
ARLITDLASS LFGRRVFDRV TTAF

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References

« Hide 'large scale' references
[1]"Arginase of Agrobacterium Ti plasmid C58. DNA sequence, properties, and comparison with eucaryotic enzymes."
Schrell A., Alt-Moerbe J., Lanz T., Schroeder J.
Eur. J. Biochem. 184:635-641(1989) [PubMed: 2806247] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The Noc region of Ti plasmid C58 codes for arginase and ornithine cyclodeaminase."
Sans N., Schroeder G., Schroeder J.
Eur. J. Biochem. 167:81-87(1987) [PubMed: 3040404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The genome of the natural genetic engineer Agrobacterium tumefaciens C58."
Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J. expand/collapse author list , Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W.
Science 294:2317-2323(2001) [PubMed: 11743193] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58."
Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C. expand/collapse author list , Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.
Science 294:2323-2328(2001) [PubMed: 11743194] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

X15884 Genomic DNA. Translation: CAA33894.1.
Z30316 Genomic DNA. Translation: CAA82964.1.
AE007871 Genomic DNA. Translation: AAK90976.2.
PIRAH3229.
S06118.
RefSeqNP_053430.1.
NP_396535.2.

3D structure databases

HSSPHSSP built from PDB template 1CEV based on UniProtKB P53608.
ModBaseSearch...

Protein-protein interaction databases

STRINGP14012.

Genome annotation databases

GeneID1137341.
1224186.
GenomeReviewsGene locus Atu6018 in contig AE007871_GR.
KEGGatc:AGR_pTi_56.
atu:Atu6018.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP14012.
OMAIDARSAP.

Enzyme and pathway databases

BioCycMetaCyc:MON-11552.

Family and domain databases

InterProIPR005924. Arginase.
IPR014033. Arginase_sub.
IPR006035. Ureohydrolase.
[Graphical view]
Gene3DG3DSA:3.40.800.10. Ureohydrolase. 1 hit.
PANTHERPTHR11358:SF2. Arginase_sub. 1 hit.
PTHR11358. Ureohydrolase. 1 hit.
PfamPF00491. Arginase. 1 hit.
[Graphical view]
PRINTSPR00116. ARGINASE.
TIGRFAMsTIGR01229. rocF_arginase. 1 hit.
PROSITEPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameARGI_AGRT5
AccessionPrimary (citable) accession number: P14012
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 3, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents