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Protein

4-aminobutyrate aminotransferase

Gene

gatA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Deaminates gamma-aminobutyric acid (GABA) to succinate-semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase (By similarity). Required for the degradation of GABA, which is important for utilization of GABA as nitrogen source.By similarity

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei222SubstrateBy similarity1
Binding sitei381Pyridoxal phosphate; shared with dimeric partnerBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular amide catabolic process Source: AspGD
  • gamma-aminobutyric acid catabolic process Source: AspGD

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
4-aminobutyrate aminotransferase (EC:2.6.1.19)
Alternative name(s):
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
Gene namesi
Name:gatA
ORF Names:AN2248
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001203791 – 4984-aminobutyrate aminotransferaseAdd BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei356N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiP14010

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00008938

Structurei

3D structure databases

ProteinModelPortaliP14010
SMRiP14010
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 165Pyridoxal phosphate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000020208
InParanoidiP14010
KOiK13524
OMAiIQTGGCG
OrthoDBiEOG092C208V

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004631 4NH2But_aminotransferase_euk
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00699 GABAtrns_euk, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

P14010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAFRSSLK LRASARLPAV RTITTTPRLR AAEKPYFPNE PTAPKLATAI
60 70 80 90 100
PGPKNKAASE QLNEVFDVRS LNMLADYTKS VGNYIADLDG NMLLDVYAQI
110 120 130 140 150
ASIPVGYNNP HLLKVAASPE MATSLINRPA LGNFPSADWA HILKTGILKV
160 170 180 190 200
APKGLDQVFT AMAGSDANET AYKAAFMYYR QQQRGGPEKE FTEEEIQSSM
210 220 230 240 250
LNQTPGSPQL SIMSFKAGFH GRLFGSLSTT RSKPIHKLDI PAFDWPQAPF
260 270 280 290 300
PSLKYPLEEH AKENAEEEQR CLQEAERLIK EWHNPVAAII VEPIQSEGGD
310 320 330 340 350
NHASPAFFRG LREITKRNNV LFIVDEVQTG VGATGKFWAH DHWNLETPPD
360 370 380 390 400
MVTFSKKAQT AGYYFGNPAL RPNKPYRQFN TWMGDPSRAL IFRGIIEEIE
410 420 430 440 450
RLFLVENTAA TGDYLYSGLE RLAKQYPEHL QNLRGKGQGT FIAWDTPKRD
460 470 480 490
EFLVKGKGVG INIGGSGQNA VRLRPMLIFQ KHHADILLES IEKIIKQL
Length:498
Mass (Da):55,489
Last modified:January 1, 1990 - v1
Checksum:i97013EF39D66D5E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15647 Genomic DNA Translation: CAA33674.1
AACD01000036 Genomic DNA Translation: EAA63933.1
BN001307 Genomic DNA Translation: CBF86462.1
PIRiJQ0197
RefSeqiXP_659852.1, XM_654760.1

Genome annotation databases

EnsemblFungiiCADANIAT00008938; CADANIAP00008938; CADANIAG00008938
EAA63933; EAA63933; AN2248.2
GeneIDi2875488
KEGGiani:AN2248.2

Similar proteinsi

Entry informationi

Entry nameiGABAT_EMENI
AccessioniPrimary (citable) accession number: P14010
Secondary accession number(s): C8VMU4, Q5BB32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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