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P14004

- ALL5_DERPT

UniProt

P14004 - ALL5_DERPT

Protein

Mite allergen Der p 5

Gene

DERP5

Organism
Dermatophagoides pteronyssinus (European house dust mite)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mite allergen Der p 5
    Alternative name(s):
    Allergen Der P V
    IgE-binding allergen
    Allergen: Der p 5
    Gene namesi
    Name:DERP5
    OrganismiDermatophagoides pteronyssinus (European house dust mite)
    Taxonomic identifieri6956 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis. Binds to IgE.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei319. Der p 5.
    3265. Der p 5.0101.
    3266. Der p 5.0102.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 132132Mite allergen Der p 5PRO_0000151066Add
    BLAST

    Structurei

    Secondary structure

    1
    132
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi35 – 6127
    Helixi65 – 9329
    Helixi100 – 12829

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3MQ1X-ray2.80A/B/C/D/E/F34-132[»]
    ProteinModelPortaliP14004.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP14004.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mite group 5 allergen family.Curated

    Family and domain databases

    InterProiIPR020306. Mite_allergen_group-5/21.
    [Graphical view]
    PfamiPF11642. Blo-t-5. 1 hit.
    [Graphical view]
    ProDomiPD081736. Mite_allergen_group_5/21. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P14004-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFIIAFFVA TLAVMTVSGE DKKHDYQNEF DFLLMERIHE QIKKGELALF    50
    YLQEQINHFE EKPTKEMKDK IVAEMDTIIA MIDGVRGVLD RLMQRKDLDI 100
    FEQYNLEMAK KSGDILERDL KKEEARVKKI EV 132
    Length:132
    Mass (Da):15,615
    Last modified:February 1, 1996 - v2
    Checksum:i3C840C3C26707C05
    GO

    Sequence cautioni

    The sequence CAA35692.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611E → A.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S76337 mRNA. Translation: AAB32841.1.
    S76340 mRNA. Translation: AAB32842.1.
    X17699 mRNA. Translation: CAA35692.1. Different initiation.
    PIRiS06734.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S76337 mRNA. Translation: AAB32841.1 .
    S76340 mRNA. Translation: AAB32842.1 .
    X17699 mRNA. Translation: CAA35692.1 . Different initiation.
    PIRi S06734.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3MQ1 X-ray 2.80 A/B/C/D/E/F 34-132 [» ]
    ProteinModelPortali P14004.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 319. Der p 5.
    3265. Der p 5.0101.
    3266. Der p 5.0102.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P14004.

    Family and domain databases

    InterProi IPR020306. Mite_allergen_group-5/21.
    [Graphical view ]
    Pfami PF11642. Blo-t-5. 1 hit.
    [Graphical view ]
    ProDomi PD081736. Mite_allergen_group_5/21. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of Der p V allergen, cDNA analysis, and IgE-mediated reactivity to the recombinant protein."
      Lin K.L., Hsieh K.H., Thomas W.R., Chiang B.L., Chua K.Y.
      J. Allergy Clin. Immunol. 94:989-996(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and sequencing of a cDNA expressing a recombinant house dust mite protein that binds human IgE and corresponds to an important low molecular weight allergen."
      Tovey E.R., Johnson M.C., Roche A.L., Cobon G.S., Baldo B.A.
      J. Exp. Med. 170:1457-1462(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cobon G.S.
      Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 132.

    Entry informationi

    Entry nameiALL5_DERPT
    AccessioniPrimary (citable) accession number: P14004
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 56 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3