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P14004

- ALL5_DERPT

UniProt

P14004 - ALL5_DERPT

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Protein

Mite allergen Der p 5

Gene

DERP5

Organism
Dermatophagoides pteronyssinus (European house dust mite)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mite allergen Der p 5
Alternative name(s):
Allergen Der P V
IgE-binding allergen
Allergen: Der p 5
Gene namesi
Name:DERP5
OrganismiDermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifieri6956 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei319. Der p 5.
3265. Der p 5.0101.
3266. Der p 5.0102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Mite allergen Der p 5PRO_0000151066Add
BLAST

Structurei

Secondary structure

1
132
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi35 – 6127
Helixi65 – 9329
Helixi100 – 12829

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MQ1X-ray2.80A/B/C/D/E/F34-132[»]
ProteinModelPortaliP14004.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14004.

Family & Domainsi

Sequence similaritiesi

Belongs to the mite group 5 allergen family.Curated

Family and domain databases

InterProiIPR020306. Mite_allergen_group-5/21.
[Graphical view]
PfamiPF11642. Blo-t-5. 1 hit.
[Graphical view]
ProDomiPD081736. Mite_allergen_group_5/21. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P14004-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFIIAFFVA TLAVMTVSGE DKKHDYQNEF DFLLMERIHE QIKKGELALF
60 70 80 90 100
YLQEQINHFE EKPTKEMKDK IVAEMDTIIA MIDGVRGVLD RLMQRKDLDI
110 120 130
FEQYNLEMAK KSGDILERDL KKEEARVKKI EV
Length:132
Mass (Da):15,615
Last modified:February 1, 1996 - v2
Checksum:i3C840C3C26707C05
GO

Sequence cautioni

The sequence CAA35692.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611E → A.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S76337 mRNA. Translation: AAB32841.1.
S76340 mRNA. Translation: AAB32842.1.
X17699 mRNA. Translation: CAA35692.1. Different initiation.
PIRiS06734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S76337 mRNA. Translation: AAB32841.1 .
S76340 mRNA. Translation: AAB32842.1 .
X17699 mRNA. Translation: CAA35692.1 . Different initiation.
PIRi S06734.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3MQ1 X-ray 2.80 A/B/C/D/E/F 34-132 [» ]
ProteinModelPortali P14004.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 319. Der p 5.
3265. Der p 5.0101.
3266. Der p 5.0102.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P14004.

Family and domain databases

InterProi IPR020306. Mite_allergen_group-5/21.
[Graphical view ]
Pfami PF11642. Blo-t-5. 1 hit.
[Graphical view ]
ProDomi PD081736. Mite_allergen_group_5/21. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of Der p V allergen, cDNA analysis, and IgE-mediated reactivity to the recombinant protein."
    Lin K.L., Hsieh K.H., Thomas W.R., Chiang B.L., Chua K.Y.
    J. Allergy Clin. Immunol. 94:989-996(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and sequencing of a cDNA expressing a recombinant house dust mite protein that binds human IgE and corresponds to an important low molecular weight allergen."
    Tovey E.R., Johnson M.C., Roche A.L., Cobon G.S., Baldo B.A.
    J. Exp. Med. 170:1457-1462(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cobon G.S.
    Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 132.

Entry informationi

Entry nameiALL5_DERPT
AccessioniPrimary (citable) accession number: P14004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3