P14004 (ALL5_DERPT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mite allergen Der p 5

Alternative name(s):
Allergen Der P V
IgE-binding allergen
Allergen=Der p 5

Gene names

Name:

DERP5

Organism

Dermatophagoides pteronyssinus (European house dust mite)

Taxonomic identifier

6956 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Psoroptidia › Analgoidea › Pyroglyphidae › Dermatophagoidinae › Dermatophagoides

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Allergenic properties	Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis. Binds to IgE.
Sequence similarities	Belongs to the mite group 5 allergen family.
Sequence caution	The sequence CAA35692.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Disease	Allergen
Technical term	3D-structure
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 132

132

Mite allergen Der p 5

PRO_0000151066

Natural variations

Natural variant

61

1

E → A.

Secondary structure

1

.

.

.

.

.

.

.

132

Helix Strand Turn

Details...

Helix

35 – 61

27

Helix

65 – 93

29

Helix

100 – 128

29

Sequences

	Sequence		Length	Mass (Da)
	P14004 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 3C840C3C26707C05	FASTA	132	15,615
	10 20 30 40 50 60 MKFIIAFFVA TLAVMTVSGE DKKHDYQNEF DFLLMERIHE QIKKGELALF YLQEQINHFE 70 80 90 100 110 120 EKPTKEMKDK IVAEMDTIIA MIDGVRGVLD RLMQRKDLDI FEQYNLEMAK KSGDILERDL 130 KKEEARVKKI EV

References

[1]	"Characterization of Der p V allergen, cDNA analysis, and IgE-mediated reactivity to the recombinant protein." Lin K.L., Hsieh K.H., Thomas W.R., Chiang B.L., Chua K.Y. J. Allergy Clin. Immunol. 94:989-996(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and sequencing of a cDNA expressing a recombinant house dust mite protein that binds human IgE and corresponds to an important low molecular weight allergen." Tovey E.R., Johnson M.C., Roche A.L., Cobon G.S., Baldo B.A. J. Exp. Med. 170:1457-1462(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Cobon G.S. Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 132.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

S76337 mRNA. Translation: AAB32841.1.
S76340 mRNA. Translation: AAB32842.1.
X17699 mRNA. Translation: CAA35692.1. Different initiation.

PIR

S06734.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3MQ1	X-ray	2.80	A/B/C/D/E/F	34-132	[»]

ProteinModelPortal

P14004.

ModBase

Search...

Protein family/group databases

Allergome

319. Der p 5.
3265. Der p 5.0101.
3266. Der p 5.0102.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR020306. Mite_allergen_group-5/21.
[Graphical view]

Pfam

PF11642. Blo-t-5. 1 hit.
[Graphical view]

ProDom

PD081736. Mite_allergen_group_5/21. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

Search...

Other

EvolutionaryTrace

P14004.

Entry information

Entry name

ALL5_DERPT

Accession

Primary (citable) accession number: P14004

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)