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Protein

Mite allergen Der p 5

Gene

DERP5

Organism
Dermatophagoides pteronyssinus (European house dust mite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mite allergen Der p 5
Alternative name(s):
Allergen Der P V
IgE-binding allergen
Allergen: Der p 5
Gene namesi
Name:DERP5
OrganismiDermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifieri6956 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei319. Der p 5.
3265. Der p 5.0101.
3266. Der p 5.0102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Mite allergen Der p 5PRO_0000151066Add
BLAST

Structurei

Secondary structure

1
132
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi35 – 6127Combined sources
Helixi65 – 9329Combined sources
Helixi100 – 12829Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MQ1X-ray2.80A/B/C/D/E/F34-132[»]
ProteinModelPortaliP14004.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14004.

Family & Domainsi

Sequence similaritiesi

Belongs to the mite group 5 allergen family.Curated

Family and domain databases

InterProiIPR020306. Mite_allergen_group-5/21.
[Graphical view]
PfamiPF11642. Blo-t-5. 1 hit.
[Graphical view]
ProDomiPD081736. Mite_allergen_group_5/21. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P14004-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFIIAFFVA TLAVMTVSGE DKKHDYQNEF DFLLMERIHE QIKKGELALF
60 70 80 90 100
YLQEQINHFE EKPTKEMKDK IVAEMDTIIA MIDGVRGVLD RLMQRKDLDI
110 120 130
FEQYNLEMAK KSGDILERDL KKEEARVKKI EV
Length:132
Mass (Da):15,615
Last modified:February 1, 1996 - v2
Checksum:i3C840C3C26707C05
GO

Sequence cautioni

The sequence CAA35692.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611E → A.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76337 mRNA. Translation: AAB32841.1.
S76340 mRNA. Translation: AAB32842.1.
X17699 mRNA. Translation: CAA35692.1. Different initiation.
PIRiS06734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76337 mRNA. Translation: AAB32841.1.
S76340 mRNA. Translation: AAB32842.1.
X17699 mRNA. Translation: CAA35692.1. Different initiation.
PIRiS06734.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MQ1X-ray2.80A/B/C/D/E/F34-132[»]
ProteinModelPortaliP14004.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei319. Der p 5.
3265. Der p 5.0101.
3266. Der p 5.0102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP14004.

Family and domain databases

InterProiIPR020306. Mite_allergen_group-5/21.
[Graphical view]
PfamiPF11642. Blo-t-5. 1 hit.
[Graphical view]
ProDomiPD081736. Mite_allergen_group_5/21. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of Der p V allergen, cDNA analysis, and IgE-mediated reactivity to the recombinant protein."
    Lin K.L., Hsieh K.H., Thomas W.R., Chiang B.L., Chua K.Y.
    J. Allergy Clin. Immunol. 94:989-996(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and sequencing of a cDNA expressing a recombinant house dust mite protein that binds human IgE and corresponds to an important low molecular weight allergen."
    Tovey E.R., Johnson M.C., Roche A.L., Cobon G.S., Baldo B.A.
    J. Exp. Med. 170:1457-1462(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cobon G.S.
    Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 132.

Entry informationi

Entry nameiALL5_DERPT
AccessioniPrimary (citable) accession number: P14004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.