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Protein

Mite allergen Der p 5

Gene

DERP5

Organism
Dermatophagoides pteronyssinus (European house dust mite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mite allergen Der p 5
Alternative name(s):
Allergen Der P V
IgE-binding allergen
Allergen: Der p 5
Gene namesi
Name:DERP5
OrganismiDermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifieri6956 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei319. Der p 5.
3265. Der p 5.0101.
3266. Der p 5.0102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001510661 – 132Mite allergen Der p 5Add BLAST132

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 61Combined sources27
Helixi65 – 93Combined sources29
Helixi100 – 128Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MQ1X-ray2.80A/B/C/D/E/F34-132[»]
ProteinModelPortaliP14004.
SMRiP14004.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14004.

Family & Domainsi

Sequence similaritiesi

Belongs to the mite group 5 allergen family.Curated

Family and domain databases

InterProiIPR020306. Mite_allergen_group-5/21.
[Graphical view]
PfamiPF11642. Blo-t-5. 1 hit.
[Graphical view]
ProDomiPD081736. Mite_allergen_group_5/21. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P14004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFIIAFFVA TLAVMTVSGE DKKHDYQNEF DFLLMERIHE QIKKGELALF
60 70 80 90 100
YLQEQINHFE EKPTKEMKDK IVAEMDTIIA MIDGVRGVLD RLMQRKDLDI
110 120 130
FEQYNLEMAK KSGDILERDL KKEEARVKKI EV
Length:132
Mass (Da):15,615
Last modified:February 1, 1996 - v2
Checksum:i3C840C3C26707C05
GO

Sequence cautioni

The sequence CAA35692 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti61E → A.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76337 mRNA. Translation: AAB32841.1.
S76340 mRNA. Translation: AAB32842.1.
X17699 mRNA. Translation: CAA35692.1. Different initiation.
PIRiS06734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76337 mRNA. Translation: AAB32841.1.
S76340 mRNA. Translation: AAB32842.1.
X17699 mRNA. Translation: CAA35692.1. Different initiation.
PIRiS06734.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MQ1X-ray2.80A/B/C/D/E/F34-132[»]
ProteinModelPortaliP14004.
SMRiP14004.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei319. Der p 5.
3265. Der p 5.0101.
3266. Der p 5.0102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP14004.

Family and domain databases

InterProiIPR020306. Mite_allergen_group-5/21.
[Graphical view]
PfamiPF11642. Blo-t-5. 1 hit.
[Graphical view]
ProDomiPD081736. Mite_allergen_group_5/21. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiALL5_DERPT
AccessioniPrimary (citable) accession number: P14004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.