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P14002

- BGLB_CLOTH

UniProt

P14002 - BGLB_CLOTH

Protein

Thermostable beta-glucosidase B

Gene

bglB

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei231 – 2311By similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    BioCyciCTHE203119:GIW8-1306-MONOMER.
    UniPathwayiUPA00696.

    Protein family/group databases

    CAZyiGH3. Glycoside Hydrolase Family 3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thermostable beta-glucosidase B (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase
    Cellobiase
    Gentiobiase
    Gene namesi
    Name:bglB
    Ordered Locus Names:Cthe_1256
    OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
    Taxonomic identifieri203119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
    ProteomesiUP000002145: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 755755Thermostable beta-glucosidase BPRO_0000210778Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203119.Cthe_1256.

    Structurei

    3D structure databases

    ProteinModelPortaliP14002.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family.Curated

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000031215.
    KOiK05349.
    OMAiYYTEGIF.
    OrthoDBiEOG6N9468.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProiIPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR30620. PTHR30620. 1 hit.
    PfamiPF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view]
    PRINTSiPR00133. GLHYDRLASE3.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 1 hit.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14002-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVDIKKIIK QMTLEEKAGL CSGLDFWHTK PVERLGIPSI MMTDGPHGLR    50
    KQREDAEIAD INNSVPATCF PSAAGLACSW DRELVERVGA ALGEECQAEN 100
    VSILLGPGAN IKRSPLCGRN FEYFSEDPYL SSELAASHIK GVQSQGVGAC 150
    LKHFAANNQE HRRMTVDTIV DERTLREIYF ASFENAVKKA RPWVVMCAYN 200
    KLNGEYCSEN RYLLTEVLKN EWMHDGFVVS DWGAVNDRVS GLDAGLDLEM 250
    PTSHGITDKK IVEAVKSGKL SENILNRAVE RILKVIFMAL ENKKENAQYD 300
    KDAHHRLARQ AAAESMVLLK NEDDVLPLKK SGTIALIGAF VKKPRYQGSG 350
    SSHITPTRLD DIYEEIKKAG GDKVNLVYSE GYRLENDGID EELINEAKKA 400
    ASSSDVAVVF AGLPDEYESE GFDRTHMSIP ENQNRLIEAV AEVQSNIVVV 450
    LLNGSPVEMP WIDKVKSVLE AYLGGQALGG ALADVLFGEV NPSGKLAETF 500
    PVKLSHNPSY LNFPGEDDRV EYKEGLFVGY RYYDTKGIEP LFPFGHGLSY 550
    TKFEYSDISV DKKDVSDNSI INVSVKVKNV GKMAGKEIVQ LYVKDVKSSV 600
    RRPEKELKGF EKVFLNPGEE KTVTFTLDKR AFAYYNTQIK DWHVESGEFL 650
    ILIGRSSRDI VLKESVRVNS TVKIRKRFTV NSAVEDVMSD SSAAAVLGPV 700
    LKEITDALQI DMDNAHDMMA ANIKNMPLRS LVGYSQGRLS EEMLEELVDK 750
    INNVE 755
    Length:755
    Mass (Da):83,900
    Last modified:April 17, 2007 - v2
    Checksum:i944A4D782E6AEAB8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti125 – 1251S → P in CAA33665. (PubMed:2505054)Curated
    Sequence conflicti287 – 2871F → I in CAA33665. (PubMed:2505054)Curated
    Sequence conflicti300 – 3012DK → EQ in CAA33665. (PubMed:2505054)Curated
    Sequence conflicti371 – 3711G → A in CAA33665. (PubMed:2505054)Curated
    Sequence conflicti481 – 49313ALADV…EVNPS → RWRMCYSVKSIV in CAA33665. (PubMed:2505054)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15644 Genomic DNA. Translation: CAA33665.1.
    CP000568 Genomic DNA. Translation: ABN52488.1.
    PIRiS04381.
    RefSeqiYP_001037681.1. NC_009012.1.

    Genome annotation databases

    EnsemblBacteriaiABN52488; ABN52488; Cthe_1256.
    GeneIDi4809761.
    KEGGicth:Cthe_1256.
    PATRICi19516291. VBICloThe47081_1326.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15644 Genomic DNA. Translation: CAA33665.1 .
    CP000568 Genomic DNA. Translation: ABN52488.1 .
    PIRi S04381.
    RefSeqi YP_001037681.1. NC_009012.1.

    3D structure databases

    ProteinModelPortali P14002.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203119.Cthe_1256.

    Protein family/group databases

    CAZyi GH3. Glycoside Hydrolase Family 3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN52488 ; ABN52488 ; Cthe_1256 .
    GeneIDi 4809761.
    KEGGi cth:Cthe_1256.
    PATRICi 19516291. VBICloThe47081_1326.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000031215.
    KOi K05349.
    OMAi YYTEGIF.
    OrthoDBi EOG6N9468.

    Enzyme and pathway databases

    UniPathwayi UPA00696 .
    BioCyci CTHE203119:GIW8-1306-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProi IPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR30620. PTHR30620. 1 hit.
    Pfami PF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00133. GLHYDRLASE3.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 1 hit.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the Clostridium thermocellum bgIB gene encoding thermostable beta-glucosidase B: homology to fungal beta-glucosidases."
      Graebnitz F., Ruecknagel K.P., Seiss M., Staudenbauer W.L.
      Mol. Gen. Genet. 217:70-76(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372.

    Entry informationi

    Entry nameiBGLB_CLOTH
    AccessioniPrimary (citable) accession number: P14002
    Secondary accession number(s): A3DEV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3