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P14002

- BGLB_CLOTH

UniProt

P14002 - BGLB_CLOTH

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Protein
Thermostable beta-glucosidase B
Gene
bglB, Cthe_1256
Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei231 – 2311 By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciCTHE203119:GIW8-1306-MONOMER.
UniPathwayiUPA00696.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Thermostable beta-glucosidase B (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
Gene namesi
Name:bglB
Ordered Locus Names:Cthe_1256
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
ProteomesiUP000002145: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755Thermostable beta-glucosidase B
PRO_0000210778Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_1256.

Structurei

3D structure databases

ProteinModelPortaliP14002.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK05349.
OMAiYYTEGIF.
OrthoDBiEOG6N9468.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 1 hit.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14002-1 [UniParc]FASTAAdd to Basket

« Hide

MAVDIKKIIK QMTLEEKAGL CSGLDFWHTK PVERLGIPSI MMTDGPHGLR    50
KQREDAEIAD INNSVPATCF PSAAGLACSW DRELVERVGA ALGEECQAEN 100
VSILLGPGAN IKRSPLCGRN FEYFSEDPYL SSELAASHIK GVQSQGVGAC 150
LKHFAANNQE HRRMTVDTIV DERTLREIYF ASFENAVKKA RPWVVMCAYN 200
KLNGEYCSEN RYLLTEVLKN EWMHDGFVVS DWGAVNDRVS GLDAGLDLEM 250
PTSHGITDKK IVEAVKSGKL SENILNRAVE RILKVIFMAL ENKKENAQYD 300
KDAHHRLARQ AAAESMVLLK NEDDVLPLKK SGTIALIGAF VKKPRYQGSG 350
SSHITPTRLD DIYEEIKKAG GDKVNLVYSE GYRLENDGID EELINEAKKA 400
ASSSDVAVVF AGLPDEYESE GFDRTHMSIP ENQNRLIEAV AEVQSNIVVV 450
LLNGSPVEMP WIDKVKSVLE AYLGGQALGG ALADVLFGEV NPSGKLAETF 500
PVKLSHNPSY LNFPGEDDRV EYKEGLFVGY RYYDTKGIEP LFPFGHGLSY 550
TKFEYSDISV DKKDVSDNSI INVSVKVKNV GKMAGKEIVQ LYVKDVKSSV 600
RRPEKELKGF EKVFLNPGEE KTVTFTLDKR AFAYYNTQIK DWHVESGEFL 650
ILIGRSSRDI VLKESVRVNS TVKIRKRFTV NSAVEDVMSD SSAAAVLGPV 700
LKEITDALQI DMDNAHDMMA ANIKNMPLRS LVGYSQGRLS EEMLEELVDK 750
INNVE 755
Length:755
Mass (Da):83,900
Last modified:April 17, 2007 - v2
Checksum:i944A4D782E6AEAB8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti125 – 1251S → P in CAA33665. 1 Publication
Sequence conflicti287 – 2871F → I in CAA33665. 1 Publication
Sequence conflicti300 – 3012DK → EQ in CAA33665. 1 Publication
Sequence conflicti371 – 3711G → A in CAA33665. 1 Publication
Sequence conflicti481 – 49313ALADV…EVNPS → RWRMCYSVKSIV in CAA33665. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15644 Genomic DNA. Translation: CAA33665.1.
CP000568 Genomic DNA. Translation: ABN52488.1.
PIRiS04381.
RefSeqiYP_001037681.1. NC_009012.1.

Genome annotation databases

EnsemblBacteriaiABN52488; ABN52488; Cthe_1256.
GeneIDi4809761.
KEGGicth:Cthe_1256.
PATRICi19516291. VBICloThe47081_1326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15644 Genomic DNA. Translation: CAA33665.1 .
CP000568 Genomic DNA. Translation: ABN52488.1 .
PIRi S04381.
RefSeqi YP_001037681.1. NC_009012.1.

3D structure databases

ProteinModelPortali P14002.
ModBasei Search...

Protein-protein interaction databases

STRINGi 203119.Cthe_1256.

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN52488 ; ABN52488 ; Cthe_1256 .
GeneIDi 4809761.
KEGGi cth:Cthe_1256.
PATRICi 19516291. VBICloThe47081_1326.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000031215.
KOi K05349.
OMAi YYTEGIF.
OrthoDBi EOG6N9468.

Enzyme and pathway databases

UniPathwayi UPA00696 .
BioCyci CTHE203119:GIW8-1306-MONOMER.

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProi IPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR30620. PTHR30620. 1 hit.
Pfami PF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view ]
PRINTSi PR00133. GLHYDRLASE3.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 1 hit.
PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the Clostridium thermocellum bgIB gene encoding thermostable beta-glucosidase B: homology to fungal beta-glucosidases."
    Graebnitz F., Ruecknagel K.P., Seiss M., Staudenbauer W.L.
    Mol. Gen. Genet. 217:70-76(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27405 / DSM 1237.

Entry informationi

Entry nameiBGLB_CLOTH
AccessioniPrimary (citable) accession number: P14002
Secondary accession number(s): A3DEV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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