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Protein

Arylsulfatase

Gene
N/A
Organism
Hemicentrotus pulcherrimus (Sea urchin) (Strongylocentrotus pulcherrimus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a structural component of the extracellular matrices involved in cell movement during morphogenesis.

Catalytic activityi

A phenol sulfate + H2O = a phenol + sulfate.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60CalciumBy similarity1
Metal bindingi61CalciumBy similarity1
Active sitei100NucleophileBy similarity1
Metal bindingi100Calcium; via 3-oxoalanineBy similarity1
Active sitei158By similarity1
Metal bindingi308CalciumBy similarity1
Metal bindingi309CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase (EC:3.1.6.1)
Short name:
AS
Alternative name(s):
Aryl-sulfate sulphohydrolase
Short name:
ARS
OrganismiHemicentrotus pulcherrimus (Sea urchin) (Strongylocentrotus pulcherrimus)
Taxonomic identifieri7650 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeHemicentrotus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000003344221 – 551ArylsulfataseAdd BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Blocked amino end (Gln)1
Modified residuei1003-oxoalanine (Cys)By similarity1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP14000.

Structurei

3D structure databases

ProteinModelPortaliP14000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiView protein in InterPro
IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core_sf.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
PfamiView protein in Pfam
PF00884. Sulfatase. 1 hit.
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiView protein in PROSITE
PS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSAPFLFLL GLLGLVTAQT QDPALLDLLR ENPDLLSLLL QSNEHRAPLV
60 70 80 90 100
KPNVVLLVAD HMGSGDLTSY GHPTQEAGFI DKMAAEGLRF TNGYVGDAVC
110 120 130 140 150
TPSRSAIMTG RLPVRIGTFG ETRVFLPWTK TGLPKSELTI AEAMKEAGYA
160 170 180 190 200
TGMVGKWHLG INENSSTDGA HLPFNHGFDF VGHNLPFTNS WSCDDTGLHK
210 220 230 240 250
DFPDSQRCYL YVNATLVSQP YQHKGLTQLF TDDALGFIED NHADPFFLYV
260 270 280 290 300
AFAHMHTSLF SSDDFSCTSR RGRYGDNLLE MHDAVQKIVD KLEENNISEN
310 320 330 340 350
TIIFFISDHG PHREYCEEGG DASIFRGGKS HSWEGGHRIP YIVYWPGTIS
360 370 380 390 400
PGISNEIVTS MDIIATAADL GGTTLPTDRI YDGKSIKDVL LEGSASPHSS
410 420 430 440 450
FFYYCKDNLM AVRVGKYKAH FRTQRVRSQD EYGLECAGGF PLEDYFDCND
460 470 480 490 500
CEGDCVTEHD PPLLFDLHRD PGEAYPLEAC GHEDVFLTVK STVEEHKAAL
510 520 530 540 550
VKGTPLLDSF DHSIVPCCNP ANGCICNYVH EPGMPECYQD QVATAARHYR

P
Length:551
Mass (Da):60,952
Last modified:January 1, 1990 - v1
Checksum:i54C1AAC14D6710C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17015 mRNA. Translation: CAA34881.1.
PIRiS01793.
S07089.

Similar proteinsi

Entry informationi

Entry nameiARS_HEMPU
AccessioniPrimary (citable) accession number: P14000
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: January 31, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families