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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

TRP1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. N-(5'-phosphoribosyl)anthranilate isomerase (TRP1)
  4. no protein annotated in this organism
  5. Tryptophan synthase (KLLA0_E10649g)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
Ordered Locus Names:KLLA0E17699g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome E

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001543331 – 210N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST210

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_454745.1

Structurei

3D structure databases

ProteinModelPortaliP13997
SMRiP13997
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiKOG4202 Eukaryota
COG0135 LUCA
HOGENOMiHOG000161598
InParanoidiP13997
KOiK01817
OMAiFYAKSPR
OrthoDBiEOG092C59PB

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

P13997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVKVCGLQT VEAAKTAVDD GADYLGIICV PGRKRTIDSS VAKGISTAVH
60 70 80 90 100
QQENVKGTKL VGVFRNQSVD DVLQLYHEYN LDVIQLHGDE DIKEYRSLIP
110 120 130 140 150
SSIPIIKRFQ FPQDCELLLD LYEHVDNVLT LFDSGEGGTG EKLNWSAISS
160 170 180 190 200
WSASHPEIKF IIAGGLNPDN VSVAINMLPN AIGVDVSGGV ETDGIKDLEK
210
VKLFIQQASQ
Length:210
Mass (Da):22,880
Last modified:January 1, 1990 - v1
Checksum:i0F406A05E83CFA95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14230 Genomic DNA Translation: CAA32445.1
CR382125 Genomic DNA Translation: CAG99832.1
PIRiS07893 ISVKNL
RefSeqiXP_454745.1, XM_454745.1

Genome annotation databases

EnsemblFungiiCAG99832; CAG99832; KLLA0_E17645g
GeneIDi2894278
KEGGikla:KLLA0E17645g

Similar proteinsi

Entry informationi

Entry nameiTRPF_KLULA
AccessioniPrimary (citable) accession number: P13997
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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