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Protein

Coiled-coil domain-containing protein 130

Gene

CCDC130

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • response to virus Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 130
Alternative name(s):
9 kDa protein
Gene namesi
Name:CCDC130
ORF Names:SB115
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28118. CCDC130.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381331.

Polymorphism and mutation databases

BioMutaiCCDC130.
DMDMi134037158.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Coiled-coil domain-containing protein 130PRO_0000064401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei306 – 3061PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP13994.
MaxQBiP13994.
PaxDbiP13994.
PRIDEiP13994.

PTM databases

iPTMnetiP13994.

Expressioni

Inductioni

By poly(RI), poly(RC) and Newcastle disease virus.1 Publication

Gene expression databases

BgeeiP13994.
CleanExiHS_CCDC130.
ExpressionAtlasiP13994. baseline and differential.
GenevisibleiP13994. HS.

Organism-specific databases

HPAiHPA056977.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF165P499102EBI-716093,EBI-741694
ZNF572A1L4E93EBI-716093,EBI-10172590
ZNF572Q7Z3I73EBI-716093,EBI-10257016

Protein-protein interaction databases

BioGridi123536. 17 interactions.
IntActiP13994. 9 interactions.
MINTiMINT-1389809.
STRINGi9606.ENSP00000221554.

Structurei

3D structure databases

ProteinModelPortaliP13994.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili182 – 21433Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CWC16 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2990. Eukaryota.
COG5134. LUCA.
GeneTreeiENSGT00530000063615.
HOGENOMiHOG000239030.
HOVERGENiHBG081031.
InParanoidiP13994.
KOiK13115.
OMAiPCCKHEI.
OrthoDBiEOG78D7KC.
PhylomeDBiP13994.

Family and domain databases

InterProiIPR007590. CWC16.
[Graphical view]
PANTHERiPTHR12111. PTHR12111. 2 hits.
PfamiPF04502. DUF572. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGERKGVNKY YPPDFNPEKH GSLNRYHNSH PLRERARKLS QGILIIRFEM
60 70 80 90 100
PYNIWCDGCK NHIGMGVRYN AEKKKVGNYY TTPIYRFRMK CHLCVNYIEM
110 120 130 140 150
QTDPANCDYV IVSGAQRKEE RWDMADNEQV LTTEHEKKQK LETDAMFRLE
160 170 180 190 200
HGEADRSTLK KALPTLSHIQ EAQSAWKDDF ALNSMLRRRF REKKKAIQEE
210 220 230 240 250
EERDQALQAK ASLTIPLVPE TEDDRKLAAL LKFHTLDSYE DKQKLKRTEI
260 270 280 290 300
ISRSWFPSAP GSASSSKVSG VLKKLAQSRR TALATSPITV GDLGIVRRRS
310 320 330 340 350
RDVPESPQHA ADTPKSGEPR VPEEAAQDRP MSPGDCPPET TETPKCSSPR
360 370 380 390
GQEGSRQDKP LSPAGSSQEA ADTPDTRHPC SLGSSLVADY SDSESE
Length:396
Mass (Da):44,802
Last modified:March 6, 2007 - v2
Checksum:i6D2EA8F4680EF89F
GO

Sequence cautioni

The sequence CAA32138.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence CAA32138.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221S → C.
Corresponds to variant rs12974461 [ dbSNP | Ensembl ].
VAR_053854
Natural varianti336 – 3361C → S.
Corresponds to variant rs35761244 [ dbSNP | Ensembl ].
VAR_053855

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250306 mRNA. Translation: AAK37425.1.
BC002905 mRNA. Translation: AAH02905.1.
X13956 Genomic DNA. Translation: CAA32138.1. Sequence problems.
CCDSiCCDS12296.1.
PIRiS02660.
RefSeqiNP_001307490.1. NM_001320561.1.
NP_001307493.1. NM_001320564.1.
NP_001307494.1. NM_001320565.1.
NP_001307495.1. NM_001320566.1.
NP_001307496.1. NM_001320567.1.
NP_001307497.1. NM_001320568.1.
NP_001307498.1. NM_001320569.1.
NP_110445.1. NM_030818.3.
XP_005260143.1. XM_005260086.3.
UniGeneiHs.24998.
Hs.734421.

Genome annotation databases

EnsembliENST00000221554; ENSP00000221554; ENSG00000104957.
ENST00000586600; ENSP00000465776; ENSG00000104957.
GeneIDi81576.
KEGGihsa:81576.
UCSCiuc002mxc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250306 mRNA. Translation: AAK37425.1.
BC002905 mRNA. Translation: AAH02905.1.
X13956 Genomic DNA. Translation: CAA32138.1. Sequence problems.
CCDSiCCDS12296.1.
PIRiS02660.
RefSeqiNP_001307490.1. NM_001320561.1.
NP_001307493.1. NM_001320564.1.
NP_001307494.1. NM_001320565.1.
NP_001307495.1. NM_001320566.1.
NP_001307496.1. NM_001320567.1.
NP_001307497.1. NM_001320568.1.
NP_001307498.1. NM_001320569.1.
NP_110445.1. NM_030818.3.
XP_005260143.1. XM_005260086.3.
UniGeneiHs.24998.
Hs.734421.

3D structure databases

ProteinModelPortaliP13994.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123536. 17 interactions.
IntActiP13994. 9 interactions.
MINTiMINT-1389809.
STRINGi9606.ENSP00000221554.

PTM databases

iPTMnetiP13994.

Polymorphism and mutation databases

BioMutaiCCDC130.
DMDMi134037158.

Proteomic databases

EPDiP13994.
MaxQBiP13994.
PaxDbiP13994.
PRIDEiP13994.

Protocols and materials databases

DNASUi81576.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221554; ENSP00000221554; ENSG00000104957.
ENST00000586600; ENSP00000465776; ENSG00000104957.
GeneIDi81576.
KEGGihsa:81576.
UCSCiuc002mxc.2. human.

Organism-specific databases

CTDi81576.
GeneCardsiCCDC130.
HGNCiHGNC:28118. CCDC130.
HPAiHPA056977.
neXtProtiNX_P13994.
PharmGKBiPA162381331.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2990. Eukaryota.
COG5134. LUCA.
GeneTreeiENSGT00530000063615.
HOGENOMiHOG000239030.
HOVERGENiHBG081031.
InParanoidiP13994.
KOiK13115.
OMAiPCCKHEI.
OrthoDBiEOG78D7KC.
PhylomeDBiP13994.

Miscellaneous databases

ChiTaRSiCCDC130. human.
GenomeRNAii81576.
PROiP13994.

Gene expression databases

BgeeiP13994.
CleanExiHS_CCDC130.
ExpressionAtlasiP13994. baseline and differential.
GenevisibleiP13994. HS.

Family and domain databases

InterProiIPR007590. CWC16.
[Graphical view]
PANTHERiPTHR12111. PTHR12111. 2 hits.
PfamiPF04502. DUF572. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Wan T., Li N., Zhang W., Cao X.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "Alternative mechanisms for gene activation induced by poly(rI).poly(rC) and Newcastle disease virus."
    Lammers R., Gross G., Mayr U., Collins J.
    Eur. J. Biochem. 178:93-99(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 192-396, INDUCTION.
    Tissue: Fibroblast.
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCC130_HUMAN
AccessioniPrimary (citable) accession number: P13994
Secondary accession number(s): Q9BQ72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: March 6, 2007
Last modified: June 8, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.