P13994 (CC130_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 130

Alternative name(s):
9 kDa protein

Gene names

Name:	CCDC130
ORF Names:	SB115

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Induction	By poly(RI), poly(RC) and Newcastle disease virus. Ref.3
Sequence similarities	Belongs to the CWC16 family.
Sequence caution	The sequence CAA32138.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAA32138.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to virus Inferred from expression pattern Ref.3. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ZNF165	P49910	2	EBI-716093,EBI-741694

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Coiled-coil domain-containing protein 130		PRO_0000064401
Regions
	Coiled coil	182 – 214	33	Potential
Amino acid modifications
	Modified residue	306	1	Phosphoserine Ref.4
Natural variations
	Natural variant	22	1	S → C. Corresponds to variant rs12974461 [ dbSNP | Ensembl ].		VAR_053854
	Natural variant	336	1	C → S. Corresponds to variant rs35761244 [ dbSNP | Ensembl ].		VAR_053855

Sequences

	Sequence		Length	Mass (Da)
	P13994 [UniParc]. Last modified March 6, 2007. Version 2. Checksum: 6D2EA8F4680EF89F	FASTA	396	44,802
	10 20 30 40 50 60 MGERKGVNKY YPPDFNPEKH GSLNRYHNSH PLRERARKLS QGILIIRFEM PYNIWCDGCK 70 80 90 100 110 120 NHIGMGVRYN AEKKKVGNYY TTPIYRFRMK CHLCVNYIEM QTDPANCDYV IVSGAQRKEE 130 140 150 160 170 180 RWDMADNEQV LTTEHEKKQK LETDAMFRLE HGEADRSTLK KALPTLSHIQ EAQSAWKDDF 190 200 210 220 230 240 ALNSMLRRRF REKKKAIQEE EERDQALQAK ASLTIPLVPE TEDDRKLAAL LKFHTLDSYE 250 260 270 280 290 300 DKQKLKRTEI ISRSWFPSAP GSASSSKVSG VLKKLAQSRR TALATSPITV GDLGIVRRRS 310 320 330 340 350 360 RDVPESPQHA ADTPKSGEPR VPEEAAQDRP MSPGDCPPET TETPKCSSPR GQEGSRQDKP 370 380 390 LSPAGSSQEA ADTPDTRHPC SLGSSLVADY SDSESE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Wan T., Li N., Zhang W., Cao X. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Alternative mechanisms for gene activation induced by poly(rI).poly(rC) and Newcastle disease virus." Lammers R., Gross G., Mayr U., Collins J. Eur. J. Biochem. 178:93-99(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 192-396, INDUCTION. Tissue: Fibroblast.
[4]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF250306 mRNA. Translation: AAK37425.1. BC002905 mRNA. Translation: AAH02905.1. X13956 Genomic DNA. Translation: CAA32138.1. Sequence problems.
IPI	IPI00011306.
PIR	S02660.
RefSeq	NP_110445.1. NM_030818.2.
UniGene	Hs.24998.
3D structure databases
ProteinModelPortal	P13994.
ModBase	Search...
Protein-protein interaction databases
IntAct	P13994. 6 interactions.
MINT	MINT-1389809.
STRING	9606.ENSP00000221554.
Polymorphism databases
DMDM	134037158.
Proteomic databases
PaxDb	P13994.
PRIDE	P13994.
Protocols and materials databases
DNASU	81576.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000221554; ENSP00000221554; ENSG00000104957. ENST00000586600; ENSP00000465776; ENSG00000104957.
GeneID	81576.
KEGG	hsa:81576.
UCSC	uc002mxc.1. human.
Organism-specific databases
CTD	81576.
GeneCards	GC19P013860.
HGNC	HGNC:28118. CCDC130.
HPA	HPA056977.
neXtProt	NX_P13994.
PharmGKB	PA162381331.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5134.
HOGENOM	HOG000239030.
HOVERGEN	HBG081031.
InParanoid	P13994.
KO	K13115.
OMA	RSWFPSA.
OrthoDB	EOG4T783D.
PhylomeDB	P13994.
Gene expression databases
Bgee	P13994.
CleanEx	HS_CCDC130.
Genevestigator	P13994.
GermOnline	ENSG00000104957. Homo sapiens.
Family and domain databases
InterPro	IPR007590. CWC16. [Graphical view]
PANTHER	PTHR12111. PTHR12111. 1 hit.
Pfam	PF04502. DUF572. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	81576.
NextBio	71888.

Entry information

Entry name

CC130_HUMAN

Accession

Primary (citable) accession number: P13994
Secondary accession number(s): Q9BQ72

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	March 6, 2007
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.