GTF2F2

Functionⁱ

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.1 Publication

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	36 – 43	ATPSequence analysis		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
DNA binding Source: UniProtKB-KW
helicase activity Source: UniProtKB-KW
transcription factor activity, core RNA polymerase II binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

7-methylguanosine mRNA capping Source: Reactome
fibroblast growth factor receptor signaling pathway Source: Reactome
mRNA splicing, via spliceosome Source: Reactome
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8662660
positive regulation of transcription elongation from RNA polymerase II promoter Source: GO_Central
positive regulation of transcription initiation from RNA polymerase II promoter Source: GO_Central
RNA metabolic process Source: Reactome
snRNA transcription by RNA polymerase II Source: Reactome
transcription by RNA polymerase II Source: Reactome
transcription elongation from RNA polymerase II promoter Source: Reactome
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Helicase, Hydrolase
Biological process	Transcription, Transcription regulation
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-113418 Formation of the Early Elongation Complex R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167158 Formation of the HIV-1 Early Elongation Complex R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167161 HIV Transcription Initiation R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167172 Transcription of the HIV genome R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167243 Tat-mediated HIV elongation arrest and recovery R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript R-HSA-167287 HIV elongation arrest and recovery R-HSA-167290 Pausing and recovery of HIV elongation R-HSA-168325 Viral Messenger RNA Synthesis R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes R-HSA-6803529 FGFR2 alternative splicing R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-72086 mRNA Capping R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE R-HSA-8851708 Signaling by FGFR2 IIIa TM R-HSA-9018519 Estrogen-dependent gene expression

Reactomeⁱ

R-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-113418 Formation of the Early Elongation Complex
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6803529 FGFR2 alternative splicing
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-72086 mRNA Capping
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-8851708 Signaling by FGFR2 IIIa TM
R-HSA-9018519 Estrogen-dependent gene expression

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: General transcription factor IIF subunit 2 (EC:3.6.4.12) Alternative name(s): ATP-dependent helicase GTF2F2 General transcription factor IIF 30 kDa subunit Transcription initiation factor IIF subunit beta Short name: TFIIF-beta Transcription initiation factor RAP30
Gene namesⁱ	Name:GTF2F2 Synonyms:RAP30
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188342.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4653 GTF2F2
MIMⁱ	189969 gene
neXtProtⁱ	NX_P13984

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2963
Open Targets More...OpenTargetsⁱ	ENSG00000188342
PharmGKBⁱ	PA29039

Polymorphism and mutation databases

BioMutaⁱ	GTF2F2
DMDMⁱ	464519

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000211235	2 – 249	General transcription factor IIF subunit 2Add BLAST		248

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	22	N6-acetyllysineCombined sources	1
Modified residueⁱ	33	N6-acetyllysineCombined sources	1
Modified residueⁱ	137	N6-acetyllysineCombined sources	1
Modified residueⁱ	142	PhosphoserineCombined sources	1
Modified residueⁱ	248	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P13984
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P13984
PaxDbⁱ	P13984
PeptideAtlas More...PeptideAtlasⁱ	P13984
PRIDEⁱ	P13984
ProteomicsDBⁱ	53012

PTM databases

iPTMnetⁱ	P13984
PhosphoSitePlusⁱ	P13984

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000188342
CleanExⁱ	HS_GTF2F2
ExpressionAtlasⁱ	P13984 baseline and differential
Genevisibleⁱ	P13984 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA006912

HPAⁱ

HPA006912

Interactionⁱ

Subunit structureⁱ

Heterodimer of an alpha and a beta subunit. Interacts with HTATSF1 and GPBP1 (By similarity). Interacts with URI1.By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
GTF2F1	P35269	2	EBI-1030560,EBI-457886
RPL27A	P46776	2	EBI-1030560,EBI-350581
TCTEX1D2	Q8WW35	2	EBI-1030560,EBI-2692044
URI1	O94763	4	EBI-1030560,EBI-357067

Show more details

Protein-protein interaction databases

BioGridⁱ	109218, 51 interactors
ComplexPortalⁱ	CPX-79 Transcription factor TFIIF complex
CORUMⁱ	P13984
Database of interacting proteins More...DIPⁱ	DIP-41680N
IntActⁱ	P13984, 43 interactors
Molecular INTeraction database More...MINTⁱ	P13984
STRINGⁱ	9606.ENSP00000340823

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	6 – 8	Combined sources	3
Helixⁱ	10 – 13	Combined sources	4
Beta strandⁱ	17 – 24	Combined sources	8
Helixⁱ	25 – 31	Combined sources	7
Beta strandⁱ	39 – 48	Combined sources	10
Beta strandⁱ	51 – 58	Combined sources	8
Helixⁱ	60 – 63	Combined sources	4
Beta strandⁱ	80 – 86	Combined sources	7
Beta strandⁱ	91 – 99	Combined sources	9
Beta strandⁱ	104 – 116	Combined sources	13
Helixⁱ	177 – 193	Combined sources	17
Helixⁱ	199 – 205	Combined sources	7
Helixⁱ	210 – 220	Combined sources	11

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BBY	NMR	-	A	175-243	[»]
	1F3U	X-ray	1.70	A/C/E/G	2-119	[»]
	2BBY	NMR	-	A	175-243	[»]
	5IY6	electron microscopy	7.20	T	1-249	[»]
	5IY7	electron microscopy	8.60	T	1-249	[»]
	5IY8	electron microscopy	7.90	T	1-249	[»]
	5IY9	electron microscopy	6.30	T	1-249	[»]
	5IYA	electron microscopy	5.40	T	1-249	[»]
	5IYB	electron microscopy	3.90	T	1-249	[»]
	5IYC	electron microscopy	3.90	T	1-249	[»]
	5IYD	electron microscopy	3.90	T	1-249	[»]
ProteinModelPortalⁱ	P13984
SMRⁱ	P13984
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P13984

EvolutionaryTraceⁱ

P13984

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TFIIF beta subunit family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2905 Eukaryota COG5090 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016051
HOGENOMⁱ	HOG000294179
HOVERGENⁱ	HBG001606
InParanoidⁱ	P13984
KEGG Orthology (KO) More...KOⁱ	K03139
OMAⁱ	NMWELKK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IN2
PhylomeDBⁱ	P13984
TreeFamⁱ	TF314290

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR003196 TFIIF_beta IPR011039 TFIIF_interaction IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR10445 PTHR10445, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02270 TFIIF_beta, 1 hit
PIRSFⁱ	PIRSF015849 TFIIF-beta, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF50916 SSF50916, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P13984-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAERGELDLT GAKQNTGVWL VKVPKYLSQQ WAKASGRGEV GKLRIAKTQG 
        60         70         80         90        100
RTEVSFTLNE DLANIHDIGG KPASVSAPRE HPFVLQSVGG QTLTVFTESS 
       110        120        130        140        150
SDKLSLEGIV VQRAECRPAA SENYMRLKRL QIEESSKPVR LSQQLDKVVT 
       160        170        180        190        200
TNYKPVANHQ YNIEYERKKK EDGKRARADK QHVLDMLFSA FEKHQYYNLK 
       210        220        230        240 
DLVDITKQPV VYLKEILKEI GVQNVKGIHK NTWELKPEYR HYQGEEKSD

Length:249

Mass (Da):28,380

Last modified:February 1, 1994 - v2

Checksum:ⁱ05A1A9F8D31B749C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X16901 mRNA Translation: CAA34775.1 X59745 mRNA Translation: CAA42419.1 AK291545 mRNA Translation: BAF84234.1 BT019525 mRNA Translation: AAV38332.1 AL138963 Genomic DNA No translation available. AL138693 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08728.1 BC001771 mRNA Translation: AAH01771.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9395.1
PIRⁱ	S06141 S18677
NCBI Reference Sequences More...RefSeqⁱ	NP_004119.1, NM_004128.2
UniGeneⁱ	Hs.654582

Genome annotation databases

Ensemblⁱ	ENST00000340473; ENSP00000340823; ENSG00000188342
GeneIDⁱ	2963
KEGGⁱ	hsa:2963
UCSC genome browser More...UCSCⁱ	uc001uzw.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P13984	General transcription factor IIF subunit 2		HUMAN		249
General transcription factor IIF subunit 2		PANTR		249
General transcription factor IIF subunit 2		PONAB		249
General transcription factor IIF subunit 2		PANPA		249
General transcription factor IIF subunit 2		GORGO		249
+41

Protein	Similar proteins		Species	Score	Length
P13984	General transcription factor IIF subunit 2		HUMAN		249
General transcription factor IIF subunit 2		PANTR		249
General transcription factor IIF subunit 2		PONAB		249
General transcription factor IIF subunit 2		PANPA		249
General transcription factor IIF subunit 2		GORGO		249
+146

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X16901 mRNA Translation: CAA34775.1 X59745 mRNA Translation: CAA42419.1 AK291545 mRNA Translation: BAF84234.1 BT019525 mRNA Translation: AAV38332.1 AL138963 Genomic DNA No translation available. AL138693 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08728.1 BC001771 mRNA Translation: AAH01771.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9395.1
PIRⁱ	S06141 S18677
NCBI Reference Sequences More...RefSeqⁱ	NP_004119.1, NM_004128.2
UniGeneⁱ	Hs.654582

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BBY	NMR	-	A	175-243	[»]
	1F3U	X-ray	1.70	A/C/E/G	2-119	[»]
	2BBY	NMR	-	A	175-243	[»]
	5IY6	electron microscopy	7.20	T	1-249	[»]
	5IY7	electron microscopy	8.60	T	1-249	[»]
	5IY8	electron microscopy	7.90	T	1-249	[»]
	5IY9	electron microscopy	6.30	T	1-249	[»]
	5IYA	electron microscopy	5.40	T	1-249	[»]
	5IYB	electron microscopy	3.90	T	1-249	[»]
	5IYC	electron microscopy	3.90	T	1-249	[»]
	5IYD	electron microscopy	3.90	T	1-249	[»]
ProteinModelPortalⁱ	P13984
SMRⁱ	P13984
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109218, 51 interactors
ComplexPortalⁱ	CPX-79 Transcription factor TFIIF complex
CORUMⁱ	P13984
Database of interacting proteins More...DIPⁱ	DIP-41680N
IntActⁱ	P13984, 43 interactors
Molecular INTeraction database More...MINTⁱ	P13984
STRINGⁱ	9606.ENSP00000340823

PTM databases

iPTMnetⁱ	P13984
PhosphoSitePlusⁱ	P13984

Polymorphism and mutation databases

BioMutaⁱ	GTF2F2
DMDMⁱ	464519

Proteomic databases

EPDⁱ	P13984
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P13984
PaxDbⁱ	P13984
PeptideAtlas More...PeptideAtlasⁱ	P13984
PRIDEⁱ	P13984
ProteomicsDBⁱ	53012

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2963
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000340473; ENSP00000340823; ENSG00000188342
GeneIDⁱ	2963
KEGGⁱ	hsa:2963
UCSC genome browser More...UCSCⁱ	uc001uzw.4 human

Organism-specific databases

CTDⁱ	2963
DisGeNET More...DisGeNETⁱ	2963
EuPathDBⁱ	HostDB:ENSG00000188342.11
GeneCardsⁱ	GTF2F2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4653 GTF2F2
Human Protein Atlas More...HPAⁱ	HPA006912
MIMⁱ	189969 gene
neXtProtⁱ	NX_P13984
Open Targets More...OpenTargetsⁱ	ENSG00000188342
PharmGKBⁱ	PA29039
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2905 Eukaryota COG5090 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016051
HOGENOMⁱ	HOG000294179
HOVERGENⁱ	HBG001606
InParanoidⁱ	P13984
KEGG Orthology (KO) More...KOⁱ	K03139
OMAⁱ	NMWELKK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IN2
PhylomeDBⁱ	P13984
TreeFamⁱ	TF314290

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-113418 Formation of the Early Elongation Complex R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167158 Formation of the HIV-1 Early Elongation Complex R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167161 HIV Transcription Initiation R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167172 Transcription of the HIV genome R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167243 Tat-mediated HIV elongation arrest and recovery R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript R-HSA-167287 HIV elongation arrest and recovery R-HSA-167290 Pausing and recovery of HIV elongation R-HSA-168325 Viral Messenger RNA Synthesis R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes R-HSA-6803529 FGFR2 alternative splicing R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-72086 mRNA Capping R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE R-HSA-8851708 Signaling by FGFR2 IIIa TM R-HSA-9018519 Estrogen-dependent gene expression

Reactomeⁱ

R-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-113418 Formation of the Early Elongation Complex
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6803529 FGFR2 alternative splicing
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-72086 mRNA Capping
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-8851708 Signaling by FGFR2 IIIa TM
R-HSA-9018519 Estrogen-dependent gene expression

Miscellaneous databases

ChiTaRSⁱ	GTF2F2 human
EvolutionaryTraceⁱ	P13984
GeneWikiⁱ	GTF2F2
GenomeRNAiⁱ	2963
Protein Ontology More...PROⁱ	PR:P13984
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000188342
CleanExⁱ	HS_GTF2F2
ExpressionAtlasⁱ	P13984 baseline and differential
Genevisibleⁱ	P13984 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR003196 TFIIF_beta IPR011039 TFIIF_interaction IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR10445 PTHR10445, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02270 TFIIF_beta, 1 hit
PIRSFⁱ	PIRSF015849 TFIIF-beta, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF50916 SSF50916, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	T2FB_HUMAN
Accessionⁱ	P13984Primary (citable) accession number: P13984 Secondary accession number(s): A6NNS5, Q5W0H3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	February 1, 1994
	Last modified:	June 20, 2018
	This is version 189 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P13984 (T2FB_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

General transcription factor IIF subunit 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ