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Protein

Beta-3 adrenergic receptor

Gene

ADRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117Agonist or antagonistBy similarity1
Binding sitei122Agonist or antagonistBy similarity1

GO - Molecular functioni

  • beta3-adrenergic receptor activity Source: HGNC
  • beta-adrenergic receptor activity Source: HGNC
  • epinephrine binding Source: GO_Central
  • norepinephrine binding Source: Ensembl
  • protein homodimerization activity Source: HGNC

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-31214-MONOMER.
ReactomeiR-HSA-390696. Adrenoceptors.
R-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-3 adrenergic receptor
Alternative name(s):
Beta-3 adrenoreceptor
Short name:
Beta-3 adrenoceptor
Gene namesi
Name:ADRB3
Synonyms:ADRB3R, B3AR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:288. ADRB3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularBy similarityAdd BLAST36
Transmembranei37 – 63Helical; Name=1By similarityAdd BLAST27
Topological domaini64 – 72CytoplasmicBy similarity9
Transmembranei73 – 91Helical; Name=2By similarityAdd BLAST19
Topological domaini92 – 111ExtracellularBy similarityAdd BLAST20
Transmembranei112 – 133Helical; Name=3By similarityAdd BLAST22
Topological domaini134 – 155CytoplasmicBy similarityAdd BLAST22
Transmembranei156 – 178Helical; Name=4By similarityAdd BLAST23
Topological domaini179 – 203ExtracellularBy similarityAdd BLAST25
Transmembranei204 – 225Helical; Name=5By similarityAdd BLAST22
Topological domaini226 – 292CytoplasmicBy similarityAdd BLAST67
Transmembranei293 – 314Helical; Name=6By similarityAdd BLAST22
Topological domaini315 – 326ExtracellularBy similarityAdd BLAST12
Transmembranei327 – 347Helical; Name=7By similarityAdd BLAST21
Topological domaini348 – 408CytoplasmicBy similarityAdd BLAST61

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • nucleus Source: Ensembl
  • plasma membrane Source: Reactome
  • receptor complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Diabetes mellitus, Obesity

Organism-specific databases

DisGeNETi155.
MalaCardsiADRB3.
OpenTargetsiENSG00000188778.
PharmGKBiPA24598.

Chemistry databases

ChEMBLiCHEMBL246.
DrugBankiDB00321. Amitriptyline.
DB00182. Amphetamine.
DB01102. Arbutamine.
DB00217. Bethanidine.
DB08807. Bopindolol.
DB08808. Bupranolol.
DB01407. Clenbuterol.
DB06262. Droxidopa.
DB01363. Ephedra.
DB00668. Epinephrine.
DB01288. Fenoterol.
DB01064. Isoprenaline.
DB01365. Mephentermine.
DB08893. Mirabegron.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00571. Propranolol.
DB00726. Trimipramine.
GuidetoPHARMACOLOGYi30.

Polymorphism and mutation databases

BioMutaiADRB3.
DMDMi461604.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691431 – 408Beta-3 adrenergic receptorAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi110 ↔ 196PROSITE-ProRule annotation
Disulfide bondi189 ↔ 195PROSITE-ProRule annotation
Lipidationi361S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP13945.
PRIDEiP13945.

PTM databases

PhosphoSitePlusiP13945.

Expressioni

Tissue specificityi

Expressed mainly in adipose tissues.

Gene expression databases

BgeeiENSG00000188778.
CleanExiHS_ADRB3.
ExpressionAtlasiP13945. baseline and differential.
GenevisibleiP13945. HS.

Interactioni

Subunit structurei

Interacts with ARRDC3.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: HGNC

Protein-protein interaction databases

BioGridi106664. 2 interactors.
DIPiDIP-61451N.
IntActiP13945. 3 interactors.
STRINGi9606.ENSP00000343782.

Chemistry databases

BindingDBiP13945.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CDWmodel-A1-408[»]
ProteinModelPortaliP13945.
SMRiP13945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 212Agonist and antagonist bindingBy similarityAdd BLAST15
Regioni305 – 312Agonist and antagonist bindingBy similarity8
Regioni332 – 336Agonist and antagonist bindingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP13945.
KOiK04143.
OMAiAPIMSKW.
OrthoDBiEOG091G06VI.
PhylomeDBiP13945.
TreeFamiTF316350.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000681. ADRB3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00563. ADRENRGCB3AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPWPHENSS LAPWPDLPTL APNTANTSGL PGVPWEAALA GALLALAVLA
60 70 80 90 100
TVGGNLLVIV AIAWTPRLQT MTNVFVTSLA AADLVMGLLV VPPAATLALT
110 120 130 140 150
GHWPLGATGC ELWTSVDVLC VTASIETLCA LAVDRYLAVT NPLRYGALVT
160 170 180 190 200
KRCARTAVVL VWVVSAAVSF APIMSQWWRV GADAEAQRCH SNPRCCAFAS
210 220 230 240 250
NMPYVLLSSS VSFYLPLLVM LFVYARVFVV ATRQLRLLRG ELGRFPPEES
260 270 280 290 300
PPAPSRSLAP APVGTCAPPE GVPACGRRPA RLLPLREHRA LCTLGLIMGT
310 320 330 340 350
FTLCWLPFFL ANVLRALGGP SLVPGPAFLA LNWLGYANSA FNPLIYCRSP
360 370 380 390 400
DFRSAFRRLL CRCGRRLPPE PCAAARPALF PSGVPAARSS PAQPRLCQRL

DGASWGVS
Length:408
Mass (Da):43,519
Last modified:February 1, 1994 - v3
Checksum:iE98BD6C130DD977B
GO

Polymorphismi

The variant Arg-64 seems to be associated with weight gain (obesity) and is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).1 Publication1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00345664W → R.5 PublicationsCorresponds to variant rs4994dbSNPEnsembl.1
Natural variantiVAR_029205249E → K.Corresponds to variant rs28364012dbSNPEnsembl.1
Natural variantiVAR_014166265T → M.1 PublicationCorresponds to variant rs4995dbSNPEnsembl.1
Natural variantiVAR_025102353R → C.1 PublicationCorresponds to variant rs36031925dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29932 Genomic DNA. Translation: AAA35550.1. Different termination.
X72861 Genomic DNA. Translation: CAA51383.1.
X70811 mRNA. Translation: CAA50141.1.
X70812 Genomic DNA. Translation: CAA50142.1. Sequence problems.
X70812 Genomic DNA. Translation: CAA50143.1. Sequence problems.
AY487247 mRNA. Translation: AAR37414.1.
DQ104441 Genomic DNA. Translation: AAY88743.1.
BC075017 mRNA. Translation: AAH75017.1.
S53291 mRNA. Translation: AAB24837.1.
CCDSiCCDS6099.1.
PIRiI57941.
S33751. QRHUBE.
RefSeqiNP_000016.1. NM_000025.2.
UniGeneiHs.2549.

Genome annotation databases

EnsembliENST00000345060; ENSP00000343782; ENSG00000188778.
GeneIDi155.
KEGGihsa:155.
UCSCiuc003xkr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29932 Genomic DNA. Translation: AAA35550.1. Different termination.
X72861 Genomic DNA. Translation: CAA51383.1.
X70811 mRNA. Translation: CAA50141.1.
X70812 Genomic DNA. Translation: CAA50142.1. Sequence problems.
X70812 Genomic DNA. Translation: CAA50143.1. Sequence problems.
AY487247 mRNA. Translation: AAR37414.1.
DQ104441 Genomic DNA. Translation: AAY88743.1.
BC075017 mRNA. Translation: AAH75017.1.
S53291 mRNA. Translation: AAB24837.1.
CCDSiCCDS6099.1.
PIRiI57941.
S33751. QRHUBE.
RefSeqiNP_000016.1. NM_000025.2.
UniGeneiHs.2549.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CDWmodel-A1-408[»]
ProteinModelPortaliP13945.
SMRiP13945.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106664. 2 interactors.
DIPiDIP-61451N.
IntActiP13945. 3 interactors.
STRINGi9606.ENSP00000343782.

Chemistry databases

BindingDBiP13945.
ChEMBLiCHEMBL246.
DrugBankiDB00321. Amitriptyline.
DB00182. Amphetamine.
DB01102. Arbutamine.
DB00217. Bethanidine.
DB08807. Bopindolol.
DB08808. Bupranolol.
DB01407. Clenbuterol.
DB06262. Droxidopa.
DB01363. Ephedra.
DB00668. Epinephrine.
DB01288. Fenoterol.
DB01064. Isoprenaline.
DB01365. Mephentermine.
DB08893. Mirabegron.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00571. Propranolol.
DB00726. Trimipramine.
GuidetoPHARMACOLOGYi30.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP13945.

Polymorphism and mutation databases

BioMutaiADRB3.
DMDMi461604.

Proteomic databases

PaxDbiP13945.
PRIDEiP13945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345060; ENSP00000343782; ENSG00000188778.
GeneIDi155.
KEGGihsa:155.
UCSCiuc003xkr.3. human.

Organism-specific databases

CTDi155.
DisGeNETi155.
GeneCardsiADRB3.
HGNCiHGNC:288. ADRB3.
MalaCardsiADRB3.
MIMi109691. gene.
neXtProtiNX_P13945.
OpenTargetsiENSG00000188778.
PharmGKBiPA24598.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP13945.
KOiK04143.
OMAiAPIMSKW.
OrthoDBiEOG091G06VI.
PhylomeDBiP13945.
TreeFamiTF316350.

Enzyme and pathway databases

BioCyciZFISH:G66-31214-MONOMER.
ReactomeiR-HSA-390696. Adrenoceptors.
R-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiBeta-3_adrenergic_receptor.
GenomeRNAii155.
PROiP13945.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188778.
CleanExiHS_ADRB3.
ExpressionAtlasiP13945. baseline and differential.
GenevisibleiP13945. HS.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000681. ADRB3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00563. ADRENRGCB3AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADRB3_HUMAN
AccessioniPrimary (citable) accession number: P13945
Secondary accession number(s): Q4JFT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 180 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.