P13942 (COBA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-2(XI) chain

Gene names

Name:

COL11A2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1736 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
Subunit structure	Trimers composed of three different chains: alpha 1(XI), alpha 2(XI), and alpha 3(XI). Alpha 3(XI) is a post-translational modification of alpha 1(II). Alpha 1(V) can also be found instead of alpha 3(XI)=1(II).
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Domain	The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.
Post-translational modification	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. A disulfide-bonded peptide called proline/arginine-rich protein or PARP is released from the N-terminus during extracellular processing and is subsequently retained in the cartilage matrix from which it can be isolated in significant amounts.
Involvement in disease	Stickler syndrome 3 (STL3) [MIM:184840]: An autosomal dominant non-ocular form of Stickler syndrome. Classical Stickler syndrome associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders and sensorineural deafness. Ocular symptoms are absent. Robin sequence includes an opening in the roof of the mouth (a cleft palate), a large tongue (macroglossia), and a small lower jaw (micrognathia). Bones are affected by slight platyspondylisis and large, often defective epiphyses. Juvenile joint laxity is followed by early signs of arthrosis. The degree of hearing loss varies among affected individuals and may become more severe over time. Syndrome expressivity is variable. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.15 Otospondylomegaepiphyseal dysplasia (OSMED) [MIM:215150]: A skeletal dysplasia characterized by enlarged epiphyses, disproportionate shortness of the limbs, abnormalities in vertebral bodies, and sensorineural hearing loss. Patients have typical facial features, including mid-face hypoplasia with a short upturned nose and depressed nasal bridge. Cleft palate and a small mandible are also common findings. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.12 Weissenbacher-Zweymueller syndrome (WZS) [MIM:277610]: An autosomal dominant disorder characterized by neonatal micrognathia and rhizomelic chondrodysplasia with dumbbell-shaped femora and humeri, and regression of bone changes and normal growth in later years. WZS is also referred to as heterozygous OSMED. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.14 Deafness, autosomal dominant, 13 (DFNA13) [MIM:601868]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.16 Deafness, autosomal recessive, 53 (DFNB53) [MIM:609706]: A form of non-syndromic sensorineural deafness characterized by prelingual, profound, non-progressive hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.17 Fibrochondrogenesis 2 (FBCG2) [MIM:614524]: A severe skeletal dysplasia characterized by a flat midface, short long bones, short ribs with broad metaphyses, and vertebral bodies that show distinctive hypoplastic posterior ends and rounded anterior ends, giving the vertebral bodies a pinched appearance on lateral radiographic views. The chest is small, causing perinatal respiratory problems which usually, but not always, result in lethality. Affected individuals who survive the neonatal period have high myopia, mild to moderate hearing loss, and severe skeletal dysplasia. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.11
Sequence similarities	Belongs to the fibrillar collagen family. Contains 8 collagen-like domains. Contains 1 fibrillar collagen NC1 domain. Contains 1 laminin G-like domain.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Deafness Disease mutation Dwarfism Non-syndromic deafness Stickler syndrome
Domain	Collagen Repeat Signal
Ligand	Calcium Metal-binding
PTM	Disulfide bond Glycoprotein Hydroxylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cartilage development Inferred from mutant phenotype PubMed 9188673. Source: UniProtKB collagen fibril organization Inferred from direct assay PubMed 9188673. Source: UniProtKB sensory perception of sound Inferred from mutant phenotype Ref.9Ref.17PubMed 9188673. Source: UniProtKB soft palate development Inferred from mutant phenotype Ref.9. Source: UniProtKB
Cellular_component	collagen type XI Non-traceable author statement Ref.12Ref.5. Source: UniProtKB endoplasmic reticulum lumen Traceable author statement. Source: Reactome
Molecular_function	extracellular matrix structural constituent conferring tensile strength Non-traceable author statement Ref.12Ref.5. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding, bridging Non-traceable author statement Ref.9. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Note: Isoforms lack exons 6, 7 or 8 or a combination of these exons. Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: P13942-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P13942-2)

The sequence of this isoform differs from the canonical sequence as follows:
     267-292: Missing.

Isoform 3 (identifier: P13942-3)

The sequence of this isoform differs from the canonical sequence as follows:
     293-313: Missing.

Isoform 4 (identifier: P13942-4)

The sequence of this isoform differs from the canonical sequence as follows:
     314-373: Missing.

Isoform 5 (identifier: P13942-5)

The sequence of this isoform differs from the canonical sequence as follows:
     267-292: Missing.
     293-313: Missing.

Isoform 6 (identifier: P13942-6)

The sequence of this isoform differs from the canonical sequence as follows:
     267-292: Missing.
     314-373: Missing.

Isoform 7 (identifier: P13942-7)

The sequence of this isoform differs from the canonical sequence as follows:
     293-313: Missing.
     314-373: Missing.

Isoform 8 (identifier: P13942-8)

The sequence of this isoform differs from the canonical sequence as follows:
     267-292: Missing.
     293-313: Missing.
     314-373: Missing.

Isoform 9 (identifier: P13942-9)

The sequence of this isoform differs from the canonical sequence as follows:
     267-290: PTESLYYDYEPPYYDVMTTGTTPD → VRELGEPPSAAHPREGRHPGISPP
     291-1736: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 1736	1709	Collagen alpha-2(XI) chain		PRO_0000005840
	Propeptide	1501 – 1736	236	C-terminal propeptide		PRO_0000005841
Regions
	Domain	57 – 228	172	Laminin G-like
	Domain	399 – 447	49	Collagen-like 1
	Domain	487 – 545	59	Collagen-like 2
	Domain	546 – 590	45	Collagen-like 3
	Domain	805 – 862	58	Collagen-like 4
	Domain	863 – 899	37	Collagen-like 5
	Domain	1099 – 1156	58	Collagen-like 6
	Domain	1157 – 1172	16	Collagen-like 7
	Domain	1441 – 1499	59	Collagen-like 8
	Domain	1541 – 1735	195	Fibrillar collagen NC1
	Region	215 – 486	272	Nonhelical region
	Region	487 – 1500	1014	Triple-helical region
	Compositional bias	298 – 301	4	Poly-Glu
Sites
	Metal binding	1589	1	Calcium By similarity
	Metal binding	1591	1	Calcium By similarity
	Metal binding	1592	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	1594	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	1597	1	Calcium By similarity
Amino acid modifications
	Glycosylation	1604	1	N-linked (GlcNAc...) Potential
	Disulfide bond	1571 ↔ 1603		By similarity
	Disulfide bond	1577		Interchain By similarity
	Disulfide bond	1594		Interchain By similarity
	Disulfide bond	1612 ↔ 1733		By similarity
	Disulfide bond	1655 ↔ 1689		By similarity
Natural variations
	Alternative sequence	267 – 292	26	Missing in isoform 2, isoform 5, isoform 6 and isoform 8.		VSP_001167
	Alternative sequence	267 – 290	24	PTESL…GTTPD → VRELGEPPSAAHPREGRHPG ISPP in isoform 9.		VSP_043432
	Alternative sequence	291 – 1736	1446	Missing in isoform 9.		VSP_043433
	Alternative sequence	293 – 313	21	Missing in isoform 3, isoform 5, isoform 7 and isoform 8.		VSP_001168
	Alternative sequence	314 – 373	60	Missing in isoform 4, isoform 6, isoform 7 and isoform 8.		VSP_001169
	Natural variant	236	1	P → S. Corresponds to variant rs35116188 [ dbSNP | Ensembl ].		VAR_048804
	Natural variant	276	1	E → K. Corresponds to variant rs9277934 [ dbSNP | Ensembl ].		VAR_048805
	Natural variant	593	1	D → G. Ref.13		VAR_013591
	Natural variant	621	1	P → T in DFNB53. Ref.17		VAR_025276
	Natural variant	661	1	G → R in OSMED. Ref.12		VAR_001907
	Natural variant	808	1	G → E in DFNA13. Ref.16		VAR_010655
	Natural variant	824	1	E → K. Ref.13 Corresponds to variant rs1799909 [ dbSNP | Ensembl ].		VAR_013592
	Natural variant	879	1	P → L. Ref.13		VAR_013593
	Natural variant	894	1	L → P. Corresponds to variant rs2855430 [ dbSNP | Ensembl ].		VAR_048806
	Natural variant	940 – 948	9	Missing in STL3.		VAR_013594
	Natural variant	1034	1	R → C in DFNA13. Ref.16		VAR_010656
	Natural variant	1316	1	P → T. Ref.13 Corresponds to variant rs2229784 [ dbSNP | Ensembl ].		VAR_013596
	Natural variant	1441	1	G → E in WZS. Ref.14		VAR_013595
	Natural variant	1600	1	R → Q. Ref.13 Corresponds to variant rs1799912 [ dbSNP | Ensembl ].		VAR_013597
	Natural variant	1628	1	E → D. Corresponds to variant rs2229790 [ dbSNP | Ensembl ].		VAR_033797
	Natural variant	1722	1	P → L. Corresponds to variant rs2229792 [ dbSNP | Ensembl ].		VAR_048807
Experimental info
	Sequence conflict	7	1	C → G in AAC50213. Ref.1
	Sequence conflict	7	1	C → G in AAC50214. Ref.1
	Sequence conflict	7	1	C → G in AAC50215. Ref.1
	Sequence conflict	85	1	S → P in AAC17464. Ref.5
	Sequence conflict	85	1	S → P in AAA35498. Ref.6
	Sequence conflict	97	1	Q → R in AAC17464. Ref.5
	Sequence conflict	97	1	Q → R in AAA35498. Ref.6
	Sequence conflict	530 – 531	2	PP → SL in AAC50213. Ref.1
	Sequence conflict	530 – 531	2	PP → SL in AAC50214. Ref.1
	Sequence conflict	530 – 531	2	PP → SL in AAC50215. Ref.1
	Sequence conflict	530 – 531	2	PP → SL in AAC17464. Ref.5
	Sequence conflict	530 – 531	2	PP → SL in AAA35498. Ref.6
	Sequence conflict	542	1	A → P in AAA35498. Ref.6
	Sequence conflict	548 – 549	2	MP → TL in AAA35498. Ref.6
	Sequence conflict	578 – 579	2	AQ → PR in AAA35498. Ref.6
	Sequence conflict	704 – 705	2	NQ → KP in AAA35498. Ref.6
	Sequence conflict	720	1	R → Q in AAA35498. Ref.6
	Sequence conflict	726	1	D → N in AAA35498. Ref.6
	Sequence conflict	843 – 846	4	TGPR → HGST in AAA52034. Ref.7
	Sequence conflict	882 – 884	3	QGP → SGS in AAA52034. Ref.7
	Sequence conflict	1031 – 1032	2	PP → RQ in AAC50213. Ref.1
	Sequence conflict	1031 – 1032	2	PP → RQ in AAC50214. Ref.1
	Sequence conflict	1031 – 1032	2	PP → RQ in AAC50215. Ref.1
	Sequence conflict	1031 – 1032	2	PP → RQ in AAA52034. Ref.7
	Sequence conflict	1091	1	D → V in AAA52034. Ref.7
	Sequence conflict	1124	1	A → R in AAA52034. Ref.7
	Sequence conflict	1127 – 1133	7	EPGARGP → GAGGLGT in AAA52034. Ref.7
	Sequence conflict	1253	1	P → A in AAC50213. Ref.1
	Sequence conflict	1253	1	P → A in AAC50214. Ref.1
	Sequence conflict	1253	1	P → A in AAC50215. Ref.1
	Sequence conflict	1253	1	P → A in AAA52034. Ref.7
	Sequence conflict	1257	1	T → Q in AAC50213. Ref.1
	Sequence conflict	1257	1	T → Q in AAC50214. Ref.1
	Sequence conflict	1257	1	T → Q in AAC50215. Ref.1
	Sequence conflict	1257	1	T → Q in AAA52034. Ref.7
	Sequence conflict	1552	1	E → R in AAA52034. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 25, 2012. Version 5. Checksum: D687B7AAD6A7774C	FASTA	1,736	171,791
	10 20 30 40 50 60 MERCSRCHRL LLLLPLVLGL SAAPGWAGAP PVDVLRALRF PSLPDGVRRA KGICPADVAY 70 80 90 100 110 120 RVARPAQLSA PTRQLFPGGF PKDFSLLTVV RTRPGLQAPL LTLYSAQGVR QLGLELGRPV 130 140 150 160 170 180 RFLYEDQTGR PQPPSQPVFR GLSLADGKWH RVAVAVKGQS VTLIVDCKKR VTRPLPRSAR 190 200 210 220 230 240 PVLDTHGVII FGARILDEEV FEGDVQELAI VPGVQAAYES CEQKELECEG GQRERPQNQQ 250 260 270 280 290 300 PHRAQRSPQQ QPSRLHRPQN QEPQSQPTES LYYDYEPPYY DVMTTGTTPD YQDPTPGEEE 310 320 330 340 350 360 EILESSLLPP LEEEQTDLQV PPTADRFQAE EYGEGGTDPP EGPYDYTYGY GDDYREETEL 370 380 390 400 410 420 GPALSAETAH SGAAAHGPRG LKGEKGEPAV LEPGMLVEGP PGPEGPAGLI GPPGIQGNPG 430 440 450 460 470 480 PVGDPGERGP PGRAGLPGSD GAPGPPGTSL MLPFRFGSGG GDKGPVVAAQ EAQAQAILQQ 490 500 510 520 530 540 ARLALRGPPG PMGYTGRPGP LGQPGSPGLK GESGDLGPQG PRGPQGLTGP PGKAGRRGRA 550 560 570 580 590 600 GADGARGMPG DPGVKGDRGF DGLPGLPGEK GHRGDTGAQG LPGPPGEDGE RGDDGEIGPR 610 620 630 640 650 660 GLPGESGPRG LLGPKGPPGI PGPPGVRGMD GPQGPKGSLG PQGEPGPPGQ QGTPGTQGLP 670 680 690 700 710 720 GPQGAIGPHG EKGPQGKPGL PGMPGSDGPP GHPGKEGPPG TKGNQGPSGP QGPLGYPGPR 730 740 750 760 770 780 GVKGVDGIRG LKGHKGEKGE DGFPGFKGDI GVKGDRGEVG VPGSRGEDGP EGPKGRTGPT 790 800 810 820 830 840 GDPGPPGLMG EKGKLGVPGL PGYPGRQGPK GSLGFPGFPG ASGEKGARGL SGKSGPRGER 850 860 870 880 890 900 GPTGPRGQRG PRGATGKSGA KGTSGGDGPH GPPGERGLPG PQGPNGFPGP KGPLGPPGKD 910 920 930 940 950 960 GLPGHPGQRG EVGFQGKTGP PGPPGVVGPQ GAAGETGPMG ERGHPGPPGP PGEQGLPGTA 970 980 990 1000 1010 1020 GKEGTKGDPG PPGAPGKDGP AGLRGFPGER GLPGTAGGPG LKGNEGPSGP PGPAGSPGER 1030 1040 1050 1060 1070 1080 GAAGSGGPIG PPGRPGPQGP PGAAGEKGVP GEKGPIGPTG RDGVQGPVGL PGPAGPPGVA 1090 1100 1110 1120 1130 1140 GEDGDKGEVG DPGQKGTKGN KGEHGPPGPP GPIGPVGQPG AAGADGEPGA RGPQGHFGAK 1150 1160 1170 1180 1190 1200 GDEGTRGFNG PPGPIGLQGL PGPSGEKGET GDVGPMGPPG PPGPRGPAGP NGADGPQGPP 1210 1220 1230 1240 1250 1260 GGVGNLGPPG EKGEPGESGS PGIQGEPGVK GPRGERGEKG ESGQPGEPGP PGPKGPTGDD 1270 1280 1290 1300 1310 1320 GPKGNPGPVG FPGDPGPPGE GGPRGQDGAK GDRGEDGEPG QPGSPGPTGE NGPPGPLGKR 1330 1340 1350 1360 1370 1380 GPAGSPGSEG RQGGKGAKGD PGAIGAPGKT GPVGPAGPAG KPGPDGLRGL PGSVGQQGRP 1390 1400 1410 1420 1430 1440 GATGQAGPPG PVGPPGLPGL RGDAGAKGEK GHPGLIGLIG PPGEQGEKGD RGLPGPQGSP 1450 1460 1470 1480 1490 1500 GQKGEMGIPG ASGPIGPGGP PGLPGPAGPK GAKGATGPGG PKGEKGVQGP PGHPGPPGEV 1510 1520 1530 1540 1550 1560 IQPLPIQMPK KTRRSVDGSR LMQEDEAIPT GGAPGSPGGL EEIFGSLDSL REEIEQMRRP 1570 1580 1590 1600 1610 1620 TGTQDSPART CQDLKLCHPE LPDGEYWVDP NQGCARDAFR VFCNFTAGGE TCVTPRDDVT 1630 1640 1650 1660 1670 1680 QFSYVDSEGS PVGVVQLTFL RLLSVSAHQD VSYPCSGAAR DGPLRLRGAN EDELSPETSP 1690 1700 1710 1720 1730 YVKEFRDGCQ TQQGRTVLEV RTPVLEQLPV LDASFSDLGA PPRRGGVLLG PVCFMG
	Isoform 2 [UniParc]. Checksum: A2EDA1C81EEA9D22	FASTA	1,710	168,698
	10 20 30 40 50 60 MERCSRCHRL LLLLPLVLGL SAAPGWAGAP PVDVLRALRF PSLPDGVRRA KGICPADVAY 70 80 90 100 110 120 RVARPAQLSA PTRQLFPGGF PKDFSLLTVV RTRPGLQAPL LTLYSAQGVR QLGLELGRPV 130 140 150 160 170 180 RFLYEDQTGR PQPPSQPVFR GLSLADGKWH RVAVAVKGQS VTLIVDCKKR VTRPLPRSAR 190 200 210 220 230 240 PVLDTHGVII FGARILDEEV FEGDVQELAI VPGVQAAYES CEQKELECEG GQRERPQNQQ 250 260 270 280 290 300 PHRAQRSPQQ QPSRLHRPQN QEPQSQDPTP GEEEEILESS LLPPLEEEQT DLQVPPTADR 310 320 330 340 350 360 FQAEEYGEGG TDPPEGPYDY TYGYGDDYRE ETELGPALSA ETAHSGAAAH GPRGLKGEKG 370 380 390 400 410 420 EPAVLEPGML VEGPPGPEGP AGLIGPPGIQ GNPGPVGDPG ERGPPGRAGL PGSDGAPGPP 430 440 450 460 470 480 GTSLMLPFRF GSGGGDKGPV VAAQEAQAQA ILQQARLALR GPPGPMGYTG RPGPLGQPGS 490 500 510 520 530 540 PGLKGESGDL GPQGPRGPQG LTGPPGKAGR RGRAGADGAR GMPGDPGVKG DRGFDGLPGL 550 560 570 580 590 600 PGEKGHRGDT GAQGLPGPPG EDGERGDDGE IGPRGLPGES GPRGLLGPKG PPGIPGPPGV 610 620 630 640 650 660 RGMDGPQGPK GSLGPQGEPG PPGQQGTPGT QGLPGPQGAI GPHGEKGPQG KPGLPGMPGS 670 680 690 700 710 720 DGPPGHPGKE GPPGTKGNQG PSGPQGPLGY PGPRGVKGVD GIRGLKGHKG EKGEDGFPGF 730 740 750 760 770 780 KGDIGVKGDR GEVGVPGSRG EDGPEGPKGR TGPTGDPGPP GLMGEKGKLG VPGLPGYPGR 790 800 810 820 830 840 QGPKGSLGFP GFPGASGEKG ARGLSGKSGP RGERGPTGPR GQRGPRGATG KSGAKGTSGG 850 860 870 880 890 900 DGPHGPPGER GLPGPQGPNG FPGPKGPLGP PGKDGLPGHP GQRGEVGFQG KTGPPGPPGV 910 920 930 940 950 960 VGPQGAAGET GPMGERGHPG PPGPPGEQGL PGTAGKEGTK GDPGPPGAPG KDGPAGLRGF 970 980 990 1000 1010 1020 PGERGLPGTA GGPGLKGNEG PSGPPGPAGS PGERGAAGSG GPIGPPGRPG PQGPPGAAGE 1030 1040 1050 1060 1070 1080 KGVPGEKGPI GPTGRDGVQG PVGLPGPAGP PGVAGEDGDK GEVGDPGQKG TKGNKGEHGP 1090 1100 1110 1120 1130 1140 PGPPGPIGPV GQPGAAGADG EPGARGPQGH FGAKGDEGTR GFNGPPGPIG LQGLPGPSGE 1150 1160 1170 1180 1190 1200 KGETGDVGPM GPPGPPGPRG PAGPNGADGP QGPPGGVGNL GPPGEKGEPG ESGSPGIQGE 1210 1220 1230 1240 1250 1260 PGVKGPRGER GEKGESGQPG EPGPPGPKGP TGDDGPKGNP GPVGFPGDPG PPGEGGPRGQ 1270 1280 1290 1300 1310 1320 DGAKGDRGED GEPGQPGSPG PTGENGPPGP LGKRGPAGSP GSEGRQGGKG AKGDPGAIGA 1330 1340 1350 1360 1370 1380 PGKTGPVGPA GPAGKPGPDG LRGLPGSVGQ QGRPGATGQA GPPGPVGPPG LPGLRGDAGA 1390 1400 1410 1420 1430 1440 KGEKGHPGLI GLIGPPGEQG EKGDRGLPGP QGSPGQKGEM GIPGASGPIG PGGPPGLPGP 1450 1460 1470 1480 1490 1500 AGPKGAKGAT GPGGPKGEKG VQGPPGHPGP PGEVIQPLPI QMPKKTRRSV DGSRLMQEDE 1510 1520 1530 1540 1550 1560 AIPTGGAPGS PGGLEEIFGS LDSLREEIEQ MRRPTGTQDS PARTCQDLKL CHPELPDGEY 1570 1580 1590 1600 1610 1620 WVDPNQGCAR DAFRVFCNFT AGGETCVTPR DDVTQFSYVD SEGSPVGVVQ LTFLRLLSVS 1630 1640 1650 1660 1670 1680 AHQDVSYPCS GAARDGPLRL RGANEDELSP ETSPYVKEFR DGCQTQQGRT VLEVRTPVLE 1690 1700 1710 QLPVLDASFS DLGAPPRRGG VLLGPVCFMG
	Isoform 3 [UniParc]. Checksum: 2362B2D6508A0C24	FASTA	1,715	169,485
	10 20 30 40 50 60 MERCSRCHRL LLLLPLVLGL SAAPGWAGAP PVDVLRALRF PSLPDGVRRA KGICPADVAY 70 80 90 100 110 120 RVARPAQLSA PTRQLFPGGF PKDFSLLTVV RTRPGLQAPL LTLYSAQGVR QLGLELGRPV 130 140 150 160 170 180 RFLYEDQTGR PQPPSQPVFR GLSLADGKWH RVAVAVKGQS VTLIVDCKKR VTRPLPRSAR 190 200 210 220 230 240 PVLDTHGVII FGARILDEEV FEGDVQELAI VPGVQAAYES CEQKELECEG GQRERPQNQQ 250 260 270 280 290 300 PHRAQRSPQQ QPSRLHRPQN QEPQSQPTES LYYDYEPPYY DVMTTGTTPD YQEQTDLQVP 310 320 330 340 350 360 PTADRFQAEE YGEGGTDPPE GPYDYTYGYG DDYREETELG PALSAETAHS GAAAHGPRGL 370 380 390 400 410 420 KGEKGEPAVL EPGMLVEGPP GPEGPAGLIG PPGIQGNPGP VGDPGERGPP GRAGLPGSDG 430 440 450 460 470 480 APGPPGTSLM LPFRFGSGGG DKGPVVAAQE AQAQAILQQA RLALRGPPGP MGYTGRPGPL 490 500 510 520 530 540 GQPGSPGLKG ESGDLGPQGP RGPQGLTGPP GKAGRRGRAG ADGARGMPGD PGVKGDRGFD 550 560 570 580 590 600 GLPGLPGEKG HRGDTGAQGL PGPPGEDGER GDDGEIGPRG LPGESGPRGL LGPKGPPGIP 610 620 630 640 650 660 GPPGVRGMDG PQGPKGSLGP QGEPGPPGQQ GTPGTQGLPG PQGAIGPHGE KGPQGKPGLP 670 680 690 700 710 720 GMPGSDGPPG HPGKEGPPGT KGNQGPSGPQ GPLGYPGPRG VKGVDGIRGL KGHKGEKGED 730 740 750 760 770 780 GFPGFKGDIG VKGDRGEVGV PGSRGEDGPE GPKGRTGPTG DPGPPGLMGE KGKLGVPGLP 790 800 810 820 830 840 GYPGRQGPKG SLGFPGFPGA SGEKGARGLS GKSGPRGERG PTGPRGQRGP RGATGKSGAK 850 860 870 880 890 900 GTSGGDGPHG PPGERGLPGP QGPNGFPGPK GPLGPPGKDG LPGHPGQRGE VGFQGKTGPP 910 920 930 940 950 960 GPPGVVGPQG AAGETGPMGE RGHPGPPGPP GEQGLPGTAG KEGTKGDPGP PGAPGKDGPA 970 980 990 1000 1010 1020 GLRGFPGERG LPGTAGGPGL KGNEGPSGPP GPAGSPGERG AAGSGGPIGP PGRPGPQGPP 1030 1040 1050 1060 1070 1080 GAAGEKGVPG EKGPIGPTGR DGVQGPVGLP GPAGPPGVAG EDGDKGEVGD PGQKGTKGNK 1090 1100 1110 1120 1130 1140 GEHGPPGPPG PIGPVGQPGA AGADGEPGAR GPQGHFGAKG DEGTRGFNGP PGPIGLQGLP 1150 1160 1170 1180 1190 1200 GPSGEKGETG DVGPMGPPGP PGPRGPAGPN GADGPQGPPG GVGNLGPPGE KGEPGESGSP 1210 1220 1230 1240 1250 1260 GIQGEPGVKG PRGERGEKGE SGQPGEPGPP GPKGPTGDDG PKGNPGPVGF PGDPGPPGEG 1270 1280 1290 1300 1310 1320 GPRGQDGAKG DRGEDGEPGQ PGSPGPTGEN GPPGPLGKRG PAGSPGSEGR QGGKGAKGDP 1330 1340 1350 1360 1370 1380 GAIGAPGKTG PVGPAGPAGK PGPDGLRGLP GSVGQQGRPG ATGQAGPPGP VGPPGLPGLR 1390 1400 1410 1420 1430 1440 GDAGAKGEKG HPGLIGLIGP PGEQGEKGDR GLPGPQGSPG QKGEMGIPGA SGPIGPGGPP 1450 1460 1470 1480 1490 1500 GLPGPAGPKG AKGATGPGGP KGEKGVQGPP GHPGPPGEVI QPLPIQMPKK TRRSVDGSRL 1510 1520 1530 1540 1550 1560 MQEDEAIPTG GAPGSPGGLE EIFGSLDSLR EEIEQMRRPT GTQDSPARTC QDLKLCHPEL 1570 1580 1590 1600 1610 1620 PDGEYWVDPN QGCARDAFRV FCNFTAGGET CVTPRDDVTQ FSYVDSEGSP VGVVQLTFLR 1630 1640 1650 1660 1670 1680 LLSVSAHQDV SYPCSGAARD GPLRLRGANE DELSPETSPY VKEFRDGCQT QQGRTVLEVR 1690 1700 1710 TPVLEQLPVL DASFSDLGAP PRRGGVLLGP VCFMG
	Isoform 4 [UniParc]. Checksum: A87540ED78D3E198	FASTA	1,676	165,293
	10 20 30 40 50 60 MERCSRCHRL LLLLPLVLGL SAAPGWAGAP PVDVLRALRF PSLPDGVRRA KGICPADVAY 70 80 90 100 110 120 RVARPAQLSA PTRQLFPGGF PKDFSLLTVV RTRPGLQAPL LTLYSAQGVR QLGLELGRPV 130 140 150 160 170 180 RFLYEDQTGR PQPPSQPVFR GLSLADGKWH RVAVAVKGQS VTLIVDCKKR VTRPLPRSAR 190 200 210 220 230 240 PVLDTHGVII FGARILDEEV FEGDVQELAI VPGVQAAYES CEQKELECEG GQRERPQNQQ 250 260 270 280 290 300 PHRAQRSPQQ QPSRLHRPQN QEPQSQPTES LYYDYEPPYY DVMTTGTTPD YQDPTPGEEE 310 320 330 340 350 360 EILESSLLPP LEEAAHGPRG LKGEKGEPAV LEPGMLVEGP PGPEGPAGLI GPPGIQGNPG 370 380 390 400 410 420 PVGDPGERGP PGRAGLPGSD GAPGPPGTSL MLPFRFGSGG GDKGPVVAAQ EAQAQAILQQ 430 440 450 460 470 480 ARLALRGPPG PMGYTGRPGP LGQPGSPGLK GESGDLGPQG PRGPQGLTGP PGKAGRRGRA 490 500 510 520 530 540 GADGARGMPG DPGVKGDRGF DGLPGLPGEK GHRGDTGAQG LPGPPGEDGE RGDDGEIGPR 550 560 570 580 590 600 GLPGESGPRG LLGPKGPPGI PGPPGVRGMD GPQGPKGSLG PQGEPGPPGQ QGTPGTQGLP 610 620 630 640 650 660 GPQGAIGPHG EKGPQGKPGL PGMPGSDGPP GHPGKEGPPG TKGNQGPSGP QGPLGYPGPR 670 680 690 700 710 720 GVKGVDGIRG LKGHKGEKGE DGFPGFKGDI GVKGDRGEVG VPGSRGEDGP EGPKGRTGPT 730 740 750 760 770 780 GDPGPPGLMG EKGKLGVPGL PGYPGRQGPK GSLGFPGFPG ASGEKGARGL SGKSGPRGER 790 800 810 820 830 840 GPTGPRGQRG PRGATGKSGA KGTSGGDGPH GPPGERGLPG PQGPNGFPGP KGPLGPPGKD 850 860 870 880 890 900 GLPGHPGQRG EVGFQGKTGP PGPPGVVGPQ GAAGETGPMG ERGHPGPPGP PGEQGLPGTA 910 920 930 940 950 960 GKEGTKGDPG PPGAPGKDGP AGLRGFPGER GLPGTAGGPG LKGNEGPSGP PGPAGSPGER 970 980 990 1000 1010 1020 GAAGSGGPIG PPGRPGPQGP PGAAGEKGVP GEKGPIGPTG RDGVQGPVGL PGPAGPPGVA 1030 1040 1050 1060 1070 1080 GEDGDKGEVG DPGQKGTKGN KGEHGPPGPP GPIGPVGQPG AAGADGEPGA RGPQGHFGAK 1090 1100 1110 1120 1130 1140 GDEGTRGFNG PPGPIGLQGL PGPSGEKGET GDVGPMGPPG PPGPRGPAGP NGADGPQGPP 1150 1160 1170 1180 1190 1200 GGVGNLGPPG EKGEPGESGS PGIQGEPGVK GPRGERGEKG ESGQPGEPGP PGPKGPTGDD 1210 1220 1230 1240 1250 1260 GPKGNPGPVG FPGDPGPPGE GGPRGQDGAK GDRGEDGEPG QPGSPGPTGE NGPPGPLGKR 1270 1280 1290 1300 1310 1320 GPAGSPGSEG RQGGKGAKGD PGAIGAPGKT GPVGPAGPAG KPGPDGLRGL PGSVGQQGRP 1330 1340 1350 1360 1370 1380 GATGQAGPPG PVGPPGLPGL RGDAGAKGEK GHPGLIGLIG PPGEQGEKGD RGLPGPQGSP 1390 1400 1410 1420 1430 1440 GQKGEMGIPG ASGPIGPGGP PGLPGPAGPK GAKGATGPGG PKGEKGVQGP PGHPGPPGEV 1450 1460 1470 1480 1490 1500 IQPLPIQMPK KTRRSVDGSR LMQEDEAIPT GGAPGSPGGL EEIFGSLDSL REEIEQMRRP 1510 1520 1530 1540 1550 1560 TGTQDSPART CQDLKLCHPE LPDGEYWVDP NQGCARDAFR VFCNFTAGGE TCVTPRDDVT 1570 1580 1590 1600 1610 1620 QFSYVDSEGS PVGVVQLTFL RLLSVSAHQD VSYPCSGAAR DGPLRLRGAN EDELSPETSP 1630 1640 1650 1660 1670 YVKEFRDGCQ TQQGRTVLEV RTPVLEQLPV LDASFSDLGA PPRRGGVLLG PVCFMG
	Isoform 5 [UniParc]. Checksum: D53384E69D99D454	FASTA	1,689	166,393
	10 20 30 40 50 60 MERCSRCHRL LLLLPLVLGL SAAPGWAGAP PVDVLRALRF PSLPDGVRRA KGICPADVAY 70 80 90 100 110 120 RVARPAQLSA PTRQLFPGGF PKDFSLLTVV RTRPGLQAPL LTLYSAQGVR QLGLELGRPV 130 140 150 160 170 180 RFLYEDQTGR PQPPSQPVFR GLSLADGKWH RVAVAVKGQS VTLIVDCKKR VTRPLPRSAR 190 200 210 220 230 240 PVLDTHGVII FGARILDEEV FEGDVQELAI VPGVQAAYES CEQKELECEG GQRERPQNQQ 250 260 270 280 290 300 PHRAQRSPQQ QPSRLHRPQN QEPQSQEQTD LQVPPTADRF QAEEYGEGGT DPPEGPYDYT 310 320 330 340 350 360 YGYGDDYREE TELGPALSAE TAHSGAAAHG PRGLKGEKGE PAVLEPGMLV EGPPGPEGPA 370 380 390 400 410 420 GLIGPPGIQG NPGPVGDPGE RGPPGRAGLP GSDGAPGPPG TSLMLPFRFG SGGGDKGPVV 430 440 450 460 470 480 AAQEAQAQAI LQQARLALRG PPGPMGYTGR PGPLGQPGSP GLKGESGDLG PQGPRGPQGL 490 500 510 520 530 540 TGPPGKAGRR GRAGADGARG MPGDPGVKGD RGFDGLPGLP GEKGHRGDTG AQGLPGPPGE 550 560 570 580 590 600 DGERGDDGEI GPRGLPGESG PRGLLGPKGP PGIPGPPGVR GMDGPQGPKG SLGPQGEPGP 610 620 630 640 650 660 PGQQGTPGTQ GLPGPQGAIG PHGEKGPQGK PGLPGMPGSD GPPGHPGKEG PPGTKGNQGP 670 680 690 700 710 720 SGPQGPLGYP GPRGVKGVDG IRGLKGHKGE KGEDGFPGFK GDIGVKGDRG EVGVPGSRGE 730 740 750 760 770 780 DGPEGPKGRT GPTGDPGPPG LMGEKGKLGV PGLPGYPGRQ GPKGSLGFPG FPGASGEKGA 790 800 810 820 830 840 RGLSGKSGPR GERGPTGPRG QRGPRGATGK SGAKGTSGGD GPHGPPGERG LPGPQGPNGF 850 860 870 880 890 900 PGPKGPLGPP GKDGLPGHPG QRGEVGFQGK TGPPGPPGVV GPQGAAGETG PMGERGHPGP 910 920 930 940 950 960 PGPPGEQGLP GTAGKEGTKG DPGPPGAPGK DGPAGLRGFP GERGLPGTAG GPGLKGNEGP 970 980 990 1000 1010 1020 SGPPGPAGSP GERGAAGSGG PIGPPGRPGP QGPPGAAGEK GVPGEKGPIG PTGRDGVQGP 1030 1040 1050 1060 1070 1080 VGLPGPAGPP GVAGEDGDKG EVGDPGQKGT KGNKGEHGPP GPPGPIGPVG QPGAAGADGE 1090 1100 1110 1120 1130 1140 PGARGPQGHF GAKGDEGTRG FNGPPGPIGL QGLPGPSGEK GETGDVGPMG PPGPPGPRGP 1150 1160 1170 1180 1190 1200 AGPNGADGPQ GPPGGVGNLG PPGEKGEPGE SGSPGIQGEP GVKGPRGERG EKGESGQPGE 1210 1220 1230 1240 1250 1260 PGPPGPKGPT GDDGPKGNPG PVGFPGDPGP PGEGGPRGQD GAKGDRGEDG EPGQPGSPGP 1270 1280 1290 1300 1310 1320 TGENGPPGPL GKRGPAGSPG SEGRQGGKGA KGDPGAIGAP GKTGPVGPAG PAGKPGPDGL 1330 1340 1350 1360 1370 1380 RGLPGSVGQQ GRPGATGQAG PPGPVGPPGL PGLRGDAGAK GEKGHPGLIG LIGPPGEQGE 1390 1400 1410 1420 1430 1440 KGDRGLPGPQ GSPGQKGEMG IPGASGPIGP GGPPGLPGPA GPKGAKGATG PGGPKGEKGV 1450 1460 1470 1480 1490 1500 QGPPGHPGPP GEVIQPLPIQ MPKKTRRSVD GSRLMQEDEA IPTGGAPGSP GGLEEIFGSL 1510 1520 1530 1540 1550 1560 DSLREEIEQM RRPTGTQDSP ARTCQDLKLC HPELPDGEYW VDPNQGCARD AFRVFCNFTA 1570 1580 1590 1600 1610 1620 GGETCVTPRD DVTQFSYVDS EGSPVGVVQL TFLRLLSVSA HQDVSYPCSG AARDGPLRLR 1630 1640 1650 1660 1670 1680 GANEDELSPE TSPYVKEFRD GCQTQQGRTV LEVRTPVLEQ LPVLDASFSD LGAPPRRGGV LLGPVCFMG
	Isoform 6 [UniParc]. Checksum: 1ECC3F4C92956F3F	FASTA	1,650	162,201
	10 20 30 40 50 60 MERCSRCHRL LLLLPLVLGL SAAPGWAGAP PVDVLRALRF PSLPDGVRRA KGICPADVAY 70 80 90 100 110 120 RVARPAQLSA PTRQLFPGGF PKDFSLLTVV RTRPGLQAPL LTLYSAQGVR QLGLELGRPV 130 140 150 160 170 180 RFLYEDQTGR PQPPSQPVFR GLSLADGKWH RVAVAVKGQS VTLIVDCKKR VTRPLPRSAR 190 200 210 220 230 240 PVLDTHGVII FGARILDEEV FEGDVQELAI VPGVQAAYES CEQKELECEG GQRERPQNQQ 250 260 270 280 290 300 PHRAQRSPQQ QPSRLHRPQN QEPQSQDPTP GEEEEILESS LLPPLEEAAH GPRGLKGEKG 310 320 330 340 350 360 EPAVLEPGML VEGPPGPEGP AGLIGPPGIQ GNPGPVGDPG ERGPPGRAGL PGSDGAPGPP 370 380 390 400 410 420 GTSLMLPFRF GSGGGDKGPV VAAQEAQAQA ILQQARLALR GPPGPMGYTG RPGPLGQPGS 430 440 450 460 470 480 PGLKGESGDL GPQGPRGPQG LTGPPGKAGR RGRAGADGAR GMPGDPGVKG DRGFDGLPGL 490 500 510 520 530 540 PGEKGHRGDT GAQGLPGPPG EDGERGDDGE IGPRGLPGES GPRGLLGPKG PPGIPGPPGV 550 560 570 580 590 600 RGMDGPQGPK GSLGPQGEPG PPGQQGTPGT QGLPGPQGAI GPHGEKGPQG KPGLPGMPGS 610 620 630 640 650 660 DGPPGHPGKE GPPGTKGNQG PSGPQGPLGY PGPRGVKGVD GIRGLKGHKG EKGEDGFPGF 670 680 690 700 710 720 KGDIGVKGDR GEVGVPGSRG EDGPEGPKGR TGPTGDPGPP GLMGEKGKLG VPGLPGYPGR 730 740 750 760 770 780 QGPKGSLGFP GFPGASGEKG ARGLSGKSGP RGERGPTGPR GQRGPRGATG KSGAKGTSGG 790 800 810 820 830 840 DGPHGPPGER GLPGPQGPNG FPGPKGPLGP PGKDGLPGHP GQRGEVGFQG KTGPPGPPGV 850 860 870 880 890 900 VGPQGAAGET GPMGERGHPG PPGPPGEQGL PGTAGKEGTK GDPGPPGAPG KDGPAGLRGF 910 920 930 940 950 960 PGERGLPGTA GGPGLKGNEG PSGPPGPAGS PGERGAAGSG GPIGPPGRPG PQGPPGAAGE 970 980 990 1000 1010 1020 KGVPGEKGPI GPTGRDGVQG PVGLPGPAGP PGVAGEDGDK GEVGDPGQKG TKGNKGEHGP 1030 1040 1050 1060 1070 1080 PGPPGPIGPV GQPGAAGADG EPGARGPQGH FGAKGDEGTR GFNGPPGPIG LQGLPGPSGE 1090 1100 1110 1120 1130 1140 KGETGDVGPM GPPGPPGPRG PAGPNGADGP QGPPGGVGNL GPPGEKGEPG ESGSPGIQGE 1150 1160 1170 1180 1190 1200 PGVKGPRGER GEKGESGQPG EPGPPGPKGP TGDDGPKGNP GPVGFPGDPG PPGEGGPRGQ 1210 1220 1230 1240 1250 1260 DGAKGDRGED GEPGQPGSPG PTGENGPPGP LGKRGPAGSP GSEGRQGGKG AKGDPGAIGA 1270 1280 1290 1300 1310 1320 PGKTGPVGPA GPAGKPGPDG LRGLPGSVGQ QGRPGATGQA GPPGPVGPPG LPGLRGDAGA 1330 1340 1350 1360 1370 1380 KGEKGHPGLI GLIGPPGEQG EKGDRGLPGP QGSPGQKGEM GIPGASGPIG PGGPPGLPGP 1390 1400 1410 1420 1430 1440 AGPKGAKGAT GPGGPKGEKG VQGPPGHPGP PGEVIQPLPI QMPKKTRRSV DGSRLMQEDE 1450 1460 1470 1480 1490 1500 AIPTGGAPGS PGGLEEIFGS LDSLREEIEQ MRRPTGTQDS PARTCQDLKL CHPELPDGEY 1510 1520 1530 1540 1550 1560 WVDPNQGCAR DAFRVFCNFT AGGETCVTPR DDVTQFSYVD SEGSPVGVVQ LTFLRLLSVS 1570 1580 1590 1600 1610 1620 AHQDVSYPCS GAARDGPLRL RGANEDELSP ETSPYVKEFR DGCQTQQGRT VLEVRTPVLE 1630 1640 1650 QLPVLDASFS DLGAPPRRGG VLLGPVCFMG
	Isoform 7 [UniParc]. Checksum: 125F75A575246E2E	FASTA	1,655	162,988
	10 20 30 40 50 60 MERCSRCHRL LLLLPLVLGL SAAPGWAGAP PVDVLRALRF PSLPDGVRRA KGICPADVAY 70 80 90 100 110 120 RVARPAQLSA PTRQLFPGGF PKDFSLLTVV RTRPGLQAPL LTLYSAQGVR QLGLELGRPV 130 140 150 160 170 180 RFLYEDQTGR PQPPSQPVFR GLSLADGKWH RVAVAVKGQS VTLIVDCKKR VTRPLPRSAR 190 200 210 220 230 240 PVLDTHGVII FGARILDEEV FEGDVQELAI VPGVQAAYES CEQKELECEG GQRERPQNQQ 250 260 270 280 290 300 PHRAQRSPQQ QPSRLHRPQN QEPQSQPTES LYYDYEPPYY DVMTTGTTPD YQAAHGPRGL 310 320 330 340 350 360 KGEKGEPAVL EPGMLVEGPP GPEGPAGLIG PPGIQGNPGP VGDPGERGPP GRAGLPGSDG 370 380 390 400 410 420 APGPPGTSLM LPFRFGSGGG DKGPVVAAQE AQAQAILQQA RLALRGPPGP MGYTGRPGPL 430 440 450 460 470 480 GQPGSPGLKG ESGDLGPQGP RGPQGLTGPP GKAGRRGRAG ADGARGMPGD PGVKGDRGFD 490 500 510 520 530 540 GLPGLPGEKG HRGDTGAQGL PGPPGEDGER GDDGEIGPRG LPGESGPRGL LGPKGPPGIP 550 560 570 580 590 600 GPPGVRGMDG PQGPKGSLGP QGEPGPPGQQ GTPGTQGLPG PQGAIGPHGE KGPQGKPGLP 610 620 630 640 650 660 GMPGSDGPPG HPGKEGPPGT KGNQGPSGPQ GPLGYPGPRG VKGVDGIRGL KGHKGEKGED 670 680 690 700 710 720 GFPGFKGDIG VKGDRGEVGV PGSRGEDGPE GPKGRTGPTG DPGPPGLMGE KGKLGVPGLP 730 740 750 760 770 780 GYPGRQGPKG SLGFPGFPGA SGEKGARGLS GKSGPRGERG PTGPRGQRGP RGATGKSGAK 790 800 810 820 830 840 GTSGGDGPHG PPGERGLPGP QGPNGFPGPK GPLGPPGKDG LPGHPGQRGE VGFQGKTGPP 850 860 870 880 890 900 GPPGVVGPQG AAGETGPMGE RGHPGPPGPP GEQGLPGTAG KEGTKGDPGP PGAPGKDGPA 910 920 930 940 950 960 GLRGFPGERG LPGTAGGPGL KGNEGPSGPP GPAGSPGERG AAGSGGPIGP PGRPGPQGPP 970 980 990 1000 1010 1020 GAAGEKGVPG EKGPIGPTGR DGVQGPVGLP GPAGPPGVAG EDGDKGEVGD PGQKGTKGNK 1030 1040 1050 1060 1070 1080 GEHGPPGPPG PIGPVGQPGA AGADGEPGAR GPQGHFGAKG DEGTRGFNGP PGPIGLQGLP 1090 1100 1110 1120 1130 1140 GPSGEKGETG DVGPMGPPGP PGPRGPAGPN GADGPQGPPG GVGNLGPPGE KGEPGESGSP 1150 1160 1170 1180 1190 1200 GIQGEPGVKG PRGERGEKGE SGQPGEPGPP GPKGPTGDDG PKGNPGPVGF PGDPGPPGEG 1210 1220 1230 1240 1250 1260 GPRGQDGAKG DRGEDGEPGQ PGSPGPTGEN GPPGPLGKRG PAGSPGSEGR QGGKGAKGDP 1270 1280 1290 1300 1310 1320 GAIGAPGKTG PVGPAGPAGK PGPDGLRGLP GSVGQQGRPG ATGQAGPPGP VGPPGLPGLR 1330 1340 1350 1360 1370 1380 GDAGAKGEKG HPGLIGLIGP PGEQGEKGDR GLPGPQGSPG QKGEMGIPGA SGPIGPGGPP 1390 1400 1410 1420 1430 1440 GLPGPAGPKG AKGATGPGGP KGEKGVQGPP GHPGPPGEVI QPLPIQMPKK TRRSVDGSRL 1450 1460 1470 1480 1490 1500 MQEDEAIPTG GAPGSPGGLE EIFGSLDSLR EEIEQMRRPT GTQDSPARTC QDLKLCHPEL 1510 1520 1530 1540 1550 1560 PDGEYWVDPN QGCARDAFRV FCNFTAGGET CVTPRDDVTQ FSYVDSEGSP VGVVQLTFLR 1570 1580 1590 1600 1610 1620 LLSVSAHQDV SYPCSGAARD GPLRLRGANE DELSPETSPY VKEFRDGCQT QQGRTVLEVR 1630 1640 1650 TPVLEQLPVL DASFSDLGAP PRRGGVLLGP VCFMG
	Isoform 8 [UniParc]. Checksum: 9E095488C4B3C32F	FASTA	1,629	159,895
	10 20 30 40 50 60 MERCSRCHRL LLLLPLVLGL SAAPGWAGAP PVDVLRALRF PSLPDGVRRA KGICPADVAY 70 80 90 100 110 120 RVARPAQLSA PTRQLFPGGF PKDFSLLTVV RTRPGLQAPL LTLYSAQGVR QLGLELGRPV 130 140 150 160 170 180 RFLYEDQTGR PQPPSQPVFR GLSLADGKWH RVAVAVKGQS VTLIVDCKKR VTRPLPRSAR 190 200 210 220 230 240 PVLDTHGVII FGARILDEEV FEGDVQELAI VPGVQAAYES CEQKELECEG GQRERPQNQQ 250 260 270 280 290 300 PHRAQRSPQQ QPSRLHRPQN QEPQSQAAHG PRGLKGEKGE PAVLEPGMLV EGPPGPEGPA 310 320 330 340 350 360 GLIGPPGIQG NPGPVGDPGE RGPPGRAGLP GSDGAPGPPG TSLMLPFRFG SGGGDKGPVV 370 380 390 400 410 420 AAQEAQAQAI LQQARLALRG PPGPMGYTGR PGPLGQPGSP GLKGESGDLG PQGPRGPQGL 430 440 450 460 470 480 TGPPGKAGRR GRAGADGARG MPGDPGVKGD RGFDGLPGLP GEKGHRGDTG AQGLPGPPGE 490 500 510 520 530 540 DGERGDDGEI GPRGLPGESG PRGLLGPKGP PGIPGPPGVR GMDGPQGPKG SLGPQGEPGP 550 560 570 580 590 600 PGQQGTPGTQ GLPGPQGAIG PHGEKGPQGK PGLPGMPGSD GPPGHPGKEG PPGTKGNQGP 610 620 630 640 650 660 SGPQGPLGYP GPRGVKGVDG IRGLKGHKGE KGEDGFPGFK GDIGVKGDRG EVGVPGSRGE 670 680 690 700 710 720 DGPEGPKGRT GPTGDPGPPG LMGEKGKLGV PGLPGYPGRQ GPKGSLGFPG FPGASGEKGA 730 740 750 760 770 780 RGLSGKSGPR GERGPTGPRG QRGPRGATGK SGAKGTSGGD GPHGPPGERG LPGPQGPNGF 790 800 810 820 830 840 PGPKGPLGPP GKDGLPGHPG QRGEVGFQGK TGPPGPPGVV GPQGAAGETG PMGERGHPGP 850 860 870 880 890 900 PGPPGEQGLP GTAGKEGTKG DPGPPGAPGK DGPAGLRGFP GERGLPGTAG GPGLKGNEGP 910 920 930 940 950 960 SGPPGPAGSP GERGAAGSGG PIGPPGRPGP QGPPGAAGEK GVPGEKGPIG PTGRDGVQGP 970 980 990 1000 1010 1020 VGLPGPAGPP GVAGEDGDKG EVGDPGQKGT KGNKGEHGPP GPPGPIGPVG QPGAAGADGE 1030 1040 1050 1060 1070 1080 PGARGPQGHF GAKGDEGTRG FNGPPGPIGL QGLPGPSGEK GETGDVGPMG PPGPPGPRGP 1090 1100 1110 1120 1130 1140 AGPNGADGPQ GPPGGVGNLG PPGEKGEPGE SGSPGIQGEP GVKGPRGERG EKGESGQPGE 1150 1160 1170 1180 1190 1200 PGPPGPKGPT GDDGPKGNPG PVGFPGDPGP PGEGGPRGQD GAKGDRGEDG EPGQPGSPGP 1210 1220 1230 1240 1250 1260 TGENGPPGPL GKRGPAGSPG SEGRQGGKGA KGDPGAIGAP GKTGPVGPAG PAGKPGPDGL 1270 1280 1290 1300 1310 1320 RGLPGSVGQQ GRPGATGQAG PPGPVGPPGL PGLRGDAGAK GEKGHPGLIG LIGPPGEQGE 1330 1340 1350 1360 1370 1380 KGDRGLPGPQ GSPGQKGEMG IPGASGPIGP GGPPGLPGPA GPKGAKGATG PGGPKGEKGV 1390 1400 1410 1420 1430 1440 QGPPGHPGPP GEVIQPLPIQ MPKKTRRSVD GSRLMQEDEA IPTGGAPGSP GGLEEIFGSL 1450 1460 1470 1480 1490 1500 DSLREEIEQM RRPTGTQDSP ARTCQDLKLC HPELPDGEYW VDPNQGCARD AFRVFCNFTA 1510 1520 1530 1540 1550 1560 GGETCVTPRD DVTQFSYVDS EGSPVGVVQL TFLRLLSVSA HQDVSYPCSG AARDGPLRLR 1570 1580 1590 1600 1610 1620 GANEDELSPE TSPYVKEFRD GCQTQQGRTV LEVRTPVLEQ LPVLDASFSD LGAPPRRGGV LLGPVCFMG
	Isoform 9 [UniParc]. Checksum: 7E59579056D3640F	FASTA	290	31,960
	10 20 30 40 50 60 MERCSRCHRL LLLLPLVLGL SAAPGWAGAP PVDVLRALRF PSLPDGVRRA KGICPADVAY 70 80 90 100 110 120 RVARPAQLSA PTRQLFPGGF PKDFSLLTVV RTRPGLQAPL LTLYSAQGVR QLGLELGRPV 130 140 150 160 170 180 RFLYEDQTGR PQPPSQPVFR GLSLADGKWH RVAVAVKGQS VTLIVDCKKR VTRPLPRSAR 190 200 210 220 230 240 PVLDTHGVII FGARILDEEV FEGDVQELAI VPGVQAAYES CEQKELECEG GQRERPQNQQ 250 260 270 280 290 PHRAQRSPQQ QPSRLHRPQN QEPQSQVREL GEPPSAAHPR EGRHPGISPP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human COL11A2 gene structure indicates that the gene has not evolved with the genes for the major fibrillar collagens." Vuoristo M.M., Pihlajamaa T., Vandenberg P., Prockop D.J., Ala-Kokko L. J. Biol. Chem. 270:22873-22881(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9). Tissue: Skin.
[5]	"The human alpha 2(XI) collagen gene (COL11A2): completion of coding information, identification of the promoter sequence, and precise localization within the major histocompatibility complex reveal overlap with the KE5 gene." Lui V.C., Ng L.J., Sat E.W., Cheah K.S. Genomics 32:401-412(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-537.
[6]	"Molecular cloning of PARP (proline/arginine-rich protein) from human cartilage and subsequent demonstration that PARP is a fragment of the NH2-terminal domain of the collagen alpha 2(XI) chain." Zhidkova N.I., Brewton R.G., Mayne R. FEBS Lett. 326:25-28(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 59-807. Tissue: Cartilage.
[7]	"The human alpha 2(XI) collagen (COL11A2) chain. Molecular cloning of cDNA and genomic DNA reveals characteristics of a fibrillar collagen with differences in genomic organization." Kimura T., Cheah K.S.E., Chan S.D.H., Lui V.C.H., Mattei M.-G., van der Rest M., Ono K., Solomon E., Ninomiya Y., Olsen B.R. J. Biol. Chem. 264:13910-13916(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 730-1690.
[8]	"Alternative mRNA processing occurs in the variable region of the pro-alpha 1(XI) and pro-alpha 2(XI) collagen chains." Zhidkova N.I., Justice S.K., Mayne R. J. Biol. Chem. 270:9486-9493(1995) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING.
[9]	"Autosomal recessive disorder otospondylomegaepiphyseal dysplasia is associated with loss-of-function mutations in the COL11A2 gene." Melkoniemi M., Brunner H.G., Manouvrier S., Hennekam R.C.M., Superti-Furga A., Kaeaeriaeinen H., Pauli R.M., van Essen T., Warman M.L., Bonaventure J., Miny P., Ala-Kokko L. Am. J. Hum. Genet. 66:368-377(2000) [PubMed] [Europe PMC] [Abstract] Cited for: DISEASE.
[10]	"Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels." Kuivaniemi H., Tromp G., Prockop D.J. Hum. Mutat. 9:300-315(1997) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW ON VARIANTS.
[11]	"Dominant and recessive forms of fibrochondrogenesis resulting from mutations at a second locus, COL11A2." Tompson S.W., Faqeih E.A., Ala-Kokko L., Hecht J.T., Miki R., Funari T., Funari V.A., Nevarez L., Krakow D., Cohn D.H. Am. J. Med. Genet. A 158:309-314(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN FBCG2.
[12]	"Autosomal dominant and recessive osteochondrodysplasias associated with the COL11A2 locus." Vikkula M., Mariman E.C.M., Lui V.C.H., Zhidkova N.I., Tiller G.E., Goldring M.B., van Beersum S.E.C., de Waal Malefijt M.C., van den Hoogen F.H.J., Ropers H.-H., Mayne R., Cheah K.S.E., Olsen B.R., Warman M.L., Brunner H.G. Cell 80:431-437(1995) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT OSMED ARG-661.
[13]	"Genetic mapping of ossification of the posterior longitudinal ligament of the spine." Koga H., Sakou T., Taketomi E., Hayashi K., Numasawa T., Harata S., Yone K., Matsunaga S., Otterud B., Inoue I., Leppert M. Am. J. Hum. Genet. 62:1460-1467(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS GLY-593; LYS-824; LEU-879; THR-1316 AND GLN-1600.
[14]	"Heterozygous glycine substitution in the COL11A2 gene in the original patient with the Weissenbacher-Zweymueller syndrome demonstrates its identity with heterozygous OSMED (nonocular Stickler syndrome)." Pihlajamaa T., Prockop D.J., Faber J., Winterpacht A., Zabel B., Giedion A., Wiesbauer P., Spranger J., Ala-Kokko L. Am. J. Med. Genet. 80:115-120(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT WZS GLU-1441.
[15]	"Stickler syndrome without eye involvement is caused by mutations in COL11A2, the gene encoding the alpha-2(XI) chain of type XI collagen." Sirko-Osadsa D.A., Murray M.A., Scott J.A., Lavery M.A., Warman M.L., Robin N.H. J. Pediatr. 132:368-371(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT STL3 940-GLY--PRO-948 DEL.
[16]	"Mutations in COL11A2 cause non-syndromic hearing loss (DFNA13)." McGuirt W.T., Prasad S.D., Griffith A.J., Kunst H.P.M., Green G.E., Shpargel K.B., Runge C., Huybrechts C., Mueller R.F., Lynch E., King M.-C., Brunner H.G., Cremers C.W.R.J., Takanosu M., Li S.-W., Arita M., Mayne R., Prockop D.J., Van Camp G., Smith R.J.H. Nat. Genet. 23:413-419(1999) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION TO 1031-1032, VARIANTS DFNA13 GLU-808 AND CYS-1034.
[17]	"Mutation of COL11A2 causes autosomal recessive non-syndromic hearing loss at the DFNB53 locus." Chen W., Kahrizi K., Meyer N.C., Riazalhosseini Y., Van Camp G., Najmabadi H., Smith R.J.H. J. Med. Genet. 42:E61-E61(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT DFNB53 THR-621.
+	Additional computationally mapped references.

Web resources

Hereditary hearing loss homepage

Gene page

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	U32169 Genomic DNA. Translation: AAC50213.1. U32169 Genomic DNA. Translation: AAC50214.1. U32169 Genomic DNA. Translation: AAC50215.1. AL031228 Genomic DNA. Translation: CAA20240.1. AL645940 Genomic DNA. Translation: CAI18063.2. AL662824 Genomic DNA. No translation available. AL844527 Genomic DNA. Translation: CAM25784.1. AL844527, AL845446 Genomic DNA. Translation: CAI41834.1. AL845446, AL844527 Genomic DNA. Translation: CAI95551.1. CR759733 Genomic DNA. Translation: CAQ10294.1. CR759733 Genomic DNA. Translation: CAQ10296.1. CR936877 Genomic DNA. Translation: CAQ09060.1. CR936877 Genomic DNA. Translation: CAQ09062.1. CH471081 Genomic DNA. Translation: EAX03676.1. BC053886 mRNA. Translation: AAH53886.1. U41069 , U41065, U41066, U41067 Genomic DNA. Translation: AAC17464.1. L18987 mRNA. Translation: AAA35498.1. J04974 mRNA. Translation: AAA52034.1.
IPI	IPI00011283. IPI00219922. IPI00219923. IPI00219924. IPI00219925. IPI00219927. IPI00413940. IPI00748259. IPI00937105.
PIR	CGHU2E. S34790.
RefSeq	NP_001157243.1. NM_001163771.1. NP_542411.2. NM_080680.2. NP_542412.2. NM_080681.2.
UniGene	Hs.390171.
3D structure databases
ProteinModelPortal	P13942.
ModBase	Search...
Protein-protein interaction databases
IntAct	P13942. 1 interaction.
MINT	MINT-5222373.
STRING	9606.ENSP00000414605.
PTM databases
PhosphoSite	P13942.
Polymorphism databases
DMDM	116241308.
Proteomic databases
PaxDb	P13942.
PRIDE	P13942.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341947; ENSP00000339915; ENSG00000204248. ENST00000383087; ENSP00000372565; ENSG00000227801. ENST00000383088; ENSP00000372566; ENSG00000206290. ENST00000395194; ENSP00000378620; ENSG00000204248. ENST00000439039; ENSP00000410284; ENSG00000227801. ENST00000447741; ENSP00000400813; ENSG00000235708. ENST00000452937; ENSP00000406347; ENSG00000230930. ENST00000547261; ENSP00000450150; ENSG00000227801. ENST00000547999; ENSP00000446903; ENSG00000227801. ENST00000549289; ENSP00000448643; ENSG00000227801. ENST00000549381; ENSP00000448464; ENSG00000227801. ENST00000549811; ENSP00000449275; ENSG00000227801. ENST00000550561; ENSP00000449393; ENSG00000227801. ENST00000551542; ENSP00000447864; ENSG00000227801. ENST00000551758; ENSP00000447062; ENSG00000230930.
GeneID	1302.
KEGG	hsa:1302.
UCSC	uc003ocx.1. human. uc003ocy.1. human. uc003ocz.1. human.
Organism-specific databases
CTD	1302.
GeneCards	GC06M033130.
H-InvDB	HIX0033301. HIX0166403. HIX0166658. HIX0166919. HIX0167181. HIX0167416. HIX0184201. HIX0207630.
HGNC	HGNC:2187. COL11A2.
MIM	120290. gene. 184840. phenotype. 215150. phenotype. 277610. phenotype. 601868. phenotype. 609706. phenotype. 614524. phenotype.
neXtProt	NX_P13942.
Orphanet	90635. Autosomal dominant nonsyndromic sensorineural deafness type DFNA. 90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB. 2021. Fibrochondrogenesis. 1427. Otospondylomegaepiphyseal dysplasia. 166100. Stickler syndrome type 3. 3450. Weissenbacher- Zweymuller syndrome.
PharmGKB	PA26703.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000205337.
HOVERGEN	HBG004933.
InParanoid	P13942.
KO	K06236.
Enzyme and pathway databases
Reactome	REACT_118779. Extracellular matrix organization.
Gene expression databases
ArrayExpress	P13942.
Bgee	P13942.
CleanEx	HS_COL11A2.
Genevestigator	P13942.
GermOnline	ENSG00000204248. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR008160. Collagen. IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000885. Fib_collagen_C. IPR001791. Laminin_G. [Graphical view]
Pfam	PF01410. COLFI. 2 hits. PF01391. Collagen. 8 hits. PF02210. Laminin_G_2. 1 hit. [Graphical view]
ProDom	PD002078. Fib_collagen_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00038. COLFI. 1 hit. SM00282. LamG. 1 hit. SM00210. TSPN. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50025. LAM_G_DOMAIN. False negative. PS51461. NC1_FIB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1302.
NextBio	5291.
SOURCE	Search...

Entry information

Entry name

COBA2_HUMAN

Accession

Primary (citable) accession number: P13942
Secondary accession number(s): A6NLX2 , E7ER90, Q07751, Q13271, Q13272, Q13273, Q5JP94, Q5SUI8, Q7Z6C3, Q99866, Q9UIP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 25, 2012
Last modified:	May 1, 2013
This is version 161 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.