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Protein

Collagen alpha-1(III) chain

Gene

Col3a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi1277CalciumBy similarity1
Metal bindingi1279CalciumBy similarity1
Metal bindingi1280Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1282Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1285CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-1442490 Collagen degradation
R-RNO-1474244 Extracellular matrix organization
R-RNO-1650814 Collagen biosynthesis and modifying enzymes
R-RNO-186797 Signaling by PDGF
R-RNO-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-2022090 Assembly of collagen fibrils and other multimeric structures
R-RNO-216083 Integrin cell surface interactions
R-RNO-3000171 Non-integrin membrane-ECM interactions
R-RNO-3000178 ECM proteoglycans
R-RNO-419037 NCAM1 interactions
R-RNO-8874081 MET activates PTK2 signaling
R-RNO-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(III) chain
Gene namesi
Name:Col3a1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi71029 Col3a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
PropeptideiPRO_000000574624 – 154N-terminal propeptideBy similarityAdd BLAST131
ChainiPRO_0000005747155 – 1218Collagen alpha-1(III) chainAdd BLAST1064
PropeptideiPRO_00000434081219 – 1463C-terminal propeptideBy similarityAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2625-hydroxylysine; alternateBy similarity1
Glycosylationi262O-linked (Gal...) hydroxylysine; alternateBy similarity1
Modified residuei2835-hydroxylysineBy similarity1
Modified residuei8595-hydroxylysineBy similarity1
Modified residuei9765-hydroxylysineBy similarity1
Modified residuei10935-hydroxylysineBy similarity1
Modified residuei11055-hydroxylysineBy similarity1
Disulfide bondi1195InterchainPROSITE-ProRule annotation
Disulfide bondi1196InterchainPROSITE-ProRule annotation
Disulfide bondi1259 ↔ 1291PROSITE-ProRule annotation
Disulfide bondi1265Interchain (with C-1282)PROSITE-ProRule annotation
Disulfide bondi1282Interchain (with C-1265)PROSITE-ProRule annotation
Disulfide bondi1299 ↔ 1461PROSITE-ProRule annotation
Disulfide bondi1369 ↔ 1414PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.By similarity
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiP13941
PRIDEiP13941

PTM databases

iPTMnetiP13941
PhosphoSitePlusiP13941

Expressioni

Gene expression databases

BgeeiENSRNOG00000003357
GenevisibleiP13941 RN

Interactioni

Subunit structurei

Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP13941, 1 interactor
STRINGi10116.ENSRNOP00000004956

Structurei

3D structure databases

ProteinModelPortaliP13941
SMRiP13941
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 90VWFCPROSITE-ProRule annotationAdd BLAST60
Domaini1229 – 1463Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni155 – 169Nonhelical region (N-terminal)Add BLAST15
Regioni170 – 1195Triple-helical regionAdd BLAST1026

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140789
HOGENOMiHOG000085654
HOVERGENiHBG004933
InParanoidiP13941
KOiK19720
OMAiCRDLKFC
OrthoDBiEOG091G03LV
TreeFamiTF344135

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 4 hits
PF00093 VWC, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00214 VWC, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSFVQCGTW FLLTLLHPSL ILAQQSNVDE LGCNYLGQSY ESRDVWKPEP
60 70 80 90 100
CQICVCDSGS VLCDDIMCDD EPLDCPNPEI PFGECCAICP QPSTPAPVIP
110 120 130 140 150
DGNRPQGPKG DPGPPGIPGR NGDPGLPGQP GLPGPPGSPG ICESCPTGGQ
160 170 180 190 200
NYSPQFDSYD VKSGVGGMGG YPGPAGPPGP PGPPGSSGHP GSPGSPGYQG
210 220 230 240 250
PPGEPGQAGP AGPPGPPGAI GPSGPAGKDG ESGRPGRPGE RGLPGPPGIK
260 270 280 290 300
GPAGIPGFPG MKGHRGFDGR NGEKGETGAP GLKGENGLPG DNGAPGPMGP
310 320 330 340 350
RGAPGERGRP GLPGAAGARG NDGARGSDGQ PGPPGPPGTA GFPGSPGAKG
360 370 380 390 400
EVGPAGSPGS NGSPGQRGEP GPQGHAGAQG PPGPPGNNGS PGGKGEMGPA
410 420 430 440 450
GIPGAPGLLG ARGPPGPAGA NGAPGQRGPS GEPGKNGAKG EPGARGERGE
460 470 480 490 500
AGSPGIPGPK GEDGKDGSPG EPGANGVPGN PGERGAPGFR GPAGPNGAPG
510 520 530 540 550
EKGPAGERGG PGPAGPRGVA GEPGRDGTPG GPGIRGMPGS PGGPGNDGKP
560 570 580 590 600
GPPGSQGESG RPGPPGPSGP RGQPGVMGFP GPKGNDGAPG KNGERGGPGG
610 620 630 640 650
PGLPGPAGKN GETGPQGPPG PTGAPGDKGD AGPPGPQGLQ GIPGTSGPPG
660 670 680 690 700
ENGKPGEPGP KGEAGAPGVP GGKGDSGAPG ERGPPGTAGT PGLRGGAGPP
710 720 730 740 750
GPEGGKGPAG PPGPPGTSGP PGLQGMPGER GGPGSPGPKG EKGEPGGAGA
760 770 780 790 800
DGVPGKDGPR GPAGPIGPPG PAGQPGDKGE GGAPGLPGIA GPRGGPGERG
810 820 830 840 850
EHGPPGPAGF PGAPGQNGEP GAKGERGAPG EKGEGGPPGA AGPPGGSGPA
860 870 880 890 900
GPPGPQGVKG ERGSPGGPGA AGFPGGRGLP GPPGNNGNPG PPGPSGAPGK
910 920 930 940 950
DGPPGPAGNS GSPGNPGVAG PKGDAGQPGE KGPPGAQGPP GSPGPLGIAG
960 970 980 990 1000
LTGARGLAGP PGMPGPRGSP GPQGIKGESG KPGASGHNGE RGPPGPQGLP
1010 1020 1030 1040 1050
GQPGTAGEPG RDGNPGSDGQ PGRDGSPGGK GDRGENGSPG APGAPGHPGP
1060 1070 1080 1090 1100
PGPVGPSGKN GDRGETGPAG PSGAPGPAGA RGAPGPQGPR GDKGETGERG
1110 1120 1130 1140 1150
SNGIKGHRGF PGNPGPPGSP GAAGHQGAVG SPGPAGPRGP VGPHGPPGKD
1160 1170 1180 1190 1200
GSSGHPGPIG PPGPRGNRGE RGSEGSPGHP GQPGPPGPPG APGPCCGGGA
1210 1220 1230 1240 1250
AIAGVGGEKS GGFSPYYGDD PMDFKINTEE IMSSLKSVNG QIESLISPDG
1260 1270 1280 1290 1300
SRKNPARNCR DLKFCHPELK SGEYWVDPNQ GCKMDAIKVF CNMETGETCI
1310 1320 1330 1340 1350
NASPMTVPRK HWWTDAGAEK KHVWFGESMN GGFQFSYGNP DLPEDVLDVQ
1360 1370 1380 1390 1400
LAFLRLLSSR ASQNITYHCK NSIAYMDQAN GNVKKSLKLM GSNEGEFKAE
1410 1420 1430 1440 1450
GNSKFTYTVL EDGCTKHTGE WSKTVFEYQT RKAMRLPIID IAPYDIGGPD
1460
QEFGVDIGPV CFL
Length:1,463
Mass (Da):138,936
Last modified:December 6, 2005 - v3
Checksum:i63C218CD2BCA47B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1167N → D in CAA06510 (Ref. 3) Curated1
Sequence conflicti1256A → G in CAA06510 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087039 mRNA Translation: AAH87039.1
X70369 mRNA Translation: CAA49832.1
AJ005395 mRNA Translation: CAA06510.1
M21354 mRNA Translation: AAA40942.1
PIRiS41067
RefSeqiNP_114474.1, NM_032085.1
UniGeneiRn.3247

Genome annotation databases

EnsembliENSRNOT00000004956; ENSRNOP00000004956; ENSRNOG00000003357
GeneIDi84032
KEGGirno:84032
UCSCiRGD:71029 rat

Similar proteinsi

Entry informationi

Entry nameiCO3A1_RAT
AccessioniPrimary (citable) accession number: P13941
Secondary accession number(s): O70604, Q5PQT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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