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P13933

- GUN1_STRSS

UniProt

P13933 - GUN1_STRSS

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Protein

Endoglucanase 1

Gene
casA
Organism
Streptomyces sp. (strain KSM-9)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

CMCase I preferentially hydrolyzes carboxymethyl cellulose (CMC).

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

pH dependencei

Optimum pH is 8.5.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei154 – 1541 By similarity
Active sitei192 – 1921Proton donor By similarity
Active sitei339 – 3391Nucleophile By similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH6. Glycoside Hydrolase Family 6.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase 1 (EC:3.2.1.4)
Alternative name(s):
CMCase I
Carboxymethyl cellulase
Cellulase
Endo-1,4-beta-glucanase
Gene namesi
Name:casA
OrganismiStreptomyces sp. (strain KSM-9)
Taxonomic identifieri74575 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 70PRO_0000007907
Signal peptidei1 – ?
Chaini71 – 359289Endoglucanase 1PRO_0000007908Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi155 ↔ 199 By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP13933.
SMRiP13933. Positions 89-358.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.40. 1 hit.
InterProiIPR016288. Beta_cellobiohydrolase.
IPR001524. Glyco_hydro_6_CS.
[Graphical view]
PfamiPF01341. Glyco_hydro_6. 1 hit.
[Graphical view]
PIRSFiPIRSF001100. Beta_cellobiohydrolase. 1 hit.
PRINTSiPR00733. GLHYDRLASE6.
SUPFAMiSSF51989. SSF51989. 1 hit.
PROSITEiPS00655. GLYCOSYL_HYDROL_F6_1. 1 hit.
PS00656. GLYCOSYL_HYDROL_F6_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13933-1 [UniParc]FASTAAdd to Basket

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MENPRTTPTP TPLRRRRSER RARGGRVLTA LTGVTLLAGL AIAPAATGAS    50
PSPAPPASPA PSADSGTADA GTTALPSMEL YRAEAGVHAW LDANPGDHRA 100
PLIAERIGSQ PQAVWFAGAY NPGTITQQVA EVTSAAAAAG QLPVVVPYMI 150
PFRDCGNHSG GGAPSFAAYA EWSGLFAAGL GSEPVVVVLE PDAIPLIDCL 200
DNQQRAERLA ALAGLAEAVT DANPEARVYY DVGHSAWHAP AAIAPTLVEA 250
GILEHGAGIA TNISNYRTTT DETAYASAVI AELGGGLGAV VDTSRNGNGP 300
LGSEWCDPPG RLVGNNPTVN PGVPGVDAFL WIKLPGELDG CDGPVGSFSP 350
AKAYELAGG 359
Length:359
Mass (Da):36,515
Last modified:June 1, 1994 - v3
Checksum:iF1300238834E906C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L03218 Genomic DNA. Translation: AAA26713.1.
X61008 Genomic DNA. Translation: CAA43330.1.
M20921 Genomic DNA. Translation: AAA26776.1. Sequence problems.
PIRiJN0544.
JT0308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L03218 Genomic DNA. Translation: AAA26713.1 .
X61008 Genomic DNA. Translation: CAA43330.1 .
M20921 Genomic DNA. Translation: AAA26776.1 . Sequence problems.
PIRi JN0544.
JT0308.

3D structure databases

ProteinModelPortali P13933.
SMRi P13933. Positions 89-358.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH6. Glycoside Hydrolase Family 6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.40. 1 hit.
InterProi IPR016288. Beta_cellobiohydrolase.
IPR001524. Glyco_hydro_6_CS.
[Graphical view ]
Pfami PF01341. Glyco_hydro_6. 1 hit.
[Graphical view ]
PIRSFi PIRSF001100. Beta_cellobiohydrolase. 1 hit.
PRINTSi PR00733. GLHYDRLASE6.
SUPFAMi SSF51989. SSF51989. 1 hit.
PROSITEi PS00655. GLYCOSYL_HYDROL_F6_1. 1 hit.
PS00656. GLYCOSYL_HYDROL_F6_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and nucleotide sequence of a cellulase gene, casA, from an alkalophilic Streptomyces strain."
    Nakai R., Horinouchi S., Beppu T.
    Gene 65:229-238(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 71-95.
  2. "Endoglucanase CasA from alkalophilic Streptomyces strain KSM-9 is a typical member of family B of beta-1,4-glucanases."
    Damude H.G., Gilkes N.R., Kilburn D.G., Miller R.C. Jr., Warren R.A.
    Gene 123:105-107(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION.
  3. Cited for: PROTEIN SEQUENCE OF 185-222, SEQUENCE REVISION.

Entry informationi

Entry nameiGUN1_STRSS
AccessioniPrimary (citable) accession number: P13933
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 1, 1994
Last modified: October 16, 2013
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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