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Protein

Annexin A8

Gene

ANXA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi266Calcium; via carbonyl oxygen1
Metal bindingi268Calcium; via carbonyl oxygen1
Metal bindingi270Calcium; via carbonyl oxygen1
Metal bindingi310Calcium1

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • calcium-dependent phospholipid binding Source: UniProtKB
  • calcium ion binding Source: UniProtKB
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  • phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB

GO - Biological processi

  • blood coagulation Source: UniProtKB-KW
  • endosomal transport Source: UniProtKB
  • endosome organization Source: UniProtKB
  • negative regulation of phospholipase A2 activity Source: UniProtKB
  • negative regulation of serine-type endopeptidase activity Source: UniProtKB

Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Calcium/phospholipid-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A8Imported
Alternative name(s):
Annexin VIII1 Publication
Annexin-81 Publication
Vascular anticoagulant-beta1 Publication
Short name:
VAC-beta1 Publication
Gene namesi
Name:ANXA8Imported
Synonyms:ANX8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000265190.6
HGNCiHGNC:546 ANXA8
MIMi602396 gene
neXtProtiNX_P13928

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi653145
728113
OpenTargetsiENSG00000265190
PharmGKBiPA134881914
PA24836

Polymorphism and mutation databases

BioMutaiANXA8
DMDMi215274181

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675031 – 327Annexin A8Add BLAST327

Proteomic databases

EPDiP13928
MaxQBiP13928
PaxDbiP13928
PeptideAtlasiP13928
PRIDEiP13928
ProteomicsDBi52998
64350

PTM databases

iPTMnetiP13928
PhosphoSitePlusiP13928

Expressioni

Gene expression databases

BgeeiENSG00000265190
CleanExiHS_ANXA8
ExpressionAtlasiP13928 baseline and differential
GenevisibleiP13928 HS

Organism-specific databases

HPAiHPA045246
HPA047451

Interactioni

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

Protein-protein interaction databases

BioGridi575558, 9 interactors
608549, 9 interactors
IntActiP13928, 7 interactors
MINTiP13928
STRINGi9606.ENSP00000341674

Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 34Combined sources11
Beta strandi35 – 38Combined sources4
Helixi41 – 48Combined sources8
Helixi53 – 67Combined sources15
Helixi71 – 78Combined sources8
Helixi81 – 91Combined sources11
Helixi96 – 107Combined sources12
Beta strandi108 – 110Combined sources3
Helixi113 – 122Combined sources10
Helixi125 – 139Combined sources15
Helixi143 – 150Combined sources8
Helixi153 – 163Combined sources11
Beta strandi167 – 170Combined sources4
Helixi176 – 191Combined sources16
Beta strandi193 – 195Combined sources3
Helixi198 – 207Combined sources10
Helixi210 – 224Combined sources15
Helixi228 – 235Combined sources8
Helixi238 – 252Combined sources15
Helixi254 – 266Combined sources13
Beta strandi267 – 270Combined sources4
Helixi273 – 283Combined sources11
Turni284 – 286Combined sources3
Helixi288 – 299Combined sources12
Helixi303 – 310Combined sources8
Helixi313 – 323Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W3WX-ray1.99A1-327[»]
1W45X-ray2.51A/B1-327[»]
ProteinModelPortaliP13928
SMRiP13928
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13928

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 90Annexin 1Add BLAST61
Repeati102 – 162Annexin 2Add BLAST61
Repeati187 – 247Annexin 3Add BLAST61
Repeati262 – 322Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP13928
KOiK17096
PhylomeDBiP13928
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR009115 ANX8
PANTHERiPTHR10502:SF133 PTHR10502:SF133, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR01808 ANNEXINVIII
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13928-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWWKSWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK
60 70 80 90 100
RSNTQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK
110 120 130 140 150
ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG SSLEEDIQAD
160 170 180 190 200
TSGYLERILV CLLQGSRDDV SSFVDPGLAL QDAQDLYAAG EKIRGTDEMK
210 220 230 240 250
FITILCTRSA THLLRVFEEY EKIANKSIED SIKSETHGSL EEAMLTVVKC
260 270 280 290 300
TQNLHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKCHFKKMYG
310 320
KTLSSMIMED TSGDYKNALL SLVGSDP
Length:327
Mass (Da):36,881
Last modified:November 25, 2008 - v3
Checksum:i5DBBDBB6E723C298
GO
Isoform 2 (identifier: P13928-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-141: DYGS → GQQG
     142-327: Missing.

Note: No experimental confirmation available.
Show »
Length:141
Mass (Da):16,070
Checksum:iD7D3F13E09C28D19
GO
Isoform 3 (identifier: P13928-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-69: Missing.

Note: No experimental confirmation available.
Show »
Length:265
Mass (Da):30,017
Checksum:iE22DABB4F9AEAE6C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32K → Q in BAG59193 (PubMed:14702039).Curated1
Sequence conflicti32K → Q in CAI12203 (PubMed:15164054).Curated1
Sequence conflicti58Q → T in AAB46383 (PubMed:1313714).Curated1
Sequence conflicti83F → L in AAB46383 (PubMed:1313714).Curated1
Sequence conflicti157R → S in AAB46383 (PubMed:1313714).Curated1
Sequence conflicti313 – 314GD → RY in AAB46383 (PubMed:1313714).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0006046S → A1 PublicationCorresponds to variant dbSNP:rs3870786Ensembl.1
Natural variantiVAR_030630177G → A2 PublicationsCorresponds to variant dbSNP:rs3013886Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0578058 – 69Missing in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_056397138 – 141DYGS → GQQG in isoform 2. 1 Publication4
Alternative sequenceiVSP_056398142 – 327Missing in isoform 2. 1 PublicationAdd BLAST186

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16662 mRNA Translation: CAA34650.1
M81844 mRNA Translation: AAB46383.1
AK296573 mRNA Translation: BAG59193.1
AK300158 mRNA Translation: BAG61941.1
AL391137 Genomic DNA Translation: CAI12203.1
AL591684 Genomic DNA No translation available.
BC004376 mRNA Translation: AAH04376.1
BC073755 mRNA Translation: AAH73755.1
CCDSiCCDS73121.1 [P13928-3]
CCDS73122.1 [P13928-1]
PIRiS06476 LUHU8
RefSeqiNP_001035173.1, NM_001040084.2 [P13928-1]
NP_001092315.2, NM_001098845.2
NP_001258631.1, NM_001271702.1
NP_001258632.1, NM_001271703.1 [P13928-3]
UniGeneiHs.535306
Hs.705389
Hs.744068

Genome annotation databases

EnsembliENST00000577813; ENSP00000463244; ENSG00000265190 [P13928-2]
ENST00000583911; ENSP00000463091; ENSG00000265190 [P13928-3]
ENST00000585281; ENSP00000462880; ENSG00000265190 [P13928-1]
GeneIDi653145
728113
KEGGihsa:653145
hsa:728113
UCSCiuc001jev.5 human [P13928-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANXA8_HUMAN
AccessioniPrimary (citable) accession number: P13928
Secondary accession number(s): A6NDE6
, A6NLM1, B4DKI1, B4DTC9, Q5T2P8, Q5VTM4, Q6GMY3, Q9BT34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 25, 2008
Last modified: June 20, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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