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Protein

Plasminogen activator inhibitor 1

Gene

SERPINE1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei369 – 370Reactive bond2

GO - Molecular functioni

  • enzyme inhibitor activity Source: AgBase
  • protease binding Source: Ensembl
  • receptor binding Source: Ensembl
  • serine-type endopeptidase inhibitor activity Source: GO_Central
  • zymogen binding Source: AgBase

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.
R-BTA-3000178. ECM proteoglycans.
R-BTA-75205. Dissolution of Fibrin Clot.

Protein family/group databases

MEROPSiI04.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 1
Short name:
PAI
Short name:
PAI-1
Alternative name(s):
Endothelial plasminogen activator inhibitor
Serpin E1
Gene namesi
Name:SERPINE1
Synonyms:PAI1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000003249824 – 402Plasminogen activator inhibitor 1Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi352N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP13909.
PRIDEiP13909.

Expressioni

Tissue specificityi

Vascular endothelial cells may be the primary site of synthesis of plasma PAI1.

Gene expression databases

BgeeiENSBTAG00000014465.
ExpressionAtlasiP13909. baseline.

Interactioni

Subunit structurei

Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation (By similarity).By similarity

GO - Molecular functioni

  • protease binding Source: Ensembl
  • receptor binding Source: Ensembl
  • zymogen binding Source: AgBase

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019232.

Structurei

3D structure databases

ProteinModelPortaliP13909.
SMRiP13909.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00890000139355.
HOGENOMiHOG000238519.
HOVERGENiHBG106493.
InParanoidiP13909.
KOiK03982.
OMAiPYEKEVP.
OrthoDBiEOG091G0ION.
TreeFamiTF352620.

Family and domain databases

InterProiView protein in InterPro
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00284. SERPIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMSPVFACL ALGLALIFGE GSASYQPQSA AASLATDFGV KVFQQVVRAS
60 70 80 90 100
KDRNVVFSPY GVASVLAMLQ LTTGGETRQQ IQEAMQFKIE EKGMAPAFHR
110 120 130 140 150
LYKELMGPWN KDEISTADAI FVQRDLELVH GFMPNFFRLF RTTVKQVDFS
160 170 180 190 200
EVERARFIVN DWVKRHTKGM ISDLLGEGAV DQLTRLVLVN ALYFNGQWKM
210 220 230 240 250
PFPESNTHHR LFHKSDGSTI SVPMMAQTNK FNYTEFTTPD GRYYDILELP
260 270 280 290 300
YHGNTLSMLI AAPYEKEVPL SALTSILDAE LISQWKGNMT RLTRLLVLPK
310 320 330 340 350
FSLETEIDLR RPLENLGMTD MFRPSQADFS SFSDQEFLYV SQALQKVKIE
360 370 380 390 400
VNESGTLASS STALVVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM

EP
Length:402
Mass (Da):45,371
Last modified:January 1, 1990 - v1
Checksum:i9053617333C7D130
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50S → L (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16383 mRNA. Translation: CAA34419.1.
BT025406 mRNA. Translation: ABF57362.1.
BC103451 mRNA. Translation: AAI03452.1.
X52906 mRNA. Translation: CAA37094.1.
PIRiS06745.
RefSeqiNP_776562.1. NM_174137.2.
XP_010817781.1. XM_010819479.2.
UniGeneiBt.5229.

Genome annotation databases

EnsembliENSBTAT00000019232; ENSBTAP00000019232; ENSBTAG00000014465.
GeneIDi281375.
KEGGibta:281375.

Similar proteinsi

Entry informationi

Entry nameiPAI1_BOVIN
AccessioniPrimary (citable) accession number: P13909
Secondary accession number(s): Q3ZBB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: August 30, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families