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Protein

Plasminogen activator inhibitor 1

Gene

SERPINE1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei369 – 370Reactive bond2

GO - Molecular functioni

  • enzyme inhibitor activity Source: AgBase
  • protease binding Source: Ensembl
  • serine-type endopeptidase inhibitor activity Source: GO_Central
  • signaling receptor binding Source: Ensembl
  • zymogen binding Source: AgBase

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-BTA-114608 Platelet degranulation
R-BTA-3000178 ECM proteoglycans
R-BTA-75205 Dissolution of Fibrin Clot

Protein family/group databases

MEROPSiI04.020

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 1
Short name:
PAI
Short name:
PAI-1
Alternative name(s):
Endothelial plasminogen activator inhibitor
Serpin E1
Gene namesi
Name:SERPINE1
Synonyms:PAI1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:34476 SERPINE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000003249824 – 402Plasminogen activator inhibitor 1Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi352N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP13909
PRIDEiP13909

Expressioni

Tissue specificityi

Vascular endothelial cells may be the primary site of synthesis of plasma PAI1.

Gene expression databases

BgeeiENSBTAG00000014465
ExpressionAtlasiP13909 baseline and differential

Interactioni

Subunit structurei

Forms a heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Interacts with PPP1CB.By similarity

GO - Molecular functioni

  • protease binding Source: Ensembl
  • signaling receptor binding Source: Ensembl
  • zymogen binding Source: AgBase

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019232

Structurei

3D structure databases

ProteinModelPortaliP13909
SMRiP13909
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00900000140788
HOGENOMiHOG000238519
HOVERGENiHBG106493
InParanoidiP13909
KOiK03982
OMAiPYEKEVP
OrthoDBiEOG091G0ION
TreeFamiTF352620

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMSPVFACL ALGLALIFGE GSASYQPQSA AASLATDFGV KVFQQVVRAS
60 70 80 90 100
KDRNVVFSPY GVASVLAMLQ LTTGGETRQQ IQEAMQFKIE EKGMAPAFHR
110 120 130 140 150
LYKELMGPWN KDEISTADAI FVQRDLELVH GFMPNFFRLF RTTVKQVDFS
160 170 180 190 200
EVERARFIVN DWVKRHTKGM ISDLLGEGAV DQLTRLVLVN ALYFNGQWKM
210 220 230 240 250
PFPESNTHHR LFHKSDGSTI SVPMMAQTNK FNYTEFTTPD GRYYDILELP
260 270 280 290 300
YHGNTLSMLI AAPYEKEVPL SALTSILDAE LISQWKGNMT RLTRLLVLPK
310 320 330 340 350
FSLETEIDLR RPLENLGMTD MFRPSQADFS SFSDQEFLYV SQALQKVKIE
360 370 380 390 400
VNESGTLASS STALVVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM

EP
Length:402
Mass (Da):45,371
Last modified:January 1, 1990 - v1
Checksum:i9053617333C7D130
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50S → L (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16383 mRNA Translation: CAA34419.1
BT025406 mRNA Translation: ABF57362.1
BC103451 mRNA Translation: AAI03452.1
X52906 mRNA Translation: CAA37094.1
PIRiS06745
RefSeqiNP_776562.1, NM_174137.2
XP_010817781.1, XM_010819479.2
UniGeneiBt.5229

Genome annotation databases

EnsembliENSBTAT00000019232; ENSBTAP00000019232; ENSBTAG00000014465
GeneIDi281375
KEGGibta:281375

Similar proteinsi

Entry informationi

Entry nameiPAI1_BOVIN
AccessioniPrimary (citable) accession number: P13909
Secondary accession number(s): Q3ZBB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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