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P13908 (ACHN2_CARAU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Neuronal acetylcholine receptor subunit non-alpha-2
Alternative name(s):
GFN-alpha-2
OrganismCarassius auratus (Goldfish)
Taxonomic identifier7957 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Carassius

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subunit structure

Neuronal AChR seems to be composed of two different type of subunits: alpha and beta.

Subcellular location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030
Chain31 – 462432Neuronal acetylcholine receptor subunit non-alpha-2
PRO_0000000393

Regions

Topological domain31 – 234204Extracellular
Transmembrane235 – 25925Helical
Transmembrane267 – 28418Helical
Transmembrane301 – 32222Helical
Topological domain323 – 428106Cytoplasmic
Transmembrane429 – 44618Helical

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation1681N-linked (GlcNAc...) Potential
Disulfide bond155 ↔ 169 By similarity

Sequences

Sequence LengthMass (Da)Tools
P13908 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 306DBDD9E683F3F6

FASTA46253,195
        10         20         30         40         50         60 
MTLAVIGLFT LFTSIIAITP AREFVSLAER EDALLRELFQ GYQRWVRPVQ HANHSVKVRF 

        70         80         90        100        110        120 
GLKISQLVDV DEKNQLMTTN VWLWQEWLDY KLRWNPENYG GITSIRVPSE SIWLPDIVLY 

       130        140        150        160        170        180 
ENADGRFEGS LMTKAIVRYN GMITWTPPAS YKSACTMDVT FFPFDRQNCS MKFGSWTYDG 

       190        200        210        220        230        240 
NMVKLVLINQ QVDRSDFFDN GEWEILSATG VKGSRQDSHL SYPYITYSFI LKRLPLFYTL 

       250        260        270        280        290        300 
FLIIPCLGLS FLTVLVFYLP SDEGEKVSLS TSVLVSLTVF LLVIEEIIPS SSKVIPLIGE 

       310        320        330        340        350        360 
YLLFIMIFVT LSIIVTIFVI NVHHRSSATY HPMSPWVRSL FLQRLPHLLC MRGNTDRYHY 

       370        380        390        400        410        420 
PELEPHSPDL KPRNKKGPPG PEGEGQALIN LLEQATNSVR YISRHIKKEH FIREVVQDWK 

       430        440        450        460 
FVAQVLDRIF LWTFLTVSVL GTILIFTPAL KMFLRTPPPP SP

« Hide

References

[1]"Identification of a novel nicotinic acetylcholine receptor structural subunit expressed in goldfish retina."
Cauley K., Agranoff B.W., Goldman D.
J. Cell Biol. 108:637-645(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X14786 mRNA. Translation: CAA32888.1.
PIRS06893.

3D structure databases

ProteinModelPortalP13908.
SMRP13908. Positions 235-327.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG003756.

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMSSF90112. Neu_channel_TM. 1 hit.
SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACHN2_CARAU
AccessionPrimary (citable) accession number: P13908
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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